3,6,9,12-Tetraoxaoctacosan-1-ol

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  • Identifiers

    CAS number
    5274-63-5

    Molecular formula
    C24H50O5

    SMILES
    CCCCCCCCCCCCCCCCOCCOCCOCCOCCO

    Safety labels

  • Odor profile

    Fragrance
    Waxy 47.11%
    Oily 34.38%
    Odorless 31.42%
    Fatty 29.77%
    Alcoholic 28.79%
    Fresh 28.12%
    Fruity 25.37%
    Sweet 25.34%
    Clean 24.6%
    Amber 19.61%

     

    Flavor
    Waxy 58.28%
    Fatty 41.65%
    Floral 40.67%
    Green 38.29%
    Mushroom 37.83%
    Oily 37.16%
    Rose 33.58%
    Sweet 32.91%
    Fruity 31.95%
    Clean 31.39%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    6.8

    pKa est.
    5.74 (weak acid)

    Molecular weight
    418.7 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    536°C

    Flash point

    • 210.02 ˚C est.

  • Synonyms

    • 5274-63-5
    • 3,6,9,12-Tetraoxaoctacosan-1-ol
    • DTXSID00967189
    • RefChem:198122
    • DTXCID501021052
    • 2-[2-[2-(2-hexadecoxyethoxy)ethoxy]ethoxy]ethanol
    • MFCD00043361
    • Tetraethylenglycolhexadecylether
    • orb1984462
    • SCHEMBL1726619
    • C24H50O5
    • AKOS028111851
    • HY-W096096
    • AS-77328
    • DA-68070
    • SY385516
    • CS-0147753
    • NS00076693
    • D84657
    • C16E4, Hexadecyl tetraethylene glycol ether, Hexadecyltetraglycol
    • 5274-63-5

  • Applications

    3,6,9,12-Tetraoxaoctacosan-1-ol is used as a nonionic surfactant/emulsifier and can function as a cosmetic emollient; it serves as a high-molecular-weight polyether polyol suitable for polyurethane production (including flexible foams, coatings, and elastomers); it can act as a processing aid and plasticizer in polymers and coatings; it is evaluated as an additive in industrial cleaners and formulated detergents; it may be used as a lubricant additive in specialty lubricants.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1.87
    methanol 3.31
    isopropanol 1.61
    water 0.14
    ethyl acetate 25.0
    n-propanol 3.13
    acetone 14.27
    n-butanol 3.37
    acetonitrile 6.8
    DMF 29.52
    toluene 12.02
    isobutanol 3.38
    1,4-dioxane 33.55
    methyl acetate 18.86
    THF 75.86
    2-butanone 20.8
    n-pentanol 4.51
    sec-butanol 4.0
    n-hexane 2.95
    ethylene glycol 0.88
    NMP 135.26
    cyclohexane 19.62
    DMSO 72.85
    n-butyl acetate 33.56
    n-octanol 11.21
    chloroform 131.89
    n-propyl acetate 34.85
    acetic acid 18.83
    dichloromethane 139.79
    cyclohexanone 87.31
    propylene glycol 1.47
    isopropyl acetate 23.29
    DMAc 81.22
    2-ethoxyethanol 16.55
    isopentanol 5.25
    n-heptane 7.0
    ethyl formate 14.54
    1,2-dichloroethane 78.17
    n-hexanol 4.72
    2-methoxyethanol 12.93
    isobutyl acetate 24.14
    tetrachloromethane 36.52
    n-pentyl acetate 63.12
    transcutol 125.45
    n-heptanol 9.26
    ethylbenzene 10.63
    MIBK 18.92
    2-propoxyethanol 16.48
    tert-butanol 4.81
    MTBE 12.67
    2-butoxyethanol 29.85
    propionic acid 14.29
    o-xylene 16.3
    formic acid 7.08
    diethyl ether 9.74
    m-xylene 11.08
    p-xylene 15.58
    chlorobenzene 25.09
    dimethyl carbonate 13.13
    n-octane 3.49
    formamide 12.17
    cyclopentanone 86.06
    2-pentanone 19.14
    anisole 21.76
    cyclopentyl methyl ether 50.55
    gamma-butyrolactone 98.71
    1-methoxy-2-propanol 13.05
    pyridine 38.47
    3-pentanone 25.25
    furfural 83.19
    n-dodecane 1.92
    diethylene glycol 8.2
    diisopropyl ether 7.93
    tert-amyl alcohol 8.88
    acetylacetone 40.19
    n-hexadecane 2.33
    acetophenone 39.1
    methyl propionate 22.88
    isopentyl acetate 34.29
    trichloroethylene 148.87
    n-nonanol 12.49
    cyclohexanol 16.32
    benzyl alcohol 13.12
    2-ethylhexanol 10.05
    isooctanol 10.95
    dipropyl ether 26.47
    1,2-dichlorobenzene 43.32
    ethyl lactate 20.97
    propylene carbonate 60.46
    n-methylformamide 12.36
    2-pentanol 3.86
    n-pentane 1.81
    1-propoxy-2-propanol 22.51
    1-methoxy-2-propyl acetate 38.82
    2-(2-methoxypropoxy) propanol 38.62
    mesitylene 11.01
    ε-caprolactone 89.6
    p-cymene 14.03
    epichlorohydrin 94.91
    1,1,1-trichloroethane 83.75
    2-aminoethanol 2.31
    morpholine-4-carbaldehyde 76.77
    sulfolane 237.85
    2,2,4-trimethylpentane 3.59
    2-methyltetrahydrofuran 52.73
    n-hexyl acetate 49.02
    isooctane 1.47
    2-(2-butoxyethoxy)ethanol 42.14
    sec-butyl acetate 29.1
    tert-butyl acetate 39.89
    decalin 8.43
    glycerin 4.77
    diglyme 122.58
    acrylic acid 13.64
    isopropyl myristate 18.52
    n-butyric acid 23.78
    acetyl acetate 31.18
    di(2-ethylhexyl) phthalate 17.84
    ethyl propionate 34.28
    nitromethane 46.06
    1,2-diethoxyethane 50.84
    benzonitrile 19.44
    trioctyl phosphate 13.42
    1-bromopropane 29.66
    gamma-valerolactone 119.19
    n-decanol 7.85
    triethyl phosphate 43.9
    4-methyl-2-pentanol 4.14
    propionitrile 7.58
    vinylene carbonate 51.65
    1,1,2-trichlorotrifluoroethane 97.38
    DMS 34.56
    cumene 9.96
    2-octanol 9.04
    2-hexanone 25.24
    octyl acetate 22.66
    limonene 24.09
    1,2-dimethoxyethane 46.34
    ethyl orthosilicate 42.64
    tributyl phosphate 19.54
    diacetone alcohol 30.84
    N,N-dimethylaniline 22.6
    acrylonitrile 10.34
    aniline 12.41
    1,3-propanediol 3.56
    bromobenzene 33.2
    dibromomethane 79.14
    1,1,2,2-tetrachloroethane 154.52
    2-methyl-cyclohexyl acetate 48.18
    tetrabutyl urea 30.72
    diisobutyl methanol 9.28
    2-phenylethanol 12.77
    styrene 11.18
    dioctyl adipate 39.56
    dimethyl sulfate 47.4
    ethyl butyrate 48.54
    methyl lactate 13.66
    butyl lactate 40.29
    diethyl carbonate 32.99
    propanediol butyl ether 20.47
    triethyl orthoformate 55.89
    p-tert-butyltoluene 12.98
    methyl 4-tert-butylbenzoate 56.96
    morpholine 38.98
    tert-butylamine 4.13
    n-dodecanol 5.65
    dimethoxymethane 19.37
    ethylene carbonate 45.44
    cyrene 50.01
    2-ethoxyethyl acetate 69.87
    2-ethylhexyl acetate 36.26
    1,2,4-trichlorobenzene 57.11
    4-methylpyridine 28.56
    dibutyl ether 31.56
    2,6-dimethyl-4-heptanol 9.28
    DEF 41.75
    dimethyl isosorbide 100.08
    tetrachloroethylene 104.03
    eugenol 42.19
    triacetin 90.57
    span 80 31.49
    1,4-butanediol 2.43
    1,1-dichloroethane 43.46
    2-methyl-1-pentanol 7.07
    methyl formate 11.24
    2-methyl-1-butanol 5.81
    n-decane 4.58
    butyronitrile 7.69
    3,7-dimethyl-1-octanol 12.86
    1-chlorooctane 18.26
    1-chlorotetradecane 5.58
    n-nonane 4.42
    undecane 2.73
    tert-butylcyclohexane 5.25
    cyclooctane 7.32
    cyclopentanol 15.45
    tetrahydropyran 41.41
    tert-amyl methyl ether 19.26
    2,5,8-trioxanonane 73.36
    1-hexene 5.47
    2-isopropoxyethanol 14.87
    2,2,2-trifluoroethanol 17.67
    methyl butyrate 44.79

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction