3,5-Dimethyl-2-propylpyrazine

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  • Identifiers

    CAS number
    32350-16-6

    Molecular formula
    C9H14N2

    SMILES
    CCCC1=NC=C(N=C1C)C

  • Odor profile

    Fragrance
    Nutty 69.03%
    Roasted 63.48%
    Earthy 56.34%
    Hazelnut 53.1%
    Cocoa 52.03%
    Burnt 51.44%
    Musty 50.24%
    Chocolate 42.87%
    Coffee 41.78%
    Potato 38.5%

     

    Flavor
    Nutty 61.57%
    Roasted 58.84%
    Earthy 55.59%
    Potato 50.01%
    Musty 47.15%
    Meaty 46.82%
    Hazelnut 44.71%
    Roast 44.19%
    Cocoa 43.18%
    Coffee 43.07%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.7

    pKa est.
    4.71 (weak acid)

    Molecular weight
    150.22 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Boiling point est.
    218°C

    Flash point

    • 82.76 ˚C est.

  • Synonyms

    • 3,5-Dimethyl-2-propylpyrazine
    • 32350-16-6
    • 2,6-Dimethyl-3-propylpyrazine
    • EINECS 251-006-7
    • 2-Propyl-3,5(3,6)-dimethylpyrazine
    • 2,6-Dimethyl-3-pyropylpyrazine
    • Pyrazine, 3,5-dimethyl-2-propyl-
    • 2,6-Dimethyl-3-propyl-Pyrazine
    • DTXSID20186072
    • Pyrazine, 2,6-dimethyl-3-propyl-
    • 3,5-DIMETHYL-2-PROPYL-PYRAZINE
    • dimethylpropylpyrazine
    • SCHEMBL7156533
    • DTXCID30108563
    • CHEBI:193683
    • AKOS006272105
    • HS-3535
    • DB-261960
    • NS00029265
    • EN300-6768682
    • 251-006-7

  • Applications

    3,5-Dimethyl-2-propylpyrazine (CAS 32350-16-6) is primarily used as an odorant and flavor/fragrance precursor in industry: in perfumery and fragrance formulations to impart savory, roasted, and nutty notes; in the food flavor sector as a flavoring agent contributing meat-like and roasted profiles; in cosmetics and personal care as a fragrance ingredient; in household products such as air fresheners and cleaners to provide a lasting aroma; and as an intermediate in industrial manufacturing for the synthesis of specialty flavors and fragrance compounds.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 546.82
    methanol 815.73
    isopropanol 364.42
    water 3.34
    ethyl acetate 412.06
    n-propanol 495.29
    acetone 446.44
    n-butanol 525.71
    acetonitrile 334.51
    DMF 684.75
    toluene 432.0
    isobutanol 460.29
    1,4-dioxane 764.37
    methyl acetate 364.39
    THF 953.93
    2-butanone 441.54
    n-pentanol 425.31
    sec-butanol 429.02
    n-hexane 252.72
    ethylene glycol 131.41
    NMP 766.4
    cyclohexane 318.83
    DMSO 521.06
    n-butyl acetate 599.24
    n-octanol 288.63
    chloroform 2191.41
    n-propyl acetate 294.47
    acetic acid 532.7
    dichloromethane 1772.27
    cyclohexanone 872.62
    propylene glycol 154.52
    isopropyl acetate 269.43
    DMAc 607.15
    2-ethoxyethanol 379.06
    isopentanol 467.64
    n-heptane 145.85
    ethyl formate 387.85
    1,2-dichloroethane 891.66
    n-hexanol 619.72
    2-methoxyethanol 561.76
    isobutyl acetate 239.36
    tetrachloromethane 528.49
    n-pentyl acetate 337.21
    transcutol 763.3
    n-heptanol 278.38
    ethylbenzene 248.65
    MIBK 277.62
    2-propoxyethanol 611.92
    tert-butanol 404.76
    MTBE 498.47
    2-butoxyethanol 352.22
    propionic acid 381.84
    o-xylene 281.18
    formic acid 214.74
    diethyl ether 559.64
    m-xylene 291.58
    p-xylene 338.63
    chlorobenzene 665.05
    dimethyl carbonate 173.41
    n-octane 68.33
    formamide 172.8
    cyclopentanone 781.44
    2-pentanone 394.56
    anisole 321.04
    cyclopentyl methyl ether 582.89
    gamma-butyrolactone 852.84
    1-methoxy-2-propanol 369.66
    pyridine 688.02
    3-pentanone 386.69
    furfural 793.88
    n-dodecane 50.42
    diethylene glycol 361.4
    diisopropyl ether 190.41
    tert-amyl alcohol 446.16
    acetylacetone 364.88
    n-hexadecane 57.15
    acetophenone 302.36
    methyl propionate 331.94
    isopentyl acetate 506.15
    trichloroethylene 1623.84
    n-nonanol 233.39
    cyclohexanol 533.42
    benzyl alcohol 308.21
    2-ethylhexanol 418.09
    isooctanol 220.18
    dipropyl ether 373.19
    1,2-dichlorobenzene 589.72
    ethyl lactate 163.4
    propylene carbonate 567.96
    n-methylformamide 340.13
    2-pentanol 342.89
    n-pentane 181.84
    1-propoxy-2-propanol 412.69
    1-methoxy-2-propyl acetate 350.36
    2-(2-methoxypropoxy) propanol 255.29
    mesitylene 193.02
    ε-caprolactone 675.0
    p-cymene 198.44
    epichlorohydrin 859.82
    1,1,1-trichloroethane 933.31
    2-aminoethanol 238.11
    morpholine-4-carbaldehyde 641.86
    sulfolane 910.18
    2,2,4-trimethylpentane 110.04
    2-methyltetrahydrofuran 771.49
    n-hexyl acetate 441.04
    isooctane 67.61
    2-(2-butoxyethoxy)ethanol 324.48
    sec-butyl acetate 215.65
    tert-butyl acetate 275.59
    decalin 138.13
    glycerin 202.97
    diglyme 570.53
    acrylic acid 336.4
    isopropyl myristate 168.72
    n-butyric acid 569.13
    acetyl acetate 292.01
    di(2-ethylhexyl) phthalate 182.44
    ethyl propionate 261.25
    nitromethane 490.58
    1,2-diethoxyethane 411.02
    benzonitrile 503.05
    trioctyl phosphate 137.68
    1-bromopropane 706.13
    gamma-valerolactone 838.7
    n-decanol 170.97
    triethyl phosphate 168.01
    4-methyl-2-pentanol 206.31
    propionitrile 412.94
    vinylene carbonate 553.21
    1,1,2-trichlorotrifluoroethane 578.08
    DMS 281.86
    cumene 193.28
    2-octanol 205.27
    2-hexanone 352.45
    octyl acetate 217.02
    limonene 301.53
    1,2-dimethoxyethane 615.84
    ethyl orthosilicate 179.48
    tributyl phosphate 177.66
    diacetone alcohol 263.85
    N,N-dimethylaniline 262.77
    acrylonitrile 426.82
    aniline 407.19
    1,3-propanediol 337.7
    bromobenzene 752.13
    dibromomethane 1251.03
    1,1,2,2-tetrachloroethane 1360.34
    2-methyl-cyclohexyl acetate 290.04
    tetrabutyl urea 211.18
    diisobutyl methanol 186.61
    2-phenylethanol 377.87
    styrene 303.5
    dioctyl adipate 216.29
    dimethyl sulfate 265.26
    ethyl butyrate 332.94
    methyl lactate 168.09
    butyl lactate 240.97
    diethyl carbonate 225.07
    propanediol butyl ether 280.13
    triethyl orthoformate 241.03
    p-tert-butyltoluene 186.31
    methyl 4-tert-butylbenzoate 268.35
    morpholine 723.61
    tert-butylamine 347.83
    n-dodecanol 133.15
    dimethoxymethane 436.84
    ethylene carbonate 466.32
    cyrene 252.92
    2-ethoxyethyl acetate 333.19
    2-ethylhexyl acetate 433.7
    1,2,4-trichlorobenzene 624.33
    4-methylpyridine 738.12
    dibutyl ether 353.59
    2,6-dimethyl-4-heptanol 186.61
    DEF 541.62
    dimethyl isosorbide 426.72
    tetrachloroethylene 1061.14
    eugenol 277.74
    triacetin 271.67
    span 80 256.24
    1,4-butanediol 194.05
    1,1-dichloroethane 881.55
    2-methyl-1-pentanol 422.05
    methyl formate 320.58
    2-methyl-1-butanol 524.19
    n-decane 84.09
    butyronitrile 527.48
    3,7-dimethyl-1-octanol 254.0
    1-chlorooctane 262.2
    1-chlorotetradecane 105.15
    n-nonane 93.98
    undecane 63.04
    tert-butylcyclohexane 128.43
    cyclooctane 113.86
    cyclopentanol 487.74
    tetrahydropyran 875.1
    tert-amyl methyl ether 418.59
    2,5,8-trioxanonane 365.63
    1-hexene 478.75
    2-isopropoxyethanol 272.07
    2,2,2-trifluoroethanol 189.1
    methyl butyrate 377.96

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction