3,5-Dimethoxyphenol

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  • Identifiers

    CAS number
    500-99-2

    Molecular formula
    C8H10O3

    SMILES
    COC1=CC(=CC(=C1)O)OC

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 72.73%
    Phenolic 62.41%
    Fruity 53.52%
    Vanilla 45.4%
    Spicy 41.71%
    Woody 39.82%
    Medicinal 36.06%
    Nutty 34.27%
    Powdery 33.67%
    Smoky 32.9%

     

    Flavor
    Bitter 37.72%
    Phenolic 30.78%
    Musty 27.35%
    Fruity 26.97%
    Spice 23.82%
    Woody 23.07%
    Eugenol 22.86%
    Smoky 22.3%
    Parsley 21.89%
    Creamy 21.78%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.6

    pKa est.
    8.67 (weak base)

    Molecular weight
    154.16 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    283°C

    Flash point

    • 107.09 ˚C est.

  • Synonyms

    • 3,5-Dimethoxyphenol
    • 500-99-2
    • Taxicatigenin
    • Phenol, 3,5-dimethoxy-
    • Phloroglucinol dimethyl ether
    • 1-Hydroxy-3,5-dimethoxybenzene
    • 23UXW8136A
    • NSC-70955
    • DTXSID7075426
    • phloroglucindimethylether
    • RefChem:486902
    • 1,3-dimethoxy-5-hydroxybenzene
    • DTXCID3040772
    • 207-917-7
    • MFCD00008388
    • 3,5-dimethoxy phenol
    • UNII-23UXW8136A
    • 35-Dimethoxyphenol
    • EINECS 207-917-7
    • NSC 70955
    • Phenol,5-dimethoxy-
    • 3,5-dimethoxy-phenol
    • 3 pound not5-Dimethoxyphenol
    • 3,5-Dimethoxyphenol, 99%
    • SCHEMBL233828
    • SCHEMBL233829
    • CHEMBL462989
    • orb1299819
    • SCHEMBL3932720
    • SCHEMBL5871900
    • CHEBI:88715
    • HMS1715K12
    • NSC70955
    • STR06179
    • BBL101113
    • s6071
    • SBB071724
    • STL554909
    • XH0635
    • AKOS000121581
    • CS-W001117
    • EBC-152031
    • FD37978
    • HY-W001117
    • 1-3-5-TRIMETHOXYBENZENE_met001
    • AC-11324
    • SY035504
    • DB-022082
    • NS00032004
    • P0320
    • ST45026898
    • EN300-16614
    • F17066
    • F013047
    • 3,5-Dimethoxyphenol(Discontinued,See C4X-221728)
    • Q27160623
    • Z56347218
    • F0001-1304
    • InChI=1/C8H10O3/c1-10-7-3-6(9)4-8(5-7)11-2/h3-5,9H,1-2H
    • 500-99-2

  • Applications

    3,5-Dimethoxyphenol (CAS 500-99-2) is used primarily as an aromatic building block in fragrance and flavor chemistry, serving as an intermediate for synthesizing other methoxyphenol-derived aroma compounds. It is also encountered as a precursor in cosmetics and personal care ingredient development, and may be used in household products as a fragrance component. In industrial manufacturing, it can be employed to prepare specialty resins and coating systems, while in polymers and plastics it may function as an antioxidant or stabilizer additive. Additionally, it serves as a chemical starting point for further synthesis of methoxyphenol derivatives used in coatings/inks.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 340.15
    methanol 503.21
    isopropanol 239.75
    water 10.73
    ethyl acetate 202.89
    n-propanol 234.47
    acetone 435.25
    n-butanol 165.12
    acetonitrile 303.49
    DMF 1263.0
    toluene 52.85
    isobutanol 154.91
    1,4-dioxane 492.05
    methyl acetate 318.37
    THF 712.08
    2-butanone 221.34
    n-pentanol 92.4
    sec-butanol 142.67
    n-hexane 8.13
    ethylene glycol 409.41
    NMP 467.74
    cyclohexane 20.57
    DMSO 1359.74
    n-butyl acetate 56.14
    n-octanol 57.94
    chloroform 359.01
    n-propyl acetate 77.03
    acetic acid 228.91
    dichloromethane 343.41
    cyclohexanone 223.9
    propylene glycol 360.66
    isopropyl acetate 79.68
    DMAc 697.79
    2-ethoxyethanol 259.56
    isopentanol 91.93
    n-heptane 12.92
    ethyl formate 265.49
    1,2-dichloroethane 209.25
    n-hexanol 104.76
    2-methoxyethanol 821.98
    isobutyl acetate 45.13
    tetrachloromethane 77.86
    n-pentyl acetate 39.0
    transcutol 200.63
    n-heptanol 47.68
    ethylbenzene 32.12
    MIBK 74.41
    2-propoxyethanol 274.07
    tert-butanol 256.84
    MTBE 95.18
    2-butoxyethanol 105.26
    propionic acid 244.79
    o-xylene 47.49
    formic acid 193.29
    diethyl ether 117.32
    m-xylene 45.41
    p-xylene 41.35
    chlorobenzene 80.43
    dimethyl carbonate 190.01
    n-octane 6.09
    formamide 333.92
    cyclopentanone 393.57
    2-pentanone 153.34
    anisole 107.51
    cyclopentyl methyl ether 189.71
    gamma-butyrolactone 496.47
    1-methoxy-2-propanol 474.86
    pyridine 209.1
    3-pentanone 128.19
    furfural 400.88
    n-dodecane 7.3
    diethylene glycol 383.28
    diisopropyl ether 25.99
    tert-amyl alcohol 135.97
    acetylacetone 220.75
    n-hexadecane 8.18
    acetophenone 97.14
    methyl propionate 271.22
    isopentyl acetate 44.66
    trichloroethylene 334.25
    n-nonanol 50.72
    cyclohexanol 153.31
    benzyl alcohol 117.57
    2-ethylhexanol 50.9
    isooctanol 36.6
    dipropyl ether 60.73
    1,2-dichlorobenzene 78.36
    ethyl lactate 96.61
    propylene carbonate 214.33
    n-methylformamide 612.37
    2-pentanol 82.0
    n-pentane 10.52
    1-propoxy-2-propanol 136.54
    1-methoxy-2-propyl acetate 107.07
    2-(2-methoxypropoxy) propanol 91.44
    mesitylene 29.43
    ε-caprolactone 180.11
    p-cymene 26.53
    epichlorohydrin 445.03
    1,1,1-trichloroethane 200.62
    2-aminoethanol 369.95
    morpholine-4-carbaldehyde 523.34
    sulfolane 565.62
    2,2,4-trimethylpentane 6.71
    2-methyltetrahydrofuran 246.53
    n-hexyl acetate 65.16
    isooctane 5.29
    2-(2-butoxyethoxy)ethanol 122.28
    sec-butyl acetate 40.94
    tert-butyl acetate 79.16
    decalin 11.77
    glycerin 497.15
    diglyme 234.07
    acrylic acid 239.63
    isopropyl myristate 32.71
    n-butyric acid 207.03
    acetyl acetate 121.92
    di(2-ethylhexyl) phthalate 39.84
    ethyl propionate 89.87
    nitromethane 620.7
    1,2-diethoxyethane 65.58
    benzonitrile 111.94
    trioctyl phosphate 34.98
    1-bromopropane 92.53
    gamma-valerolactone 453.9
    n-decanol 40.67
    triethyl phosphate 51.39
    4-methyl-2-pentanol 43.53
    propionitrile 199.34
    vinylene carbonate 217.08
    1,1,2-trichlorotrifluoroethane 451.81
    DMS 95.67
    cumene 25.58
    2-octanol 33.18
    2-hexanone 72.3
    octyl acetate 46.6
    limonene 38.19
    1,2-dimethoxyethane 375.22
    ethyl orthosilicate 41.27
    tributyl phosphate 37.51
    diacetone alcohol 153.37
    N,N-dimethylaniline 78.3
    acrylonitrile 292.95
    aniline 124.64
    1,3-propanediol 389.2
    bromobenzene 76.24
    dibromomethane 204.2
    1,1,2,2-tetrachloroethane 308.17
    2-methyl-cyclohexyl acetate 48.5
    tetrabutyl urea 53.53
    diisobutyl methanol 33.46
    2-phenylethanol 92.1
    styrene 39.89
    dioctyl adipate 54.42
    dimethyl sulfate 362.95
    ethyl butyrate 60.35
    methyl lactate 247.02
    butyl lactate 55.59
    diethyl carbonate 55.02
    propanediol butyl ether 109.75
    triethyl orthoformate 45.95
    p-tert-butyltoluene 28.46
    methyl 4-tert-butylbenzoate 90.78
    morpholine 510.42
    tert-butylamine 111.87
    n-dodecanol 33.42
    dimethoxymethane 573.84
    ethylene carbonate 171.36
    cyrene 130.94
    2-ethoxyethyl acetate 65.33
    2-ethylhexyl acetate 34.08
    1,2,4-trichlorobenzene 92.11
    4-methylpyridine 182.37
    dibutyl ether 40.5
    2,6-dimethyl-4-heptanol 33.46
    DEF 244.07
    dimethyl isosorbide 146.81
    tetrachloroethylene 199.24
    eugenol 87.2
    triacetin 79.47
    span 80 81.39
    1,4-butanediol 157.86
    1,1-dichloroethane 196.04
    2-methyl-1-pentanol 53.51
    methyl formate 572.91
    2-methyl-1-butanol 93.9
    n-decane 10.16
    butyronitrile 159.84
    3,7-dimethyl-1-octanol 43.8
    1-chlorooctane 33.92
    1-chlorotetradecane 17.31
    n-nonane 9.41
    undecane 8.37
    tert-butylcyclohexane 11.28
    cyclooctane 8.02
    cyclopentanol 234.62
    tetrahydropyran 253.17
    tert-amyl methyl ether 73.52
    2,5,8-trioxanonane 173.13
    1-hexene 27.18
    2-isopropoxyethanol 134.51
    2,2,2-trifluoroethanol 170.44
    methyl butyrate 124.81

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction