3,5-Dihydroxyphenyl beta-D-glucopyranoside

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  • Identifiers

    CAS number
    28217-60-9

    Molecular formula
    C12H16O8

    SMILES
    C1=C(C=C(C=C1O)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 76.24%
    Phenolic 28.32%
    Sweet 25.86%
    Vanilla 24.56%
    Savory 19.67%
    Bitter 18.75%
    Milky 18.62%
    Smoky 17.7%
    Burnt 17.24%
    Creamy 17.14%

     

    Flavor
    Bitter 58.94%
    Odorless 43.07%
    Sweet-like 30.37%
    Bland 29.87%
    Sweet 27.27%
    Very mild 22.06%
    Mild 21.95%
    Very slight 21.4%
    Eugenol 20.64%
    Cauliflower 20.6%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -1.2

    pKa est.
    7.54 (neutral)

    Molecular weight
    288.25 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    1651°C

    Flash point

    • 267.87 ˚C est.

  • Synonyms

    • 28217-60-9
    • 3,5-Dihydroxyphenyl beta-D-glucopyranoside
    • RefChem:271799
    • (2S,3R,4S,5S,6R)-2-(3,5-dihydroxyphenoxy)-6-(hydroxymethyl)oxane-3,4,5-triol
    • orb1681095
    • SCHEMBL8657183
    • DTXSID901279756
    • HY-N3079
    • AKOS032948575
    • FS-9709
    • phloroglucinol 1-beta-d-glucopyranoside
    • 3,5-Dihydroxyphenyl I(2)-D-glucopyranoside
    • CS-0023174
    • Phloroglucinol-1-O-.beta.-D-glucopyranoside
    • Phloroglucinol 1-O--D-glucopyranoside; Phloroglucinol 1-O--D-glucoside
    • (2S,3R,4S,5S,6R)-2-(3,5-dihydroxyphenoxy)-6-(hydroxymethyl)tetrahydropyran-3,4,5-triol
    • 28217-60-9

  • Applications

    3,5-Dihydroxyphenyl beta-D-glucopyranoside (CAS 28217-60-9) is primarily used as a synthetic intermediate for polyphenol-derived derivatives in industrial manufacturing. It can be incorporated into cosmetic and personal care formulations as a glycosylated phenol derivative. In pharmaceutical and agrochemical research, it serves as a glycoside building block for the synthesis of related compounds. In polymer and biomaterial contexts, it may act as an antioxidant precursor or stabilizing additive to improve formulation durability.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2.17
    methanol 16.32
    isopropanol 0.83
    water 22.76
    ethyl acetate 0.12
    n-propanol 1.32
    acetone 0.43
    n-butanol 0.72
    acetonitrile 0.2
    DMF 71.48
    toluene 0.07
    isobutanol 0.46
    1,4-dioxane 0.98
    methyl acetate 0.16
    THF 2.79
    2-butanone 0.4
    n-pentanol 0.37
    sec-butanol 0.75
    n-hexane 0.02
    ethylene glycol 53.26
    NMP 67.39
    cyclohexane 0.09
    DMSO 297.96
    n-butyl acetate 0.18
    n-octanol 0.58
    chloroform 0.01
    n-propyl acetate 0.12
    acetic acid 9.33
    dichloromethane 0.01
    cyclohexanone 1.28
    propylene glycol 36.68
    isopropyl acetate 0.14
    DMAc 52.2
    2-ethoxyethanol 10.54
    isopentanol 0.52
    n-heptane 0.13
    ethyl formate 0.28
    1,2-dichloroethane 0.03
    n-hexanol 0.78
    2-methoxyethanol 43.04
    isobutyl acetate 0.06
    tetrachloromethane 0.02
    n-pentyl acetate 0.23
    transcutol 17.01
    n-heptanol 0.89
    ethylbenzene 0.05
    MIBK 0.38
    2-propoxyethanol 9.08
    tert-butanol 1.4
    MTBE 0.17
    2-butoxyethanol 5.04
    propionic acid 2.31
    o-xylene 0.15
    formic acid 143.55
    diethyl ether 0.18
    m-xylene 0.11
    p-xylene 0.05
    chlorobenzene 0.01
    dimethyl carbonate 1.11
    n-octane 0.05
    formamide 111.69
    cyclopentanone 2.17
    2-pentanone 0.38
    anisole 0.17
    cyclopentyl methyl ether 0.94
    gamma-butyrolactone 3.29
    1-methoxy-2-propanol 22.82
    pyridine 0.43
    3-pentanone 0.36
    furfural 4.55
    n-dodecane 0.03
    diethylene glycol 32.35
    diisopropyl ether 0.09
    tert-amyl alcohol 1.29
    acetylacetone 0.93
    n-hexadecane 0.03
    acetophenone 0.42
    methyl propionate 0.54
    isopentyl acetate 0.21
    trichloroethylene 0.04
    n-nonanol 0.61
    cyclohexanol 1.33
    benzyl alcohol 0.55
    2-ethylhexanol 0.42
    isooctanol 0.61
    dipropyl ether 0.55
    1,2-dichlorobenzene 0.02
    ethyl lactate 2.04
    propylene carbonate 0.95
    n-methylformamide 20.56
    2-pentanol 0.48
    n-pentane 0.04
    1-propoxy-2-propanol 5.19
    1-methoxy-2-propyl acetate 1.53
    2-(2-methoxypropoxy) propanol 6.92
    mesitylene 0.1
    ε-caprolactone 1.4
    p-cymene 0.13
    epichlorohydrin 0.71
    1,1,1-trichloroethane 0.01
    2-aminoethanol 40.76
    morpholine-4-carbaldehyde 32.39
    sulfolane 34.81
    2,2,4-trimethylpentane 0.02
    2-methyltetrahydrofuran 0.61
    n-hexyl acetate 0.4
    isooctane 0.02
    2-(2-butoxyethoxy)ethanol 8.34
    sec-butyl acetate 0.08
    tert-butyl acetate 0.4
    decalin 0.03
    glycerin 143.8
    diglyme 12.26
    acrylic acid 5.2
    isopropyl myristate 0.21
    n-butyric acid 1.12
    acetyl acetate 0.14
    di(2-ethylhexyl) phthalate 0.56
    ethyl propionate 0.17
    nitromethane 7.42
    1,2-diethoxyethane 0.61
    benzonitrile 0.14
    trioctyl phosphate 0.54
    1-bromopropane 0.02
    gamma-valerolactone 8.88
    n-decanol 0.47
    triethyl phosphate 0.54
    4-methyl-2-pentanol 0.36
    propionitrile 0.21
    vinylene carbonate 0.79
    1,1,2-trichlorotrifluoroethane 11.1
    DMS 0.53
    cumene 0.05
    2-octanol 0.41
    2-hexanone 0.19
    octyl acetate 0.34
    limonene 0.25
    1,2-dimethoxyethane 4.96
    ethyl orthosilicate 0.46
    tributyl phosphate 0.46
    diacetone alcohol 4.7
    N,N-dimethylaniline 0.4
    acrylonitrile 0.51
    aniline 0.29
    1,3-propanediol 16.98
    bromobenzene 0.01
    dibromomethane 0.01
    1,1,2,2-tetrachloroethane 0.08
    2-methyl-cyclohexyl acetate 0.41
    tetrabutyl urea 1.22
    diisobutyl methanol 0.37
    2-phenylethanol 0.65
    styrene 0.03
    dioctyl adipate 0.54
    dimethyl sulfate 6.25
    ethyl butyrate 0.31
    methyl lactate 9.85
    butyl lactate 1.6
    diethyl carbonate 0.21
    propanediol butyl ether 8.18
    triethyl orthoformate 0.52
    p-tert-butyltoluene 0.15
    methyl 4-tert-butylbenzoate 2.14
    morpholine 3.0
    tert-butylamine 0.41
    n-dodecanol 0.34
    dimethoxymethane 8.16
    ethylene carbonate 0.49
    cyrene 13.53
    2-ethoxyethyl acetate 0.46
    2-ethylhexyl acetate 0.15
    1,2,4-trichlorobenzene 0.04
    4-methylpyridine 0.24
    dibutyl ether 0.23
    2,6-dimethyl-4-heptanol 0.37
    DEF 2.68
    dimethyl isosorbide 9.61
    tetrachloroethylene 0.09
    eugenol 2.98
    triacetin 1.41
    span 80 5.16
    1,4-butanediol 5.12
    1,1-dichloroethane 0.01
    2-methyl-1-pentanol 0.29
    methyl formate 5.73
    2-methyl-1-butanol 0.54
    n-decane 0.06
    butyronitrile 0.14
    3,7-dimethyl-1-octanol 0.45
    1-chlorooctane 0.09
    1-chlorotetradecane 0.05
    n-nonane 0.05
    undecane 0.04
    tert-butylcyclohexane 0.02
    cyclooctane 0.06
    cyclopentanol 1.62
    tetrahydropyran 0.47
    tert-amyl methyl ether 0.37
    2,5,8-trioxanonane 11.84
    1-hexene 0.04
    2-isopropoxyethanol 2.97
    2,2,2-trifluoroethanol 6.57
    methyl butyrate 0.28

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction