3,5-Dihydroxybenzaldehyde

Overview IFRA Request a quote

  • Identifiers

    CAS number
    26153-38-8

    Molecular formula
    C7H6O3

    SMILES
    C1=C(C=C(C=C1O)O)C=O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Phenolic 54.55%
    Odorless 46.94%
    Burnt 36.0%
    Nutty 32.73%
    Bitter 31.79%
    Vanilla 29.75%
    Medicinal 28.23%
    Spicy 25.69%
    Sweet 25.67%
    Almond 24.98%

     

    Flavor
    Bitter 61.87%
    Phenolic 38.79%
    Nutty 35.22%
    Almond 28.31%
    Mild 27.18%
    Medical 26.98%
    Odorless 25.56%
    Musty 23.17%
    Almond shell 22.62%
    Curry 21.97%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    0.7

    pKa est.
    9.48 (weak base)

    Molecular weight
    138.12 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    368°C

    Flash point

    • 151.32 ˚C est.

  • Synonyms

    • 3,5-Dihydroxybenzaldehyde
    • 26153-38-8
    • Benzaldehyde, 3,5-dihydroxy-
    • EINECS 247-479-4
    • .alpha.-Resorcylic aldehyde
    • CHEBI:50204
    • DTXSID60180776
    • RefChem:91543
    • alpha-Resorcylic aldehyde
    • DTXCID00103267
    • 247-479-4
    • HAQLHRYUDBKTJG-UHFFFAOYSA-N
    • InChI=1/C7H6O3/c8-4-5-1-6(9)3-7(10)2-5/h1-4,9-10
    • MFCD00016611
    • 3,5-dihydroxy benzaldehyde
    • ALPHA-RESORCYLALDEHYDE
    • P9FU6Z2MAA
    • 3,5-dihydroxy-benzaldehyde
    • Others Impurity _x000D_
    • SCHEMBL37131
    • orb1694131
    • SCHEMBL3019632
    • 3,5-Dihydroxybenzaldehyde, 98%
    • 3,5-dihydroxybenzaldehyde_x000D_
    • (Discontinued,See C4X-118355)
    • BBL101356
    • SBB063018
    • STL555152
    • AKOS005258327
    • AB01206
    • AC-5752
    • CS-W007416
    • FD34163
    • AS-32854
    • BP-14074
    • PD131130
    • SY041237
    • DB-022061
    • NS00028036
    • ST51028397
    • 153D388
    • F043665
    • doi:10.14272/HAQLHRYUDBKTJG-UHFFFAOYSA-N.1
    • Q27121981
    • 26153-38-8

  • Applications

    3,5-Dihydroxybenzaldehyde is primarily used as an organic synthesis intermediate, providing a versatile building block for phenolic resins, dye and pigment precursors, and various heterocyclic or pharmaceutical intermediates. In fragrance and flavor applications, it can serve as a fragrance precursor or aroma note, while in cosmetics and personal care it may be employed as a fragrance ingredient or functional intermediate. It also finds use in polymers and coatings as a monomer-derived precursor for polyphenolic materials and dye chemistry, and in general industrial manufacturing as a starting material for specialty chemicals. In research contexts, it may be utilized to prepare catechol-like ligands and related compounds.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 295.77
    methanol 500.68
    isopropanol 199.78
    water 13.44
    ethyl acetate 86.43
    n-propanol 175.69
    acetone 254.13
    n-butanol 122.68
    acetonitrile 148.97
    DMF 567.97
    toluene 4.53
    isobutanol 96.58
    1,4-dioxane 169.15
    methyl acetate 117.03
    THF 717.52
    2-butanone 119.6
    n-pentanol 98.44
    sec-butanol 102.0
    n-hexane 1.47
    ethylene glycol 216.56
    NMP 183.08
    cyclohexane 0.49
    DMSO 770.68
    n-butyl acetate 39.92
    n-octanol 41.43
    chloroform 3.38
    n-propyl acetate 62.99
    acetic acid 141.28
    dichloromethane 4.52
    cyclohexanone 58.53
    propylene glycol 148.15
    isopropyl acetate 56.13
    DMAc 293.54
    2-ethoxyethanol 273.0
    isopentanol 97.73
    n-heptane 3.09
    ethyl formate 65.91
    1,2-dichloroethane 10.19
    n-hexanol 73.09
    2-methoxyethanol 477.15
    isobutyl acetate 35.8
    tetrachloromethane 2.05
    n-pentyl acetate 26.33
    transcutol 304.58
    n-heptanol 37.22
    ethylbenzene 4.65
    MIBK 80.54
    2-propoxyethanol 199.31
    tert-butanol 246.41
    MTBE 70.62
    2-butoxyethanol 88.55
    propionic acid 93.46
    o-xylene 6.11
    formic acid 161.33
    diethyl ether 84.98
    m-xylene 8.18
    p-xylene 5.28
    chlorobenzene 3.96
    dimethyl carbonate 72.81
    n-octane 1.32
    formamide 239.27
    cyclopentanone 148.2
    2-pentanone 110.92
    anisole 41.61
    cyclopentyl methyl ether 95.63
    gamma-butyrolactone 185.39
    1-methoxy-2-propanol 324.98
    pyridine 28.83
    3-pentanone 55.11
    furfural 95.73
    n-dodecane 2.0
    diethylene glycol 256.55
    diisopropyl ether 22.01
    tert-amyl alcohol 113.92
    acetylacetone 125.87
    n-hexadecane 2.15
    acetophenone 36.23
    methyl propionate 91.6
    isopentyl acetate 36.51
    trichloroethylene 11.97
    n-nonanol 37.48
    cyclohexanol 42.2
    benzyl alcohol 37.71
    2-ethylhexanol 33.49
    isooctanol 29.15
    dipropyl ether 45.37
    1,2-dichlorobenzene 5.35
    ethyl lactate 59.21
    propylene carbonate 70.76
    n-methylformamide 265.46
    2-pentanol 80.44
    n-pentane 1.56
    1-propoxy-2-propanol 119.37
    1-methoxy-2-propyl acetate 73.29
    2-(2-methoxypropoxy) propanol 88.92
    mesitylene 6.85
    ε-caprolactone 59.29
    p-cymene 7.95
    epichlorohydrin 151.35
    1,1,1-trichloroethane 8.31
    2-aminoethanol 242.1
    morpholine-4-carbaldehyde 192.82
    sulfolane 189.37
    2,2,4-trimethylpentane 1.94
    2-methyltetrahydrofuran 149.19
    n-hexyl acetate 41.4
    isooctane 2.54
    2-(2-butoxyethoxy)ethanol 120.94
    sec-butyl acetate 39.73
    tert-butyl acetate 71.21
    decalin 1.41
    glycerin 223.07
    diglyme 193.12
    acrylic acid 84.56
    isopropyl myristate 22.56
    n-butyric acid 82.26
    acetyl acetate 44.5
    di(2-ethylhexyl) phthalate 20.63
    ethyl propionate 60.56
    nitromethane 285.22
    1,2-diethoxyethane 64.53
    benzonitrile 23.54
    trioctyl phosphate 20.71
    1-bromopropane 7.08
    gamma-valerolactone 155.23
    n-decanol 29.28
    triethyl phosphate 26.52
    4-methyl-2-pentanol 52.75
    propionitrile 85.34
    vinylene carbonate 47.56
    1,1,2-trichlorotrifluoroethane 91.7
    DMS 35.85
    cumene 5.77
    2-octanol 23.75
    2-hexanone 72.85
    octyl acetate 29.57
    limonene 11.54
    1,2-dimethoxyethane 299.97
    ethyl orthosilicate 24.12
    tributyl phosphate 22.23
    diacetone alcohol 135.55
    N,N-dimethylaniline 31.4
    acrylonitrile 94.52
    aniline 19.07
    1,3-propanediol 231.84
    bromobenzene 2.25
    dibromomethane 2.75
    1,1,2,2-tetrachloroethane 12.77
    2-methyl-cyclohexyl acetate 31.17
    tetrabutyl urea 33.82
    diisobutyl methanol 25.63
    2-phenylethanol 38.37
    styrene 4.78
    dioctyl adipate 34.39
    dimethyl sulfate 103.75
    ethyl butyrate 40.72
    methyl lactate 95.04
    butyl lactate 34.03
    diethyl carbonate 31.12
    propanediol butyl ether 84.62
    triethyl orthoformate 32.54
    p-tert-butyltoluene 8.8
    methyl 4-tert-butylbenzoate 47.24
    morpholine 227.43
    tert-butylamine 87.83
    n-dodecanol 22.57
    dimethoxymethane 339.55
    ethylene carbonate 44.3
    cyrene 86.22
    2-ethoxyethyl acetate 43.29
    2-ethylhexyl acetate 23.99
    1,2,4-trichlorobenzene 8.04
    4-methylpyridine 30.19
    dibutyl ether 29.39
    2,6-dimethyl-4-heptanol 25.63
    DEF 101.73
    dimethyl isosorbide 124.79
    tetrachloroethylene 7.83
    eugenol 55.7
    triacetin 45.55
    span 80 56.64
    1,4-butanediol 117.63
    1,1-dichloroethane 7.6
    2-methyl-1-pentanol 63.81
    methyl formate 189.97
    2-methyl-1-butanol 76.79
    n-decane 2.93
    butyronitrile 73.51
    3,7-dimethyl-1-octanol 34.87
    1-chlorooctane 12.17
    1-chlorotetradecane 5.8
    n-nonane 2.51
    undecane 2.39
    tert-butylcyclohexane 2.32
    cyclooctane 0.55
    cyclopentanol 82.02
    tetrahydropyran 85.06
    tert-amyl methyl ether 51.22
    2,5,8-trioxanonane 150.7
    1-hexene 7.78
    2-isopropoxyethanol 147.48
    2,2,2-trifluoroethanol 69.25
    methyl butyrate 72.98

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction