3',4',7-Trihydroxyflavone

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  • Identifiers

    CAS number
    2150-11-0

    Molecular formula
    C15H10O5

    SMILES
    C1=CC(=C(C=C1C2=CC(=O)C3=C(O2)C=C(C=C3)O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Phenolic 65.54%
    Odorless 51.0%
    Burnt 42.86%
    Medicinal 29.68%
    Smoky 28.59%
    Vanilla 25.83%
    Spicy 24.89%
    Balsamic 23.32%
    Bitter 22.52%
    Savory 22.44%

     

    Flavor
    Bitter 94.89%
    Very strong 20.57%
    Sweet-like 20.35%
    Indole 20.1%
    Odorless 19.96%
    Nitrile 19.83%
    Cedarleaf 19.7%
    Curry 19.46%
    Lovage 19.44%
    Rotten 19.41%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.9

    pKa est.
    9.66 (weak base)

    Molecular weight
    270.24 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    613°C

    Flash point

    • 227.4 ˚C est.

  • Synonyms

    • 2150-11-0
    • 3',4',7-Trihydroxyflavone
    • 2-(3,4-Dihydroxyphenyl)-7-hydroxy-4H-1-benzopyran-4-one
    • 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-7-hydroxy-
    • Flavone, 7,3',4'-trihydroxy-
    • DTXSID30175836
    • RefChem:864983
    • DTXCID7098327
    • 7,3',4'-Trihydroxyflavone
    • 2-(3,4-dihydroxyphenyl)-7-hydroxy-4H-chromen-4-one
    • 2-(3,4-dihydroxyphenyl)-7-hydroxychromen-4-one
    • MFCD00017434
    • CHEMBL301624
    • 3',4',7- TRIHYDROXY FLAVONE
    • T 414
    • 3 inverted exclamation marka,4 inverted exclamation marka,7-Trihydroxyflavone
    • 104666-14-0
    • 2-(3,4-dihydroxyphenyl)-7-hydroxy-chromen-4-one
    • Flavone, 3',4',7-trihydroxy- (6CI,7CI,8CI); 2-(3,4-Dihydroxyphenyl)-7-hydroxy-4H-1-benzopyran-4-one; 3',4',7-Trihydroxyflavone; 3',4',7-Trihydroxylflavone; 5-Deoxyluteolin; 7,3',4'-Trihydroxyflavone
    • BRN 0253031
    • 4hlf
    • 2-(3,4-Dihydroxy-phenyl)-7-hydroxy-chromen-4-one
    • NS7F7K27CD
    • SCHEMBL34405
    • 7, 3',4'-Trihydroxyflavone
    • 3'',4'',7-trihydroxyflavon
    • orb1297127
    • 7,3'',4''-Trihydroxyflavone
    • SCHEMBL29678122
    • CHEBI:196247
    • PVFGJHYLIHMCQD-UHFFFAOYSA-N
    • HY-N2736
    • BDBM50077325
    • LMPK12110042
    • AKOS016009456
    • EBC-421054
    • FT66567
    • BS-49064
    • ST056259
    • DB-045596
    • CS-0023236
    • NS00116328
    • D81760
    • 5-18-04-00590 (Beilstein Handbook Reference)
    • F239589
    • Q23055239
    • 2-(3,4-Bis(oxidanyl)phenyl)-7-oxidanyl-chromen-4-one
    • 15Z
    • 2150-11-0

  • Applications

    3',4',7-Trihydroxyflavone (CAS 2150-11-0) is mainly used as an intermediate in organic synthesis to prepare flavone derivatives for pharmaceutical and agricultural chemical development; in cosmetics and personal care, it is often considered an antioxidant and stabilizing additive for skin care formulations. In the plastics and coatings sector, it is researched as a UV absorber and photostabilizer for polymers and coatings, and can serve as a precursor for dyes or pigments in coatings and inks. Additionally, it is used as a building block for flavone scaffolds in agricultural chemistry research and for developing related derivatives.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1.91
    methanol 1.3
    isopropanol 2.89
    water 0.01
    ethyl acetate 1.09
    n-propanol 3.5
    acetone 0.5
    n-butanol 3.21
    acetonitrile 0.41
    DMF 12.66
    toluene 0.05
    isobutanol 1.59
    1,4-dioxane 6.85
    methyl acetate 1.82
    THF 26.79
    2-butanone 3.36
    n-pentanol 1.56
    sec-butanol 5.08
    n-hexane 0.0
    ethylene glycol 4.93
    NMP 4.13
    cyclohexane 0.0
    DMSO 49.09
    n-butyl acetate 1.12
    n-octanol 0.46
    chloroform 0.0
    n-propyl acetate 1.26
    acetic acid 2.55
    dichloromethane 0.0
    cyclohexanone 2.15
    propylene glycol 5.78
    isopropyl acetate 1.42
    DMAc 36.14
    2-ethoxyethanol 23.62
    isopentanol 2.81
    n-heptane 0.01
    ethyl formate 0.68
    1,2-dichloroethane 0.01
    n-hexanol 0.65
    2-methoxyethanol 53.0
    isobutyl acetate 0.55
    tetrachloromethane 0.0
    n-pentyl acetate 1.12
    transcutol 76.76
    n-heptanol 0.78
    ethylbenzene 0.06
    MIBK 1.53
    2-propoxyethanol 15.23
    tert-butanol 4.61
    MTBE 1.8
    2-butoxyethanol 7.54
    propionic acid 2.5
    o-xylene 0.08
    formic acid 3.28
    diethyl ether 0.5
    m-xylene 0.06
    p-xylene 0.06
    chlorobenzene 0.01
    dimethyl carbonate 1.56
    n-octane 0.01
    formamide 11.38
    cyclopentanone 4.03
    2-pentanone 1.51
    anisole 1.17
    cyclopentyl methyl ether 1.57
    gamma-butyrolactone 5.92
    1-methoxy-2-propanol 35.03
    pyridine 1.69
    3-pentanone 0.71
    furfural 5.02
    n-dodecane 0.01
    diethylene glycol 20.71
    diisopropyl ether 0.16
    tert-amyl alcohol 5.85
    acetylacetone 3.54
    n-hexadecane 0.01
    acetophenone 1.33
    methyl propionate 1.75
    isopentyl acetate 1.67
    trichloroethylene 0.01
    n-nonanol 0.68
    cyclohexanol 1.45
    benzyl alcohol 1.69
    2-ethylhexanol 0.6
    isooctanol 0.82
    dipropyl ether 1.03
    1,2-dichlorobenzene 0.02
    ethyl lactate 2.86
    propylene carbonate 1.38
    n-methylformamide 5.04
    2-pentanol 1.88
    n-pentane 0.0
    1-propoxy-2-propanol 10.95
    1-methoxy-2-propyl acetate 5.98
    2-(2-methoxypropoxy) propanol 14.86
    mesitylene 0.05
    ε-caprolactone 3.57
    p-cymene 0.14
    epichlorohydrin 5.35
    1,1,1-trichloroethane 0.0
    2-aminoethanol 7.85
    morpholine-4-carbaldehyde 20.24
    sulfolane 10.17
    2,2,4-trimethylpentane 0.01
    2-methyltetrahydrofuran 5.08
    n-hexyl acetate 1.31
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 20.25
    sec-butyl acetate 1.16
    tert-butyl acetate 3.24
    decalin 0.0
    glycerin 21.51
    diglyme 35.09
    acrylic acid 2.34
    isopropyl myristate 0.98
    n-butyric acid 2.54
    acetyl acetate 0.65
    di(2-ethylhexyl) phthalate 1.25
    ethyl propionate 1.24
    nitromethane 6.25
    1,2-diethoxyethane 8.02
    benzonitrile 0.43
    trioctyl phosphate 0.78
    1-bromopropane 0.01
    gamma-valerolactone 19.46
    n-decanol 0.59
    triethyl phosphate 1.28
    4-methyl-2-pentanol 1.14
    propionitrile 0.61
    vinylene carbonate 0.94
    1,1,2-trichlorotrifluoroethane 6.06
    DMS 1.8
    cumene 0.06
    2-octanol 0.48
    2-hexanone 1.33
    octyl acetate 1.09
    limonene 0.16
    1,2-dimethoxyethane 28.82
    ethyl orthosilicate 1.34
    tributyl phosphate 1.05
    diacetone alcohol 13.62
    N,N-dimethylaniline 0.83
    acrylonitrile 1.05
    aniline 0.68
    1,3-propanediol 15.94
    bromobenzene 0.0
    dibromomethane 0.0
    1,1,2,2-tetrachloroethane 0.02
    2-methyl-cyclohexyl acetate 1.39
    tetrabutyl urea 1.89
    diisobutyl methanol 0.84
    2-phenylethanol 1.44
    styrene 0.05
    dioctyl adipate 2.05
    dimethyl sulfate 3.7
    ethyl butyrate 1.37
    methyl lactate 6.58
    butyl lactate 2.78
    diethyl carbonate 0.89
    propanediol butyl ether 7.38
    triethyl orthoformate 2.29
    p-tert-butyltoluene 0.17
    methyl 4-tert-butylbenzoate 3.4
    morpholine 18.14
    tert-butylamine 0.75
    n-dodecanol 0.47
    dimethoxymethane 12.33
    ethylene carbonate 0.78
    cyrene 8.5
    2-ethoxyethyl acetate 4.17
    2-ethylhexyl acetate 0.94
    1,2,4-trichlorobenzene 0.07
    4-methylpyridine 0.88
    dibutyl ether 1.09
    2,6-dimethyl-4-heptanol 0.84
    DEF 4.18
    dimethyl isosorbide 17.12
    tetrachloroethylene 0.01
    eugenol 4.96
    triacetin 3.7
    span 80 6.33
    1,4-butanediol 3.49
    1,1-dichloroethane 0.0
    2-methyl-1-pentanol 1.89
    methyl formate 2.19
    2-methyl-1-butanol 2.92
    n-decane 0.01
    butyronitrile 0.6
    3,7-dimethyl-1-octanol 0.85
    1-chlorooctane 0.06
    1-chlorotetradecane 0.05
    n-nonane 0.01
    undecane 0.01
    tert-butylcyclohexane 0.01
    cyclooctane 0.0
    cyclopentanol 2.09
    tetrahydropyran 1.69
    tert-amyl methyl ether 2.27
    2,5,8-trioxanonane 26.06
    1-hexene 0.01
    2-isopropoxyethanol 11.58
    2,2,2-trifluoroethanol 1.0
    methyl butyrate 1.67

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction