3',4'-Dihydroxyflavone

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  • Identifiers

    CAS number
    4143-64-0

    Molecular formula
    C15H10O4

    SMILES
    C1=CC=C2C(=C1)C(=O)C=C(O2)C3=CC(=C(C=C3)O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Phenolic 65.46%
    Burnt 46.29%
    Odorless 41.44%
    Medicinal 32.84%
    Vanilla 31.5%
    Smoky 31.27%
    Spicy 30.09%
    Balsamic 28.45%
    Bitter 25.49%
    Savory 23.76%

     

    Flavor
    Bitter 94.47%
    Very strong 20.52%
    Indole 19.95%
    Curry 19.66%
    Nitrile 19.47%
    Moth ball 19.41%
    Lovage 19.25%
    Sweet-like 19.25%
    Naphthelene 19.22%
    Cedarleaf 19.11%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.8

    pKa est.
    9.23 (weak base)

    Molecular weight
    254.24 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    531°C

    Flash point

    • 207.24 ˚C est.

  • Synonyms

    • 3',4'-Dihydroxyflavone
    • 4143-64-0
    • 2-(3,4-dihydroxyphenyl)chromen-4-one
    • KOH101S66V
    • DTXSID70194349
    • 3',4'-dihydroxy-flavone
    • RefChem:90233
    • DTXCID30116840
    • 2-(3,4-dihydroxyphenyl)-4H-chromen-4-one
    • 3,4-DIHYDROXYFLAVONE
    • MFCD00017600
    • CHEMBL222556
    • 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-
    • 4-Hydroxyflavonol
    • 3'',4''-dihydroxyflavone
    • UNII-KOH101S66V
    • 4hlm
    • 3,4-Dihydroxy flavone
    • 2-(3,4-Dihydroxyphenyl)-4H-1-benzopyran-4-one
    • Oprea1_301189
    • 3'',4''-dihydroxy flavone
    • SCHEMBL345706
    • SPECTRUM1505139
    • orb1299093
    • SCHEMBL29664745
    • BDBM50157555
    • AKOS001656361
    • EBC-470102
    • FD07751
    • NCGC00096030-01
    • AS-64531
    • PD000604
    • ST059621
    • SY050122
    • DB-049758
    • HY-127167
    • CS-0094406
    • D4884
    • EU-0042517
    • T70898
    • AN-829/41868376
    • EN300-22867936
    • F827763
    • SR-01000471684
    • SR-01000471684-1
    • Q27282353
    • 4143-64-0

  • Applications

    3',4'-Dihydroxyflavone (CAS 4143-64-0) is primarily used as an intermediate in the synthesis of flavonoid derivatives for pharmaceutical research, where it serves as a scaffold for exploring structure–activity relationships. In cosmetics and personal care, it is studied as an antioxidant additive in formulations to help stabilize products. In polymers and coatings, it has been investigated as a stabilizer and functional additive, potentially providing antioxidant protection and UV-related performance in films and composites. In agricultural and plant science research, it is used as a chemical scaffold to probe flavonoid-related bioactivity and as a starting point for agrochemical development. Additionally, it has been explored as a building block for organic electronic materials and dye-based applications in research settings, including dye-sensitized solar cells.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2.06
    methanol 1.77
    isopropanol 2.85
    water 0.01
    ethyl acetate 1.74
    n-propanol 3.13
    acetone 3.44
    n-butanol 2.68
    acetonitrile 1.58
    DMF 6.68
    toluene 0.67
    isobutanol 1.81
    1,4-dioxane 12.78
    methyl acetate 3.46
    THF 39.32
    2-butanone 6.27
    n-pentanol 2.37
    sec-butanol 3.76
    n-hexane 0.01
    ethylene glycol 2.69
    NMP 1.44
    cyclohexane 0.01
    DMSO 25.67
    n-butyl acetate 2.07
    n-octanol 1.18
    chloroform 0.03
    n-propyl acetate 2.23
    acetic acid 3.9
    dichloromethane 0.09
    cyclohexanone 3.41
    propylene glycol 2.82
    isopropyl acetate 2.68
    DMAc 16.99
    2-ethoxyethanol 14.55
    isopentanol 3.18
    n-heptane 0.04
    ethyl formate 1.35
    1,2-dichloroethane 0.33
    n-hexanol 1.69
    2-methoxyethanol 23.27
    isobutyl acetate 1.57
    tetrachloromethane 0.01
    n-pentyl acetate 2.78
    transcutol 97.75
    n-heptanol 1.67
    ethylbenzene 0.58
    MIBK 3.77
    2-propoxyethanol 11.08
    tert-butanol 5.7
    MTBE 3.76
    2-butoxyethanol 8.05
    propionic acid 2.21
    o-xylene 0.62
    formic acid 2.6
    diethyl ether 1.84
    m-xylene 0.51
    p-xylene 0.63
    chlorobenzene 0.2
    dimethyl carbonate 2.44
    n-octane 0.04
    formamide 7.92
    cyclopentanone 4.19
    2-pentanone 2.92
    anisole 4.01
    cyclopentyl methyl ether 3.33
    gamma-butyrolactone 5.03
    1-methoxy-2-propanol 16.06
    pyridine 5.87
    3-pentanone 1.8
    furfural 6.21
    n-dodecane 0.09
    diethylene glycol 13.45
    diisopropyl ether 0.74
    tert-amyl alcohol 5.32
    acetylacetone 6.76
    n-hexadecane 0.1
    acetophenone 3.37
    methyl propionate 2.2
    isopentyl acetate 3.32
    trichloroethylene 0.53
    n-nonanol 1.68
    cyclohexanol 2.04
    benzyl alcohol 3.42
    2-ethylhexanol 1.64
    isooctanol 1.87
    dipropyl ether 2.75
    1,2-dichlorobenzene 0.29
    ethyl lactate 2.65
    propylene carbonate 2.0
    n-methylformamide 3.36
    2-pentanol 2.1
    n-pentane 0.01
    1-propoxy-2-propanol 8.33
    1-methoxy-2-propyl acetate 7.25
    2-(2-methoxypropoxy) propanol 15.11
    mesitylene 0.38
    ε-caprolactone 3.64
    p-cymene 0.81
    epichlorohydrin 12.35
    1,1,1-trichloroethane 0.09
    2-aminoethanol 3.99
    morpholine-4-carbaldehyde 10.53
    sulfolane 5.41
    2,2,4-trimethylpentane 0.05
    2-methyltetrahydrofuran 6.28
    n-hexyl acetate 3.05
    isooctane 0.03
    2-(2-butoxyethoxy)ethanol 21.95
    sec-butyl acetate 2.24
    tert-butyl acetate 6.07
    decalin 0.04
    glycerin 8.96
    diglyme 43.08
    acrylic acid 2.32
    isopropyl myristate 2.51
    n-butyric acid 2.59
    acetyl acetate 1.73
    di(2-ethylhexyl) phthalate 2.57
    ethyl propionate 2.04
    nitromethane 8.84
    1,2-diethoxyethane 16.35
    benzonitrile 1.83
    trioctyl phosphate 1.56
    1-bromopropane 0.15
    gamma-valerolactone 12.09
    n-decanol 1.45
    triethyl phosphate 2.11
    4-methyl-2-pentanol 1.9
    propionitrile 1.91
    vinylene carbonate 1.9
    1,1,2-trichlorotrifluoroethane 6.17
    DMS 3.72
    cumene 0.52
    2-octanol 1.22
    2-hexanone 3.28
    octyl acetate 2.41
    limonene 0.75
    1,2-dimethoxyethane 26.89
    ethyl orthosilicate 2.39
    tributyl phosphate 2.09
    diacetone alcohol 12.23
    N,N-dimethylaniline 2.63
    acrylonitrile 2.86
    aniline 2.13
    1,3-propanediol 8.3
    bromobenzene 0.13
    dibromomethane 0.04
    1,1,2,2-tetrachloroethane 0.51
    2-methyl-cyclohexyl acetate 2.72
    tetrabutyl urea 3.53
    diisobutyl methanol 2.25
    2-phenylethanol 3.67
    styrene 0.55
    dioctyl adipate 4.18
    dimethyl sulfate 3.7
    ethyl butyrate 2.29
    methyl lactate 4.23
    butyl lactate 3.44
    diethyl carbonate 1.82
    propanediol butyl ether 7.04
    triethyl orthoformate 3.5
    p-tert-butyltoluene 0.88
    methyl 4-tert-butylbenzoate 6.0
    morpholine 15.48
    tert-butylamine 1.55
    n-dodecanol 1.25
    dimethoxymethane 13.63
    ethylene carbonate 1.5
    cyrene 6.75
    2-ethoxyethyl acetate 7.65
    2-ethylhexyl acetate 2.14
    1,2,4-trichlorobenzene 0.63
    4-methylpyridine 2.64
    dibutyl ether 3.58
    2,6-dimethyl-4-heptanol 2.25
    DEF 3.71
    dimethyl isosorbide 19.76
    tetrachloroethylene 0.29
    eugenol 7.54
    triacetin 6.16
    span 80 7.38
    1,4-butanediol 2.56
    1,1-dichloroethane 0.08
    2-methyl-1-pentanol 3.14
    methyl formate 2.58
    2-methyl-1-butanol 2.79
    n-decane 0.11
    butyronitrile 1.61
    3,7-dimethyl-1-octanol 2.02
    1-chlorooctane 0.48
    1-chlorotetradecane 0.35
    n-nonane 0.06
    undecane 0.09
    tert-butylcyclohexane 0.05
    cyclooctane 0.01
    cyclopentanol 1.89
    tetrahydropyran 5.42
    tert-amyl methyl ether 3.8
    2,5,8-trioxanonane 32.57
    1-hexene 0.09
    2-isopropoxyethanol 8.9
    2,2,2-trifluoroethanol 1.22
    methyl butyrate 2.4

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction