3,3',4,4'-Tetrahydroxy-5,5'-diisopropyl-2,2'-dimethylbiphenyl

Overview IFRA Request a quote

  • Identifiers

    CAS number
    120901-51-1

    Molecular formula
    C20H26O4

    SMILES
    CC1=C(C(=C(C=C1C2=CC(=C(C(=C2C)O)O)C(C)C)C(C)C)O)O

    Safety labels

  • Odor profile

    Fragrance
    Phenolic 74.09%
    Smoky 50.0%
    Spicy 47.4%
    Burnt 46.45%
    Medicinal 38.16%
    Woody 36.2%
    Leathery 29.08%
    Dry 27.15%
    Odorless 22.53%
    Balsamic 22.07%

     

    Flavor
    Bitter 58.83%
    Phenolic 29.78%
    Medicinal 24.53%
    Mild 24.24%
    Bland 23.6%
    Camphor 23.21%
    Eugenol 22.08%
    Thymol 22.01%
    Odorless 21.73%
    Creosote 21.6%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    5.1

    pKa est.
    10.36 (weak base)

    Molecular weight
    330.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    902°C

    Melting point expt.

    • 104 °C

    Flash point

    • 218.87 ˚C est.

  • Synonyms

    • 3,3',4,4'-Tetrahydroxy-5,5'-diisopropyl-2,2'-dimethylbiphenyl
    • 3,4,3',4'-tetrahydroxy-5,5'-diisopropyl-2,2'-dimethylbiphenyl
    • CHEBI:171857
    • 5,5'-diisopropyl-2,2'-dimethylbiphenyl-3,3',4,4'-tetrol
    • DTXSID301157782
    • 4-(3,4-dihydroxy-2-methyl-5-propan-2-ylphenyl)-3-methyl-6-propan-2-ylbenzene-1,2-diol
    • 120901-51-1
    • 2,2'-Dimethyl-5,5'-di(propan-2-yl)[1,1'-biphenyl]-3,3',4,4'-tetrol
    • [1,1'-biphenyl]-3,3',4,4'-tetrol, 2,2'-dimethyl-5,5'-bis(1-methylethyl)-
    • 2,2a(2)-Dimethyl-5,5a(2)-bis(1-methylethyl)[1,1a(2)-biphenyl]-3,3a(2),4,4a(2)-tetrol
    • 4-[3,4-dihydroxy-2-methyl-5-(propan-2-yl)phenyl]-3-methyl-6-(propan-2-yl)benzene-1,2-diol
    • InChI=1/C20H26O4/c1-9(2)13-7-15(11(5)17(21)19(13)23)16-8-14(10(3)4)20(24)18(22)12(16)6/h7-10,21-24H,1-6H
    • 120901-51-1

  • Applications

    3,3',4,4'-Tetrahydroxy-5,5'-diisopropyl-2,2'-dimethylbiphenyl (CAS 120901-51-1) is primarily used as a polyphenolic stabilizer in materials processing, commonly evaluated as a thermal/oxidative antioxidant for polymers and rubber compounds. It is also employed as a stabilizing additive in coatings and inks to improve aging resistance and color stability, and may act as a crosslinking modifier or curing aid in epoxy resin systems. In specialty polymer synthesis, it serves as an intermediate for polyphenolic materials or for preparing tailored stabilization additives, with use governed by regulatory and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 75.43
    methanol 58.88
    isopropanol 57.62
    water 0.09
    ethyl acetate 48.74
    n-propanol 68.1
    acetone 91.79
    n-butanol 51.11
    acetonitrile 13.96
    DMF 201.08
    toluene 14.72
    isobutanol 39.21
    1,4-dioxane 130.76
    methyl acetate 52.1
    THF 278.95
    2-butanone 85.19
    n-pentanol 45.79
    sec-butanol 53.26
    n-hexane 4.16
    ethylene glycol 10.07
    NMP 133.97
    cyclohexane 4.0
    DMSO 160.07
    n-butyl acetate 52.88
    n-octanol 27.43
    chloroform 58.11
    n-propyl acetate 31.68
    acetic acid 51.36
    dichloromethane 50.72
    cyclohexanone 89.66
    propylene glycol 16.84
    isopropyl acetate 36.08
    DMAc 188.39
    2-ethoxyethanol 90.86
    isopentanol 39.52
    n-heptane 3.98
    ethyl formate 29.89
    1,2-dichloroethane 53.81
    n-hexanol 58.22
    2-methoxyethanol 133.51
    isobutyl acetate 23.77
    tetrachloromethane 10.95
    n-pentyl acetate 60.06
    transcutol 102.54
    n-heptanol 48.85
    ethylbenzene 14.15
    MIBK 35.05
    2-propoxyethanol 124.98
    tert-butanol 74.3
    MTBE 69.49
    2-butoxyethanol 94.38
    propionic acid 34.73
    o-xylene 12.97
    formic acid 18.42
    diethyl ether 66.71
    m-xylene 13.46
    p-xylene 17.01
    chlorobenzene 17.76
    dimethyl carbonate 31.36
    n-octane 3.7
    formamide 49.12
    cyclopentanone 139.27
    2-pentanone 57.61
    anisole 28.17
    cyclopentyl methyl ether 64.28
    gamma-butyrolactone 140.13
    1-methoxy-2-propanol 95.24
    pyridine 75.54
    3-pentanone 46.03
    furfural 74.28
    n-dodecane 1.92
    diethylene glycol 73.79
    diisopropyl ether 18.2
    tert-amyl alcohol 63.34
    acetylacetone 66.59
    n-hexadecane 2.2
    acetophenone 32.37
    methyl propionate 50.91
    isopentyl acetate 53.61
    trichloroethylene 90.29
    n-nonanol 28.85
    cyclohexanol 34.62
    benzyl alcohol 32.89
    2-ethylhexanol 29.78
    isooctanol 36.9
    dipropyl ether 32.69
    1,2-dichlorobenzene 20.36
    ethyl lactate 20.89
    propylene carbonate 49.89
    n-methylformamide 68.35
    2-pentanol 33.95
    n-pentane 3.71
    1-propoxy-2-propanol 74.73
    1-methoxy-2-propyl acetate 63.37
    2-(2-methoxypropoxy) propanol 42.07
    mesitylene 8.84
    ε-caprolactone 75.15
    p-cymene 13.35
    epichlorohydrin 144.73
    1,1,1-trichloroethane 34.65
    2-aminoethanol 28.32
    morpholine-4-carbaldehyde 128.87
    sulfolane 146.09
    2,2,4-trimethylpentane 3.02
    2-methyltetrahydrofuran 111.68
    n-hexyl acetate 52.99
    isooctane 2.14
    2-(2-butoxyethoxy)ethanol 69.79
    sec-butyl acetate 23.24
    tert-butyl acetate 50.23
    decalin 3.39
    glycerin 26.3
    diglyme 118.29
    acrylic acid 30.19
    isopropyl myristate 17.54
    n-butyric acid 47.35
    acetyl acetate 26.27
    di(2-ethylhexyl) phthalate 20.85
    ethyl propionate 26.29
    nitromethane 80.95
    1,2-diethoxyethane 58.15
    benzonitrile 19.64
    trioctyl phosphate 18.27
    1-bromopropane 28.03
    gamma-valerolactone 168.33
    n-decanol 20.36
    triethyl phosphate 18.01
    4-methyl-2-pentanol 20.9
    propionitrile 21.49
    vinylene carbonate 38.04
    1,1,2-trichlorotrifluoroethane 74.43
    DMS 40.07
    cumene 11.1
    2-octanol 33.18
    2-hexanone 42.37
    octyl acetate 25.6
    limonene 16.59
    1,2-dimethoxyethane 127.24
    ethyl orthosilicate 20.7
    tributyl phosphate 16.27
    diacetone alcohol 62.25
    N,N-dimethylaniline 27.48
    acrylonitrile 27.56
    aniline 26.26
    1,3-propanediol 55.95
    bromobenzene 15.98
    dibromomethane 36.4
    1,1,2,2-tetrachloroethane 75.1
    2-methyl-cyclohexyl acetate 30.54
    tetrabutyl urea 24.51
    diisobutyl methanol 17.99
    2-phenylethanol 50.12
    styrene 12.55
    dioctyl adipate 23.58
    dimethyl sulfate 54.14
    ethyl butyrate 26.71
    methyl lactate 30.08
    butyl lactate 40.48
    diethyl carbonate 17.88
    propanediol butyl ether 52.03
    triethyl orthoformate 27.22
    p-tert-butyltoluene 14.54
    methyl 4-tert-butylbenzoate 46.5
    morpholine 166.94
    tert-butylamine 35.01
    n-dodecanol 14.24
    dimethoxymethane 136.04
    ethylene carbonate 33.83
    cyrene 55.06
    2-ethoxyethyl acetate 73.95
    2-ethylhexyl acetate 41.48
    1,2,4-trichlorobenzene 25.73
    4-methylpyridine 50.83
    dibutyl ether 23.74
    2,6-dimethyl-4-heptanol 17.99
    DEF 70.17
    dimethyl isosorbide 84.3
    tetrachloroethylene 55.03
    eugenol 46.85
    triacetin 37.3
    span 80 42.34
    1,4-butanediol 22.6
    1,1-dichloroethane 32.92
    2-methyl-1-pentanol 40.05
    methyl formate 48.15
    2-methyl-1-butanol 39.91
    n-decane 3.89
    butyronitrile 22.01
    3,7-dimethyl-1-octanol 21.36
    1-chlorooctane 15.73
    1-chlorotetradecane 5.59
    n-nonane 3.47
    undecane 2.66
    tert-butylcyclohexane 3.79
    cyclooctane 1.94
    cyclopentanol 47.42
    tetrahydropyran 94.35
    tert-amyl methyl ether 48.82
    2,5,8-trioxanonane 71.76
    1-hexene 13.98
    2-isopropoxyethanol 63.37
    2,2,2-trifluoroethanol 21.05
    methyl butyrate 34.93

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction