(3,3,3-Trifluoropropyl)methylsiloxane cyclic tetramer

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  • Identifiers

    CAS number
    429-67-4

    Molecular formula
    C16H28F12O4Si4

    SMILES
    C[Si]1(O[Si](O[Si](O[Si](O1)(C)CCC(F)(F)F)(C)CCC(F)(F)F)(C)CCC(F)(F)F)CCC(F)(F)F

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 52.72%
    Sweet 29.39%
    Cooling 20.99%
    Savory 19.78%
    Fishy 19.06%
    Fatty 17.66%
    Animal 17.65%
    Woody 17.59%
    Balsamic 16.97%
    Floral 16.48%

     

    Flavor
    Sulfurous 34.09%
    Odorless 25.83%
    Sulfury 25.6%
    Roasted 23.42%
    Meaty 23.28%
    Mild 21.94%
    Bland 21.32%
    Bouillon 20.34%
    Blackberry 19.94%
    Catty 19.39%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    3.34 (weak acid)

    Molecular weight
    624.71 g/mol

    Flash point

    • 130.13 ˚C est.

  • Synonyms

    • 429-67-4
    • Cyclotetrasiloxane, 2,4,6,8-tetramethyl-2,4,6,8-tetrakis(3,3,3-trifluoropropyl)-
    • 6UZH4CP48X
    • EINECS 207-060-9
    • (3,3,3-Trifluoropropyl)methylsiloxane cyclic tetramer
    • 2,4,6,8-Tetramethyl-2,4,6,8-tetrakis(3,3,3-trifluoropropyl)cyclotetrasiloxane
    • DTXSID7059985
    • 1,3,5,7-tetrakis(3,3,3-trifluoropropyl)-1,3,5,7-tetramethylcyclotetrasiloxane
    • RefChem:399202
    • DTXCID4040185
    • 1,3,5,7Tetrakis(3,3,3trifluoropropyl)1,3,5,7tetramethylcyclotetrasiloxane
    • 2,4,6,8Tetramethyl2,4,6,8tetrakis(3,3,3trifluoropropyl)cyclotetrasiloxane
    • 207-060-9
    • 2,4,6,8-tetramethyl-2,4,6,8-tetrakis(3,3,3-trifluoropropyl)-1,3,5,7,2,4,6,8-tetraoxatetrasilocane
    • MFCD00069177
    • C16H28F12O4Si4
    • Tetramethyl tetra-3-trifluoropropyl cyclotetrasiloxane
    • UNII-6UZH4CP48X
    • SCHEMBL2310729
    • trifluoropropyl cyclotetrasiloxane
    • 1,3,5,7-Tetrakis(3,3,3-trifluoroprop-1-yl)-1,3,5,7-tetramethylcyclotetrasiloxane
    • NS00043399
    • Q27893825
    • (3,3,3-TRIFLUOROPROPYL)METHYLCYCLOTETRASILOXANE
    • 1,3,5,7-Tetrakis(3,3,3-trifluoropropyl)-1,3,5,7-tetramethylcyclosiloxane
    • 1,3,5,7-Tetrakis(3,3,3-Trifluoropropyl)Tetramethylcyclotetrasiloxane
    • 2,4,6,8-Tetramethyl-2,4,6,8-tetrakis(3,3,3-trifluoropropyl)-1,3,5,7,2,4,6,8-tetroxatetrasilocane
    • 429-67-4

  • Applications

    For (3,3,3-Trifluoropropyl)methylsiloxane cyclic tetramer (CAS 429-67-4), this fluorinated silicone cyclic tetramer is used as a surface-modifying agent and a synthetic intermediate in silicone chemistry. Real-world applications include modifying coatings and inks to reduce surface energy and improve release characteristics; serving as an intermediate for the synthesis of fluorinated silicone fluids and resins; acting as a processing aid in polymer formulations to enhance lubricity and water/oil repellency; used as an additive in adhesives and sealants to improve moisture and solvent resistance; and may be considered for electronics-related uses such as dielectric formulations or encapsulation materials. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 68.73
    methanol 94.08
    isopropanol 36.81
    water 1.64
    ethyl acetate 93.78
    n-propanol 47.13
    acetone 159.88
    n-butanol 31.93
    acetonitrile 75.16
    DMF 473.96
    toluene 11.69
    isobutanol 24.64
    1,4-dioxane 111.09
    methyl acetate 127.74
    THF 217.78
    2-butanone 121.18
    n-pentanol 21.29
    sec-butanol 35.12
    n-hexane 1.64
    ethylene glycol 22.58
    NMP 401.83
    cyclohexane 2.22
    DMSO 661.19
    n-butyl acetate 55.04
    n-octanol 13.69
    chloroform 132.1
    n-propyl acetate 54.63
    acetic acid 142.15
    dichloromethane 159.78
    cyclohexanone 90.91
    propylene glycol 27.23
    isopropyl acetate 50.28
    DMAc 449.89
    2-ethoxyethanol 101.23
    isopentanol 19.37
    n-heptane 1.63
    ethyl formate 100.4
    1,2-dichloroethane 91.98
    n-hexanol 17.28
    2-methoxyethanol 201.67
    isobutyl acetate 18.95
    tetrachloromethane 15.11
    n-pentyl acetate 42.04
    transcutol 137.31
    n-heptanol 13.49
    ethylbenzene 6.91
    MIBK 30.09
    2-propoxyethanol 86.58
    tert-butanol 28.55
    MTBE 36.32
    2-butoxyethanol 53.59
    propionic acid 68.43
    o-xylene 9.85
    formic acid 113.14
    diethyl ether 52.65
    m-xylene 5.97
    p-xylene 7.65
    chlorobenzene 20.74
    dimethyl carbonate 91.04
    n-octane 0.88
    formamide 210.03
    cyclopentanone 171.42
    2-pentanone 72.54
    anisole 34.99
    cyclopentyl methyl ether 47.98
    gamma-butyrolactone 239.02
    1-methoxy-2-propanol 117.0
    pyridine 88.93
    3-pentanone 66.61
    furfural 232.47
    n-dodecane 0.73
    diethylene glycol 69.06
    diisopropyl ether 9.5
    tert-amyl alcohol 32.07
    acetylacetone 120.15
    n-hexadecane 0.8
    acetophenone 47.54
    methyl propionate 99.05
    isopentyl acetate 35.94
    trichloroethylene 160.97
    n-nonanol 13.73
    cyclohexanol 19.05
    benzyl alcohol 25.17
    2-ethylhexanol 10.32
    isooctanol 9.14
    dipropyl ether 25.77
    1,2-dichlorobenzene 25.72
    ethyl lactate 39.51
    propylene carbonate 103.61
    n-methylformamide 222.11
    2-pentanol 18.04
    n-pentane 2.2
    1-propoxy-2-propanol 55.02
    1-methoxy-2-propyl acetate 78.94
    2-(2-methoxypropoxy) propanol 64.16
    mesitylene 3.6
    ε-caprolactone 107.81
    p-cymene 6.31
    epichlorohydrin 225.29
    1,1,1-trichloroethane 49.12
    2-aminoethanol 44.08
    morpholine-4-carbaldehyde 305.22
    sulfolane 311.56
    2,2,4-trimethylpentane 1.06
    2-methyltetrahydrofuran 96.23
    n-hexyl acetate 43.86
    isooctane 0.42
    2-(2-butoxyethoxy)ethanol 66.74
    sec-butyl acetate 30.34
    tert-butyl acetate 43.64
    decalin 1.07
    glycerin 54.92
    diglyme 166.38
    acrylic acid 76.07
    isopropyl myristate 16.36
    n-butyric acid 69.37
    acetyl acetate 81.07
    di(2-ethylhexyl) phthalate 24.2
    ethyl propionate 59.11
    nitromethane 436.13
    1,2-diethoxyethane 56.08
    benzonitrile 28.1
    trioctyl phosphate 15.69
    1-bromopropane 41.74
    gamma-valerolactone 296.55
    n-decanol 9.52
    triethyl phosphate 36.38
    4-methyl-2-pentanol 7.96
    propionitrile 41.68
    vinylene carbonate 104.12
    1,1,2-trichlorotrifluoroethane 180.55
    DMS 58.11
    cumene 4.58
    2-octanol 9.28
    2-hexanone 47.94
    octyl acetate 25.25
    limonene 10.43
    1,2-dimethoxyethane 204.21
    ethyl orthosilicate 29.02
    tributyl phosphate 19.64
    diacetone alcohol 49.36
    N,N-dimethylaniline 26.3
    acrylonitrile 63.08
    aniline 22.53
    1,3-propanediol 55.56
    bromobenzene 18.81
    dibromomethane 84.76
    1,1,2,2-tetrachloroethane 119.07
    2-methyl-cyclohexyl acetate 35.46
    tetrabutyl urea 37.71
    diisobutyl methanol 6.06
    2-phenylethanol 23.37
    styrene 8.78
    dioctyl adipate 33.27
    dimethyl sulfate 197.46
    ethyl butyrate 50.82
    methyl lactate 76.91
    butyl lactate 38.35
    diethyl carbonate 41.79
    propanediol butyl ether 41.27
    triethyl orthoformate 38.0
    p-tert-butyltoluene 5.99
    methyl 4-tert-butylbenzoate 50.17
    morpholine 143.02
    tert-butylamine 13.4
    n-dodecanol 6.78
    dimethoxymethane 229.82
    ethylene carbonate 74.86
    cyrene 72.3
    2-ethoxyethyl acetate 77.96
    2-ethylhexyl acetate 29.55
    1,2,4-trichlorobenzene 35.67
    4-methylpyridine 70.54
    dibutyl ether 17.43
    2,6-dimethyl-4-heptanol 6.06
    DEF 134.85
    dimethyl isosorbide 108.89
    tetrachloroethylene 70.15
    eugenol 45.33
    triacetin 71.06
    span 80 41.84
    1,4-butanediol 20.23
    1,1-dichloroethane 56.87
    2-methyl-1-pentanol 15.79
    methyl formate 188.84
    2-methyl-1-butanol 23.88
    n-decane 1.36
    butyronitrile 36.83
    3,7-dimethyl-1-octanol 10.47
    1-chlorooctane 7.59
    1-chlorotetradecane 2.97
    n-nonane 1.15
    undecane 0.96
    tert-butylcyclohexane 0.86
    cyclooctane 0.68
    cyclopentanol 34.59
    tetrahydropyran 64.56
    tert-amyl methyl ether 33.34
    2,5,8-trioxanonane 105.11
    1-hexene 7.29
    2-isopropoxyethanol 49.69
    2,2,2-trifluoroethanol 85.86
    methyl butyrate 75.3

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction