3,3-Dichloro-1,1,1,2,2-pentafluoropropane

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  • Identifiers

    CAS number
    422-56-0

    Molecular formula
    C3HCl2F5

    SMILES
    C(C(C(F)(F)F)(F)F)(Cl)Cl

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 57.66%
    Fishy 26.59%
    Sweet 22.91%
    Cooling 21.77%
    Woody 21.51%
    Balsamic 17.05%
    Savory 15.93%
    Animal 15.85%
    Mint 15.48%
    Dry 14.61%

     

    Flavor
    Odorless 32.43%
    Bland 21.61%
    Sulfurous 21.0%
    Mild 18.17%
    Bitter 17.85%
    Sweet-like 17.82%
    Bloody 17.7%
    Glue 17.56%
    Bouillon 17.35%
    Skunky 17.05%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    3.4

    pKa est.
    3.89 (weak acid)

    Molecular weight
    202.93 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    47°C

    Flash point

    • -6.12 ˚C est.

  • Synonyms

    • 3,3-DICHLORO-1,1,1,2,2-PENTAFLUOROPROPANE
    • 422-56-0
    • HCFC-225ca
    • 127564-92-5
    • 1,1-Dichloro-2,2,3,3,3-pentafluoropropane
    • Propane, dichloropentafluoro-
    • DICHLOROPENTAFLUOROPROPANE
    • Propane, 3,3-dichloro-1,1,1,2,2-pentafluoro-
    • 0976Z0010M
    • Fron 225
    • HCFC 225ca
    • R 225ca
    • HSDB 6976
    • R 225b
    • EINECS 207-016-9
    • CCRIS 8666
    • UNII-0976Z0010M
    • HCFC-225ca/cb
    • SCHEMBL62551
    • DTXSID1042027
    • R-225CA
    • MFCD00198019
    • R-225B
    • AKOS025310243
    • FD86333
    • DB-050884
    • NS00002843
    • 1,1,1,2,2-pentafluoro-3,3-dichloropropane
    • 1,1-dichloro-2,2,3,3,3-pentafluoro-propane
    • 3,3-Dichloro-1,1,1,2,2-pentafluoropropane #
    • Q27236466
    • Dichloropentafluoropropane(s), Technical grade (HCFC-225ca/cb/aa)

  • Applications

    3,3-Dichloro-1,1,1,2,2-pentafluoropropane (CAS 422-56-0) is a halogenated propane derivative primarily used as an intermediate in the synthesis of fluorinated organochlorine compounds. It may be used as a specialty solvent or cleaning agent for electronics, precision manufacturing, and coatings. It can serve as a processing aid or diluent for polymer and plastic formulations. Depending on local regulations, it may be considered as a blowing agent for polymer foams or as a component in specialty refrigeration systems; use is subject to regulatory and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 145.48
    methanol 251.9
    isopropanol 86.07
    water 21.0
    ethyl acetate 133.86
    n-propanol 81.54
    acetone 418.09
    n-butanol 66.26
    acetonitrile 195.1
    DMF 752.11
    toluene 85.59
    isobutanol 53.91
    1,4-dioxane 247.92
    methyl acetate 164.27
    THF 342.41
    2-butanone 190.47
    n-pentanol 63.45
    sec-butanol 70.56
    n-hexane 24.73
    ethylene glycol 71.51
    NMP 598.49
    cyclohexane 46.47
    DMSO 1363.48
    n-butyl acetate 77.83
    n-octanol 72.81
    chloroform 106.68
    n-propyl acetate 100.48
    acetic acid 115.97
    dichloromethane 198.63
    cyclohexanone 184.95
    propylene glycol 37.1
    isopropyl acetate 90.1
    DMAc 618.97
    2-ethoxyethanol 222.84
    isopentanol 56.39
    n-heptane 36.67
    ethyl formate 105.33
    1,2-dichloroethane 194.07
    n-hexanol 56.85
    2-methoxyethanol 286.08
    isobutyl acetate 34.41
    tetrachloromethane 24.87
    n-pentyl acetate 79.12
    transcutol 398.92
    n-heptanol 49.87
    ethylbenzene 54.4
    MIBK 97.07
    2-propoxyethanol 144.94
    tert-butanol 98.56
    MTBE 109.84
    2-butoxyethanol 99.52
    propionic acid 62.76
    o-xylene 100.18
    formic acid 148.7
    diethyl ether 184.75
    m-xylene 71.53
    p-xylene 59.95
    chlorobenzene 42.65
    dimethyl carbonate 114.26
    n-octane 20.93
    formamide 350.61
    cyclopentanone 239.58
    2-pentanone 174.14
    anisole 131.59
    cyclopentyl methyl ether 166.04
    gamma-butyrolactone 245.06
    1-methoxy-2-propanol 193.14
    pyridine 197.4
    3-pentanone 158.82
    furfural 232.09
    n-dodecane 14.41
    diethylene glycol 140.44
    diisopropyl ether 64.14
    tert-amyl alcohol 82.25
    acetylacetone 236.35
    n-hexadecane 15.87
    acetophenone 155.4
    methyl propionate 149.98
    isopentyl acetate 49.7
    trichloroethylene 202.61
    n-nonanol 67.53
    cyclohexanol 73.97
    benzyl alcohol 86.82
    2-ethylhexanol 43.24
    isooctanol 39.18
    dipropyl ether 102.09
    1,2-dichlorobenzene 48.06
    ethyl lactate 61.75
    propylene carbonate 84.7
    n-methylformamide 310.79
    2-pentanol 63.21
    n-pentane 36.55
    1-propoxy-2-propanol 102.02
    1-methoxy-2-propyl acetate 100.73
    2-(2-methoxypropoxy) propanol 115.95
    mesitylene 57.86
    ε-caprolactone 141.96
    p-cymene 48.47
    epichlorohydrin 252.94
    1,1,1-trichloroethane 64.54
    2-aminoethanol 79.82
    morpholine-4-carbaldehyde 442.76
    sulfolane 402.67
    2,2,4-trimethylpentane 14.67
    2-methyltetrahydrofuran 179.95
    n-hexyl acetate 98.82
    isooctane 10.35
    2-(2-butoxyethoxy)ethanol 152.56
    sec-butyl acetate 57.37
    tert-butyl acetate 95.05
    decalin 18.14
    glycerin 66.58
    diglyme 333.09
    acrylic acid 69.83
    isopropyl myristate 51.03
    n-butyric acid 61.61
    acetyl acetate 91.15
    di(2-ethylhexyl) phthalate 38.78
    ethyl propionate 98.87
    nitromethane 439.51
    1,2-diethoxyethane 165.5
    benzonitrile 76.19
    trioctyl phosphate 33.81
    1-bromopropane 101.12
    gamma-valerolactone 294.68
    n-decanol 52.08
    triethyl phosphate 45.24
    4-methyl-2-pentanol 41.18
    propionitrile 91.94
    vinylene carbonate 80.38
    1,1,2-trichlorotrifluoroethane 149.39
    DMS 89.16
    cumene 41.72
    2-octanol 45.59
    2-hexanone 110.53
    octyl acetate 63.17
    limonene 71.2
    1,2-dimethoxyethane 378.79
    ethyl orthosilicate 42.9
    tributyl phosphate 34.84
    diacetone alcohol 117.18
    N,N-dimethylaniline 152.06
    acrylonitrile 136.42
    aniline 86.92
    1,3-propanediol 87.22
    bromobenzene 42.78
    dibromomethane 142.96
    1,1,2,2-tetrachloroethane 153.43
    2-methyl-cyclohexyl acetate 60.0
    tetrabutyl urea 80.6
    diisobutyl methanol 36.84
    2-phenylethanol 67.91
    styrene 64.72
    dioctyl adipate 68.88
    dimethyl sulfate 226.36
    ethyl butyrate 76.55
    methyl lactate 100.46
    butyl lactate 56.54
    diethyl carbonate 49.59
    propanediol butyl ether 87.08
    triethyl orthoformate 57.73
    p-tert-butyltoluene 46.54
    methyl 4-tert-butylbenzoate 120.41
    morpholine 260.35
    tert-butylamine 70.51
    n-dodecanol 40.56
    dimethoxymethane 405.99
    ethylene carbonate 68.33
    cyrene 119.5
    2-ethoxyethyl acetate 114.12
    2-ethylhexyl acetate 43.95
    1,2,4-trichlorobenzene 56.02
    4-methylpyridine 180.55
    dibutyl ether 81.94
    2,6-dimethyl-4-heptanol 36.84
    DEF 271.94
    dimethyl isosorbide 181.95
    tetrachloroethylene 131.41
    eugenol 104.17
    triacetin 108.27
    span 80 79.81
    1,4-butanediol 55.14
    1,1-dichloroethane 91.54
    2-methyl-1-pentanol 51.55
    methyl formate 244.23
    2-methyl-1-butanol 54.4
    n-decane 23.74
    butyronitrile 75.55
    3,7-dimethyl-1-octanol 54.21
    1-chlorooctane 48.49
    1-chlorotetradecane 24.38
    n-nonane 24.07
    undecane 18.26
    tert-butylcyclohexane 12.57
    cyclooctane 27.17
    cyclopentanol 79.99
    tetrahydropyran 152.73
    tert-amyl methyl ether 112.26
    2,5,8-trioxanonane 250.29
    1-hexene 50.05
    2-isopropoxyethanol 128.8
    2,2,2-trifluoroethanol 76.96
    methyl butyrate 115.44

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction