3-O-Ethylascorbic acid

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  • Identifiers

    CAS number
    86404-04-8

    Molecular formula
    C8H12O6

    SMILES
    CCOC1=C(C(=O)O[C@@H]1[C@H](CO)O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Caramellic 56.86%
    Odorless 43.73%
    Sweet 38.75%
    Fruity 37.26%
    Buttery 32.77%
    Milky 25.56%
    Burnt 23.81%
    Creamy 21.64%
    Winey 20.98%
    Lactonic 19.65%

     

    Flavor
    Odorless 37.32%
    Bitter 36.57%
    Very mild 33.35%
    Sweet-like 26.37%
    Bland 25.8%
    Cotton candy 21.29%
    Seedy 21.25%
    Extremely sweet 21.23%
    Caramel 21.13%
    Toffee 20.97%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -1.5

    pKa est.
    6.34 (neutral)

    Molecular weight
    204.18 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    559°C

    Flash point

    • 188.74 ˚C est.

  • Synonyms

    • 86404-04-8
    • 3-O-Ethylascorbic acid
    • 3-o-ethyl ascorbic acid
    • ethyl ascorbic acid
    • Vitamin C ethyl
    • 6MW60CB71P
    • ACTIVITA C
    • CORUM 9515
    • DTXSID8020595
    • Whitening serum
    • Shower Gel
    • Brightening Gream
    • Whitening Shower Gel
    • RefChem:95144
    • Whitening facial cleanser
    • DTXCID80595
    • 3-0-ETHYL ASCORBIC ACID
    • Beautyturess Exfoliating Peeling Oil
    • 617-849-3
    • 3-O-Ethyl-L-ascorbic acid
    • (R)-5-((S)-1,2-Dihydroxyethyl)-4-ethoxy-3-hydroxyfuran-2(5H)-one
    • MFCD09261382
    • (2R)-2-[(1S)-1,2-dihydroxyethyl]-3-ethoxy-4-hydroxy-2H-furan-5-one
    • L-Ascorbic acid, 3-O-ethyl-
    • 3-O-Ethyl Ascorbyl Ether
    • CCRIS 7479
    • (5R)-5-[(1S)-1,2-dihydroxyethyl]-4-ethoxy-3-hydroxyfuran-2(5H)-one
    • 3-O-Ethyl-L-ascorbicacid
    • 3-o-ethylascorbicacid
    • UNII-6MW60CB71P
    • ethyl ascorbyl ether
    • 3-o-ethyl-ascorbic acid
    • EC 617-849-3
    • 3-O-ETHYL ASCORBATE
    • SCHEMBL352408
    • orb1299341
    • orb3026021
    • MSK1605
    • CHEBI:189226
    • (5R)-5-((1S)-1,2-Dihydroxyethyl)-4-ethoxy-3-hydroxy-5H-furan-2-one
    • (5R,1'S)-5-(1,2-Dihydroxy-ethyl)-4-ethoxy-3-hydroxy-5H-furan-2-one
    • AKOS015920304
    • CS-W003607
    • GS-4098
    • HY-W003607
    • (5R)-5-[(1S)-1,2-dihydroxyethyl]-4-ethoxy-3-hydroxy-2,5-dihydrofuran-2-one
    • 3-o-Ethyl-L-ascorbic acid, AldrichCPR
    • L-ASCORBIC ACID 3-O-ETHYL ETHER
    • FD140067
    • PD150806
    • SY031031
    • 404E048
    • F049982
    • Q27265176
    • (2R)-2-[(1S)-1,2-dihydroxyethyl]-3-ethoxy-4-hydroxy-2H-uran-5-one
    • 86404-04-8

  • Applications

    3-O-Ethylascorbic acid, CAS 86404-04-8, is a vitamin C derivative used primarily as an antioxidant and formulation stabilizer in cosmetics and personal care, where its stability and relatively improved skin-penetration profile support antioxidant protection and brightening effects in certain skin-care products. It is also employed as a stabilizer and reducing agent in polymer, coating, and ink systems to mitigate oxidation and degradation from light, heat, and oxygen. In the pharmaceutical and chemical-synthesis arena, it can serve as an intermediate or synthetic precursor for organic compounds and vitamin C derivatives. Additionally, it may be evaluated for industrial manufacturing applications as a stabilizer and reducing agent in various process formulations to extend shelf life and product stability.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 46.89
    methanol 177.42
    isopropanol 17.29
    water 144.37
    ethyl acetate 3.67
    n-propanol 19.0
    acetone 11.03
    n-butanol 13.01
    acetonitrile 7.06
    DMF 228.15
    toluene 1.64
    isobutanol 8.55
    1,4-dioxane 19.86
    methyl acetate 5.89
    THF 19.77
    2-butanone 5.94
    n-pentanol 10.63
    sec-butanol 10.73
    n-hexane 0.26
    ethylene glycol 216.23
    NMP 184.23
    cyclohexane 1.09
    DMSO 740.16
    n-butyl acetate 4.26
    n-octanol 7.33
    chloroform 4.6
    n-propyl acetate 3.61
    acetic acid 46.99
    dichloromethane 13.1
    cyclohexanone 16.27
    propylene glycol 70.84
    isopropyl acetate 2.76
    DMAc 160.12
    2-ethoxyethanol 70.41
    isopentanol 9.17
    n-heptane 0.84
    ethyl formate 13.8
    1,2-dichloroethane 11.23
    n-hexanol 9.02
    2-methoxyethanol 146.49
    isobutyl acetate 2.08
    tetrachloromethane 1.43
    n-pentyl acetate 4.46
    transcutol 49.36
    n-heptanol 8.61
    ethylbenzene 2.06
    MIBK 3.65
    2-propoxyethanol 39.36
    tert-butanol 17.42
    MTBE 3.77
    2-butoxyethanol 27.29
    propionic acid 19.1
    o-xylene 3.78
    formic acid 294.32
    diethyl ether 2.74
    m-xylene 2.29
    p-xylene 2.36
    chlorobenzene 2.66
    dimethyl carbonate 13.02
    n-octane 0.53
    formamide 280.59
    cyclopentanone 19.64
    2-pentanone 4.08
    anisole 6.38
    cyclopentyl methyl ether 6.28
    gamma-butyrolactone 38.49
    1-methoxy-2-propanol 59.16
    pyridine 12.89
    3-pentanone 3.52
    furfural 67.93
    n-dodecane 0.52
    diethylene glycol 108.68
    diisopropyl ether 1.08
    tert-amyl alcohol 13.13
    acetylacetone 10.94
    n-hexadecane 0.57
    acetophenone 12.3
    methyl propionate 7.89
    isopentyl acetate 4.39
    trichloroethylene 12.78
    n-nonanol 6.76
    cyclohexanol 12.15
    benzyl alcohol 19.68
    2-ethylhexanol 5.5
    isooctanol 6.59
    dipropyl ether 3.39
    1,2-dichlorobenzene 5.09
    ethyl lactate 15.32
    propylene carbonate 19.72
    n-methylformamide 113.35
    2-pentanol 5.23
    n-pentane 0.44
    1-propoxy-2-propanol 20.09
    1-methoxy-2-propyl acetate 10.97
    2-(2-methoxypropoxy) propanol 25.31
    mesitylene 2.2
    ε-caprolactone 19.4
    p-cymene 3.14
    epichlorohydrin 29.68
    1,1,1-trichloroethane 2.09
    2-aminoethanol 122.08
    morpholine-4-carbaldehyde 120.39
    sulfolane 142.8
    2,2,4-trimethylpentane 0.41
    2-methyltetrahydrofuran 8.66
    n-hexyl acetate 5.85
    isooctane 0.24
    2-(2-butoxyethoxy)ethanol 30.57
    sec-butyl acetate 2.1
    tert-butyl acetate 4.32
    decalin 0.72
    glycerin 185.42
    diglyme 54.24
    acrylic acid 34.8
    isopropyl myristate 2.96
    n-butyric acid 14.51
    acetyl acetate 4.21
    di(2-ethylhexyl) phthalate 8.66
    ethyl propionate 3.6
    nitromethane 62.07
    1,2-diethoxyethane 7.12
    benzonitrile 10.13
    trioctyl phosphate 6.75
    1-bromopropane 2.55
    gamma-valerolactone 55.39
    n-decanol 5.35
    triethyl phosphate 6.78
    4-methyl-2-pentanol 3.72
    propionitrile 5.06
    vinylene carbonate 22.51
    1,1,2-trichlorotrifluoroethane 82.32
    DMS 8.61
    cumene 2.19
    2-octanol 4.4
    2-hexanone 3.81
    octyl acetate 4.62
    limonene 4.02
    1,2-dimethoxyethane 45.45
    ethyl orthosilicate 5.76
    tributyl phosphate 5.25
    diacetone alcohol 18.36
    N,N-dimethylaniline 10.43
    acrylonitrile 14.24
    aniline 7.87
    1,3-propanediol 85.27
    bromobenzene 2.14
    dibromomethane 5.85
    1,1,2,2-tetrachloroethane 12.7
    2-methyl-cyclohexyl acetate 6.82
    tetrabutyl urea 11.07
    diisobutyl methanol 3.93
    2-phenylethanol 15.17
    styrene 2.14
    dioctyl adipate 7.11
    dimethyl sulfate 47.95
    ethyl butyrate 4.6
    methyl lactate 35.36
    butyl lactate 10.57
    diethyl carbonate 4.58
    propanediol butyl ether 28.04
    triethyl orthoformate 5.49
    p-tert-butyltoluene 3.05
    methyl 4-tert-butylbenzoate 18.87
    morpholine 30.33
    tert-butylamine 6.7
    n-dodecanol 4.26
    dimethoxymethane 46.52
    ethylene carbonate 15.43
    cyrene 50.85
    2-ethoxyethyl acetate 7.99
    2-ethylhexyl acetate 3.32
    1,2,4-trichlorobenzene 6.83
    4-methylpyridine 10.01
    dibutyl ether 2.51
    2,6-dimethyl-4-heptanol 3.93
    DEF 23.01
    dimethyl isosorbide 37.01
    tetrachloroethylene 10.75
    eugenol 22.9
    triacetin 11.73
    span 80 20.21
    1,4-butanediol 54.5
    1,1-dichloroethane 2.5
    2-methyl-1-pentanol 7.88
    methyl formate 74.03
    2-methyl-1-butanol 8.63
    n-decane 0.71
    butyronitrile 4.55
    3,7-dimethyl-1-octanol 5.54
    1-chlorooctane 2.12
    1-chlorotetradecane 1.22
    n-nonane 0.64
    undecane 0.59
    tert-butylcyclohexane 0.45
    cyclooctane 0.65
    cyclopentanol 14.02
    tetrahydropyran 6.17
    tert-amyl methyl ether 4.34
    2,5,8-trioxanonane 46.55
    1-hexene 0.76
    2-isopropoxyethanol 28.43
    2,2,2-trifluoroethanol 44.37
    methyl butyrate 6.51

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction