3-Methoxysalicyl alcohol

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  • Identifiers

    CAS number
    4383-05-5

    Molecular formula
    C8H10O3

    SMILES
    COC1=CC=CC(=C1O)CO

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 87.34%
    Vanilla 85.71%
    Phenolic 68.06%
    Balsamic 57.06%
    Creamy 51.99%
    Smoky 48.78%
    Powdery 46.88%
    Spicy 45.55%
    Medicinal 40.47%
    Aromatic 39.48%

     

    Flavor
    Sweet 87.01%
    Vanilla 65.39%
    Phenolic 59.62%
    Powdery 52.64%
    Smoky 51.22%
    Woody 47.55%
    Bitter 44.18%
    Spicy 43.93%
    Creamy 42.44%
    Clove 41.06%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.2

    pKa est.
    9.31 (weak base)

    Molecular weight
    154.16 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    329°C

    Flash point

    • 135.28 ˚C est.

  • Synonyms

    • 4383-05-5
    • o-Vanillyl alcohol
    • 3-Methoxysalicyl alcohol
    • Benzenemethanol, 2-hydroxy-3-methoxy-
    • 2-hydroxy-3-methoxybenzenemethanol
    • DTXSID80195948
    • EINECS 224-488-1
    • RefChem:503306
    • DTXCID20118439
    • 224-488-1
    • 2-(Hydroxymethyl)-6-methoxyphenol
    • 2-Hydroxy-3-methoxybenzyl alcohol
    • MFCD00008362
    • 2-(hydroxymethyl)-6-methoxy-phenol
    • 2-hydroxymethyl-6-methoxyphenol
    • 6-(hydroxymethyl)-2-methoxyphenol
    • 2-Vanillyl alcohol
    • OKE
    • Ortho-vanillyl alcohol
    • 2-Hydroxy-3-methoxy-hydroxymethyl benzene
    • o-(Hydroxymethyl)guaiacol
    • CR6WC34BRQ
    • SCHEMBL828720
    • SCHEMBL2292046
    • CHEMBL3786715
    • 2-Hydroxy-3-(hydroxymethyl)anisole
    • phenol, 2-hydroxymethyl-6-methoxy-
    • SBB064806
    • 2-(Hydroxymethyl)-6-methoxyphenol #
    • AKOS000248911
    • AC-6161
    • FH70966
    • 2-Hydroxy-3-methoxybenzyl alcohol, 97%
    • AS-61261
    • SY051739
    • DB-051169
    • CS-0150322
    • H1273
    • NS00047855
    • ST50824472
    • EN300-698225
    • F240605
    • InChI=1/C8H10O3/c1-11-7-4-2-3-6(5-9)8(7)10/h2-4,9-10H,5H2,1H
    • 4383-05-5

  • Applications

    3-Methoxysalicyl alcohol (CAS 4383-05-5) is predominantly used as a chemical intermediate and fragrance component in perfumery and flavor formulation; as a building block it participates in the synthesis of more complex aroma compounds. It is also employed in cosmetics and personal care as a fragrance ingredient or precursor for products such as skin and hair care formulations. In household products, it may contribute to scent profiles in cleaners and air fresheners. In industrial manufacturing, it serves as a building block for specialty chemicals and can be considered for applications in coatings, inks, and other aroma-enabled formulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 330.5
    methanol 412.62
    isopropanol 142.5
    water 17.26
    ethyl acetate 96.76
    n-propanol 192.83
    acetone 228.4
    n-butanol 99.33
    acetonitrile 178.26
    DMF 534.65
    toluene 14.56
    isobutanol 90.56
    1,4-dioxane 449.99
    methyl acetate 164.71
    THF 439.16
    2-butanone 129.06
    n-pentanol 81.78
    sec-butanol 98.57
    n-hexane 2.91
    ethylene glycol 460.84
    NMP 280.05
    cyclohexane 7.98
    DMSO 1412.51
    n-butyl acetate 53.69
    n-octanol 63.96
    chloroform 174.68
    n-propyl acetate 84.39
    acetic acid 360.26
    dichloromethane 319.16
    cyclohexanone 158.23
    propylene glycol 202.86
    isopropyl acetate 49.56
    DMAc 243.22
    2-ethoxyethanol 320.74
    isopentanol 65.59
    n-heptane 9.21
    ethyl formate 163.87
    1,2-dichloroethane 212.16
    n-hexanol 74.31
    2-methoxyethanol 571.73
    isobutyl acetate 42.62
    tetrachloromethane 34.88
    n-pentyl acetate 51.91
    transcutol 294.73
    n-heptanol 62.92
    ethylbenzene 17.81
    MIBK 55.24
    2-propoxyethanol 188.51
    tert-butanol 196.68
    MTBE 76.89
    2-butoxyethanol 134.49
    propionic acid 187.47
    o-xylene 20.4
    formic acid 361.52
    diethyl ether 73.08
    m-xylene 19.38
    p-xylene 23.15
    chlorobenzene 45.12
    dimethyl carbonate 90.22
    n-octane 5.5
    formamide 683.59
    cyclopentanone 270.91
    2-pentanone 76.5
    anisole 79.46
    cyclopentyl methyl ether 94.14
    gamma-butyrolactone 425.24
    1-methoxy-2-propanol 256.22
    pyridine 131.3
    3-pentanone 56.6
    furfural 298.17
    n-dodecane 5.45
    diethylene glycol 281.18
    diisopropyl ether 20.02
    tert-amyl alcohol 116.43
    acetylacetone 130.72
    n-hexadecane 5.99
    acetophenone 80.78
    methyl propionate 105.51
    isopentyl acetate 46.31
    trichloroethylene 283.98
    n-nonanol 54.57
    cyclohexanol 74.54
    benzyl alcohol 82.74
    2-ethylhexanol 44.88
    isooctanol 50.95
    dipropyl ether 48.95
    1,2-dichlorobenzene 56.75
    ethyl lactate 78.78
    propylene carbonate 171.92
    n-methylformamide 464.0
    2-pentanol 51.02
    n-pentane 3.9
    1-propoxy-2-propanol 115.78
    1-methoxy-2-propyl acetate 79.06
    2-(2-methoxypropoxy) propanol 99.52
    mesitylene 17.05
    ε-caprolactone 146.83
    p-cymene 20.98
    epichlorohydrin 438.55
    1,1,1-trichloroethane 104.26
    2-aminoethanol 389.86
    morpholine-4-carbaldehyde 347.81
    sulfolane 609.48
    2,2,4-trimethylpentane 4.49
    2-methyltetrahydrofuran 182.21
    n-hexyl acetate 72.66
    isooctane 4.17
    2-(2-butoxyethoxy)ethanol 147.05
    sec-butyl acetate 38.41
    tert-butyl acetate 67.75
    decalin 6.06
    glycerin 343.59
    diglyme 305.86
    acrylic acid 200.94
    isopropyl myristate 33.44
    n-butyric acid 145.35
    acetyl acetate 72.27
    di(2-ethylhexyl) phthalate 37.37
    ethyl propionate 60.87
    nitromethane 687.71
    1,2-diethoxyethane 83.34
    benzonitrile 83.12
    trioctyl phosphate 36.0
    1-bromopropane 56.06
    gamma-valerolactone 352.78
    n-decanol 43.23
    triethyl phosphate 41.38
    4-methyl-2-pentanol 34.03
    propionitrile 111.88
    vinylene carbonate 162.32
    1,1,2-trichlorotrifluoroethane 314.92
    DMS 65.85
    cumene 18.43
    2-octanol 40.93
    2-hexanone 69.58
    octyl acetate 47.22
    limonene 29.7
    1,2-dimethoxyethane 333.65
    ethyl orthosilicate 36.51
    tributyl phosphate 32.62
    diacetone alcohol 126.04
    N,N-dimethylaniline 56.79
    acrylonitrile 187.89
    aniline 50.93
    1,3-propanediol 338.18
    bromobenzene 37.19
    dibromomethane 154.45
    1,1,2,2-tetrachloroethane 194.61
    2-methyl-cyclohexyl acetate 51.24
    tetrabutyl urea 47.96
    diisobutyl methanol 33.43
    2-phenylethanol 71.82
    styrene 21.49
    dioctyl adipate 56.32
    dimethyl sulfate 173.57
    ethyl butyrate 55.32
    methyl lactate 116.58
    butyl lactate 53.92
    diethyl carbonate 45.24
    propanediol butyl ether 113.54
    triethyl orthoformate 44.47
    p-tert-butyltoluene 21.06
    methyl 4-tert-butylbenzoate 88.72
    morpholine 406.34
    tert-butylamine 84.17
    n-dodecanol 34.33
    dimethoxymethane 272.8
    ethylene carbonate 132.53
    cyrene 130.3
    2-ethoxyethyl acetate 74.78
    2-ethylhexyl acetate 33.56
    1,2,4-trichlorobenzene 67.94
    4-methylpyridine 81.43
    dibutyl ether 43.05
    2,6-dimethyl-4-heptanol 33.43
    DEF 123.56
    dimethyl isosorbide 162.18
    tetrachloroethylene 143.58
    eugenol 96.95
    triacetin 88.38
    span 80 83.44
    1,4-butanediol 161.0
    1,1-dichloroethane 109.15
    2-methyl-1-pentanol 55.4
    methyl formate 394.25
    2-methyl-1-butanol 62.22
    n-decane 8.3
    butyronitrile 88.88
    3,7-dimethyl-1-octanol 46.18
    1-chlorooctane 33.8
    1-chlorotetradecane 14.2
    n-nonane 7.64
    undecane 6.61
    tert-butylcyclohexane 5.93
    cyclooctane 3.95
    cyclopentanol 139.06
    tetrahydropyran 167.84
    tert-amyl methyl ether 51.89
    2,5,8-trioxanonane 205.98
    1-hexene 11.72
    2-isopropoxyethanol 165.3
    2,2,2-trifluoroethanol 190.47
    methyl butyrate 93.27

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction