3-Methoxyphenol

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  • Identifiers

    CAS number
    150-19-6

    Molecular formula
    C7H8O2

    SMILES
    COC1=CC=CC(=C1)O

    Safety labels

    Corrosive
    Corrosive

    Acute Toxic
    Acute Toxic

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 84.45%
    Phenolic 81.81%
    Medicinal 56.73%
    Nutty 46.28%
    Vanilla 45.04%
    Smoky 41.82%
    Woody 41.15%
    Musty 37.65%
    Spicy 37.46%
    Fruity 36.89%

     

    Flavor
    Phenolic 66.63%
    Medicinal 39.0%
    Smoky 34.65%
    Bitter 34.54%
    Musty 33.23%
    Woody 32.32%
    Nutty 32.13%
    Smoke 31.9%
    Phenol 29.45%
    Creamy 28.69%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.6

    pKa est.
    9.02 (weak base)

    Molecular weight
    124.14 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Melting point expt.

    • <1.4 °F

    Boiling point

    • 471.2 °F

    Flash point

    • 90.69 ˚C est.

  • Synonyms

    • 3-METHOXYPHENOL
    • 150-19-6
    • m-Methoxyphenol
    • 3-Hydroxyanisole
    • Phenol, 3-methoxy-
    • m-Hydroxyanisole
    • m-Guaiacol
    • Resorcinol monomethyl ether
    • 1-Hydroxy-3-methoxybenzene
    • Resorcinol methyl ether
    • Phenol, m-methoxy-
    • 3-(methyloxy)phenol
    • m-Hydroxyanisol
    • 3-METHOXY-PHENOL
    • EINECS 205-754-6
    • MFCD00002267
    • NSC 21735
    • UNII-HXB7441U87
    • DTXSID0022012
    • CHEBI:52678
    • ORISTAR HOA
    • AI3-00796
    • NSC-21735
    • DTXCID302012
    • HXB7441U87
    • 3-methoxy phenol
    • 3-Hydroxyanisol
    • mHydroxyanisole
    • mMethoxyphenol
    • mGuaiacol
    • Guaiacol Imp. H (EP); 3-Methoxyphenol; Guaiacol Impurity H
    • 3Hydroxyanisole
    • m-methoxy-phenol
    • 3-methoxy-pheno
    • Phenol, mmethoxy
    • 3-methyloxyphenol
    • Phenol, 3methoxy
    • 1Hydroxy3methoxybenzene
    • 3-Methoxyphenol, 96%
    • 3-Methoxyphenol - 98%
    • 3-Methoxyphenol (Standard)
    • SCHEMBL28256
    • CHEMBL57891
    • M-HYDROXYANISOLE [INCI]
    • SCHEMBL12015261
    • BDBM36297
    • HY-Y1840R
    • CS-D1677
    • HY-Y1840
    • NSC21735
    • 3-Methoxyphenol, analytical standard
    • Tox21_303820
    • CK1184
    • STL141067
    • AKOS000120300
    • FM25316
    • NCGC00357098-01
    • AC-18515
    • AS-45839
    • CAS-150-19-6
    • DB-002515
    • M0122
    • NS00020150
    • EN300-20543
    • Q27123546
    • F0001-0533
    • Z104478798
    • 1-Hydroxy-3-methoxybenzene;3-Hydroxyanisole;Resorcinol monomethyl ether;m-Hydroxyanisole

  • Applications

    3-Methoxyphenol (CAS number: 150-19-6) is primarily used as an intermediate in the synthesis of fragrance and flavor compounds, serving as a building block for aroma chemicals and as a precursor to related methoxyphenol derivatives. It also appears in cosmetics and personal care formulations as a fragrance ingredient or aroma contributor. In pharmaceutical and broader chemical manufacturing, it is applied as a synthetic intermediate for the preparation of more complex organic compounds. Additionally, it is used in industrial manufacturing as a building block for specialty chemicals, dyes, or resin-related products, and may be considered in research and development for new fragrance or material applications. Subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1330.19
    methanol 1250.5
    isopropanol 1147.31
    water 8.13
    ethyl acetate 746.79
    n-propanol 1026.59
    acetone 1367.56
    n-butanol 689.23
    acetonitrile 990.18
    DMF 1438.66
    toluene 123.57
    isobutanol 641.44
    1,4-dioxane 1640.73
    methyl acetate 943.75
    THF 1938.16
    2-butanone 800.17
    n-pentanol 406.09
    sec-butanol 769.45
    n-hexane 43.6
    ethylene glycol 650.05
    NMP 641.43
    cyclohexane 40.55
    DMSO 2436.34
    n-butyl acetate 158.27
    n-octanol 165.9
    chloroform 668.22
    n-propyl acetate 254.66
    acetic acid 701.95
    dichloromethane 619.48
    cyclohexanone 542.49
    propylene glycol 811.2
    isopropyl acetate 297.84
    DMAc 834.4
    2-ethoxyethanol 767.22
    isopentanol 396.59
    n-heptane 32.58
    ethyl formate 415.52
    1,2-dichloroethane 460.91
    n-hexanol 352.21
    2-methoxyethanol 1541.03
    isobutyl acetate 146.39
    tetrachloromethane 130.15
    n-pentyl acetate 112.45
    transcutol 787.88
    n-heptanol 145.99
    ethylbenzene 62.33
    MIBK 282.85
    2-propoxyethanol 639.86
    tert-butanol 1098.8
    MTBE 538.27
    2-butoxyethanol 264.42
    propionic acid 752.73
    o-xylene 83.64
    formic acid 301.69
    diethyl ether 661.8
    m-xylene 99.02
    p-xylene 77.88
    chlorobenzene 149.78
    dimethyl carbonate 311.0
    n-octane 16.76
    formamide 511.37
    cyclopentanone 913.23
    2-pentanone 587.84
    anisole 252.43
    cyclopentyl methyl ether 557.97
    gamma-butyrolactone 994.04
    1-methoxy-2-propanol 1088.13
    pyridine 428.77
    3-pentanone 380.27
    furfural 552.15
    n-dodecane 18.65
    diethylene glycol 714.41
    diisopropyl ether 136.02
    tert-amyl alcohol 633.64
    acetylacetone 606.05
    n-hexadecane 20.39
    acetophenone 170.59
    methyl propionate 632.62
    isopentyl acetate 137.09
    trichloroethylene 624.35
    n-nonanol 137.02
    cyclohexanol 397.72
    benzyl alcohol 196.64
    2-ethylhexanol 140.52
    isooctanol 111.03
    dipropyl ether 185.6
    1,2-dichlorobenzene 128.47
    ethyl lactate 168.77
    propylene carbonate 377.94
    n-methylformamide 851.47
    2-pentanol 423.14
    n-pentane 47.35
    1-propoxy-2-propanol 343.55
    1-methoxy-2-propyl acetate 241.14
    2-(2-methoxypropoxy) propanol 228.18
    mesitylene 67.76
    ε-caprolactone 411.7
    p-cymene 46.62
    epichlorohydrin 1020.23
    1,1,1-trichloroethane 459.62
    2-aminoethanol 839.55
    morpholine-4-carbaldehyde 836.87
    sulfolane 989.25
    2,2,4-trimethylpentane 27.4
    2-methyltetrahydrofuran 956.19
    n-hexyl acetate 192.11
    isooctane 27.18
    2-(2-butoxyethoxy)ethanol 323.98
    sec-butyl acetate 144.59
    tert-butyl acetate 311.26
    decalin 26.97
    glycerin 794.8
    diglyme 570.73
    acrylic acid 533.61
    isopropyl myristate 87.98
    n-butyric acid 606.59
    acetyl acetate 331.63
    di(2-ethylhexyl) phthalate 74.35
    ethyl propionate 250.84
    nitromethane 1279.27
    1,2-diethoxyethane 212.96
    benzonitrile 182.67
    trioctyl phosphate 69.21
    1-bromopropane 277.41
    gamma-valerolactone 904.31
    n-decanol 109.6
    triethyl phosphate 82.09
    4-methyl-2-pentanol 194.01
    propionitrile 582.85
    vinylene carbonate 314.62
    1,1,2-trichlorotrifluoroethane 627.83
    DMS 187.06
    cumene 52.08
    2-octanol 106.23
    2-hexanone 270.84
    octyl acetate 114.44
    limonene 71.25
    1,2-dimethoxyethane 847.03
    ethyl orthosilicate 77.26
    tributyl phosphate 74.96
    diacetone alcohol 456.75
    N,N-dimethylaniline 144.95
    acrylonitrile 677.23
    aniline 256.82
    1,3-propanediol 937.95
    bromobenzene 131.33
    dibromomethane 378.91
    1,1,2,2-tetrachloroethane 510.64
    2-methyl-cyclohexyl acetate 106.45
    tetrabutyl urea 95.26
    diisobutyl methanol 90.5
    2-phenylethanol 178.2
    styrene 81.06
    dioctyl adipate 117.75
    dimethyl sulfate 480.65
    ethyl butyrate 134.83
    methyl lactate 381.84
    butyl lactate 112.06
    diethyl carbonate 97.46
    propanediol butyl ether 265.43
    triethyl orthoformate 96.22
    p-tert-butyltoluene 52.39
    methyl 4-tert-butylbenzoate 163.95
    morpholine 1600.04
    tert-butylamine 480.05
    n-dodecanol 87.98
    dimethoxymethane 985.37
    ethylene carbonate 286.1
    cyrene 222.97
    2-ethoxyethyl acetate 173.74
    2-ethylhexyl acetate 96.93
    1,2,4-trichlorobenzene 155.87
    4-methylpyridine 367.74
    dibutyl ether 136.82
    2,6-dimethyl-4-heptanol 90.5
    DEF 503.55
    dimethyl isosorbide 304.83
    tetrachloroethylene 299.27
    eugenol 171.15
    triacetin 179.71
    span 80 199.76
    1,4-butanediol 378.26
    1,1-dichloroethane 558.44
    2-methyl-1-pentanol 239.29
    methyl formate 639.67
    2-methyl-1-butanol 410.71
    n-decane 27.69
    butyronitrile 441.71
    3,7-dimethyl-1-octanol 134.79
    1-chlorooctane 94.73
    1-chlorotetradecane 43.6
    n-nonane 27.68
    undecane 22.22
    tert-butylcyclohexane 32.81
    cyclooctane 17.74
    cyclopentanol 617.79
    tetrahydropyran 1037.04
    tert-amyl methyl ether 310.46
    2,5,8-trioxanonane 399.0
    1-hexene 137.77
    2-isopropoxyethanol 431.08
    2,2,2-trifluoroethanol 275.4
    methyl butyrate 304.73

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction