3-Methoxycinnamic Acid

Overview IFRA Request a quote

  • Identifiers

    CAS number
    6099-04-3

    Molecular formula
    C10H10O3

    SMILES
    COC1=CC=CC(=C1)/C=C/C(=O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 63.15%
    Balsamic 63.12%
    Spicy 52.37%
    Vanilla 44.01%
    Phenolic 41.99%
    Honey 41.0%
    Cinnamon 37.83%
    Powdery 36.66%
    Aromatic 32.67%
    Fruity 31.43%

     

    Flavor
    Balsam 44.17%
    Sweet 38.48%
    Odorless 32.93%
    Balsamic 29.96%
    Faint 28.64%
    Honey 25.88%
    Cinnamon 25.46%
    Phenolic 23.0%
    Mild 22.39%
    Sour 21.89%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.1

    pKa est.
    7.45 (neutral)

    Molecular weight
    178.18 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    337°C

    Flash point

    • 164.35 ˚C est.

  • Synonyms

    • 3-Methoxycinnamic acid
    • 6099-04-3
    • (2E)-3-(3-methoxyphenyl)prop-2-enoic acid
    • (E)-3-(3-methoxyphenyl)prop-2-enoic acid
    • trans-3-Methoxycinnamic acid
    • NSC 5234
    • EINECS 228-049-5
    • DTXSID501035148
    • RefChem:503247
    • DTXCID201060704
    • 228-049-5
    • 861-306-5
    • 17570-26-2
    • 3-(3-Methoxyphenyl)acrylic acid
    • (E)-3-(3-Methoxyphenyl)acrylic acid
    • m-Methoxycinnamic acid
    • (2E)-3-(3-methoxyphenyl)acrylic acid
    • 2-Propenoic acid, 3-(3-methoxyphenyl)-, (2E)-
    • MFCD00004386
    • O-Methyl-m-coumaric Acid
    • (E)-3-methoxycinnamic acid
    • CHEMBL95769
    • (E)-3-(3-Methoxyphenyl)acrylicacid
    • 3-Methoxycinnamic Acid, Predominantly trans
    • 2-Propenoic acid,3-(3-methoxyphenyl)-, (2E)-
    • trans-3-(3-Methoxyphenyl)acrylic acid
    • trans-m-Methoxycinnamic acid
    • Cinnamic acid, m-methoxy-, (E)-
    • O-Methyl-m-cumaric Acid
    • Cinnamic acid, m-methoxy-
    • Cinnamic acid, 3-methoxy-
    • SCHEMBL80786
    • trans-3-methoxy-cinnamic acid
    • 3-Methoxycinnamic acid, 97%
    • SCHEMBL7380255
    • SCHEMBL30584119
    • DTXSID70875904
    • NSC5234
    • CHEBI:192607
    • HMS1538H06
    • BB_NC-02329
    • NSC-5234
    • BBL019132
    • BDBM50486904
    • E-3-(3-methoxyphenyl)propenoic acid
    • SBB042486
    • STK398162
    • AKOS000120394
    • CS-W017339
    • EBC-618258
    • FM37085
    • PS-5776
    • SDCCGSBI-0660327.P001
    • (E)-3-(3-methoxyphenyl) acrylic acid
    • NCGC00174293-01
    • (E)-3-(3-Methoxy-phenyl)-acrylic acid
    • LS-13767
    • ST023772
    • SY015385
    • M0444
    • NS00015849
    • EN300-21248
    • EN300-33979
    • A10219
    • Propenoic acid, 3-(3-methoxyphenyl)-, trans-
    • (2E)-3-(3-Methoxyphenyl)-2-propenoic acid #
    • 2-Propenoic acid,3-(3-methoxyphenyl)-,(2E)-
    • AE-848/02128047
    • F551699
    • F791467
    • 055FCE22-12AE-47AE-BB4F-BF75F6AECF94
    • Q63409580
    • Z104494816
    • 6099-04-3

  • Applications

    3-Methoxycinnamic Acid (CAS 6099-04-3) is commonly used as an organic synthesis intermediate to access a range of cinnamate derivatives. In fragrance and flavor applications, it serves as a precursor for aroma compounds and fragrance ingredients; in cosmetics and personal care, it can be used as a fragrance component or a starting point for more complex actives. In pharmaceutical and agrochemical development, it functions as a building block for ester and amide derivatives. In industrial manufacturing and materials science, it is employed to prepare cinnamate esters and related compounds for specialty chemicals, polymers, and coatings. The compound's use is typically as an intermediate rather than a final formulation ingredient, and actual applications are subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 98.58
    methanol 113.07
    isopropanol 67.47
    water 0.59
    ethyl acetate 33.78
    n-propanol 66.51
    acetone 103.21
    n-butanol 49.83
    acetonitrile 38.99
    DMF 241.16
    toluene 9.12
    isobutanol 37.44
    1,4-dioxane 87.82
    methyl acetate 60.31
    THF 182.27
    2-butanone 79.93
    n-pentanol 40.76
    sec-butanol 55.38
    n-hexane 0.97
    ethylene glycol 66.2
    NMP 117.41
    cyclohexane 0.49
    DMSO 404.94
    n-butyl acetate 25.54
    n-octanol 16.09
    chloroform 32.97
    n-propyl acetate 26.35
    acetic acid 46.05
    dichloromethane 35.05
    cyclohexanone 52.35
    propylene glycol 78.87
    isopropyl acetate 20.67
    DMAc 291.77
    2-ethoxyethanol 118.77
    isopentanol 41.2
    n-heptane 0.88
    ethyl formate 26.39
    1,2-dichloroethane 37.45
    n-hexanol 37.03
    2-methoxyethanol 174.48
    isobutyl acetate 15.93
    tetrachloromethane 5.24
    n-pentyl acetate 13.38
    transcutol 193.46
    n-heptanol 15.94
    ethylbenzene 9.73
    MIBK 31.7
    2-propoxyethanol 88.29
    tert-butanol 113.53
    MTBE 46.0
    2-butoxyethanol 43.02
    propionic acid 48.94
    o-xylene 11.23
    formic acid 48.76
    diethyl ether 32.23
    m-xylene 9.19
    p-xylene 11.24
    chlorobenzene 11.98
    dimethyl carbonate 29.92
    n-octane 0.65
    formamide 90.78
    cyclopentanone 96.62
    2-pentanone 45.59
    anisole 46.36
    cyclopentyl methyl ether 44.84
    gamma-butyrolactone 97.34
    1-methoxy-2-propanol 114.61
    pyridine 39.32
    3-pentanone 34.9
    furfural 77.16
    n-dodecane 0.84
    diethylene glycol 105.46
    diisopropyl ether 8.09
    tert-amyl alcohol 80.89
    acetylacetone 47.47
    n-hexadecane 0.95
    acetophenone 36.95
    methyl propionate 47.71
    isopentyl acetate 27.03
    trichloroethylene 63.69
    n-nonanol 14.87
    cyclohexanol 27.71
    benzyl alcohol 37.92
    2-ethylhexanol 19.89
    isooctanol 13.91
    dipropyl ether 15.61
    1,2-dichlorobenzene 15.27
    ethyl lactate 27.99
    propylene carbonate 37.9
    n-methylformamide 101.41
    2-pentanol 31.01
    n-pentane 0.48
    1-propoxy-2-propanol 54.07
    1-methoxy-2-propyl acetate 41.97
    2-(2-methoxypropoxy) propanol 56.99
    mesitylene 6.67
    ε-caprolactone 45.33
    p-cymene 8.84
    epichlorohydrin 121.24
    1,1,1-trichloroethane 23.7
    2-aminoethanol 97.85
    morpholine-4-carbaldehyde 114.27
    sulfolane 159.93
    2,2,4-trimethylpentane 1.51
    2-methyltetrahydrofuran 81.06
    n-hexyl acetate 24.02
    isooctane 1.09
    2-(2-butoxyethoxy)ethanol 69.31
    sec-butyl acetate 18.13
    tert-butyl acetate 35.88
    decalin 1.65
    glycerin 112.5
    diglyme 112.96
    acrylic acid 43.46
    isopropyl myristate 11.38
    n-butyric acid 39.11
    acetyl acetate 17.03
    di(2-ethylhexyl) phthalate 15.13
    ethyl propionate 26.57
    nitromethane 100.82
    1,2-diethoxyethane 38.26
    benzonitrile 23.87
    trioctyl phosphate 11.08
    1-bromopropane 16.27
    gamma-valerolactone 101.61
    n-decanol 11.73
    triethyl phosphate 19.63
    4-methyl-2-pentanol 20.69
    propionitrile 36.4
    vinylene carbonate 32.65
    1,1,2-trichlorotrifluoroethane 98.91
    DMS 28.12
    cumene 8.99
    2-octanol 10.46
    2-hexanone 35.08
    octyl acetate 14.93
    limonene 11.14
    1,2-dimethoxyethane 128.32
    ethyl orthosilicate 18.0
    tributyl phosphate 13.95
    diacetone alcohol 74.42
    N,N-dimethylaniline 32.32
    acrylonitrile 43.26
    aniline 30.37
    1,3-propanediol 93.93
    bromobenzene 9.56
    dibromomethane 20.1
    1,1,2,2-tetrachloroethane 56.74
    2-methyl-cyclohexyl acetate 23.51
    tetrabutyl urea 21.18
    diisobutyl methanol 12.59
    2-phenylethanol 33.55
    styrene 10.71
    dioctyl adipate 19.81
    dimethyl sulfate 75.27
    ethyl butyrate 22.37
    methyl lactate 45.22
    butyl lactate 20.64
    diethyl carbonate 18.21
    propanediol butyl ether 45.08
    triethyl orthoformate 20.15
    p-tert-butyltoluene 8.87
    methyl 4-tert-butylbenzoate 35.61
    morpholine 132.47
    tert-butylamine 42.24
    n-dodecanol 9.26
    dimethoxymethane 104.85
    ethylene carbonate 25.02
    cyrene 54.06
    2-ethoxyethyl acetate 26.22
    2-ethylhexyl acetate 19.58
    1,2,4-trichlorobenzene 22.28
    4-methylpyridine 42.36
    dibutyl ether 14.43
    2,6-dimethyl-4-heptanol 12.59
    DEF 56.12
    dimethyl isosorbide 79.37
    tetrachloroethylene 32.05
    eugenol 40.35
    triacetin 30.34
    span 80 36.03
    1,4-butanediol 43.2
    1,1-dichloroethane 26.68
    2-methyl-1-pentanol 35.05
    methyl formate 59.72
    2-methyl-1-butanol 38.24
    n-decane 1.26
    butyronitrile 29.43
    3,7-dimethyl-1-octanol 17.46
    1-chlorooctane 6.96
    1-chlorotetradecane 3.22
    n-nonane 1.09
    undecane 1.0
    tert-butylcyclohexane 2.18
    cyclooctane 0.35
    cyclopentanol 37.05
    tetrahydropyran 48.83
    tert-amyl methyl ether 39.1
    2,5,8-trioxanonane 90.51
    1-hexene 7.39
    2-isopropoxyethanol 69.84
    2,2,2-trifluoroethanol 25.78
    methyl butyrate 33.89

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction