3-Methoxyaniline

Overview IFRA Request a quote

  • Identifiers

    CAS number
    536-90-3

    Molecular formula
    C7H9NO

    SMILES
    COC1=CC=CC(=C1)N

    Safety labels

    Acute Toxic
    Acute Toxic

    Irritant
    Irritant

    Health Hazard
    Health

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Sweet 66.1%
    Floral 51.82%
    Phenolic 50.43%
    Fruity 49.11%
    Animal 40.11%
    Powdery 33.87%
    Woody 33.0%
    Grape 31.51%
    Musty 31.33%
    Medicinal 29.53%

     

    Flavor
    Phenolic 54.64%
    Sweet 45.34%
    Floral 38.07%
    Fruity 35.55%
    Medicinal 35.3%
    Spicy 34.78%
    Smoky 29.65%
    Powdery 29.58%
    Woody 29.34%
    Spice 28.82%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    0.9

    pKa est.
    5.02 (weak acid)

    Molecular weight
    123.15 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Melting point expt.

    • 30 to 34 °F (NTP, 1992)
    • -1 °C

    Boiling point

    • 484 °F at 760 mmHg (NTP, 1992)
    • 251 °C

    Flash point

    • 101.37 ˚C est.
    • greater than 235 °F (NTP, 1992)
    • 126 °C (259 °F) - closed cup
    • >112 °C

    Solubility expt.

    • less than 1 mg/mL at 66 °F (NTP, 1992)
    • Slightly soluble in carbon tetrachloride; soluble in ethanol, ethylene, acetone, benzene
    • Solubility in water, g/100ml at 20 °C: 2.05

  • Synonyms

    • m-Anisidine
    • 3-METHOXYANILINE
    • 536-90-3
    • m-Methoxyaniline
    • 3-Aminoanisole
    • 3-Methoxybenzenamine
    • Benzenamine, 3-methoxy-
    • m-Aminoanisole
    • m-Anisylamine
    • 1-Amino-3-methoxybenzene
    • 3-methoxyphenylamine
    • JXA144KX2I
    • m-Aminomethoxybenzene
    • DTXSID8024529
    • NSC-7631
    • 3-Aminophenol methyl ether
    • DTXCID604529
    • RefChem:154857
    • 208-651-4
    • 3-Anisidine
    • MFCD00007783
    • NSC 7631
    • 3-Methoxy-phenylamine
    • Aniline, 3-methoxy-
    • 3-Methoxy aniline
    • CCRIS 5886
    • EINECS 208-651-4
    • UNII-JXA144KX2I
    • BRN 0386119
    • meta-anisidine
    • AI3-52519
    • HSDB 7816
    • 3-methoxylaniline
    • 3-methoxy-aniline
    • meta-methoxyaniline
    • 3-methyoxy-aniline
    • 3-(methyloxy)aniline
    • 3-methoxy-benzenamine
    • m-Anisidine, 97%
    • (3-methoxyphenyl)-amine
    • ANISIDINE, M-
    • 3-Methoxy-1-aminobenzene
    • 14?-Hydroxy Prednisolone
    • M-ANISIDINE [HSDB]
    • SCHEMBL66691
    • SCHEMBL66692
    • 4-13-00-00953 (Beilstein Handbook Reference)
    • MLS001050108
    • SCHEMBL2021195
    • SCHEMBL2890991
    • SCHEMBL4256585
    • SCHEMBL7355750
    • SCHEMBL7824984
    • CHEMBL1500995
    • SCHEMBL29371962
    • NSC7631
    • CHEBI:194944
    • BB_SC-07166
    • CS-D1422
    • MSK15059
    • Tox21_200820
    • SBB040499
    • STL163332
    • AKOS000119110
    • EBC-151148
    • FM41595
    • PS-4590
    • NCGC00091221-01
    • NCGC00091221-02
    • NCGC00258374-01
    • AC-10034
    • CAS-536-90-3
    • SMR000112350
    • DB-050406
    • A0485
    • m-Anisidine(Discontinued,See C4X-113158)
    • NS00022326
    • ST45255318
    • EN300-19067
    • A15634
    • F88243
    • F043402
    • Q3296585
    • F2190-0440
    • Z104472536
    • InChI=1/C7H9NO/c1-9-7-4-2-3-6(8)5-7/h2-5H,8H2,1H
    • 104350-19-8
    • 536-90-3

  • Applications

    3-Methoxyaniline is primarily used as an organic intermediate for the synthesis of azo dyes and pigment formulations, providing a methoxy-substituted aniline building block for colorants used in textiles, coatings, and inks; it serves as a key precursor in the manufacture of pharmaceutical and agrochemical intermediates; it is also employed as a starting material in polymer and specialty resin development, including high-performance polymers and materials for advanced applications; it can be used in research and development as a versatile building block for various synthetic routes. Subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 662.96
    methanol 651.3
    isopropanol 492.45
    water 14.78
    ethyl acetate 426.27
    n-propanol 466.41
    acetone 1051.74
    n-butanol 335.45
    acetonitrile 670.08
    DMF 941.56
    toluene 84.91
    isobutanol 290.26
    1,4-dioxane 911.28
    methyl acetate 541.65
    THF 1138.26
    2-butanone 502.45
    n-pentanol 191.7
    sec-butanol 314.85
    n-hexane 14.49
    ethylene glycol 291.66
    NMP 463.66
    cyclohexane 15.68
    DMSO 1620.09
    n-butyl acetate 96.53
    n-octanol 82.42
    chloroform 488.73
    n-propyl acetate 125.08
    acetic acid 641.51
    dichloromethane 420.64
    cyclohexanone 380.06
    propylene glycol 340.87
    isopropyl acetate 150.11
    DMAc 514.71
    2-ethoxyethanol 371.3
    isopentanol 201.23
    n-heptane 16.81
    ethyl formate 262.27
    1,2-dichloroethane 257.07
    n-hexanol 179.31
    2-methoxyethanol 793.01
    isobutyl acetate 76.29
    tetrachloromethane 89.73
    n-pentyl acetate 63.62
    transcutol 376.51
    n-heptanol 82.7
    ethylbenzene 28.23
    MIBK 149.15
    2-propoxyethanol 309.33
    tert-butanol 480.57
    MTBE 250.2
    2-butoxyethanol 155.38
    propionic acid 442.55
    o-xylene 50.18
    formic acid 283.45
    diethyl ether 315.9
    m-xylene 62.18
    p-xylene 38.92
    chlorobenzene 109.73
    dimethyl carbonate 180.11
    n-octane 7.37
    formamide 350.72
    cyclopentanone 680.43
    2-pentanone 343.02
    anisole 117.87
    cyclopentyl methyl ether 314.56
    gamma-butyrolactone 708.47
    1-methoxy-2-propanol 503.31
    pyridine 287.9
    3-pentanone 229.7
    furfural 435.04
    n-dodecane 7.0
    diethylene glycol 345.38
    diisopropyl ether 54.0
    tert-amyl alcohol 261.79
    acetylacetone 358.66
    n-hexadecane 7.64
    acetophenone 92.57
    methyl propionate 355.02
    isopentyl acetate 78.93
    trichloroethylene 428.92
    n-nonanol 69.25
    cyclohexanol 199.83
    benzyl alcohol 106.99
    2-ethylhexanol 76.83
    isooctanol 61.18
    dipropyl ether 99.47
    1,2-dichlorobenzene 85.09
    ethyl lactate 88.66
    propylene carbonate 267.5
    n-methylformamide 549.96
    2-pentanol 187.13
    n-pentane 17.84
    1-propoxy-2-propanol 177.36
    1-methoxy-2-propyl acetate 130.54
    2-(2-methoxypropoxy) propanol 113.14
    mesitylene 37.0
    ε-caprolactone 259.74
    p-cymene 26.65
    epichlorohydrin 600.57
    1,1,1-trichloroethane 288.86
    2-aminoethanol 402.83
    morpholine-4-carbaldehyde 468.16
    sulfolane 698.67
    2,2,4-trimethylpentane 11.85
    2-methyltetrahydrofuran 541.17
    n-hexyl acetate 100.67
    isooctane 10.17
    2-(2-butoxyethoxy)ethanol 165.03
    sec-butyl acetate 70.05
    tert-butyl acetate 143.26
    decalin 10.48
    glycerin 421.25
    diglyme 308.89
    acrylic acid 350.75
    isopropyl myristate 40.56
    n-butyric acid 400.93
    acetyl acetate 215.86
    di(2-ethylhexyl) phthalate 42.37
    ethyl propionate 121.31
    nitromethane 1114.28
    1,2-diethoxyethane 110.7
    benzonitrile 113.71
    trioctyl phosphate 36.83
    1-bromopropane 152.91
    gamma-valerolactone 619.68
    n-decanol 53.29
    triethyl phosphate 47.57
    4-methyl-2-pentanol 87.46
    propionitrile 312.48
    vinylene carbonate 226.51
    1,1,2-trichlorotrifluoroethane 393.71
    DMS 91.42
    cumene 24.92
    2-octanol 52.72
    2-hexanone 147.43
    octyl acetate 58.04
    limonene 43.16
    1,2-dimethoxyethane 426.57
    ethyl orthosilicate 44.26
    tributyl phosphate 38.21
    diacetone alcohol 221.07
    N,N-dimethylaniline 70.55
    acrylonitrile 366.49
    aniline 166.18
    1,3-propanediol 462.35
    bromobenzene 92.55
    dibromomethane 255.26
    1,1,2,2-tetrachloroethane 334.81
    2-methyl-cyclohexyl acetate 61.02
    tetrabutyl urea 50.85
    diisobutyl methanol 45.84
    2-phenylethanol 98.33
    styrene 39.68
    dioctyl adipate 58.03
    dimethyl sulfate 280.94
    ethyl butyrate 79.94
    methyl lactate 201.66
    butyl lactate 62.69
    diethyl carbonate 55.3
    propanediol butyl ether 132.86
    triethyl orthoformate 57.07
    p-tert-butyltoluene 29.56
    methyl 4-tert-butylbenzoate 92.98
    morpholine 812.3
    tert-butylamine 203.05
    n-dodecanol 41.27
    dimethoxymethane 508.76
    ethylene carbonate 195.71
    cyrene 124.9
    2-ethoxyethyl acetate 96.17
    2-ethylhexyl acetate 58.35
    1,2,4-trichlorobenzene 104.39
    4-methylpyridine 237.17
    dibutyl ether 64.51
    2,6-dimethyl-4-heptanol 45.84
    DEF 286.59
    dimethyl isosorbide 163.09
    tetrachloroethylene 199.83
    eugenol 93.95
    triacetin 98.31
    span 80 103.96
    1,4-butanediol 182.2
    1,1-dichloroethane 330.23
    2-methyl-1-pentanol 115.76
    methyl formate 430.89
    2-methyl-1-butanol 201.48
    n-decane 11.29
    butyronitrile 262.74
    3,7-dimethyl-1-octanol 65.6
    1-chlorooctane 45.15
    1-chlorotetradecane 18.72
    n-nonane 11.04
    undecane 8.56
    tert-butylcyclohexane 12.84
    cyclooctane 7.25
    cyclopentanol 319.9
    tetrahydropyran 557.63
    tert-amyl methyl ether 145.77
    2,5,8-trioxanonane 206.36
    1-hexene 56.44
    2-isopropoxyethanol 190.9
    2,2,2-trifluoroethanol 234.65
    methyl butyrate 158.78

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction