3-Methoxy-1,2-propanediol

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  • Identifiers

    CAS number
    623-39-2

    Molecular formula
    C4H10O3

    SMILES
    COCC(CO)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 52.24%
    Ethereal 40.71%
    Alcoholic 40.15%
    Fruity 30.91%
    Sweet 30.85%
    Solvent 27.38%
    Buttery 23.57%
    Caramellic 23.3%
    Fermented 20.54%
    Oily 19.97%

     

    Flavor
    Odorless 59.79%
    Sweet 58.9%
    Alcoholic 38.77%
    Bitter 30.93%
    Sweet-like 29.41%
    Musty 28.01%
    Very slight 26.59%
    Buttery 25.46%
    Creamy 24.9%
    Fruit 23.31%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -1.2

    pKa est.
    7.12 (neutral)

    Molecular weight
    106.12 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    220°C

    Flash point

    • 100.76 ˚C est.

  • Synonyms

    • 3-Methoxy-1,2-propanediol
    • 623-39-2
    • 1-O-Methylglycerol
    • Glycerol 1-monomethyl ether
    • glycerin 1-methyl ether
    • Glycerin-alpha-monomethyl ether
    • 4G03VY2NKP
    • DTXSID3049336
    • NSC-6752
    • DTXCID7029293
    • RefChem:435105
    • 210-791-6
    • 3-Methoxypropane-1,2-diol
    • 1,2-Propanediol, 3-methoxy-
    • 1-o-methyl-rac-glycerol
    • 36887-04-4
    • MFCD00004719
    • NSC 6752
    • Glycerin-.alpha.-monomethyl ether
    • EINECS 210-791-6
    • UNII-4G03VY2NKP
    • BRN 1719407
    • Glycerol alpha-Monomethyl Ether
    • SCHEMBL87687
    • SCHEMBL262267
    • 3-Methoxy-propane-1,2 -diol
    • SCHEMBL2380002
    • SCHEMBL5419822
    • SCHEMBL6433094
    • SCHEMBL6435128
    • SCHEMBL6437312
    • CHEMBL3187682
    • SCHEMBL11371320
    • NSC6752
    • CHEBI:180970
    • 1-METHOXY-2,3-PROPANEDIOL
    • 3-Methoxy-1,2-propanediol, 98%
    • Tox21_202859
    • AKOS009156850
    • SB83843
    • 3-METHOXY-1,2-DIHYDROXYPROPANE
    • NCGC00260405-01
    • AS-17523
    • CAS-623-39-2
    • SY049862
    • M0125
    • NS00035014
    • EN300-207136
    • H10736
    • A823439
    • Q27259541
    • InChI=1/C4H10O3/c1-7-3-4(6)2-5/h4-6H,2-3H2,1H
    • 623-39-2

  • Applications

    3-Methoxy-1,2-propanediol (CAS 623-39-2) is commonly used as a solvent and processing aid in coatings, inks, and cleaning formulations; it serves as a chemical intermediate in the synthesis of polyurethane and polyester polyols and can function as a reactive diluent in polymer systems; in cosmetics and personal care, it may act as a humectant and solvent in a range of formulations; in electronics and specialty coatings, it is evaluated as a processing solvent or additive for coatings and electronic materials; in adhesives and sealants it can serve as a reactive diluent or plasticizer to help control viscosity and cure behavior.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 506.32
    methanol 1573.27
    isopropanol 200.31
    water 2261.9
    ethyl acetate 28.64
    n-propanol 265.25
    acetone 65.26
    n-butanol 142.19
    acetonitrile 68.47
    DMF 750.27
    toluene 2.05
    isobutanol 117.24
    1,4-dioxane 122.94
    methyl acetate 48.58
    THF 118.61
    2-butanone 38.93
    n-pentanol 52.45
    sec-butanol 128.16
    n-hexane 0.96
    ethylene glycol 1548.31
    NMP 406.3
    cyclohexane 3.18
    DMSO 875.87
    n-butyl acetate 16.08
    n-octanol 20.55
    chloroform 29.07
    n-propyl acetate 15.32
    acetic acid 1321.81
    dichloromethane 32.83
    cyclohexanone 64.19
    propylene glycol 765.99
    isopropyl acetate 12.1
    DMAc 351.44
    2-ethoxyethanol 289.69
    isopentanol 60.13
    n-heptane 3.05
    ethyl formate 71.71
    1,2-dichloroethane 21.81
    n-hexanol 47.11
    2-methoxyethanol 864.01
    isobutyl acetate 7.99
    tetrachloromethane 11.69
    n-pentyl acetate 9.86
    transcutol 211.34
    n-heptanol 24.36
    ethylbenzene 1.6
    MIBK 11.73
    2-propoxyethanol 171.16
    tert-butanol 157.1
    MTBE 23.91
    2-butoxyethanol 80.28
    propionic acid 348.58
    o-xylene 4.08
    formic acid 2806.52
    diethyl ether 18.34
    m-xylene 2.83
    p-xylene 2.31
    chlorobenzene 5.41
    dimethyl carbonate 24.55
    n-octane 0.97
    formamide 1418.34
    cyclopentanone 91.43
    2-pentanone 23.16
    anisole 11.51
    cyclopentyl methyl ether 32.3
    gamma-butyrolactone 160.72
    1-methoxy-2-propanol 315.28
    pyridine 36.73
    3-pentanone 16.78
    furfural 192.6
    n-dodecane 0.83
    diethylene glycol 397.83
    diisopropyl ether 4.11
    tert-amyl alcohol 108.86
    acetylacetone 31.28
    n-hexadecane 0.85
    acetophenone 17.62
    methyl propionate 41.56
    isopentyl acetate 12.28
    trichloroethylene 41.58
    n-nonanol 16.41
    cyclohexanol 90.04
    benzyl alcohol 35.8
    2-ethylhexanol 19.02
    isooctanol 16.62
    dipropyl ether 14.07
    1,2-dichlorobenzene 8.16
    ethyl lactate 44.73
    propylene carbonate 62.34
    n-methylformamide 587.27
    2-pentanol 47.99
    n-pentane 1.85
    1-propoxy-2-propanol 94.46
    1-methoxy-2-propyl acetate 31.17
    2-(2-methoxypropoxy) propanol 63.91
    mesitylene 2.84
    ε-caprolactone 71.31
    p-cymene 4.49
    epichlorohydrin 97.16
    1,1,1-trichloroethane 11.41
    2-aminoethanol 1160.08
    morpholine-4-carbaldehyde 399.66
    sulfolane 267.66
    2,2,4-trimethylpentane 1.79
    2-methyltetrahydrofuran 54.65
    n-hexyl acetate 15.71
    isooctane 1.0
    2-(2-butoxyethoxy)ethanol 83.51
    sec-butyl acetate 7.82
    tert-butyl acetate 14.12
    decalin 1.29
    glycerin 1285.93
    diglyme 153.5
    acrylic acid 445.11
    isopropyl myristate 6.26
    n-butyric acid 211.74
    acetyl acetate 19.11
    di(2-ethylhexyl) phthalate 15.48
    ethyl propionate 13.7
    nitromethane 597.52
    1,2-diethoxyethane 18.83
    benzonitrile 17.5
    trioctyl phosphate 11.98
    1-bromopropane 7.34
    gamma-valerolactone 214.45
    n-decanol 11.47
    triethyl phosphate 14.95
    4-methyl-2-pentanol 17.41
    propionitrile 41.46
    vinylene carbonate 66.46
    1,1,2-trichlorotrifluoroethane 315.18
    DMS 17.36
    cumene 2.28
    2-octanol 10.8
    2-hexanone 12.09
    octyl acetate 10.41
    limonene 7.87
    1,2-dimethoxyethane 156.01
    ethyl orthosilicate 13.96
    tributyl phosphate 11.85
    diacetone alcohol 59.68
    N,N-dimethylaniline 13.25
    acrylonitrile 79.64
    aniline 24.81
    1,3-propanediol 784.52
    bromobenzene 3.01
    dibromomethane 17.32
    1,1,2,2-tetrachloroethane 40.29
    2-methyl-cyclohexyl acetate 15.78
    tetrabutyl urea 18.91
    diisobutyl methanol 11.45
    2-phenylethanol 26.42
    styrene 2.01
    dioctyl adipate 15.26
    dimethyl sulfate 75.42
    ethyl butyrate 15.5
    methyl lactate 112.2
    butyl lactate 26.87
    diethyl carbonate 11.23
    propanediol butyl ether 90.87
    triethyl orthoformate 15.91
    p-tert-butyltoluene 5.09
    methyl 4-tert-butylbenzoate 29.19
    morpholine 228.99
    tert-butylamine 52.67
    n-dodecanol 8.77
    dimethoxymethane 119.09
    ethylene carbonate 48.55
    cyrene 101.03
    2-ethoxyethyl acetate 17.35
    2-ethylhexyl acetate 8.96
    1,2,4-trichlorobenzene 11.91
    4-methylpyridine 21.46
    dibutyl ether 6.62
    2,6-dimethyl-4-heptanol 11.45
    DEF 86.47
    dimethyl isosorbide 83.47
    tetrachloroethylene 41.97
    eugenol 47.12
    triacetin 27.19
    span 80 66.88
    1,4-butanediol 310.45
    1,1-dichloroethane 11.36
    2-methyl-1-pentanol 28.98
    methyl formate 288.15
    2-methyl-1-butanol 77.36
    n-decane 1.22
    butyronitrile 31.97
    3,7-dimethyl-1-octanol 16.02
    1-chlorooctane 4.34
    1-chlorotetradecane 1.98
    n-nonane 1.23
    undecane 0.95
    tert-butylcyclohexane 1.32
    cyclooctane 1.23
    cyclopentanol 147.45
    tetrahydropyran 47.16
    tert-amyl methyl ether 21.12
    2,5,8-trioxanonane 112.27
    1-hexene 2.4
    2-isopropoxyethanol 106.14
    2,2,2-trifluoroethanol 552.74
    methyl butyrate 25.95

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction