(3-Mercaptopropyl)trimethoxysilane

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  • Identifiers

    CAS number
    4420-74-0

    Molecular formula
    C6H16O3SSi

    SMILES
    CO[Si](CCCS)(OC)OC

    Safety labels

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Sulfurous 59.13%
    Meaty 48.33%
    Savory 36.33%
    Onion 34.35%
    Fruity 30.28%
    Roasted 29.89%
    Tropical 28.15%
    Cooked 27.2%
    Cheesy 26.82%
    Sweet 25.64%

     

    Flavor
    Sulfurous 41.96%
    Fruity 41.89%
    Vegetable 34.87%
    Onion 33.8%
    Green 33.58%
    Sweet 32.21%
    Fatty 30.18%
    Tropical 28.9%
    Sulfury 28.42%
    Meaty 27.7%

     

    Odor impact est.
    Medium

  • Properties

    pKa est.
    8.42 (weak base)

    Molecular weight
    196.34 g/mol

    Flash point

    • 64.55 ˚C est.

  • Synonyms

    • 4420-74-0
    • (3-Mercaptopropyl)trimethoxysilane
    • 3-Mercaptopropyltrimethoxysilane
    • 3-(Trimethoxysilyl)propanethiol
    • 1-Propanethiol, 3-(trimethoxysilyl)-
    • Silquest A 189
    • 3-(Trimethoxysilyl)-1-Propanethiol
    • Prosil 196
    • Silane A 189
    • (3-Thiopropyl)trimethoxysilane
    • NUCA 189
    • 3-(Sulfanylpropyl)trimethoxysilane
    • M 8500 (coupling agent)
    • 3-(Trimethoxysilyl)propyl mercaptan
    • A 189 (silicone)
    • KBE 803
    • KBM 803
    • GF 70
    • TSL 8380
    • (gamma-mercaptopropyl)trimethoxysilane
    • TSL8380E
    • AZ 6129
    • SH 6062
    • Z 6062
    • 8CB1M08OIW
    • M 8500
    • DTXSID2044428
    • 3-MPTMS
    • DTXCID0024428
    • RefChem:69126
    • (3-mercaptopropyl)trimethoxylsilane
    • gamma-mercapto propyl trimethoxysilane
    • 224-588-5
    • Trimethoxysilylpropanethiol
    • 3-Trimethoxysilylpropane-1-thiol
    • 3-(trimethoxysilyl)propane-1-thiol
    • (3-MERCAPTOPROPYL)-TRIMETHOXYSILANE
    • Union carbide A-189
    • Sila-Ace S 810
    • MPS-M
    • gamma-Mercaptopropyltrimethoxysilane
    • 3-mercaptopropyl trimethoxylsilane
    • Mercaptopropyltrimethoxysilane
    • MFCD00004901
    • (.gamma.-Mercaptopropyl)trimethoxysilane
    • 3-(Mercapto)propyltrimethoxysilane
    • (3-Mercaptopropyl)trimethoxysilane, 95%
    • S10475
    • C6H16O3SSi
    • 29295-80-5
    • Silane, 3-mercaptopropyltrimethoxy-
    • EINECS 224-588-5
    • UNII-8CB1M08OIW
    • BRN 2038119
    • Dynasylan MTMO
    • Silicone A-189
    • Aktisil MM (Salt/Mix)
    • A 189
    • SCHEMBL22838
    • 3mercaptopropyltrimethoxysilane
    • mercaptopropyl trimethoxysilane
    • mercaptopropyltrimethoxy silane
    • GF70
    • HSCH2CH2CH2Si(OCH3)3
    • SCHEMBL3910273
    • 3- mercaptopropyltrimethoxysilane
    • 3-mercaptopropyl trimethoxysilane
    • 3-mercaptopropyl-trimethoxysilane
    • 3-mercaptopropyltrimethoxy silane
    • CHEMBL3185147
    • 3-trimethoxysilyl-1-propanethiol
    • Propanethiol, 3-trimethoxysilyl-
    • TSL 8380E
    • UUEWCQRISZBELL-UHFFFAOYSA-
    • 1-mercapto-3-trimethoxysilylpropane
    • 3-mercapto-1-propyltrimethoxysilane
    • 3-mercaptopropyl-(trimethoxy)silane
    • BB_SC-02629
    • gamma mercaptopropyltrimethoxy silane
    • gamma-mercaptopropyltrimethoxy silane
    • Tox21_302177
    • BBL027487
    • STK802174
    • AKOS006220486
    • Silane, (3-Mercaptopropyl)trimethoxy-
    • FM54858
    • NCGC00255809-01
    • AS-13395
    • CAS-4420-74-0
    • CS-0090511
    • M0928
    • NS00049279
    • F20302
    • A826511
    • 3-Mercaptopropyltrimethoxysilane Silane Coupling Agent
    • Q27270178
    • InChI=1/C6H16O3SSi/c1-7-11(8-2,9-3)6-4-5-10/h10H,4-6H2,1-3H3
    • 4420-74-0

  • Applications

    (3-Mercaptopropyl)trimethoxysilane, CAS 4420-74-0, is primarily used as a silane coupling agent and surface modifier that introduces thiol groups onto inorganic and organic interfaces, enabling stronger adhesion and further functionalization. It is commonly applied to functionalize glass, silica, ceramics, and metals to improve coatings, inks, and adhesive performance; to promote interfacial bonding in polymer composites; and as a precursor to thiol-terminated polymers or crosslinkers. In electronics and sensing, it facilitates surface immobilization and thiol-based linkages for sensors, microelectronic interfaces, and nanoparticle assembly. It can also be employed to prepare thiol-functionalized particle or filler surfaces to improve dispersion in polymers. Use is typically for surface modification and materials preparation, with handling and formulation governed by local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1174.92
    methanol 2447.85
    isopropanol 742.53
    water 204.12
    ethyl acetate 146.23
    n-propanol 825.29
    acetone 233.15
    n-butanol 697.15
    acetonitrile 266.34
    DMF 578.52
    toluene 98.23
    isobutanol 478.76
    1,4-dioxane 607.87
    methyl acetate 181.64
    THF 727.41
    2-butanone 202.2
    n-pentanol 507.35
    sec-butanol 619.31
    n-hexane 46.73
    ethylene glycol 532.71
    NMP 377.04
    cyclohexane 112.06
    DMSO 614.17
    n-butyl acetate 128.99
    n-octanol 233.48
    chloroform 1063.8
    n-propyl acetate 136.59
    acetic acid 831.82
    dichloromethane 740.34
    cyclohexanone 290.95
    propylene glycol 486.69
    isopropyl acetate 99.81
    DMAc 352.8
    2-ethoxyethanol 788.12
    isopentanol 389.14
    n-heptane 80.68
    ethyl formate 240.61
    1,2-dichloroethane 296.17
    n-hexanol 370.15
    2-methoxyethanol 1271.38
    isobutyl acetate 88.69
    tetrachloromethane 251.65
    n-pentyl acetate 155.24
    transcutol 553.09
    n-heptanol 314.45
    ethylbenzene 59.78
    MIBK 99.59
    2-propoxyethanol 527.37
    tert-butanol 609.34
    MTBE 268.82
    2-butoxyethanol 473.95
    propionic acid 380.59
    o-xylene 82.85
    formic acid 980.91
    diethyl ether 336.74
    m-xylene 64.86
    p-xylene 78.88
    chlorobenzene 126.93
    dimethyl carbonate 72.04
    n-octane 37.52
    formamide 861.35
    cyclopentanone 307.78
    2-pentanone 159.16
    anisole 137.85
    cyclopentyl methyl ether 256.55
    gamma-butyrolactone 313.39
    1-methoxy-2-propanol 620.65
    pyridine 367.18
    3-pentanone 113.6
    furfural 365.13
    n-dodecane 23.27
    diethylene glycol 500.35
    diisopropyl ether 77.79
    tert-amyl alcohol 485.04
    acetylacetone 114.22
    n-hexadecane 24.34
    acetophenone 120.23
    methyl propionate 132.38
    isopentyl acetate 112.34
    trichloroethylene 459.83
    n-nonanol 204.51
    cyclohexanol 462.29
    benzyl alcohol 207.07
    2-ethylhexanol 186.14
    isooctanol 215.42
    dipropyl ether 189.66
    1,2-dichlorobenzene 124.19
    ethyl lactate 111.72
    propylene carbonate 178.24
    n-methylformamide 543.66
    2-pentanol 369.76
    n-pentane 93.95
    1-propoxy-2-propanol 342.54
    1-methoxy-2-propyl acetate 108.2
    2-(2-methoxypropoxy) propanol 166.23
    mesitylene 49.57
    ε-caprolactone 263.57
    p-cymene 66.03
    epichlorohydrin 397.63
    1,1,1-trichloroethane 250.93
    2-aminoethanol 875.34
    morpholine-4-carbaldehyde 446.92
    sulfolane 328.55
    2,2,4-trimethylpentane 41.36
    2-methyltetrahydrofuran 437.54
    n-hexyl acetate 168.24
    isooctane 26.97
    2-(2-butoxyethoxy)ethanol 295.08
    sec-butyl acetate 86.22
    tert-butyl acetate 108.0
    decalin 35.38
    glycerin 655.92
    diglyme 522.72
    acrylic acid 357.54
    isopropyl myristate 66.8
    n-butyric acid 423.79
    acetyl acetate 83.93
    di(2-ethylhexyl) phthalate 77.88
    ethyl propionate 98.09
    nitromethane 574.44
    1,2-diethoxyethane 213.97
    benzonitrile 172.13
    trioctyl phosphate 73.38
    1-bromopropane 232.49
    gamma-valerolactone 426.19
    n-decanol 140.26
    triethyl phosphate 69.85
    4-methyl-2-pentanol 174.04
    propionitrile 253.0
    vinylene carbonate 192.32
    1,1,2-trichlorotrifluoroethane 476.82
    DMS 63.86
    cumene 52.93
    2-octanol 199.3
    2-hexanone 150.73
    octyl acetate 95.0
    limonene 103.63
    1,2-dimethoxyethane 673.73
    ethyl orthosilicate 84.8
    tributyl phosphate 62.68
    diacetone alcohol 158.6
    N,N-dimethylaniline 127.7
    acrylonitrile 278.27
    aniline 204.27
    1,3-propanediol 925.51
    bromobenzene 107.97
    dibromomethane 504.26
    1,1,2,2-tetrachloroethane 462.87
    2-methyl-cyclohexyl acetate 112.92
    tetrabutyl urea 87.37
    diisobutyl methanol 116.15
    2-phenylethanol 184.09
    styrene 72.0
    dioctyl adipate 88.89
    dimethyl sulfate 95.45
    ethyl butyrate 119.86
    methyl lactate 140.31
    butyl lactate 144.77
    diethyl carbonate 78.6
    propanediol butyl ether 297.8
    triethyl orthoformate 116.32
    p-tert-butyltoluene 66.16
    methyl 4-tert-butylbenzoate 149.6
    morpholine 746.75
    tert-butylamine 424.65
    n-dodecanol 102.24
    dimethoxymethane 385.04
    ethylene carbonate 165.3
    cyrene 195.78
    2-ethoxyethyl acetate 149.53
    2-ethylhexyl acetate 92.16
    1,2,4-trichlorobenzene 142.43
    4-methylpyridine 247.24
    dibutyl ether 136.45
    2,6-dimethyl-4-heptanol 116.15
    DEF 229.95
    dimethyl isosorbide 210.87
    tetrachloroethylene 382.76
    eugenol 182.58
    triacetin 115.27
    span 80 192.99
    1,4-butanediol 462.79
    1,1-dichloroethane 292.32
    2-methyl-1-pentanol 311.01
    methyl formate 307.63
    2-methyl-1-butanol 422.52
    n-decane 42.19
    butyronitrile 282.5
    3,7-dimethyl-1-octanol 151.61
    1-chlorooctane 110.63
    1-chlorotetradecane 42.13
    n-nonane 42.82
    undecane 29.08
    tert-butylcyclohexane 33.62
    cyclooctane 44.59
    cyclopentanol 508.29
    tetrahydropyran 499.4
    tert-amyl methyl ether 210.03
    2,5,8-trioxanonane 306.71
    1-hexene 103.8
    2-isopropoxyethanol 399.38
    2,2,2-trifluoroethanol 338.69
    methyl butyrate 150.58

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction