3-Isopropyl-2-methoxy-5-methylpyrazine

Overview IFRA Botanical Request a quote

  • Identifiers

    CAS number
    32021-41-3

    Molecular formula
    C9H14N2O

    SMILES
    CC1=CN=C(C(=N1)C(C)C)OC

  • Odor profile

    Earthy 67.18%
    Green 64.89%
    Nutty 62.27%
    Roasted 51.57%
    Vegetable 44.67%
    Potato 43.06%
    Cocoa 40.39%
    Musty 39.8%
    Woody 37.8%
    Hazelnut 37.31%

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  • Properties

    XLogP3-AA
    1.6

    Molecular weight
    166.22 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    248°C

    Flash point est.
    92.1 ˚C

  • Synonyms

    • 3-Isopropyl-2-methoxy-5-methylpyrazine
    • 32021-41-3
    • 2-methoxy-5-methyl-3-propan-2-ylpyrazine
    • 2-methoxy-5-methyl-3-(propan-2-yl)pyrazine
    • CHEMBL328943
    • SCHEMBL2554455
    • DTXSID10575259
    • CHEBI:172421
    • NCKFIUKGRGDXBF-UHFFFAOYSA-N
    • AKOS006370457
    • 5-Methyl-3-isopropyl-2-methoxypyrazine
    • 2-Methoxy-5-methyl-3-(1-methylethyl)pyrazine, 9CI

  • Applications

    3-Isopropyl-2-methoxy-5-methylpyrazine (CAS 32021-41-3) is a methoxypyrazine with an intensely green, vegetal/bell‑pepper and slightly earthy odor, applied at trace levels as a high‑impact flavor and fragrance modifier in savory seasonings, beverages, vegetable-based foods, tobacco, and perfumery to deliver green top notes or fine‑tune natural nuances; it also serves as an analytical reference/calibration standard in GC‑MS/GC‑O for tracking methoxypyrazines in wine, grapes, coffee, cocoa, hops, bell pepper, and packaging‑related taint studies; a tool for sensory panel training, odor‑threshold work, and structure–odor relationship research; a quality/raw‑material indicator and aid in R&D of plant‑based formulations; and is used in environmental odor impact assessments and olfactory perception studies, with the caveat that methoxypyrazines have extremely low odor thresholds, requiring careful handling, storage, and dose control.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 472.32
    methanol 482.48
    isopropanol 439.41
    water 3.17
    ethyl acetate 542.07
    n-propanol 470.58
    acetone 853.69
    n-butanol 414.0
    acetonitrile 570.69
    DMF 1096.89
    toluene 344.39
    isobutanol 409.83
    1,4-dioxane 814.63
    methyl acetate 590.27
    THF 1069.47
    2-butanone 631.12
    n-pentanol 327.56
    sec-butanol 469.44
    n-hexane 54.74
    ethylene glycol 206.93
    NMP 799.5
    cyclohexane 119.75
    DMSO 763.06
    n-butyl acetate 481.13
    n-octanol 263.64
    chloroform 2417.34
    n-propyl acetate 379.99
    acetic acid 727.48
    dichloromethane 2234.29
    cyclohexanone 891.11
    propylene glycol 263.31
    isopropyl acetate 307.28
    DMAc 673.82
    2-ethoxyethanol 431.16
    isopentanol 315.01
    n-heptane 68.26
    ethyl formate 634.09
    1,2-dichloroethane 1097.94
    n-hexanol 410.7
    2-methoxyethanol 707.76
    isobutyl acetate 229.72
    tetrachloromethane 443.32
    n-pentyl acetate 327.68
    transcutol 446.31
    n-heptanol 254.02
    ethylbenzene 222.91
    MIBK 259.92
    2-propoxyethanol 506.69
    tert-butanol 444.7
    MTBE 370.41
    2-butoxyethanol 324.41
    propionic acid 548.09
    o-xylene 276.32
    formic acid 235.13
    diethyl ether 352.42
    m-xylene 260.87
    p-xylene 354.0
    chlorobenzene 603.48
    dimethyl carbonate 278.08
    n-octane 44.19
    formamide 287.76
    cyclopentanone 1021.83
    2-pentanone 456.23
    anisole 342.1
    cyclopentyl methyl ether 482.73
    gamma-butyrolactone 1169.84
    1-methoxy-2-propanol 519.28
    pyridine 848.28
    3-pentanone 390.04
    furfural 1159.83
    n-dodecane 42.87
    diethylene glycol 364.41
    diisopropyl ether 121.44
    tert-amyl alcohol 431.25
    acetylacetone 514.99
    n-hexadecane 48.6
    acetophenone 361.59
    methyl propionate 512.08
    isopentyl acetate 368.21
    trichloroethylene 2196.44
    n-nonanol 212.58
    cyclohexanol 482.6
    benzyl alcohol 359.56
    2-ethylhexanol 256.36
    isooctanol 200.56
    dipropyl ether 230.28
    1,2-dichlorobenzene 577.35
    ethyl lactate 237.81
    propylene carbonate 775.2
    n-methylformamide 633.69
    2-pentanol 304.76
    n-pentane 65.89
    1-propoxy-2-propanol 356.32
    1-methoxy-2-propyl acetate 341.44
    2-(2-methoxypropoxy) propanol 218.45
    mesitylene 176.83
    ε-caprolactone 725.95
    p-cymene 202.33
    epichlorohydrin 1224.5
    1,1,1-trichloroethane 1215.57
    2-aminoethanol 298.76
    morpholine-4-carbaldehyde 781.69
    sulfolane 1248.6
    2,2,4-trimethylpentane 52.96
    2-methyltetrahydrofuran 722.34
    n-hexyl acetate 434.37
    isooctane 34.08
    2-(2-butoxyethoxy)ethanol 286.71
    sec-butyl acetate 213.7
    tert-butyl acetate 288.53
    decalin 72.54
    glycerin 305.85
    diglyme 565.5
    acrylic acid 534.18
    isopropyl myristate 158.8
    n-butyric acid 627.38
    acetyl acetate 356.94
    di(2-ethylhexyl) phthalate 170.78
    ethyl propionate 309.18
    nitromethane 1081.29
    1,2-diethoxyethane 272.58
    benzonitrile 566.42
    trioctyl phosphate 148.45
    1-bromopropane 593.82
    gamma-valerolactone 1130.3
    n-decanol 162.63
    triethyl phosphate 164.92
    4-methyl-2-pentanol 158.43
    propionitrile 483.52
    vinylene carbonate 804.66
    1,1,2-trichlorotrifluoroethane 867.69
    DMS 317.49
    cumene 174.1
    2-octanol 220.83
    2-hexanone 343.16
    octyl acetate 227.3
    limonene 253.49
    1,2-dimethoxyethane 651.28
    ethyl orthosilicate 149.97
    tributyl phosphate 154.52
    diacetone alcohol 325.8
    N,N-dimethylaniline 252.94
    acrylonitrile 657.36
    aniline 389.49
    1,3-propanediol 395.56
    bromobenzene 672.86
    dibromomethane 1450.94
    1,1,2,2-tetrachloroethane 1926.24
    2-methyl-cyclohexyl acetate 256.18
    tetrabutyl urea 192.46
    diisobutyl methanol 148.95
    2-phenylethanol 363.86
    styrene 258.35
    dioctyl adipate 221.75
    dimethyl sulfate 427.76
    ethyl butyrate 300.96
    methyl lactate 297.83
    butyl lactate 244.52
    diethyl carbonate 236.94
    propanediol butyl ether 318.79
    triethyl orthoformate 208.84
    p-tert-butyltoluene 193.95
    methyl 4-tert-butylbenzoate 316.49
    morpholine 802.77
    tert-butylamine 286.54
    n-dodecanol 133.3
    dimethoxymethane 618.95
    ethylene carbonate 619.12
    cyrene 294.12
    2-ethoxyethyl acetate 338.77
    2-ethylhexyl acetate 302.41
    1,2,4-trichlorobenzene 658.01
    4-methylpyridine 730.85
    dibutyl ether 216.6
    2,6-dimethyl-4-heptanol 148.95
    DEF 544.43
    dimethyl isosorbide 396.52
    tetrachloroethylene 1254.57
    eugenol 292.14
    triacetin 306.18
    span 80 248.47
    1,4-butanediol 222.19
    1,1-dichloroethane 1195.33
    2-methyl-1-pentanol 271.26
    methyl formate 661.32
    2-methyl-1-butanol 355.12
    n-decane 62.59
    butyronitrile 542.35
    3,7-dimethyl-1-octanol 212.94
    1-chlorooctane 220.42
    1-chlorotetradecane 97.35
    n-nonane 62.05
    undecane 51.1
    tert-butylcyclohexane 68.06
    cyclooctane 46.1
    cyclopentanol 577.34
    tetrahydropyran 700.21
    tert-amyl methyl ether 299.77
    2,5,8-trioxanonane 341.91
    1-hexene 177.34
    2-isopropoxyethanol 297.35
    2,2,2-trifluoroethanol 285.88
    methyl butyrate 465.1

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1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Galbanum 4 9000-24-2 Ferula galbaniflua Boiss. et Buhse, fam. Apiaceae (Umbelliferae) 0.01%