3-Hydroxypyridine

Overview IFRA Request a quote

  • Identifiers

    CAS number
    109-00-2

    Molecular formula
    C5H5NO

    SMILES
    C1=CC(=CN=C1)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Nutty 52.93%
    Burnt 49.55%
    Phenolic 48.74%
    Roasted 45.98%
    Sweet 45.35%
    Musty 38.02%
    Smoky 36.34%
    Caramellic 35.97%
    Coffee 35.09%
    Meaty 34.35%

     

    Flavor
    Nutty 54.89%
    Phenolic 40.83%
    Musty 40.35%
    Bitter 37.1%
    Woody 35.74%
    Medical 33.26%
    Leather 31.0%
    Coffee 30.88%
    Almond 27.53%
    Medicinal 26.32%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    0.5

    pKa est.
    8.18 (weak base)

    Molecular weight
    95.1 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately slow

    Boiling point est.
    216°C

    Flash point

    • 101.61 ˚C est.

  • Synonyms

    • 3-HYDROXYPYRIDINE
    • pyridin-3-ol
    • 109-00-2
    • 3-Pyridinol
    • 3-Pyridol
    • beta-Hydroxypyridine
    • m-Hydroxypyridine
    • 4KBE4P5B6S
    • NSC-18470
    • DTXSID1051563
    • CHEBI:87440
    • RefChem:94397
    • DTXCID5030115
    • 203-637-4
    • 3-Pyridone
    • 3-Oxopyridine
    • MFCD00006378
    • .beta.-Hydroxypyridine
    • 3-hydoxypyridine
    • 3-hydroxy pyridine
    • CHEMBL237847
    • SR-1C8
    • 3-Pyridyl alcohol
    • 3-hydroxy-pyridine
    • EINECS 203-637-4
    • NSC 18470
    • UNII-4KBE4P5B6S
    • PYRIDINE, 3-HYDROXY-
    • AI3-19237
    • 3-oxypyridine
    • 3-oxidopyridinium
    • 3-hydroxylpyridine
    • Pyridine-3-ol
    • 3-Hydroxypyridine, 98%
    • 3-Hydroxypyridine (NIST)
    • 3-Pyridinol; Pyridin-3-ol
    • SCHEMBL49656
    • SCHEMBL60851
    • SCHEMBL129766
    • SCHEMBL387530
    • SCHEMBL596043
    • orb1909105
    • SCHEMBL1144402
    • SCHEMBL5744810
    • SCHEMBL7145695
    • BB_SC-00238
    • HY-Y1129
    • NSC18470
    • STR00285
    • BBL010946
    • BDBM50225189
    • MSK161855
    • SBB004391
    • STK802047
    • AKOS000119647
    • BS-3731
    • CS-W009147
    • EBC-613085
    • MSK161855-100M
    • SB52272
    • MSK161855-1000M
    • BP-12457
    • PD158448
    • DB-016011
    • UU7701400
    • H0331
    • NS00000983
    • ST51044357
    • EN300-20091
    • D70736
    • 3-Hydroxypyridine Solution in Methanol, 100ug/mL
    • 3-Hydroxypyridine, Vetec(TM) reagent grade, 99%
    • AC-907/25014060
    • AC-907/25014061
    • Q223089
    • 3-Hydroxypyridine Solution in Methanol, 1000ug/mL
    • F1995-0197
    • Z104476790
    • InChI=1/C5H5NO/c7-5-2-1-3-6-4-5/h1-4,7
    • 467D3257-37E0-4666-B266-CF679BC6CE5A
    • 71A
    • 80618-81-1
    • 109-00-2

  • Applications

    3-Hydroxypyridine is used as an intermediate in the synthesis of pharmaceutical and agrochemical intermediates; it also serves as a building block for other heterocycles and pyridine-based ligands or metal-ligand precursors for coordination and catalysis in organic synthesis; in the coatings and pigment industry, it is used to prepare pyridine-derived derivatives with hydroxyl groups for color development; in polymer and materials chemistry, it can be converted into functional pyridine motifs to enhance binding and electrochemical properties; in addition, it is commonly considered as a precursor for related pyridine compounds and metal complexes for industrial applications, subject to local regulations. CAS 109-00-2.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 195.45
    methanol 294.42
    isopropanol 101.26
    water 49.57
    ethyl acetate 38.09
    n-propanol 129.71
    acetone 55.77
    n-butanol 94.5
    acetonitrile 55.93
    DMF 261.51
    toluene 7.64
    isobutanol 80.2
    1,4-dioxane 88.04
    methyl acetate 59.87
    THF 163.97
    2-butanone 60.02
    n-pentanol 82.8
    sec-butanol 76.79
    n-hexane 1.71
    ethylene glycol 62.45
    NMP 255.72
    cyclohexane 1.42
    DMSO 273.91
    n-butyl acetate 94.89
    n-octanol 21.79
    chloroform 16.77
    n-propyl acetate 47.4
    acetic acid 335.48
    dichloromethane 16.0
    cyclohexanone 82.73
    propylene glycol 51.76
    isopropyl acetate 22.68
    DMAc 225.44
    2-ethoxyethanol 135.32
    isopentanol 73.08
    n-heptane 4.56
    ethyl formate 53.38
    1,2-dichloroethane 13.56
    n-hexanol 73.66
    2-methoxyethanol 192.27
    isobutyl acetate 27.15
    tetrachloromethane 4.68
    n-pentyl acetate 36.27
    transcutol 337.6
    n-heptanol 31.65
    ethylbenzene 2.86
    MIBK 30.02
    2-propoxyethanol 136.47
    tert-butanol 104.95
    MTBE 35.47
    2-butoxyethanol 72.86
    propionic acid 151.36
    o-xylene 7.51
    formic acid 333.92
    diethyl ether 30.67
    m-xylene 8.17
    p-xylene 5.44
    chlorobenzene 10.41
    dimethyl carbonate 17.97
    n-octane 1.27
    formamide 349.47
    cyclopentanone 110.8
    2-pentanone 48.25
    anisole 18.05
    cyclopentyl methyl ether 56.03
    gamma-butyrolactone 164.03
    1-methoxy-2-propanol 109.21
    pyridine 61.96
    3-pentanone 27.33
    furfural 133.21
    n-dodecane 1.04
    diethylene glycol 117.81
    diisopropyl ether 9.38
    tert-amyl alcohol 76.84
    acetylacetone 39.81
    n-hexadecane 1.08
    acetophenone 25.15
    methyl propionate 42.31
    isopentyl acetate 50.57
    trichloroethylene 28.48
    n-nonanol 19.44
    cyclohexanol 49.94
    benzyl alcohol 29.2
    2-ethylhexanol 34.03
    isooctanol 25.21
    dipropyl ether 36.51
    1,2-dichlorobenzene 9.18
    ethyl lactate 26.22
    propylene carbonate 69.3
    n-methylformamide 198.94
    2-pentanol 52.36
    n-pentane 2.35
    1-propoxy-2-propanol 100.0
    1-methoxy-2-propyl acetate 52.27
    2-(2-methoxypropoxy) propanol 69.33
    mesitylene 5.47
    ε-caprolactone 89.07
    p-cymene 7.63
    epichlorohydrin 96.46
    1,1,1-trichloroethane 10.59
    2-aminoethanol 132.61
    morpholine-4-carbaldehyde 194.64
    sulfolane 163.54
    2,2,4-trimethylpentane 2.0
    2-methyltetrahydrofuran 103.3
    n-hexyl acetate 33.89
    isooctane 1.82
    2-(2-butoxyethoxy)ethanol 97.9
    sec-butyl acetate 23.14
    tert-butyl acetate 26.82
    decalin 1.03
    glycerin 93.87
    diglyme 160.41
    acrylic acid 124.45
    isopropyl myristate 13.01
    n-butyric acid 137.4
    acetyl acetate 21.06
    di(2-ethylhexyl) phthalate 17.6
    ethyl propionate 23.45
    nitromethane 262.36
    1,2-diethoxyethane 69.7
    benzonitrile 32.3
    trioctyl phosphate 13.41
    1-bromopropane 9.05
    gamma-valerolactone 175.41
    n-decanol 14.85
    triethyl phosphate 16.21
    4-methyl-2-pentanol 30.39
    propionitrile 46.47
    vinylene carbonate 59.51
    1,1,2-trichlorotrifluoroethane 90.23
    DMS 22.81
    cumene 3.77
    2-octanol 18.63
    2-hexanone 46.82
    octyl acetate 19.37
    limonene 12.56
    1,2-dimethoxyethane 124.43
    ethyl orthosilicate 16.86
    tributyl phosphate 18.16
    diacetone alcohol 58.47
    N,N-dimethylaniline 17.01
    acrylonitrile 65.11
    aniline 36.36
    1,3-propanediol 140.92
    bromobenzene 5.74
    dibromomethane 9.53
    1,1,2,2-tetrachloroethane 23.73
    2-methyl-cyclohexyl acetate 25.26
    tetrabutyl urea 26.07
    diisobutyl methanol 19.27
    2-phenylethanol 35.13
    styrene 3.54
    dioctyl adipate 22.43
    dimethyl sulfate 39.86
    ethyl butyrate 43.42
    methyl lactate 36.57
    butyl lactate 37.11
    diethyl carbonate 21.0
    propanediol butyl ether 63.42
    triethyl orthoformate 29.4
    p-tert-butyltoluene 7.13
    methyl 4-tert-butylbenzoate 31.48
    morpholine 154.1
    tert-butylamine 45.13
    n-dodecanol 11.49
    dimethoxymethane 76.57
    ethylene carbonate 47.77
    cyrene 56.17
    2-ethoxyethyl acetate 48.75
    2-ethylhexyl acetate 37.3
    1,2,4-trichlorobenzene 14.17
    4-methylpyridine 56.39
    dibutyl ether 21.46
    2,6-dimethyl-4-heptanol 19.27
    DEF 85.42
    dimethyl isosorbide 89.84
    tetrachloroethylene 20.48
    eugenol 40.19
    triacetin 35.62
    span 80 48.67
    1,4-butanediol 67.03
    1,1-dichloroethane 10.79
    2-methyl-1-pentanol 60.42
    methyl formate 101.86
    2-methyl-1-butanol 69.26
    n-decane 1.62
    butyronitrile 52.11
    3,7-dimethyl-1-octanol 24.06
    1-chlorooctane 6.24
    1-chlorotetradecane 2.84
    n-nonane 1.52
    undecane 1.25
    tert-butylcyclohexane 1.58
    cyclooctane 0.77
    cyclopentanol 85.22
    tetrahydropyran 64.29
    tert-amyl methyl ether 29.35
    2,5,8-trioxanonane 114.89
    1-hexene 7.01
    2-isopropoxyethanol 79.56
    2,2,2-trifluoroethanol 98.4
    methyl butyrate 41.89

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction