3-(Hydroxymethyl)-5-methoxyphenol

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  • Identifiers

    CAS number
    30891-29-3

    Molecular formula
    C8H10O3

    SMILES
    COC1=CC(=CC(=C1)O)CO

    Safety labels

  • Odor profile

    Fragrance
    Sweet 73.33%
    Vanilla 59.11%
    Phenolic 53.02%
    Fruity 52.77%
    Powdery 41.42%
    Floral 40.93%
    Balsamic 40.23%
    Creamy 37.75%
    Aromatic 31.01%
    Woody 30.1%

     

    Flavor
    Bitter 50.39%
    Sweet 42.86%
    Phenolic 36.11%
    Vanilla 33.06%
    Mild 31.77%
    Woody 31.57%
    Creamy 31.42%
    Powdery 29.96%
    Smoky 27.93%
    Musty 26.58%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    0.7

    pKa est.
    9.71 (weak base)

    Molecular weight
    154.16 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    349°C

    Melting point expt.

    • 85 - 86 °C

    Flash point

    • 140.45 ˚C est.

  • Synonyms

    • 3-(Hydroxymethyl)-5-methoxyphenol
    • Sylvopinol
    • 30891-29-3
    • 5-Hydroxy-3-methoxybenzyl alcohol
    • 3-hydroxy-5-methoxybenzenemethanol
    • 3-hydroxy-5-methoxybenzyl alcohol
    • SCHEMBL1650366
    • 3-hydroxymethyl-5-methoxyphenol
    • SCHEMBL29389280
    • CHEBI:173658
    • DTXSID201297094
    • 3-(hydroxymethyl)-5-methoxy-phenol
    • 3-(Hydroxymethyl)-5-methoxyphenol #
    • Benzenemethanol, 3-hydroxy-5-methoxy-
    • CS-0378441
    • 30891-29-3

  • Applications

    3-(Hydroxymethyl)-5-methoxyphenol, CAS 30891-29-3, is commonly used as a fragrance ingredient and an aroma-chemical intermediate in perfumery and cosmetics. It can serve as a building block for synthesizing other aroma compounds and functionalized phenols intended for personal-care formulations. In the polymers and coatings industries, it may act as a starting material for further chemical modification and can function as a stabilizer or processing aid in certain polymer systems and coatings. It is also employed as an industrial chemical intermediate for the synthesis of specialty organics, offering a versatile handle for downstream transformations, with specific use governed by local regulations and formulation constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 218.48
    methanol 295.39
    isopropanol 148.66
    water 15.12
    ethyl acetate 57.12
    n-propanol 143.07
    acetone 163.04
    n-butanol 97.45
    acetonitrile 111.79
    DMF 586.8
    toluene 11.35
    isobutanol 90.72
    1,4-dioxane 198.49
    methyl acetate 97.55
    THF 325.64
    2-butanone 89.63
    n-pentanol 69.16
    sec-butanol 86.78
    n-hexane 1.76
    ethylene glycol 350.09
    NMP 208.47
    cyclohexane 2.86
    DMSO 973.86
    n-butyl acetate 26.45
    n-octanol 41.91
    chloroform 67.44
    n-propyl acetate 36.65
    acetic acid 138.44
    dichloromethane 98.12
    cyclohexanone 86.29
    propylene glycol 235.79
    isopropyl acetate 29.04
    DMAc 325.91
    2-ethoxyethanol 198.3
    isopentanol 64.75
    n-heptane 5.3
    ethyl formate 89.27
    1,2-dichloroethane 60.08
    n-hexanol 72.71
    2-methoxyethanol 434.7
    isobutyl acetate 23.67
    tetrachloromethane 13.89
    n-pentyl acetate 21.24
    transcutol 115.5
    n-heptanol 42.08
    ethylbenzene 11.39
    MIBK 41.76
    2-propoxyethanol 165.8
    tert-butanol 175.14
    MTBE 46.72
    2-butoxyethanol 81.03
    propionic acid 113.02
    o-xylene 15.74
    formic acid 140.88
    diethyl ether 34.57
    m-xylene 16.86
    p-xylene 13.63
    chlorobenzene 19.9
    dimethyl carbonate 62.94
    n-octane 2.56
    formamide 214.95
    cyclopentanone 174.7
    2-pentanone 63.51
    anisole 52.67
    cyclopentyl methyl ether 71.16
    gamma-butyrolactone 215.61
    1-methoxy-2-propanol 240.48
    pyridine 60.09
    3-pentanone 41.35
    furfural 166.37
    n-dodecane 3.09
    diethylene glycol 251.53
    diisopropyl ether 10.52
    tert-amyl alcohol 94.71
    acetylacetone 87.03
    n-hexadecane 3.36
    acetophenone 52.71
    methyl propionate 80.75
    isopentyl acetate 24.8
    trichloroethylene 96.48
    n-nonanol 35.95
    cyclohexanol 67.79
    benzyl alcohol 62.5
    2-ethylhexanol 36.61
    isooctanol 32.85
    dipropyl ether 30.95
    1,2-dichlorobenzene 27.13
    ethyl lactate 55.32
    propylene carbonate 91.67
    n-methylformamide 305.2
    2-pentanol 48.39
    n-pentane 1.99
    1-propoxy-2-propanol 88.07
    1-methoxy-2-propyl acetate 54.85
    2-(2-methoxypropoxy) propanol 67.72
    mesitylene 12.73
    ε-caprolactone 74.01
    p-cymene 13.96
    epichlorohydrin 202.76
    1,1,1-trichloroethane 44.84
    2-aminoethanol 314.59
    morpholine-4-carbaldehyde 239.71
    sulfolane 304.63
    2,2,4-trimethylpentane 2.45
    2-methyltetrahydrofuran 108.92
    n-hexyl acetate 36.38
    isooctane 2.46
    2-(2-butoxyethoxy)ethanol 82.67
    sec-butyl acetate 20.56
    tert-butyl acetate 40.09
    decalin 3.31
    glycerin 327.88
    diglyme 157.22
    acrylic acid 118.51
    isopropyl myristate 19.41
    n-butyric acid 94.95
    acetyl acetate 39.38
    di(2-ethylhexyl) phthalate 26.53
    ethyl propionate 36.39
    nitromethane 277.6
    1,2-diethoxyethane 32.15
    benzonitrile 46.86
    trioctyl phosphate 23.35
    1-bromopropane 24.02
    gamma-valerolactone 186.58
    n-decanol 29.01
    triethyl phosphate 26.62
    4-methyl-2-pentanol 31.04
    propionitrile 76.61
    vinylene carbonate 83.58
    1,1,2-trichlorotrifluoroethane 193.54
    DMS 35.81
    cumene 12.21
    2-octanol 24.42
    2-hexanone 39.79
    octyl acetate 26.8
    limonene 19.84
    1,2-dimethoxyethane 208.67
    ethyl orthosilicate 22.4
    tributyl phosphate 21.75
    diacetone alcohol 96.87
    N,N-dimethylaniline 43.71
    acrylonitrile 120.21
    aniline 39.44
    1,3-propanediol 264.22
    bromobenzene 15.86
    dibromomethane 43.89
    1,1,2,2-tetrachloroethane 79.65
    2-methyl-cyclohexyl acetate 32.48
    tetrabutyl urea 35.27
    diisobutyl methanol 23.44
    2-phenylethanol 56.06
    styrene 11.99
    dioctyl adipate 33.45
    dimethyl sulfate 132.93
    ethyl butyrate 30.4
    methyl lactate 105.55
    butyl lactate 31.26
    diethyl carbonate 25.45
    propanediol butyl ether 71.38
    triethyl orthoformate 23.53
    p-tert-butyltoluene 14.65
    methyl 4-tert-butylbenzoate 57.65
    morpholine 219.47
    tert-butylamine 65.45
    n-dodecanol 23.31
    dimethoxymethane 219.04
    ethylene carbonate 66.49
    cyrene 97.28
    2-ethoxyethyl acetate 32.27
    2-ethylhexyl acetate 17.76
    1,2,4-trichlorobenzene 34.34
    4-methylpyridine 56.29
    dibutyl ether 20.16
    2,6-dimethyl-4-heptanol 23.44
    DEF 98.82
    dimethyl isosorbide 104.49
    tetrachloroethylene 48.0
    eugenol 64.57
    triacetin 42.04
    span 80 57.79
    1,4-butanediol 132.47
    1,1-dichloroethane 49.12
    2-methyl-1-pentanol 46.61
    methyl formate 244.25
    2-methyl-1-butanol 63.28
    n-decane 4.25
    butyronitrile 61.21
    3,7-dimethyl-1-octanol 33.24
    1-chlorooctane 16.96
    1-chlorotetradecane 8.54
    n-nonane 3.87
    undecane 3.57
    tert-butylcyclohexane 3.75
    cyclooctane 1.87
    cyclopentanol 111.42
    tetrahydropyran 82.32
    tert-amyl methyl ether 36.03
    2,5,8-trioxanonane 122.63
    1-hexene 8.31
    2-isopropoxyethanol 104.87
    2,2,2-trifluoroethanol 90.95
    methyl butyrate 53.6

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction