3-Hydroxyglabrol

Overview IFRA Request a quote

  • Identifiers

    CAS number
    74148-41-7

    Molecular formula
    C25H28O5

    SMILES
    CC(=CCC1=C(C=CC(=C1)[C@@H]2[C@H](C(=O)C3=C(O2)C(=C(C=C3)O)CC=C(C)C)O)O)C

    Safety labels

  • Odor profile

    Fragrance
    Spicy 52.66%
    Sweet 41.85%
    Phenolic 40.44%
    Woody 28.8%
    Herbal 28.7%
    Smoky 26.03%
    Balsamic 25.91%
    Fruity 25.76%
    Warm 24.37%
    Dry 23.28%

     

    Flavor
    Bitter 85.07%
    Lovage 19.89%
    Cedarleaf 19.77%
    Parsley 19.49%
    Basil 18.38%
    Herbal 18.3%
    Leaves 18.17%
    Heather 18.12%
    Nitrile 18.02%
    Broom 17.89%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    5.5

    pKa est.
    8.58 (weak base)

    Molecular weight
    408.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    1010°C

    Flash point

    • 213.07 ˚C est.

  • Synonyms

    • 3-Hydroxyglabrol
    • UNII-FTR3GY7U1I
    • 74148-41-7
    • FTR3GY7U1I
    • 4H-1-Benzopyran-4-one, 2,3-dihydro-3,7-dihydroxy-2-(4-hydroxy-3-(3-methyl-2-buten-1-yl)phenyl)-8-(3-methyl-2-buten-1-yl)-, (2R,3R)-
    • RefChem:25961
    • 3-hydroxy-glabrol
    • 3-hydroxy glabrol
    • orb2893272
    • SCHEMBL30819254
    • CHEBI:191827
    • DTXSID701316697
    • (2R,3R)-3,7-dihydroxy-2-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]-8-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one
    • Q27278192
    • (2R,3R)-3,7-Dihydroxy-2-[4-hydroxy-3-((E)-3-methyl-but-2-enyl)-phenyl]-8-(3-methyl-but-2-enyl)-1-benzopyran-4-one
    • (2R,3R)-3,7-Dihydroxy-2-[4-hydroxy-3-(3-methylbut-2-en-1-yl)phenyl]-8-(3-methylbut-2-en-1-yl)-2,3-dihydro-4H-1-benzopyran-4-one
    • (2R,3R)-3,7-dihydroxy-2-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]-8-(3-methylbut-2-enyl)chroman-4-one
    • 74148-41-7

  • Applications

    3-Hydroxyglabrol (CAS 74148-41-7) is viewed as an organic intermediate with potential real-world applications across several sectors: as an odorant or fragrance intermediate in perfumery, as a precursor or starting material for cosmetics and personal care formulations, as an intermediate in industrial chemical synthesis and in the preparation of complex organic compounds, and may function as a solvent or processing aid in formulations. It may also serve as a precursor for polymer-related chemicals or plastic additives, depending on local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 12.14
    methanol 20.35
    isopropanol 12.57
    water 0.04
    ethyl acetate 32.85
    n-propanol 17.14
    acetone 53.88
    n-butanol 13.68
    acetonitrile 14.39
    DMF 81.82
    toluene 15.12
    isobutanol 11.14
    1,4-dioxane 70.46
    methyl acetate 39.33
    THF 252.06
    2-butanone 52.34
    n-pentanol 13.22
    sec-butanol 14.38
    n-hexane 0.52
    ethylene glycol 3.8
    NMP 75.19
    cyclohexane 0.85
    DMSO 136.44
    n-butyl acetate 17.57
    n-octanol 12.45
    chloroform 90.9
    n-propyl acetate 19.54
    acetic acid 60.09
    dichloromethane 59.24
    cyclohexanone 62.93
    propylene glycol 11.87
    isopropyl acetate 23.86
    DMAc 169.45
    2-ethoxyethanol 47.01
    isopentanol 13.48
    n-heptane 0.71
    ethyl formate 14.86
    1,2-dichloroethane 36.11
    n-hexanol 12.54
    2-methoxyethanol 69.28
    isobutyl acetate 14.6
    tetrachloromethane 5.64
    n-pentyl acetate 24.13
    transcutol 182.46
    n-heptanol 13.44
    ethylbenzene 7.11
    MIBK 24.43
    2-propoxyethanol 59.35
    tert-butanol 23.14
    MTBE 23.03
    2-butoxyethanol 42.44
    propionic acid 26.49
    o-xylene 9.02
    formic acid 16.76
    diethyl ether 18.05
    m-xylene 9.51
    p-xylene 9.22
    chlorobenzene 18.69
    dimethyl carbonate 33.02
    n-octane 0.57
    formamide 31.46
    cyclopentanone 97.69
    2-pentanone 36.38
    anisole 25.09
    cyclopentyl methyl ether 43.26
    gamma-butyrolactone 88.91
    1-methoxy-2-propanol 69.55
    pyridine 51.0
    3-pentanone 30.94
    furfural 59.79
    n-dodecane 0.62
    diethylene glycol 38.18
    diisopropyl ether 5.88
    tert-amyl alcohol 21.25
    acetylacetone 65.49
    n-hexadecane 0.73
    acetophenone 28.08
    methyl propionate 39.07
    isopentyl acetate 21.04
    trichloroethylene 114.1
    n-nonanol 13.95
    cyclohexanol 14.72
    benzyl alcohol 23.34
    2-ethylhexanol 9.14
    isooctanol 12.86
    dipropyl ether 14.29
    1,2-dichlorobenzene 17.81
    ethyl lactate 19.52
    propylene carbonate 36.81
    n-methylformamide 27.56
    2-pentanol 10.62
    n-pentane 0.5
    1-propoxy-2-propanol 41.49
    1-methoxy-2-propyl acetate 42.27
    2-(2-methoxypropoxy) propanol 48.2
    mesitylene 5.83
    ε-caprolactone 52.62
    p-cymene 5.54
    epichlorohydrin 135.2
    1,1,1-trichloroethane 30.71
    2-aminoethanol 11.63
    morpholine-4-carbaldehyde 108.12
    sulfolane 116.6
    2,2,4-trimethylpentane 0.73
    2-methyltetrahydrofuran 58.33
    n-hexyl acetate 27.96
    isooctane 0.54
    2-(2-butoxyethoxy)ethanol 66.42
    sec-butyl acetate 16.09
    tert-butyl acetate 34.19
    decalin 0.91
    glycerin 22.41
    diglyme 118.08
    acrylic acid 27.11
    isopropyl myristate 12.4
    n-butyric acid 33.36
    acetyl acetate 30.16
    di(2-ethylhexyl) phthalate 16.12
    ethyl propionate 20.18
    nitromethane 104.18
    1,2-diethoxyethane 43.42
    benzonitrile 15.16
    trioctyl phosphate 11.57
    1-bromopropane 13.42
    gamma-valerolactone 139.93
    n-decanol 9.94
    triethyl phosphate 12.54
    4-methyl-2-pentanol 9.36
    propionitrile 14.21
    vinylene carbonate 33.34
    1,1,2-trichlorotrifluoroethane 91.63
    DMS 31.8
    cumene 5.19
    2-octanol 9.45
    2-hexanone 24.16
    octyl acetate 16.46
    limonene 7.16
    1,2-dimethoxyethane 80.76
    ethyl orthosilicate 13.36
    tributyl phosphate 12.06
    diacetone alcohol 53.28
    N,N-dimethylaniline 19.16
    acrylonitrile 20.93
    aniline 22.68
    1,3-propanediol 19.72
    bromobenzene 18.11
    dibromomethane 29.48
    1,1,2,2-tetrachloroethane 85.14
    2-methyl-cyclohexyl acetate 18.31
    tetrabutyl urea 17.8
    diisobutyl methanol 8.25
    2-phenylethanol 22.43
    styrene 8.67
    dioctyl adipate 21.14
    dimethyl sulfate 54.61
    ethyl butyrate 15.52
    methyl lactate 34.32
    butyl lactate 24.14
    diethyl carbonate 11.56
    propanediol butyl ether 40.04
    triethyl orthoformate 17.09
    p-tert-butyltoluene 6.08
    methyl 4-tert-butylbenzoate 39.25
    morpholine 83.98
    tert-butylamine 8.72
    n-dodecanol 7.08
    dimethoxymethane 89.89
    ethylene carbonate 26.77
    cyrene 51.84
    2-ethoxyethyl acetate 45.17
    2-ethylhexyl acetate 15.29
    1,2,4-trichlorobenzene 27.76
    4-methylpyridine 38.26
    dibutyl ether 14.03
    2,6-dimethyl-4-heptanol 8.25
    DEF 40.29
    dimethyl isosorbide 82.18
    tetrachloroethylene 41.8
    eugenol 35.09
    triacetin 44.02
    span 80 37.63
    1,4-butanediol 8.67
    1,1-dichloroethane 32.08
    2-methyl-1-pentanol 14.3
    methyl formate 26.22
    2-methyl-1-butanol 13.06
    n-decane 1.16
    butyronitrile 11.23
    3,7-dimethyl-1-octanol 12.84
    1-chlorooctane 6.2
    1-chlorotetradecane 2.53
    n-nonane 0.92
    undecane 0.82
    tert-butylcyclohexane 0.97
    cyclooctane 0.44
    cyclopentanol 21.76
    tetrahydropyran 45.75
    tert-amyl methyl ether 19.77
    2,5,8-trioxanonane 86.95
    1-hexene 2.61
    2-isopropoxyethanol 35.05
    2,2,2-trifluoroethanol 17.95
    methyl butyrate 24.23

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction