3-Hydroxyethyl sorbitol

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  • Identifiers

    CAS number
    110204-69-8

    Molecular formula
    C8H18O7

    SMILES
    C(CO[C@H]([C@@H](CO)O)[C@@H]([C@H](CO)O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 68.87%
    Sweet 43.62%
    Alcoholic 29.41%
    Fishy 18.29%
    Buttery 18.15%
    Clean 16.92%
    Oily 16.71%
    Cooling 15.72%
    Caramellic 15.28%
    Solvent 13.99%

     

    Flavor
    Odorless 71.96%
    Sweet 58.87%
    Sweet-like 34.71%
    Very mild 24.14%
    Very slight 22.85%
    Bland 21.8%
    Mild 21.16%
    Cauliflower 20.02%
    Yeast 19.51%
    Bitter 19.35%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -3.8

    pKa est.
    5.22 (weak acid)

    Molecular weight
    226.22 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    1048°C

    Flash point

    • 247.56 ˚C est.

  • Synonyms

    • 3-Hydroxyethyl sorbitol
    • 3J54OAL90N
    • 110204-69-8
    • UNII-3J54OAL90N
    • D-Glucitol, 3-O-(2-hydroxyethyl)-
    • RefChem:94306
    • (2S,3R,4R,5R)-4-(2-hydroxyethoxy)hexane-1,2,3,5,6-pentol
    • DTXSID301021387
    • Q27257283
    • 110204-69-8

  • Applications

    3-Hydroxyethyl sorbitol (CAS 110204-69-8) is commonly used as a humectant and plasticizer in cosmetic and personal care formulations, helping to retain moisture and improve texture; it also acts as a mild solvent and fragrance carrier in fragrance systems. In polymers and coatings, it functions as a diol/polyol intermediate for the synthesis of polyurethanes and polyesters and as a plasticizer to enhance flexibility and processing of coatings and inks. In adhesive formulations it can serve as a plasticizer and humectant to adjust open time and tack. In pharmaceutical applications, it may be used as an excipient or processing aid, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 4.46
    methanol 46.89
    isopropanol 1.51
    water 1638.11
    ethyl acetate 0.71
    n-propanol 2.88
    acetone 0.9
    n-butanol 1.47
    acetonitrile 0.83
    DMF 177.77
    toluene 0.15
    isobutanol 1.25
    1,4-dioxane 4.21
    methyl acetate 0.63
    THF 2.36
    2-butanone 0.72
    n-pentanol 0.71
    sec-butanol 1.55
    n-hexane 0.06
    ethylene glycol 234.3
    NMP 151.53
    cyclohexane 0.49
    DMSO 540.42
    n-butyl acetate 0.53
    n-octanol 0.84
    chloroform 0.23
    n-propyl acetate 0.36
    acetic acid 20.78
    dichloromethane 0.43
    cyclohexanone 3.03
    propylene glycol 68.44
    isopropyl acetate 0.45
    DMAc 72.65
    2-ethoxyethanol 13.67
    isopentanol 0.89
    n-heptane 0.36
    ethyl formate 1.33
    1,2-dichloroethane 0.64
    n-hexanol 1.2
    2-methoxyethanol 52.16
    isobutyl acetate 0.17
    tetrachloromethane 0.18
    n-pentyl acetate 0.47
    transcutol 14.63
    n-heptanol 1.21
    ethylbenzene 0.16
    MIBK 0.45
    2-propoxyethanol 8.71
    tert-butanol 1.73
    MTBE 0.4
    2-butoxyethanol 5.1
    propionic acid 8.06
    o-xylene 0.47
    formic acid 469.28
    diethyl ether 0.39
    m-xylene 0.26
    p-xylene 0.19
    chlorobenzene 0.12
    dimethyl carbonate 3.64
    n-octane 0.14
    formamide 263.0
    cyclopentanone 3.94
    2-pentanone 0.64
    anisole 0.44
    cyclopentyl methyl ether 1.73
    gamma-butyrolactone 7.87
    1-methoxy-2-propanol 20.44
    pyridine 1.4
    3-pentanone 0.9
    furfural 13.25
    n-dodecane 0.08
    diethylene glycol 44.51
    diisopropyl ether 0.2
    tert-amyl alcohol 1.91
    acetylacetone 1.78
    n-hexadecane 0.08
    acetophenone 1.14
    methyl propionate 2.17
    isopentyl acetate 0.41
    trichloroethylene 0.68
    n-nonanol 0.78
    cyclohexanol 3.43
    benzyl alcohol 1.67
    2-ethylhexanol 0.76
    isooctanol 0.86
    dipropyl ether 0.76
    1,2-dichlorobenzene 0.27
    ethyl lactate 3.65
    propylene carbonate 3.24
    n-methylformamide 60.35
    2-pentanol 0.79
    n-pentane 0.11
    1-propoxy-2-propanol 5.31
    1-methoxy-2-propyl acetate 2.49
    2-(2-methoxypropoxy) propanol 5.39
    mesitylene 0.32
    ε-caprolactone 4.25
    p-cymene 0.45
    epichlorohydrin 2.38
    1,1,1-trichloroethane 0.12
    2-aminoethanol 98.34
    morpholine-4-carbaldehyde 79.7
    sulfolane 77.83
    2,2,4-trimethylpentane 0.1
    2-methyltetrahydrofuran 1.26
    n-hexyl acetate 0.6
    isooctane 0.04
    2-(2-butoxyethoxy)ethanol 7.0
    sec-butyl acetate 0.23
    tert-butyl acetate 0.64
    decalin 0.14
    glycerin 289.25
    diglyme 12.17
    acrylic acid 19.43
    isopropyl myristate 0.26
    n-butyric acid 3.69
    acetyl acetate 0.78
    di(2-ethylhexyl) phthalate 0.87
    ethyl propionate 0.57
    nitromethane 17.7
    1,2-diethoxyethane 0.96
    benzonitrile 0.58
    trioctyl phosphate 0.79
    1-bromopropane 0.17
    gamma-valerolactone 14.73
    n-decanol 0.58
    triethyl phosphate 1.23
    4-methyl-2-pentanol 0.48
    propionitrile 0.62
    vinylene carbonate 3.67
    1,1,2-trichlorotrifluoroethane 31.83
    DMS 1.38
    cumene 0.19
    2-octanol 0.62
    2-hexanone 0.3
    octyl acetate 0.42
    limonene 0.75
    1,2-dimethoxyethane 5.77
    ethyl orthosilicate 0.98
    tributyl phosphate 0.67
    diacetone alcohol 3.83
    N,N-dimethylaniline 1.11
    acrylonitrile 1.7
    aniline 0.86
    1,3-propanediol 35.74
    bromobenzene 0.1
    dibromomethane 0.25
    1,1,2,2-tetrachloroethane 1.04
    2-methyl-cyclohexyl acetate 0.77
    tetrabutyl urea 1.56
    diisobutyl methanol 0.65
    2-phenylethanol 1.48
    styrene 0.13
    dioctyl adipate 0.74
    dimethyl sulfate 20.19
    ethyl butyrate 0.69
    methyl lactate 18.02
    butyl lactate 2.27
    diethyl carbonate 0.56
    propanediol butyl ether 9.48
    triethyl orthoformate 0.99
    p-tert-butyltoluene 0.48
    methyl 4-tert-butylbenzoate 2.79
    morpholine 8.47
    tert-butylamine 0.66
    n-dodecanol 0.45
    dimethoxymethane 11.47
    ethylene carbonate 2.52
    cyrene 19.67
    2-ethoxyethyl acetate 0.91
    2-ethylhexyl acetate 0.37
    1,2,4-trichlorobenzene 0.43
    4-methylpyridine 0.8
    dibutyl ether 0.33
    2,6-dimethyl-4-heptanol 0.65
    DEF 8.13
    dimethyl isosorbide 9.34
    tetrachloroethylene 1.17
    eugenol 3.71
    triacetin 1.98
    span 80 6.45
    1,4-butanediol 14.28
    1,1-dichloroethane 0.12
    2-methyl-1-pentanol 0.55
    methyl formate 18.95
    2-methyl-1-butanol 1.18
    n-decane 0.13
    butyronitrile 0.4
    3,7-dimethyl-1-octanol 0.61
    1-chlorooctane 0.22
    1-chlorotetradecane 0.11
    n-nonane 0.14
    undecane 0.1
    tert-butylcyclohexane 0.07
    cyclooctane 0.3
    cyclopentanol 3.99
    tetrahydropyran 1.21
    tert-amyl methyl ether 0.72
    2,5,8-trioxanonane 11.26
    1-hexene 0.08
    2-isopropoxyethanol 3.93
    2,2,2-trifluoroethanol 33.04
    methyl butyrate 0.78

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction