3-Hydroxybenzyl alcohol

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  • Identifiers

    CAS number
    620-24-6

    Molecular formula
    C7H8O2

    SMILES
    C1=CC(=CC(=C1)O)CO

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 79.07%
    Phenolic 67.29%
    Fruity 56.73%
    Vanilla 52.1%
    Almond 43.04%
    Medicinal 42.2%
    Floral 42.07%
    Balsamic 41.59%
    Powdery 38.13%
    Bitter 35.91%

     

    Flavor
    Sweet 69.29%
    Fruity 52.99%
    Phenolic 52.06%
    Bitter 48.3%
    Almond 40.96%
    Mild 37.78%
    Powdery 36.52%
    Hawthorn 35.8%
    Creamy 34.64%
    Vanilla 32.85%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    0.5

    pKa est.
    9.48 (weak base)

    Molecular weight
    124.14 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    288°C

    Flash point

    • 137.07 ˚C est.

  • Synonyms

    • 3-hydroxybenzyl alcohol
    • 620-24-6
    • 3-(Hydroxymethyl)phenol
    • Benzenemethanol, 3-hydroxy-
    • 3-Hydroxybenzenemethanol
    • m-Hydroxybenzyl alcohol
    • Benzyl alcohol, m-hydroxy-
    • H652F6XF7Y
    • DTXSID20211035
    • NSC-60735
    • CHEBI:17069
    • 3-methylol phenol
    • meta-hydroxybenzyl alcohol
    • RefChem:502532
    • DTXCID20133526
    • 210-633-6
    • KSD 2405
    • MFCD00004643
    • 3-Hydroxybenzylalcohol
    • 3-Hydroxymethyl-phenol
    • 3-(hydroxymethyl)-phenol
    • 3-hydroxymethylphenol
    • EINECS 210-633-6
    • NSC 60735
    • AI3-31880
    • 3-Hydroxybenzenemethanol; m-Hydroxybenzyl Alcohol; 3-(Hydroxymethyl)phenol; KSD 2405; NSC 60735;
    • 3-hydroxymethyl phenol
    • 3-(Hydroxymethy)phenol
    • 3-hydroxy benzyl alcohol
    • 3-hydroxy-phenyl-methanol
    • phenol, 3-hydroxymethyl-
    • 3-(hydroxy)benzyl alcohol
    • 3-(Hydroxymethyl)phenol #
    • 3-[(Hydroxy)methyl]phenol
    • UNII-H652F6XF7Y
    • SCHEMBL96097
    • 3-Hydroxybenzyl alcohol, 99%
    • orb1302585
    • SCHEMBL1373747
    • SCHEMBL2643295
    • SCHEMBL3928821
    • SCHEMBL5504193
    • CHEMBL3337531
    • SCHEMBL16898847
    • SCHEMBL17046321
    • SCHEMBL29462087
    • HYDROXYBENZYL ALCOHOL, M-
    • NSC60735
    • EBC-14266
    • s6363
    • SBB068731
    • AKOS000249424
    • FH64467
    • MSK167822-100M
    • AC-10893
    • AS-12681
    • HY-78446
    • SY006445
    • DB-054044
    • CS-0008490
    • H0918
    • NS00014669
    • ST45021353
    • EN300-55888
    • C03351
    • 620H246
    • F019221
    • Q27102196
    • 3-Hydroxybenzyl alcohol Solution in Methanol, 100ug/mL
    • F0001-1652
    • Z335245000
    • InChI=1/C7H8O2/c8-5-6-2-1-3-7(9)4-6/h1-4,8-9H,5H
    • 3HY
    • 620-24-6

  • Applications

    3-Hydroxybenzyl alcohol (CAS 620-24-6) is commonly used as a chemical intermediate in fragrance and flavor chemistry, serving as a building block for hydroxylated benzyl compounds and can be oxidized to 3-hydroxybenzaldehyde derivatives for specialty aroma materials. It is also employed as an intermediate in pharmaceutical synthesis, providing a versatile phenylmethyl alcohol backbone for constructing more complex drug molecules. In the dyes and pigments sector it can serve as a precursor to phenolic dye intermediates and related specialty chemicals. In polymers and coatings, it is used as a building block for functionalized resins and crosslinkers, or to prepare benzyl ether derivatives for polymer formulations. In R&D settings, it may be used as a general synthetic building block in organic synthesis, with use controlled by regulatory and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 482.46
    methanol 634.78
    isopropanol 346.2
    water 20.7
    ethyl acetate 177.71
    n-propanol 346.29
    acetone 308.67
    n-butanol 256.29
    acetonitrile 171.08
    DMF 641.99
    toluene 21.74
    isobutanol 198.36
    1,4-dioxane 631.41
    methyl acetate 219.58
    THF 917.25
    2-butanone 199.28
    n-pentanol 187.3
    sec-butanol 216.93
    n-hexane 6.2
    ethylene glycol 257.27
    NMP 254.65
    cyclohexane 3.7
    DMSO 868.17
    n-butyl acetate 99.86
    n-octanol 96.59
    chloroform 81.79
    n-propyl acetate 137.09
    acetic acid 303.71
    dichloromethane 60.86
    cyclohexanone 180.61
    propylene glycol 172.04
    isopropyl acetate 100.09
    DMAc 336.08
    2-ethoxyethanol 365.32
    isopentanol 172.76
    n-heptane 11.85
    ethyl formate 133.65
    1,2-dichloroethane 68.84
    n-hexanol 214.28
    2-methoxyethanol 553.84
    isobutyl acetate 87.65
    tetrachloromethane 28.04
    n-pentyl acetate 64.56
    transcutol 382.78
    n-heptanol 117.46
    ethylbenzene 19.97
    MIBK 134.01
    2-propoxyethanol 378.51
    tert-butanol 399.8
    MTBE 174.38
    2-butoxyethanol 199.21
    propionic acid 238.36
    o-xylene 23.62
    formic acid 251.29
    diethyl ether 150.09
    m-xylene 31.96
    p-xylene 24.0
    chlorobenzene 31.01
    dimethyl carbonate 96.36
    n-octane 6.04
    formamide 348.12
    cyclopentanone 330.2
    2-pentanone 182.86
    anisole 100.13
    cyclopentyl methyl ether 211.44
    gamma-butyrolactone 384.17
    1-methoxy-2-propanol 377.44
    pyridine 122.92
    3-pentanone 96.25
    furfural 232.48
    n-dodecane 5.89
    diethylene glycol 385.89
    diisopropyl ether 44.57
    tert-amyl alcohol 234.36
    acetylacetone 196.89
    n-hexadecane 6.23
    acetophenone 82.19
    methyl propionate 157.12
    isopentyl acetate 80.61
    trichloroethylene 118.07
    n-nonanol 82.6
    cyclohexanol 118.23
    benzyl alcohol 85.17
    2-ethylhexanol 93.72
    isooctanol 88.79
    dipropyl ether 99.24
    1,2-dichlorobenzene 32.65
    ethyl lactate 87.53
    propylene carbonate 157.55
    n-methylformamide 399.65
    2-pentanol 154.38
    n-pentane 5.25
    1-propoxy-2-propanol 220.67
    1-methoxy-2-propyl acetate 124.63
    2-(2-methoxypropoxy) propanol 135.27
    mesitylene 23.81
    ε-caprolactone 157.13
    p-cymene 23.07
    epichlorohydrin 348.2
    1,1,1-trichloroethane 68.29
    2-aminoethanol 361.71
    morpholine-4-carbaldehyde 384.93
    sulfolane 409.87
    2,2,4-trimethylpentane 6.29
    2-methyltetrahydrofuran 338.51
    n-hexyl acetate 89.36
    isooctane 7.88
    2-(2-butoxyethoxy)ethanol 208.49
    sec-butyl acetate 74.35
    tert-butyl acetate 131.11
    decalin 5.54
    glycerin 281.72
    diglyme 337.51
    acrylic acid 186.97
    isopropyl myristate 43.09
    n-butyric acid 226.81
    acetyl acetate 87.23
    di(2-ethylhexyl) phthalate 37.72
    ethyl propionate 100.94
    nitromethane 457.53
    1,2-diethoxyethane 109.2
    benzonitrile 64.71
    trioctyl phosphate 39.08
    1-bromopropane 31.58
    gamma-valerolactone 367.44
    n-decanol 63.27
    triethyl phosphate 43.62
    4-methyl-2-pentanol 98.02
    propionitrile 136.02
    vinylene carbonate 120.92
    1,1,2-trichlorotrifluoroethane 236.26
    DMS 60.05
    cumene 20.99
    2-octanol 68.42
    2-hexanone 135.63
    octyl acetate 57.49
    limonene 32.55
    1,2-dimethoxyethane 412.66
    ethyl orthosilicate 42.38
    tributyl phosphate 39.32
    diacetone alcohol 221.55
    N,N-dimethylaniline 69.54
    acrylonitrile 176.92
    aniline 63.76
    1,3-propanediol 396.94
    bromobenzene 22.1
    dibromomethane 34.43
    1,1,2,2-tetrachloroethane 108.83
    2-methyl-cyclohexyl acetate 62.44
    tetrabutyl urea 52.29
    diisobutyl methanol 57.72
    2-phenylethanol 104.15
    styrene 20.92
    dioctyl adipate 54.28
    dimethyl sulfate 158.93
    ethyl butyrate 82.11
    methyl lactate 133.69
    butyl lactate 63.52
    diethyl carbonate 51.9
    propanediol butyl ether 138.27
    triethyl orthoformate 56.02
    p-tert-butyltoluene 26.68
    methyl 4-tert-butylbenzoate 91.45
    morpholine 564.4
    tert-butylamine 181.86
    n-dodecanol 48.81
    dimethoxymethane 371.18
    ethylene carbonate 107.33
    cyrene 126.97
    2-ethoxyethyl acetate 84.79
    2-ethylhexyl acetate 54.44
    1,2,4-trichlorobenzene 39.05
    4-methylpyridine 106.31
    dibutyl ether 59.1
    2,6-dimethyl-4-heptanol 57.72
    DEF 183.1
    dimethyl isosorbide 189.53
    tetrachloroethylene 82.94
    eugenol 107.87
    triacetin 72.13
    span 80 110.71
    1,4-butanediol 193.62
    1,1-dichloroethane 66.34
    2-methyl-1-pentanol 123.6
    methyl formate 284.92
    2-methyl-1-butanol 147.69
    n-decane 8.8
    butyronitrile 128.95
    3,7-dimethyl-1-octanol 73.81
    1-chlorooctane 37.27
    1-chlorotetradecane 15.67
    n-nonane 8.1
    undecane 6.97
    tert-butylcyclohexane 8.38
    cyclooctane 2.8
    cyclopentanol 201.89
    tetrahydropyran 306.4
    tert-amyl methyl ether 108.89
    2,5,8-trioxanonane 242.77
    1-hexene 28.54
    2-isopropoxyethanol 240.0
    2,2,2-trifluoroethanol 149.35
    methyl butyrate 138.17

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction