3-Hydroxy-2-methoxybenzyl alcohol

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  • Identifiers

    CAS number
    84864-62-0

    Molecular formula
    C8H10O3

    SMILES
    COC1=C(C=CC=C1O)CO

    Safety labels

  • Odor profile

    Fragrance
    Vanilla 81.32%
    Sweet 79.32%
    Phenolic 66.1%
    Balsamic 54.43%
    Creamy 47.51%
    Smoky 46.75%
    Spicy 44.19%
    Powdery 43.24%
    Medicinal 38.72%
    Aromatic 35.72%

     

    Flavor
    Sweet 80.57%
    Vanilla 58.49%
    Phenolic 54.24%
    Powdery 48.26%
    Woody 46.87%
    Smoky 46.57%
    Spicy 44.01%
    Bitter 42.08%
    Creamy 40.19%
    Clove 38.52%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    0.7

    pKa est.
    9.78 (weak base)

    Molecular weight
    154.16 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    280°C

    Flash point

    • 135.28 ˚C est.

  • Synonyms

    • 3-Hydroxy-2-methoxybenzyl alcohol
    • 3-(hydroxymethyl)-2-methoxyphenol
    • 84864-62-0
    • EINECS 284-385-2
    • 3-Hydroxy-2-methoxybenzenemethanol
    • S9RL2U2HTL
    • SCHEMBL1836066
    • SCHEMBL16952390
    • DTXSID50233922
    • ZJXAUXOXMRUTTF-UHFFFAOYSA-N
    • AKOS006329190
    • Benzenemethanol, 3-hydroxy-2-methoxy-
    • NS00038693
    • 84864-62-0

  • Applications

    3-Hydroxy-2-methoxybenzyl alcohol (CAS number: 84864-62-0) is primarily used as a chemical building block in the synthesis of aromatic compounds for fragrances and flavors, serving as an intermediate to derive more complex phenolic scent molecules. It is also encountered as a precursor in cosmetics and personal care formulations where it contributes to fragrance notes. In addition, it can function as a pharmaceutical intermediate and as a starting material for producing related phenolic derivatives for coatings, inks, or polymer formulations. It may be evaluated for use in household products as a fragrance additive due to its aromatic character, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 509.75
    methanol 781.58
    isopropanol 240.41
    water 17.59
    ethyl acetate 232.26
    n-propanol 303.86
    acetone 479.06
    n-butanol 188.32
    acetonitrile 383.66
    DMF 748.34
    toluene 29.24
    isobutanol 142.09
    1,4-dioxane 975.39
    methyl acetate 268.56
    THF 983.05
    2-butanone 226.91
    n-pentanol 145.79
    sec-butanol 146.45
    n-hexane 9.89
    ethylene glycol 521.75
    NMP 327.87
    cyclohexane 12.89
    DMSO 1783.84
    n-butyl acetate 123.13
    n-octanol 81.97
    chloroform 243.71
    n-propyl acetate 166.62
    acetic acid 460.85
    dichloromethane 321.59
    cyclohexanone 245.01
    propylene glycol 206.94
    isopropyl acetate 119.9
    DMAc 249.57
    2-ethoxyethanol 521.4
    isopentanol 123.23
    n-heptane 14.3
    ethyl formate 238.29
    1,2-dichloroethane 300.49
    n-hexanol 138.1
    2-methoxyethanol 912.73
    isobutyl acetate 90.4
    tetrachloromethane 55.74
    n-pentyl acetate 80.71
    transcutol 437.15
    n-heptanol 81.95
    ethylbenzene 29.34
    MIBK 129.29
    2-propoxyethanol 363.85
    tert-butanol 312.24
    MTBE 181.18
    2-butoxyethanol 188.12
    propionic acid 230.15
    o-xylene 29.83
    formic acid 497.38
    diethyl ether 244.7
    m-xylene 32.9
    p-xylene 32.36
    chlorobenzene 69.44
    dimethyl carbonate 162.27
    n-octane 7.89
    formamide 746.38
    cyclopentanone 462.27
    2-pentanone 206.09
    anisole 126.72
    cyclopentyl methyl ether 209.48
    gamma-butyrolactone 642.65
    1-methoxy-2-propanol 427.63
    pyridine 181.6
    3-pentanone 133.94
    furfural 428.23
    n-dodecane 7.35
    diethylene glycol 502.71
    diisopropyl ether 56.68
    tert-amyl alcohol 172.46
    acetylacetone 281.71
    n-hexadecane 8.25
    acetophenone 103.01
    methyl propionate 207.22
    isopentyl acetate 94.59
    trichloroethylene 371.38
    n-nonanol 68.84
    cyclohexanol 118.0
    benzyl alcohol 110.72
    2-ethylhexanol 71.12
    isooctanol 65.42
    dipropyl ether 98.25
    1,2-dichlorobenzene 74.33
    ethyl lactate 117.55
    propylene carbonate 236.38
    n-methylformamide 558.56
    2-pentanol 106.73
    n-pentane 11.28
    1-propoxy-2-propanol 203.41
    1-methoxy-2-propyl acetate 148.13
    2-(2-methoxypropoxy) propanol 130.65
    mesitylene 29.01
    ε-caprolactone 218.83
    p-cymene 29.0
    epichlorohydrin 719.35
    1,1,1-trichloroethane 165.16
    2-aminoethanol 465.98
    morpholine-4-carbaldehyde 492.91
    sulfolane 838.29
    2,2,4-trimethylpentane 8.87
    2-methyltetrahydrofuran 364.95
    n-hexyl acetate 110.59
    isooctane 9.67
    2-(2-butoxyethoxy)ethanol 204.01
    sec-butyl acetate 87.13
    tert-butyl acetate 161.38
    decalin 10.17
    glycerin 401.97
    diglyme 393.42
    acrylic acid 235.79
    isopropyl myristate 51.17
    n-butyric acid 238.7
    acetyl acetate 136.53
    di(2-ethylhexyl) phthalate 44.32
    ethyl propionate 129.26
    nitromethane 892.21
    1,2-diethoxyethane 151.39
    benzonitrile 101.61
    trioctyl phosphate 48.15
    1-bromopropane 112.1
    gamma-valerolactone 527.83
    n-decanol 54.0
    triethyl phosphate 61.24
    4-methyl-2-pentanol 70.14
    propionitrile 206.65
    vinylene carbonate 217.09
    1,1,2-trichlorotrifluoroethane 429.84
    DMS 98.72
    cumene 26.76
    2-octanol 56.76
    2-hexanone 144.95
    octyl acetate 68.17
    limonene 40.7
    1,2-dimethoxyethane 584.11
    ethyl orthosilicate 56.72
    tributyl phosphate 46.79
    diacetone alcohol 216.82
    N,N-dimethylaniline 73.2
    acrylonitrile 284.5
    aniline 83.63
    1,3-propanediol 502.77
    bromobenzene 56.12
    dibromomethane 198.01
    1,1,2,2-tetrachloroethane 262.66
    2-methyl-cyclohexyl acetate 73.54
    tetrabutyl urea 61.51
    diisobutyl methanol 52.13
    2-phenylethanol 102.58
    styrene 36.97
    dioctyl adipate 70.83
    dimethyl sulfate 279.51
    ethyl butyrate 99.03
    methyl lactate 172.0
    butyl lactate 73.54
    diethyl carbonate 71.51
    propanediol butyl ether 144.06
    triethyl orthoformate 73.5
    p-tert-butyltoluene 31.24
    methyl 4-tert-butylbenzoate 105.74
    morpholine 736.5
    tert-butylamine 134.85
    n-dodecanol 42.72
    dimethoxymethane 545.83
    ethylene carbonate 196.84
    cyrene 155.53
    2-ethoxyethyl acetate 122.63
    2-ethylhexyl acetate 68.73
    1,2,4-trichlorobenzene 83.72
    4-methylpyridine 121.62
    dibutyl ether 65.99
    2,6-dimethyl-4-heptanol 52.13
    DEF 203.23
    dimethyl isosorbide 223.59
    tetrachloroethylene 200.98
    eugenol 118.57
    triacetin 100.31
    span 80 105.77
    1,4-butanediol 224.28
    1,1-dichloroethane 187.6
    2-methyl-1-pentanol 97.35
    methyl formate 514.44
    2-methyl-1-butanol 108.46
    n-decane 11.8
    butyronitrile 175.65
    3,7-dimethyl-1-octanol 60.06
    1-chlorooctane 47.65
    1-chlorotetradecane 20.36
    n-nonane 11.3
    undecane 9.1
    tert-butylcyclohexane 11.65
    cyclooctane 7.18
    cyclopentanol 195.17
    tetrahydropyran 389.39
    tert-amyl methyl ether 112.92
    2,5,8-trioxanonane 258.04
    1-hexene 36.22
    2-isopropoxyethanol 260.06
    2,2,2-trifluoroethanol 234.11
    methyl butyrate 170.96

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction