3-Hexyloxypropylene glycol

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  • Identifiers

    CAS number
    10305-38-1

    Molecular formula
    C9H20O3

    SMILES
    CCCCCCOCC(CO)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fruity 61.99%
    Oily 57.17%
    Green 54.67%
    Sweet 49.89%
    Fresh 42.01%
    Alcoholic 40.69%
    Herbal 34.35%
    Fermented 34.01%
    Musty 31.72%
    Ethereal 30.87%

     

    Flavor
    Sweet 53.15%
    Odorless 33.45%
    Oily 31.25%
    Fatty 30.78%
    Musty 27.98%
    Waxy 26.76%
    Mushroom 25.97%
    Mild 25.76%
    Herbal 25.71%
    Green 25.06%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.1

    pKa est.
    7.08 (neutral)

    Molecular weight
    176.25 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    269°C

    Flash point

    • 134.47 ˚C est.

  • Synonyms

    • 3-(Hexyloxy)propane-1,2-diol
    • 10305-38-1
    • 3-hexoxypropane-1,2-diol
    • 3-Hexyloxypropylene glycol
    • 1-O-hexylglycerol
    • 1,2-Propanediol, 3-(hexyloxy)-
    • 1,2-Propanediol, 3-hexyloxy-
    • 3-(hexyloxy)-1,2-propanediol
    • 1-Hexyloxy-2,3-propanediol
    • 3-Hexyloxy-1,2-propanediol
    • 3485P35DA4
    • BRN 1901988
    • J50.837C
    • DTXSID90893620
    • EC 600-386-6
    • 3-(HEX-1-YLOXY)-1,2-PROPANEDIOL
    • RefChem:502218
    • ANTIPERSPIRANT DEODORANT
    • DTXCID201323649
    • 600-386-6
    • 1,2-Propanediol,3-(hexyloxy)-
    • 1-o-hexyl-rac-glycerol
    • MFCD00167017
    • 3-hexyloxypropane-1,2-diol
    • UNII-3485P35DA4
    • hexyl glyceryl ether
    • glycerol n-hexyl ether
    • glycerol-1-hexyl ether
    • SCHEMBL114473
    • orb2944020
    • SBB060186
    • AKOS006344757
    • HY-W127318
    • CS-0185560
    • NS00009536
    • ST51046417
    • Q27256343
    • 10305-38-1

  • Applications

    3-Hexyloxypropylene glycol, CAS 10305-38-1, is used as a solvent and co-solvent in coatings, inks, and adhesives; serves as a humectant and solvent in cosmetics and personal care formulations; can act as an intermediate or diluent in polymer synthesis for polyurethanes and acrylic resins; can function as a plasticizer for certain polymer systems; is employed as a solvent or carrier for fragrance components in perfumery; and can serve as a co-solvent in cleaning and industrial formulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 4433.31
    methanol 7762.16
    isopropanol 2738.11
    water 8.75
    ethyl acetate 992.15
    n-propanol 2866.66
    acetone 1576.48
    n-butanol 2362.93
    acetonitrile 725.61
    DMF 1483.28
    toluene 78.42
    isobutanol 1704.22
    1,4-dioxane 1498.77
    methyl acetate 657.07
    THF 2057.51
    2-butanone 735.37
    n-pentanol 1093.25
    sec-butanol 1600.68
    n-hexane 49.9
    ethylene glycol 1311.53
    NMP 648.34
    cyclohexane 136.21
    DMSO 4692.67
    n-butyl acetate 710.69
    n-octanol 258.91
    chloroform 693.96
    n-propyl acetate 626.59
    acetic acid 3240.63
    dichloromethane 726.46
    cyclohexanone 1227.88
    propylene glycol 1422.62
    isopropyl acetate 527.18
    DMAc 660.42
    2-ethoxyethanol 1904.01
    isopentanol 1503.66
    n-heptane 60.82
    ethyl formate 797.1
    1,2-dichloroethane 656.02
    n-hexanol 1024.95
    2-methoxyethanol 4171.56
    isobutyl acetate 350.56
    tetrachloromethane 139.14
    n-pentyl acetate 291.31
    transcutol 3009.29
    n-heptanol 332.51
    ethylbenzene 58.47
    MIBK 424.79
    2-propoxyethanol 1514.93
    tert-butanol 2632.16
    MTBE 795.75
    2-butoxyethanol 721.48
    propionic acid 1497.48
    o-xylene 77.07
    formic acid 1597.11
    diethyl ether 665.5
    m-xylene 80.47
    p-xylene 83.34
    chlorobenzene 161.27
    dimethyl carbonate 155.62
    n-octane 18.68
    formamide 1544.43
    cyclopentanone 1066.5
    2-pentanone 793.29
    anisole 193.97
    cyclopentyl methyl ether 737.41
    gamma-butyrolactone 1165.44
    1-methoxy-2-propanol 2366.42
    pyridine 585.42
    3-pentanone 336.11
    furfural 981.45
    n-dodecane 12.42
    diethylene glycol 1564.93
    diisopropyl ether 177.81
    tert-amyl alcohol 1419.48
    acetylacetone 765.49
    n-hexadecane 13.66
    acetophenone 241.9
    methyl propionate 557.58
    isopentyl acetate 548.42
    trichloroethylene 969.58
    n-nonanol 207.48
    cyclohexanol 1322.62
    benzyl alcohol 326.36
    2-ethylhexanol 455.78
    isooctanol 261.35
    dipropyl ether 429.34
    1,2-dichlorobenzene 169.29
    ethyl lactate 330.05
    propylene carbonate 642.54
    n-methylformamide 1307.69
    2-pentanol 1134.17
    n-pentane 59.46
    1-propoxy-2-propanol 1089.18
    1-methoxy-2-propyl acetate 558.32
    2-(2-methoxypropoxy) propanol 424.67
    mesitylene 69.38
    ε-caprolactone 974.09
    p-cymene 80.13
    epichlorohydrin 1231.92
    1,1,1-trichloroethane 403.51
    2-aminoethanol 2206.39
    morpholine-4-carbaldehyde 1074.15
    sulfolane 1330.69
    2,2,4-trimethylpentane 36.91
    2-methyltetrahydrofuran 1201.3
    n-hexyl acetate 361.55
    isooctane 30.41
    2-(2-butoxyethoxy)ethanol 741.87
    sec-butyl acetate 336.02
    tert-butyl acetate 549.41
    decalin 38.71
    glycerin 1693.05
    diglyme 1414.48
    acrylic acid 979.33
    isopropyl myristate 119.16
    n-butyric acid 2549.88
    acetyl acetate 490.68
    di(2-ethylhexyl) phthalate 130.78
    ethyl propionate 376.97
    nitromethane 2539.47
    1,2-diethoxyethane 676.54
    benzonitrile 289.81
    trioctyl phosphate 116.77
    1-bromopropane 305.8
    gamma-valerolactone 1504.01
    n-decanol 139.76
    triethyl phosphate 171.55
    4-methyl-2-pentanol 472.26
    propionitrile 607.93
    vinylene carbonate 516.82
    1,1,2-trichlorotrifluoroethane 1363.52
    DMS 223.53
    cumene 58.53
    2-octanol 176.04
    2-hexanone 515.7
    octyl acetate 154.95
    limonene 157.59
    1,2-dimethoxyethane 1817.62
    ethyl orthosilicate 181.83
    tributyl phosphate 145.13
    diacetone alcohol 824.53
    N,N-dimethylaniline 133.68
    acrylonitrile 685.32
    aniline 305.76
    1,3-propanediol 3082.81
    bromobenzene 127.84
    dibromomethane 469.36
    1,1,2,2-tetrachloroethane 903.81
    2-methyl-cyclohexyl acetate 293.82
    tetrabutyl urea 173.94
    diisobutyl methanol 239.23
    2-phenylethanol 307.26
    styrene 79.04
    dioctyl adipate 216.11
    dimethyl sulfate 277.02
    ethyl butyrate 462.57
    methyl lactate 450.74
    butyl lactate 346.51
    diethyl carbonate 251.61
    propanediol butyl ether 672.33
    triethyl orthoformate 320.41
    p-tert-butyltoluene 79.96
    methyl 4-tert-butylbenzoate 245.52
    morpholine 2213.83
    tert-butylamine 1201.33
    n-dodecanol 103.53
    dimethoxymethane 880.56
    ethylene carbonate 520.8
    cyrene 351.87
    2-ethoxyethyl acetate 396.17
    2-ethylhexyl acetate 358.22
    1,2,4-trichlorobenzene 207.73
    4-methylpyridine 413.67
    dibutyl ether 256.63
    2,6-dimethyl-4-heptanol 239.23
    DEF 816.46
    dimethyl isosorbide 550.25
    tetrachloroethylene 724.39
    eugenol 268.67
    triacetin 356.6
    span 80 445.94
    1,4-butanediol 976.3
    1,1-dichloroethane 458.01
    2-methyl-1-pentanol 701.95
    methyl formate 758.12
    2-methyl-1-butanol 1217.29
    n-decane 22.33
    butyronitrile 836.44
    3,7-dimethyl-1-octanol 253.87
    1-chlorooctane 96.57
    1-chlorotetradecane 34.76
    n-nonane 23.5
    undecane 15.49
    tert-butylcyclohexane 37.82
    cyclooctane 35.42
    cyclopentanol 1413.23
    tetrahydropyran 1423.93
    tert-amyl methyl ether 449.47
    2,5,8-trioxanonane 816.8
    1-hexene 182.82
    2-isopropoxyethanol 996.42
    2,2,2-trifluoroethanol 696.96
    methyl butyrate 684.87

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction