3-Ethoxy-4-methoxyphenol

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  • Identifiers

    CAS number
    65383-57-5

    Molecular formula
    C9H12O3

    SMILES
    CCOC1=C(C=CC(=C1)O)OC

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Phenolic 78.12%
    Vanilla 75.62%
    Sweet 73.81%
    Spicy 64.81%
    Smoky 62.28%
    Woody 54.6%
    Balsamic 46.75%
    Clove 44.54%
    Medicinal 44.1%
    Powdery 43.72%

     

    Flavor
    Phenolic 49.76%
    Bitter 48.48%
    Spice 42.84%
    Vanilla 42.63%
    Smoky 41.7%
    Woody 41.46%
    Sweet 37.56%
    Smoke 32.78%
    Bacon 32.59%
    Powdery 31.18%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    2.1

    pKa est.
    9.21 (weak base)

    Molecular weight
    168.19 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    281°C

    Flash point

    • 112.11 ˚C est.

  • Synonyms

    • 3-Ethoxy-4-methoxyphenol
    • 65383-57-5
    • AI3-38508
    • EINECS 265-725-9
    • DTXSID90983999
    • Phenol, 3-ethoxy-4-methoxy-, monohydrate
    • RefChem:93789
    • DTXCID201411222
    • 265-725-9
    • YYXJGWHFSNJMDX-UHFFFAOYSA-N
    • 3-ethoxy-4-methoxy-phenol
    • MFCD00009093
    • SCHEMBL2100295
    • SCHEMBL5961721
    • AKOS006282836
    • BS-29244
    • CS-0207117
    • NS00056182
    • EN300-1829272
    • 65383-57-5

  • Applications

    3-Ethoxy-4-methoxyphenol (CAS 65383-57-5) is a substituted phenolic ether with ethoxy and methoxy groups; in industry it is typically used as an intermediate and functional additive across several sectors: as a fragrance component or fragrance intermediate in perfumery and cosmetics; as an antioxidant and stabilizer for polymers, coatings, and plastics to retard oxidation and help color stability; as a synthetic building block in pharmaceutical manufacturing; as a processing aid or intermediate in coatings/inks and cleaning formulations; and may be evaluated for other uses in electronics or adhesives, subject to regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 392.13
    methanol 559.78
    isopropanol 228.48
    water 1.74
    ethyl acetate 204.48
    n-propanol 238.81
    acetone 465.97
    n-butanol 183.87
    acetonitrile 385.92
    DMF 607.53
    toluene 75.39
    isobutanol 152.14
    1,4-dioxane 556.99
    methyl acetate 325.43
    THF 700.99
    2-butanone 245.63
    n-pentanol 148.46
    sec-butanol 168.95
    n-hexane 14.36
    ethylene glycol 296.17
    NMP 396.54
    cyclohexane 54.1
    DMSO 1282.71
    n-butyl acetate 149.52
    n-octanol 103.77
    chloroform 628.49
    n-propyl acetate 153.68
    acetic acid 455.7
    dichloromethane 981.07
    cyclohexanone 329.8
    propylene glycol 206.72
    isopropyl acetate 93.2
    DMAc 412.13
    2-ethoxyethanol 351.65
    isopentanol 124.86
    n-heptane 27.53
    ethyl formate 278.57
    1,2-dichloroethane 527.09
    n-hexanol 142.15
    2-methoxyethanol 567.3
    isobutyl acetate 90.41
    tetrachloromethane 108.62
    n-pentyl acetate 89.07
    transcutol 405.92
    n-heptanol 76.72
    ethylbenzene 62.22
    MIBK 86.61
    2-propoxyethanol 276.91
    tert-butanol 311.85
    MTBE 148.44
    2-butoxyethanol 144.2
    propionic acid 252.0
    o-xylene 71.41
    formic acid 167.74
    diethyl ether 160.44
    m-xylene 60.72
    p-xylene 92.45
    chlorobenzene 160.01
    dimethyl carbonate 136.95
    n-octane 13.58
    formamide 312.06
    cyclopentanone 430.89
    2-pentanone 151.03
    anisole 165.4
    cyclopentyl methyl ether 178.84
    gamma-butyrolactone 523.16
    1-methoxy-2-propanol 304.44
    pyridine 306.32
    3-pentanone 126.6
    furfural 461.61
    n-dodecane 16.17
    diethylene glycol 332.39
    diisopropyl ether 40.69
    tert-amyl alcohol 208.06
    acetylacetone 224.75
    n-hexadecane 17.91
    acetophenone 161.13
    methyl propionate 193.05
    isopentyl acetate 116.61
    trichloroethylene 715.32
    n-nonanol 88.93
    cyclohexanol 181.51
    benzyl alcohol 155.92
    2-ethylhexanol 97.34
    isooctanol 62.09
    dipropyl ether 113.81
    1,2-dichlorobenzene 162.92
    ethyl lactate 116.44
    propylene carbonate 300.35
    n-methylformamide 354.82
    2-pentanol 91.92
    n-pentane 17.08
    1-propoxy-2-propanol 170.36
    1-methoxy-2-propyl acetate 149.41
    2-(2-methoxypropoxy) propanol 150.81
    mesitylene 45.14
    ε-caprolactone 257.39
    p-cymene 60.35
    epichlorohydrin 632.76
    1,1,1-trichloroethane 342.96
    2-aminoethanol 282.81
    morpholine-4-carbaldehyde 456.58
    sulfolane 685.18
    2,2,4-trimethylpentane 13.3
    2-methyltetrahydrofuran 308.43
    n-hexyl acetate 142.27
    isooctane 9.76
    2-(2-butoxyethoxy)ethanol 204.27
    sec-butyl acetate 80.37
    tert-butyl acetate 113.22
    decalin 25.67
    glycerin 286.1
    diglyme 413.67
    acrylic acid 254.54
    isopropyl myristate 71.3
    n-butyric acid 227.36
    acetyl acetate 169.25
    di(2-ethylhexyl) phthalate 77.69
    ethyl propionate 127.44
    nitromethane 686.42
    1,2-diethoxyethane 159.99
    benzonitrile 191.51
    trioctyl phosphate 63.99
    1-bromopropane 195.51
    gamma-valerolactone 430.68
    n-decanol 72.03
    triethyl phosphate 96.57
    4-methyl-2-pentanol 53.35
    propionitrile 226.22
    vinylene carbonate 315.85
    1,1,2-trichlorotrifluoroethane 431.56
    DMS 141.43
    cumene 52.99
    2-octanol 58.09
    2-hexanone 135.87
    octyl acetate 94.11
    limonene 88.02
    1,2-dimethoxyethane 557.02
    ethyl orthosilicate 83.45
    tributyl phosphate 74.23
    diacetone alcohol 163.87
    N,N-dimethylaniline 111.63
    acrylonitrile 312.84
    aniline 131.82
    1,3-propanediol 307.66
    bromobenzene 171.21
    dibromomethane 538.34
    1,1,2,2-tetrachloroethane 523.11
    2-methyl-cyclohexyl acetate 120.22
    tetrabutyl urea 97.95
    diisobutyl methanol 59.69
    2-phenylethanol 132.3
    styrene 81.19
    dioctyl adipate 117.71
    dimethyl sulfate 233.89
    ethyl butyrate 149.91
    methyl lactate 155.02
    butyl lactate 90.8
    diethyl carbonate 136.12
    propanediol butyl ether 151.13
    triethyl orthoformate 108.58
    p-tert-butyltoluene 56.88
    methyl 4-tert-butylbenzoate 136.08
    morpholine 516.68
    tert-butylamine 164.83
    n-dodecanol 61.64
    dimethoxymethane 401.16
    ethylene carbonate 254.01
    cyrene 178.49
    2-ethoxyethyl acetate 131.32
    2-ethylhexyl acetate 91.85
    1,2,4-trichlorobenzene 194.93
    4-methylpyridine 222.82
    dibutyl ether 100.87
    2,6-dimethyl-4-heptanol 59.69
    DEF 220.98
    dimethyl isosorbide 248.06
    tetrachloroethylene 335.0
    eugenol 144.8
    triacetin 157.23
    span 80 136.51
    1,4-butanediol 165.75
    1,1-dichloroethane 348.52
    2-methyl-1-pentanol 111.18
    methyl formate 385.2
    2-methyl-1-butanol 121.98
    n-decane 22.27
    butyronitrile 197.34
    3,7-dimethyl-1-octanol 90.99
    1-chlorooctane 74.54
    1-chlorotetradecane 40.48
    n-nonane 21.61
    undecane 18.38
    tert-butylcyclohexane 21.85
    cyclooctane 16.05
    cyclopentanol 229.33
    tetrahydropyran 338.21
    tert-amyl methyl ether 105.99
    2,5,8-trioxanonane 300.12
    1-hexene 51.71
    2-isopropoxyethanol 202.84
    2,2,2-trifluoroethanol 165.12
    methyl butyrate 192.04

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction