3-Chlorophenol

Overview IFRA Request a quote

  • Identifiers

    CAS number
    108-43-0

    Molecular formula
    C6H5ClO

    SMILES
    C1=CC(=CC(=C1)Cl)O

    Safety labels

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Phenolic 78.89%
    Medicinal 51.43%
    Woody 44.23%
    Animal 40.37%
    Smoky 38.77%
    Burnt 36.32%
    Leathery 35.02%
    Sweet 34.74%
    Musty 33.47%
    Spicy 30.64%

     

    Flavor
    Phenolic 56.93%
    Medicinal 32.74%
    Mild 32.33%
    Nutty 31.36%
    Musty 27.59%
    Bitter 27.48%
    Medical 26.88%
    Meaty 24.98%
    Phenol 24.95%
    Plastic 24.57%

     

    Odor impact est.
    High

    Odor threshold

    • [ICSC] Odor threshold = 0.0189-6.5224 mg/m3 (recognition or detection unspecified)
    • Odor detection in air: 1.8x10-4 mg/l (gas), in water 1.24 ppm, chemically pure /Chlorophenol/
    • 0.2 ug/l for water at 30 °C

  • Properties

    XLogP3-AA
    2.5

    pKa est.
    8.59 (weak base)

    Molecular weight
    128.55 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately slow

    Melting point expt.

    • 91 °F (NTP, 1992)
    • 32.6 °C
    • 33.5 °C
    • 33 °C

    Boiling point

    • 417 °F at 760 mmHg (NTP, 1992)
    • 214 °C

    Flash point

    • 86.6 ˚C est.
    • greater than 233.6 °F (NTP, 1992)
    • Flash point > 112 °C
    • >112 °C (closed cup)
    • >112 °C

    Solubility expt.

    • 10 to 50 mg/mL at 59 °F (NTP, 1992)
    • 26000 mg/L (at 20 °C)
    • Slightly sol in chloroform; soluble in ethanol and ether; very sol in benzene
    • Soluble in caustic alkali
    • In water, 2.60X10+4 mg/L at 20 °C
    • Solubility in water, g/100ml at 20 °C: 2.6

  • Synonyms

    • 3-Chlorophenol
    • 108-43-0
    • m-Chlorophenol
    • Phenol, 3-chloro-
    • Phenol, m-chloro-
    • 3-Hydroxychlorobenzene
    • m-Chlorophenic acid
    • meta-Chlorophenol
    • 3-Chloro-Phenol
    • NSC 59700
    • Chlorophenol, m-
    • 3-Chloro-1-hydroxybenzene
    • CCRIS 641
    • HSDB 1413
    • UNII-Z2Z7M2FTAD
    • EINECS 203-582-6
    • DTXSID4024800
    • CHEBI:38855
    • AI3-23961
    • MFCD00002256
    • NSC-59700
    • Z2Z7M2FTAD
    • M-CHLOROPHENOL [MI]
    • UN 2020 (Salt/Mix)
    • UN 2021 (Salt/Mix)
    • CHEMBL41172
    • 3-CHLOROPHENOL [HSDB]
    • DTXCID004800
    • m-monochlorophenol
    • 3CH
    • meta-monochlorophenol
    • mChlorophenol
    • m-chloro-phenol
    • Phenol, mchloro
    • 3-chloro phenol
    • Phenol, 3chloro
    • mChlorophenic acid
    • 3Hydroxychlorobenzene
    • m-Chlorophenol, solid
    • 3Chloro1hydroxybenzene
    • m-Chlorophenol, liquid
    • 1li3
    • 3-Chlorophenol, 98%
    • WLN: QR CG
    • SCHEMBL49772
    • NSC59700
    • Tox21_200833
    • BDBM50167952
    • STL183823
    • AKOS000118748
    • CS-W020573
    • DB01957
    • PS-6042
    • NCGC00091698-01
    • NCGC00091698-02
    • NCGC00258387-01
    • CAS-108-43-0
    • PD008270
    • 3-Chlorophenol 100 microg/mL in Methanol
    • DB-040829
    • NS00001752
    • EN300-19378
    • D95297
    • 3-Chlorophenol, PESTANAL(R), analytical standard
    • Q3973362
    • F0001-0169
    • m-Chlorophenol, solid [UN2020] [Keep away from food]
    • Z104473668
    • m-Chlorophenol, liquid [UN2021] [Keep away from food]

  • Applications

    3-Chlorophenol (CAS 108-43-0) is primarily used as an intermediate in the manufacture of dyes and pigments, as an intermediate for agrochemicals and pesticides, and as a pharmaceutical intermediate. It is also used as a building block for the synthesis of chlorinated phenol derivatives employed in specialty polymers, resins, coatings, and inks. Additionally, it can serve as a reactive intermediate or precursor for the preparation of other chlorinated phenol derivatives. Use is typically governed by local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 893.43
    methanol 843.98
    isopropanol 608.3
    water 4.76
    ethyl acetate 354.28
    n-propanol 599.91
    acetone 661.85
    n-butanol 475.05
    acetonitrile 314.44
    DMF 508.37
    toluene 44.32
    isobutanol 387.56
    1,4-dioxane 724.37
    methyl acetate 346.96
    THF 1120.6
    2-butanone 417.0
    n-pentanol 388.68
    sec-butanol 442.54
    n-hexane 31.61
    ethylene glycol 163.79
    NMP 349.97
    cyclohexane 17.49
    DMSO 701.78
    n-butyl acetate 263.3
    n-octanol 179.36
    chloroform 127.71
    n-propyl acetate 268.46
    acetic acid 489.56
    dichloromethane 106.41
    cyclohexanone 326.9
    propylene glycol 185.81
    isopropyl acetate 219.83
    DMAc 311.13
    2-ethoxyethanol 560.74
    isopentanol 352.05
    n-heptane 41.67
    ethyl formate 234.24
    1,2-dichloroethane 119.45
    n-hexanol 341.23
    2-methoxyethanol 756.54
    isobutyl acetate 178.35
    tetrachloromethane 27.04
    n-pentyl acetate 181.85
    transcutol 1628.02
    n-heptanol 160.78
    ethylbenzene 30.28
    MIBK 238.75
    2-propoxyethanol 590.18
    tert-butanol 597.42
    MTBE 365.39
    2-butoxyethanol 320.15
    propionic acid 295.88
    o-xylene 38.06
    formic acid 214.71
    diethyl ether 510.11
    m-xylene 47.85
    p-xylene 41.59
    chlorobenzene 55.84
    dimethyl carbonate 135.5
    n-octane 14.61
    formamide 334.1
    cyclopentanone 390.97
    2-pentanone 385.42
    anisole 164.14
    cyclopentyl methyl ether 367.3
    gamma-butyrolactone 460.12
    1-methoxy-2-propanol 591.86
    pyridine 172.21
    3-pentanone 204.46
    furfural 330.06
    n-dodecane 15.57
    diethylene glycol 486.66
    diisopropyl ether 139.53
    tert-amyl alcohol 398.29
    acetylacetone 371.63
    n-hexadecane 16.84
    acetophenone 134.48
    methyl propionate 239.85
    isopentyl acetate 224.28
    trichloroethylene 159.59
    n-nonanol 158.92
    cyclohexanol 252.62
    benzyl alcohol 128.22
    2-ethylhexanol 167.4
    isooctanol 133.96
    dipropyl ether 250.52
    1,2-dichlorobenzene 54.36
    ethyl lactate 134.8
    propylene carbonate 264.28
    n-methylformamide 328.59
    2-pentanol 341.36
    n-pentane 34.68
    1-propoxy-2-propanol 414.8
    1-methoxy-2-propyl acetate 296.12
    2-(2-methoxypropoxy) propanol 334.57
    mesitylene 38.43
    ε-caprolactone 327.55
    p-cymene 46.61
    epichlorohydrin 485.73
    1,1,1-trichloroethane 118.57
    2-aminoethanol 304.18
    morpholine-4-carbaldehyde 538.88
    sulfolane 458.81
    2,2,4-trimethylpentane 23.07
    2-methyltetrahydrofuran 607.15
    n-hexyl acetate 258.24
    isooctane 25.81
    2-(2-butoxyethoxy)ethanol 501.85
    sec-butyl acetate 181.83
    tert-butyl acetate 278.03
    decalin 17.17
    glycerin 246.22
    diglyme 717.75
    acrylic acid 213.87
    isopropyl myristate 122.84
    n-butyric acid 363.99
    acetyl acetate 202.86
    di(2-ethylhexyl) phthalate 97.92
    ethyl propionate 192.62
    nitromethane 611.32
    1,2-diethoxyethane 485.73
    benzonitrile 117.75
    trioctyl phosphate 86.03
    1-bromopropane 101.35
    gamma-valerolactone 554.43
    n-decanol 125.47
    triethyl phosphate 96.08
    4-methyl-2-pentanol 186.81
    propionitrile 209.95
    vinylene carbonate 199.78
    1,1,2-trichlorotrifluoroethane 284.09
    DMS 170.45
    cumene 33.23
    2-octanol 124.6
    2-hexanone 309.22
    octyl acetate 151.23
    limonene 76.88
    1,2-dimethoxyethane 666.35
    ethyl orthosilicate 102.09
    tributyl phosphate 106.18
    diacetone alcohol 365.55
    N,N-dimethylaniline 111.47
    acrylonitrile 178.83
    aniline 106.06
    1,3-propanediol 439.17
    bromobenzene 40.28
    dibromomethane 77.97
    1,1,2,2-tetrachloroethane 144.29
    2-methyl-cyclohexyl acetate 153.19
    tetrabutyl urea 125.19
    diisobutyl methanol 114.94
    2-phenylethanol 172.07
    styrene 36.24
    dioctyl adipate 163.49
    dimethyl sulfate 178.66
    ethyl butyrate 186.63
    methyl lactate 172.54
    butyl lactate 161.87
    diethyl carbonate 122.47
    propanediol butyl ether 331.06
    triethyl orthoformate 151.19
    p-tert-butyltoluene 52.81
    methyl 4-tert-butylbenzoate 185.7
    morpholine 734.1
    tert-butylamine 310.03
    n-dodecanol 101.05
    dimethoxymethane 535.79
    ethylene carbonate 187.89
    cyrene 236.17
    2-ethoxyethyl acetate 272.16
    2-ethylhexyl acetate 167.95
    1,2,4-trichlorobenzene 71.28
    4-methylpyridine 160.41
    dibutyl ether 205.85
    2,6-dimethyl-4-heptanol 114.94
    DEF 293.57
    dimethyl isosorbide 466.51
    tetrachloroethylene 88.33
    eugenol 198.74
    triacetin 249.51
    span 80 279.79
    1,4-butanediol 201.69
    1,1-dichloroethane 128.41
    2-methyl-1-pentanol 269.54
    methyl formate 254.36
    2-methyl-1-butanol 325.26
    n-decane 23.27
    butyronitrile 254.02
    3,7-dimethyl-1-octanol 169.65
    1-chlorooctane 84.03
    1-chlorotetradecane 40.87
    n-nonane 21.57
    undecane 18.63
    tert-butylcyclohexane 23.22
    cyclooctane 9.52
    cyclopentanol 302.23
    tetrahydropyran 582.97
    tert-amyl methyl ether 252.17
    2,5,8-trioxanonane 553.6
    1-hexene 105.19
    2-isopropoxyethanol 379.04
    2,2,2-trifluoroethanol 163.81
    methyl butyrate 237.19

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction