(3-Chloro-2-hydroxypropyl)trimethylammonium chloride

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  • Identifiers

    CAS number
    3327-22-8

    Molecular formula
    C6H15Cl2NO

    SMILES
    C[N+](C)(C)CC(CCl)O.[Cl-]

    Safety labels

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Mint 34.25%
    Fishy 31.37%
    Oily 30.81%
    Alcoholic 27.99%
    Odorless 27.78%
    Woody 26.77%
    Cooling 25.86%
    Fermented 25.03%
    Sweet 24.66%
    Green 23.77%

     

    Flavor
    Sulfurous 36.29%
    Mild 30.22%
    Bland 25.86%
    Odorless 25.26%
    Sulfury 22.74%
    Yeasty 21.88%
    Meaty 21.57%
    Onion 21.19%
    Bloody 20.99%
    Glue 20.7%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    6.02 (neutral)

    Molecular weight
    188.09 g/mol

    Flash point

    • -80.54 ˚C est.

    Solubility expt.

    • Solubility in water: miscible

  • Synonyms

    • 3327-22-8
    • (3-Chloro-2-hydroxypropyl)trimethylammonium chloride
    • Dextrosil
    • 3-Chloro-2-hydroxypropylammonium chloride
    • 1-Propanaminium, 3-chloro-2-hydroxy-N,N,N-trimethyl-, chloride
    • APK4X6ZD79
    • 3-Chloro-2-hydroxypropyltrimethylammonium chloride
    • DTXSID3027534
    • NSC-51216
    • AMMONIUM, (3-CHLORO-2-HYDROXYPROPYL)TRIMETHYL-, CHLORIDE
    • DTXCID207534
    • 1-Propanaminium, 3-chloro-2-hydroxy-N,N,N-trimethyl-, chloride (1:1)
    • CHPTAC cpd
    • RefChem:69106
    • 3-Cl-2-HP-TACl
    • 222-048-3
    • 3-Chloro-2-hydroxypropyltrimethyl ammonium chloride
    • Dextrosil KA
    • (3-Chloro-2-hydroxypropyl)-N,N,N-trimethylammonium chloride
    • 3-Chloro-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride(65% in water)
    • MFCD00055655
    • (3-chloro-2-hydroxypropyl)-trimethylazanium;chloride
    • Levocarnitine Impurity 8
    • 3-chloro-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride
    • 2-Hydroxy-3-chloropropyltrimethylammonium chloride
    • Trimethyl(2-hydroxy-3-chloropropyl)ammonium chloride
    • Catiomaster C
    • C6H15Cl2NO
    • Verolan KAF
    • Dowquat 188
    • QUAB
    • Quat 188
    • 3-Chloro-2-hydroxypropyltrimethyl Ammonium Chloride (60% in Water)
    • (3-Chloro-2-hydroxypropyl)trimethylammonium Chloride (ca. 65% in Water)
    • NT 21
    • EINECS 222-048-3
    • NSC 51216
    • UNII-APK4X6ZD79
    • EC 222-048-3
    • SCHEMBL97002
    • orb2939273
    • CHEMBL1866981
    • 3-Chloro-2-hydroxypropyltrimethyl ammonium chloride, Powder
    • HY-D0176
    • NSC51216
    • Tox21_202563
    • c1180
    • MSK171342
    • SBB070751
    • AKOS015900634
    • Levocarnitine Impurity N3065% in water
    • NCGC00163979-01
    • NCGC00260112-01
    • AS-14532
    • SY112093
    • CAS-3327-22-8
    • DB-048377
    • CS-0010102
    • NS00078289
    • D72484
    • 1-chloro-3-(trimethylamino)propan-2-ol, chloride
    • F242955
    • Q223065
    • (2-Hydroxy-3-chloropropyl)trimethylammonium chloride
    • 3-chloro-2-hydroxy-propyltrimethylammonium chloride
    • 3-chloro-2-hydroxypropyl trimethyl ammonium chloride
    • 3-chloro-2-hydroxypropyl trimethylammonium chloride
    • (3-chloro-2-hydroxypropyl)trimethyl ammonium chloride
    • N-(3-chloro-2-hydroxypropyl)trimethylammonium chloride
    • (3-chloro-2-hydroxy-n-propyl)trimethylammonium chloride
    • (3-chloro-2-hydroxy-propyl)-trimethyl-ammonium;chloride
    • (S)-(?)-(3-Chloro-2-Hydroxypropyl)Trimethylammonium Chloride
    • (3-Chloro-2-hydroxypropyl)trimethylammonium Chloride (50% in Water)
    • (3-Chloro-2-hydroxypropyl)trimethylammonium chloride (65% in water)
    • 3-Chloro-2-hydroxy-N,N,N-trimethylpropan-1-aminium Chloride,65wt.%in H2O
    • 3-Chloro-2-hydroxy-N,N,N-trimethylpropan-1-aminiumchloride(65%inwater)
    • 3-Chloro-2-hydroxypropyltrimethyl Ammonium Chloride (60per cent in Water)
    • 3-Chloro-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride (65% in water)
    • 3-Chloro-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride, ca. 65% in water, w/w%
    • 3327-22-8

  • Applications

    (3-Chloro-2-hydroxypropyl)trimethylammonium chloride (CAS 3327-22-8) is commonly used as a reactive intermediate for the synthesis of quaternary ammonium monomers and cationic polymers, including those employed in water treatment as flocculants and retention aids in papermaking; may be used to prepare cationic surfactants and conditioning agents for household cleaners and personal care products; functions as a functional monomer in coatings, inks, and adhesives to confer permanent positive charge and improved substrate affinity; serves as a building block for textile finishing agents to enhance dye uptake; and can act as a reactive intermediate in epoxy- and polymer systems to introduce chlorohydrin/cationic functionalities and enable further crosslinking.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 170.73
    methanol 461.38
    isopropanol 44.42
    water 479.92
    ethyl acetate 10.06
    n-propanol 91.42
    acetone 11.05
    n-butanol 42.36
    acetonitrile 14.21
    DMF 57.99
    toluene 2.05
    isobutanol 35.88
    1,4-dioxane 31.52
    methyl acetate 19.73
    THF 32.89
    2-butanone 11.91
    n-pentanol 13.85
    sec-butanol 34.9
    n-hexane 1.31
    ethylene glycol 329.08
    NMP 124.84
    cyclohexane 3.09
    DMSO 38.91
    n-butyl acetate 16.03
    n-octanol 16.57
    chloroform 64.15
    n-propyl acetate 9.4
    acetic acid 804.13
    dichloromethane 38.34
    cyclohexanone 28.34
    propylene glycol 210.7
    isopropyl acetate 4.2
    DMAc 61.18
    2-ethoxyethanol 61.19
    isopentanol 13.21
    n-heptane 4.13
    ethyl formate 29.28
    1,2-dichloroethane 13.61
    n-hexanol 35.22
    2-methoxyethanol 182.24
    isobutyl acetate 6.52
    tetrachloromethane 17.01
    n-pentyl acetate 11.4
    transcutol 94.11
    n-heptanol 25.11
    ethylbenzene 1.76
    MIBK 2.52
    2-propoxyethanol 84.16
    tert-butanol 27.06
    MTBE 5.52
    2-butoxyethanol 58.42
    propionic acid 164.63
    o-xylene 3.34
    formic acid 992.43
    diethyl ether 5.61
    m-xylene 2.22
    p-xylene 2.85
    chlorobenzene 7.15
    dimethyl carbonate 8.11
    n-octane 1.22
    formamide 335.66
    cyclopentanone 32.58
    2-pentanone 4.88
    anisole 5.73
    cyclopentyl methyl ether 11.89
    gamma-butyrolactone 71.41
    1-methoxy-2-propanol 60.12
    pyridine 23.85
    3-pentanone 6.52
    furfural 94.49
    n-dodecane 0.91
    diethylene glycol 136.03
    diisopropyl ether 1.31
    tert-amyl alcohol 28.17
    acetylacetone 6.73
    n-hexadecane 0.95
    acetophenone 10.2
    methyl propionate 14.86
    isopentyl acetate 12.3
    trichloroethylene 45.17
    n-nonanol 14.44
    cyclohexanol 35.66
    benzyl alcohol 16.7
    2-ethylhexanol 16.87
    isooctanol 16.64
    dipropyl ether 10.28
    1,2-dichlorobenzene 10.79
    ethyl lactate 22.71
    propylene carbonate 42.55
    n-methylformamide 110.63
    2-pentanol 12.09
    n-pentane 1.76
    1-propoxy-2-propanol 51.89
    1-methoxy-2-propyl acetate 19.12
    2-(2-methoxypropoxy) propanol 42.31
    mesitylene 1.81
    ε-caprolactone 44.57
    p-cymene 6.21
    epichlorohydrin 34.8
    1,1,1-trichloroethane 13.44
    2-aminoethanol 314.43
    morpholine-4-carbaldehyde 97.58
    sulfolane 94.21
    2,2,4-trimethylpentane 1.44
    2-methyltetrahydrofuran 21.21
    n-hexyl acetate 16.06
    isooctane 0.61
    2-(2-butoxyethoxy)ethanol 54.58
    sec-butyl acetate 4.55
    tert-butyl acetate 5.35
    decalin 1.32
    glycerin 337.52
    diglyme 71.16
    acrylic acid 221.36
    isopropyl myristate 5.45
    n-butyric acid 92.7
    acetyl acetate 9.94
    di(2-ethylhexyl) phthalate 16.85
    ethyl propionate 7.2
    nitromethane 166.31
    1,2-diethoxyethane 9.22
    benzonitrile 12.09
    trioctyl phosphate 11.82
    1-bromopropane 6.82
    gamma-valerolactone 71.01
    n-decanol 10.04
    triethyl phosphate 12.06
    4-methyl-2-pentanol 4.41
    propionitrile 12.92
    vinylene carbonate 51.2
    1,1,2-trichlorotrifluoroethane 172.58
    DMS 14.74
    cumene 2.33
    2-octanol 10.58
    2-hexanone 5.0
    octyl acetate 10.19
    limonene 9.05
    1,2-dimethoxyethane 28.97
    ethyl orthosilicate 11.65
    tributyl phosphate 12.26
    diacetone alcohol 16.3
    N,N-dimethylaniline 7.22
    acrylonitrile 25.13
    aniline 15.63
    1,3-propanediol 189.39
    bromobenzene 4.64
    dibromomethane 22.81
    1,1,2,2-tetrachloroethane 40.52
    2-methyl-cyclohexyl acetate 18.77
    tetrabutyl urea 14.69
    diisobutyl methanol 7.59
    2-phenylethanol 24.9
    styrene 1.93
    dioctyl adipate 13.48
    dimethyl sulfate 19.57
    ethyl butyrate 12.89
    methyl lactate 34.45
    butyl lactate 27.73
    diethyl carbonate 10.43
    propanediol butyl ether 61.43
    triethyl orthoformate 14.01
    p-tert-butyltoluene 6.84
    methyl 4-tert-butylbenzoate 25.87
    morpholine 58.25
    tert-butylamine 14.72
    n-dodecanol 7.25
    dimethoxymethane 18.39
    ethylene carbonate 31.5
    cyrene 52.38
    2-ethoxyethyl acetate 16.53
    2-ethylhexyl acetate 11.03
    1,2,4-trichlorobenzene 18.2
    4-methylpyridine 12.03
    dibutyl ether 4.68
    2,6-dimethyl-4-heptanol 7.59
    DEF 16.36
    dimethyl isosorbide 55.72
    tetrachloroethylene 48.3
    eugenol 37.56
    triacetin 27.98
    span 80 52.93
    1,4-butanediol 58.12
    1,1-dichloroethane 10.39
    2-methyl-1-pentanol 8.11
    methyl formate 71.62
    2-methyl-1-butanol 22.92
    n-decane 1.41
    butyronitrile 8.72
    3,7-dimethyl-1-octanol 11.04
    1-chlorooctane 4.84
    1-chlorotetradecane 2.17
    n-nonane 1.34
    undecane 1.08
    tert-butylcyclohexane 1.54
    cyclooctane 1.06
    cyclopentanol 53.12
    tetrahydropyran 17.13
    tert-amyl methyl ether 6.86
    2,5,8-trioxanonane 56.11
    1-hexene 2.45
    2-isopropoxyethanol 27.54
    2,2,2-trifluoroethanol 310.39
    methyl butyrate 11.16

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction