3-Chloro-1,2-propanediol

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  • Identifiers

    CAS number
    96-24-2

    Molecular formula
    C3H7ClO2

    SMILES
    C(C(CCl)O)O

    Safety labels

    Corrosive
    Corrosive

    Acute Toxic
    Acute Toxic

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Odorless 66.86%
    Fishy 31.37%
    Sweet 31.22%
    Alcoholic 28.49%
    Buttery 19.45%
    Oily 19.16%
    Caramellic 16.39%
    Solvent 16.19%
    Ethereal 15.34%
    Clean 14.62%

     

    Flavor
    Odorless 72.36%
    Sweet 41.92%
    Sweet-like 28.69%
    Mild 23.01%
    Very slight 22.98%
    Sulfurous 21.39%
    Cauliflower 20.28%
    Soup 20.02%
    Soy 19.17%
    Meat broth 19.0%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    -0.5

    pKa est.
    6.07 (neutral)

    Molecular weight
    110.54 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Melting point expt.

    • -40 °F (NTP, 1992)
    • -40 °C

    Boiling point

    • 415 °F at 760 mmHg (decomposes) (NTP, 1992)
    • 213 °C (decomposes)
    • at 1.9kPa: 114-120 °C

    Flash point

    • 119.24 ˚C est.
    • 138 °F (NTP, 1992)
    • 145 °C
    • 113 °C c.c.

    Solubility expt.

    • greater than or equal to 100 mg/mL at 70 °F (NTP, 1992)
    • SOL IN WATER, ALCOHOL, & ETHER
    • Immiscible with oils
    • Soluble in oxygenated solvents
    • Miscible in water
    • 1000 mg/mL at 20 °C
    • Solubility in water: miscible

  • Synonyms

    • 3-Chloro-1,2-propanediol
    • 3-Chloropropane-1,2-diol
    • 96-24-2
    • alpha-Chlorohydrin
    • Glycerol alpha-monochlorohydrin
    • Epibloc
    • Chlorodeoxyglycerol
    • Chloropropanediol
    • 1,2-Propanediol, 3-chloro-
    • 3-Chloropropanediol
    • Glycerol chlorohydrin
    • 3-Chloropropylene glycol
    • Glyceryl chloride
    • 1-Chloro-2,3-dihydroxypropane
    • 1-Chloropropane-2,3-diol
    • Monochlorohydrin
    • 1-Chloro-2,3-propanediol
    • Glycerin epichlorohydrin
    • Glycerol 3-chlorohydrin
    • Monochlorhydrin
    • Chlorhydrin
    • 2,3-Dihydroxypropyl chloride
    • 1-Chloro-1-deoxyglycerol
    • alpha-Monochlorohydrin
    • (RS)-3-chloro-1,2-propanediol
    • 1,2-Dihydroxy-3-chloropropane
    • Glyceryl alpha-chlorohydrin
    • 3-Chloro-1,2-propylene glycol
    • u 5897
    • Glycerin alpha-monochlorhydrin
    • 3-Monochloro-1,2-propanediol
    • 3-Monochloropropane-1,2-diol
    • Ekorod A
    • (+-)-2,3-Dihydroxychloropropane
    • beta,beta'-Dihydroxyisopropyl chloride
    • DTXSID4020664
    • QGS78A3T6P
    • U5897
    • DTXCID00664
    • CHEBI:18721
    • alpha Chlorhydrin
    • alpha-Chlorhydrin
    • Glycerol alpha-chlorohydrin
    • alpha Chlorohydrin
    • 3 Chloropropanediol
    • dl-alpha-Chlorohydrin
    • 3 Chloro 1,2 propanediol
    • 3 Monochloropropane 1,2 diol
    • Glycerol alpha Monochlorohydrin
    • alpha-Monochlorohydrin, Glycerol
    • I+--Chlorohydrin
    • RefChem:555449
    • GlyTouCan:G99968MY
    • G99968MY
    • 202-492-4
    • a-chlorohydrin
    • 3-MCPD
    • alpha-Chlorohydrine
    • Chlorohydrin
    • 3-CHLORO-1,2-DIHYDROXYPROPANE
    • Glyceryl-alpha-chlorohydrin
    • (+/-)-3-Chloro-1,2-propanediol
    • 1,2-Propanediol, 3-dichloro-
    • U-5897
    • 3-Chloro-1,2-propandiol
    • a-Monochlorohydrin
    • MFCD00004712
    • .alpha.-Chlorohydrin
    • Chloropropylene glycol
    • a-Glycerol chlorohydrin
    • C3H7ClO2
    • Chloro-1,2-propanediol
    • Chloro-1,2-dihydroxypropane
    • Glycerine alpha-monochlorohydrin
    • Glycerin .alpha.-monochlorhydrin
    • (R)-(-)-3-Glycerol alpha-monochlorohydrin
    • 3-chloro-propane-1,2-diol
    • Caswell No. 214A
    • CAS-96-24-2
    • CCRIS 4607
    • HSDB 2052
    • EINECS 202-492-4
    • UN2689
    • 3-MCDP
    • UNII-QGS78A3T6P
    • EPA Pesticide Chemical Code 117101
    • BRN 0635684
    • AI3-11200
    • CHLOROHYDRIN-
    • .alpha.-Monochlorohydrine
    • 3-chloro1,2-propanediol
    • alpha-Glycerol chlorohydrin
    • Glycerol a-monochlorohydrin
    • (+/-)-alpha-chlorohydrin
    • EC 202-492-4
    • 3-chloro-1,2-propan-diol
    • Glycerol alpha -chlorohydrin
    • Glyceryl alpha -chlorohydrin
    • 3-Chloropropandiol-(1,2)
    • 3-chloro-1,2-propane diol
    • 3-chloro-1,2-propane-diol
    • SCHEMBL19213
    • 3-Dichloro-1,2-Propanediol
    • 4-01-00-02484 (Beilstein Handbook Reference)
    • Glycerol .alpha.-chlorohydrin
    • Glyceryl .alpha.-chlorohydrin
    • MLS000028887
    • alpha-Chlorohydrin, (+/-)-
    • Glycerin alpha -monochlorhydrin
    • SCHEMBL1051280
    • SCHEMBL2483126
    • SCHEMBL7568579
    • .ALPHA.-MONOCHLOROHYDRIN
    • DL-.ALPHA.-CHLOROHYDRIN
    • Glycerol-alpha -monochlorohydrin
    • CHEMBL3185949
    • 3-CHLORO-1,2-PROANDIOL
    • Glycerol-.alpha.-monochlorohydrin
    • MSK7911
    • racemic 3-chloro-1,2-propanediol
    • .ALPHA.-CHLOROHYDRIN [MI]
    • 3-chloro-1,2-dihydroxy-n-propane
    • BB_SC-06682
    • Tox21_202262
    • Tox21_302959
    • BBL011374
    • SBB060480
    • 96-24-2

  • Applications

    3-Chloro-1,2-propanediol is primarily employed as an intermediate to synthesize glycidyl derivatives (glycidyl ethers) and glycidol, which are building blocks for epoxy resins, coatings, and related polymers. It can be converted to glycidol by dehydrohalogenation, and glycidol and glycidyl derivatives are widely used as monomers or reactive intermediates in epoxy and polyurethane systems. It also serves as a reactive diol that can participate in crosslinking reactions in coatings, adhesives, and plastics formulations. In electronics, epoxy resins with glycidyl moieties are common for encapsulants and adhesives. As a chemical intermediate, CPD is often used to synthesize specialty monomers for plastics and performance additives. Usage is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 176.19
    methanol 448.76
    isopropanol 77.7
    water 1013.68
    ethyl acetate 11.08
    n-propanol 93.26
    acetone 64.56
    n-butanol 60.93
    acetonitrile 25.94
    DMF 502.38
    toluene 1.36
    isobutanol 44.9
    1,4-dioxane 43.88
    methyl acetate 16.15
    THF 74.73
    2-butanone 21.85
    n-pentanol 29.77
    sec-butanol 42.54
    n-hexane 0.95
    ethylene glycol 380.13
    NMP 257.75
    cyclohexane 3.35
    DMSO 604.95
    n-butyl acetate 10.61
    n-octanol 12.28
    chloroform 5.34
    n-propyl acetate 11.86
    acetic acid 417.74
    dichloromethane 6.5
    cyclohexanone 40.84
    propylene glycol 187.23
    isopropyl acetate 7.92
    DMAc 232.0
    2-ethoxyethanol 140.3
    isopentanol 35.34
    n-heptane 3.18
    ethyl formate 30.49
    1,2-dichloroethane 7.05
    n-hexanol 22.15
    2-methoxyethanol 315.71
    isobutyl acetate 6.21
    tetrachloromethane 3.16
    n-pentyl acetate 9.02
    transcutol 157.72
    n-heptanol 16.67
    ethylbenzene 1.2
    MIBK 11.26
    2-propoxyethanol 72.98
    tert-butanol 76.21
    MTBE 12.31
    2-butoxyethanol 55.92
    propionic acid 101.57
    o-xylene 2.86
    formic acid 859.33
    diethyl ether 9.46
    m-xylene 2.21
    p-xylene 2.01
    chlorobenzene 2.02
    dimethyl carbonate 12.27
    n-octane 1.07
    formamide 697.76
    cyclopentanone 62.56
    2-pentanone 18.21
    anisole 6.56
    cyclopentyl methyl ether 21.07
    gamma-butyrolactone 71.06
    1-methoxy-2-propanol 131.77
    pyridine 17.21
    3-pentanone 11.04
    furfural 84.36
    n-dodecane 0.79
    diethylene glycol 146.97
    diisopropyl ether 3.67
    tert-amyl alcohol 47.05
    acetylacetone 26.62
    n-hexadecane 0.81
    acetophenone 12.6
    methyl propionate 15.78
    isopentyl acetate 9.61
    trichloroethylene 10.67
    n-nonanol 10.35
    cyclohexanol 38.26
    benzyl alcohol 16.52
    2-ethylhexanol 12.14
    isooctanol 12.55
    dipropyl ether 11.0
    1,2-dichlorobenzene 2.86
    ethyl lactate 20.31
    propylene carbonate 26.33
    n-methylformamide 272.09
    2-pentanol 24.88
    n-pentane 1.68
    1-propoxy-2-propanol 48.34
    1-methoxy-2-propyl acetate 17.49
    2-(2-methoxypropoxy) propanol 47.17
    mesitylene 2.47
    ε-caprolactone 38.12
    p-cymene 3.18
    epichlorohydrin 37.69
    1,1,1-trichloroethane 3.59
    2-aminoethanol 348.95
    morpholine-4-carbaldehyde 198.58
    sulfolane 162.52
    2,2,4-trimethylpentane 1.14
    2-methyltetrahydrofuran 30.61
    n-hexyl acetate 10.92
    isooctane 0.94
    2-(2-butoxyethoxy)ethanol 65.74
    sec-butyl acetate 5.77
    tert-butyl acetate 11.25
    decalin 1.01
    glycerin 345.11
    diglyme 117.61
    acrylic acid 135.21
    isopropyl myristate 4.94
    n-butyric acid 75.79
    acetyl acetate 9.05
    di(2-ethylhexyl) phthalate 10.2
    ethyl propionate 7.72
    nitromethane 230.58
    1,2-diethoxyethane 17.76
    benzonitrile 7.94
    trioctyl phosphate 8.54
    1-bromopropane 2.83
    gamma-valerolactone 114.86
    n-decanol 7.68
    triethyl phosphate 8.61
    4-methyl-2-pentanol 12.11
    propionitrile 12.91
    vinylene carbonate 24.01
    1,1,2-trichlorotrifluoroethane 111.74
    DMS 8.47
    cumene 1.67
    2-octanol 8.07
    2-hexanone 11.88
    octyl acetate 7.66
    limonene 5.7
    1,2-dimethoxyethane 97.79
    ethyl orthosilicate 9.04
    tributyl phosphate 8.57
    diacetone alcohol 43.71
    N,N-dimethylaniline 10.4
    acrylonitrile 25.43
    aniline 10.16
    1,3-propanediol 288.29
    bromobenzene 1.17
    dibromomethane 4.12
    1,1,2,2-tetrachloroethane 10.93
    2-methyl-cyclohexyl acetate 11.04
    tetrabutyl urea 16.58
    diisobutyl methanol 8.98
    2-phenylethanol 13.06
    styrene 1.43
    dioctyl adipate 12.13
    dimethyl sulfate 33.83
    ethyl butyrate 11.23
    methyl lactate 39.53
    butyl lactate 20.51
    diethyl carbonate 7.29
    propanediol butyl ether 62.54
    triethyl orthoformate 11.44
    p-tert-butyltoluene 3.59
    methyl 4-tert-butylbenzoate 22.32
    morpholine 91.3
    tert-butylamine 25.96
    n-dodecanol 6.1
    dimethoxymethane 71.52
    ethylene carbonate 18.31
    cyrene 60.86
    2-ethoxyethyl acetate 12.92
    2-ethylhexyl acetate 6.96
    1,2,4-trichlorobenzene 4.16
    4-methylpyridine 12.14
    dibutyl ether 6.25
    2,6-dimethyl-4-heptanol 8.98
    DEF 59.77
    dimethyl isosorbide 58.12
    tetrachloroethylene 12.85
    eugenol 29.79
    triacetin 19.9
    span 80 44.5
    1,4-butanediol 111.9
    1,1-dichloroethane 3.39
    2-methyl-1-pentanol 20.62
    methyl formate 121.42
    2-methyl-1-butanol 35.56
    n-decane 1.09
    butyronitrile 13.04
    3,7-dimethyl-1-octanol 10.75
    1-chlorooctane 2.63
    1-chlorotetradecane 1.41
    n-nonane 1.08
    undecane 0.89
    tert-butylcyclohexane 0.97
    cyclooctane 1.39
    cyclopentanol 62.16
    tetrahydropyran 22.45
    tert-amyl methyl ether 10.99
    2,5,8-trioxanonane 91.29
    1-hexene 2.02
    2-isopropoxyethanol 62.17
    2,2,2-trifluoroethanol 177.08
    methyl butyrate 16.19

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction