3-Chloro-1-propanol

Overview IFRA Request a quote

  • Identifiers

    CAS number
    627-30-5

    Molecular formula
    C3H7ClO

    SMILES
    C(CO)CCl

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Alcoholic 51.72%
    Oily 41.18%
    Sweet 41.1%
    Fishy 39.99%
    Fermented 38.28%
    Odorless 35.64%
    Solvent 34.4%
    Ethereal 33.0%
    Fruity 32.01%
    Pungent 31.5%

     

    Flavor
    Sweet 42.36%
    Odorless 41.63%
    Sulfurous 33.38%
    Alcoholic 31.16%
    Fishy 28.27%
    Bitter 28.05%
    Very slight 23.89%
    Onion 23.84%
    Soup 23.81%
    Sweet-like 23.53%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    0.5

    pKa est.
    7.63 (neutral)

    Molecular weight
    94.54 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very fast

    Boiling point

    • 320 to 329 °F at 760 mmHg (NTP, 1992)

    Flash point

    • 63.09 ˚C est.
    • 164 °F (NTP, 1992)

    Solubility expt.

    • 50 to 100 mg/mL at 73 °F (NTP, 1992)

  • Synonyms

    • 3-CHLORO-1-PROPANOL
    • 3-Chloropropan-1-ol
    • 627-30-5
    • 3-Chloropropanol
    • Trimethylene chlorohydrin
    • 1-Propanol, 3-chloro-
    • 1-Chloro-3-hydroxypropane
    • 3-Chlorpropan-1-ol
    • 3-Choro-1-propanol
    • 1-Chloro-3-propanol
    • 3-chloro-propan-1-ol
    • 3-Chloropropanol-1
    • 3-Chloro-l-propanol
    • NSC 60190
    • 3-Chlorpropan-1-ol [German]
    • CCRIS 4767
    • 3-Chloro-1-hydroxypropane
    • EINECS 210-992-9
    • UN2849
    • BRN 0773655
    • 28064-81-5
    • DTXSID9024809
    • AI3-61821
    • NSC-60190
    • DTXCID604809
    • 148011U61G
    • CHLORO-1-PROPANOL, 3-
    • 4-01-00-01441 (Beilstein Handbook Reference)
    • Propanol, chloro-
    • 3-chloropropyl alcohol
    • MFCD00002943
    • 3chloropropanol
    • 3Chlorpropan1ol
    • 1Chloro3propanol
    • 3Chloropropanol1
    • 3-chloro-propanol
    • Chloro3 propanol1
    • UNII-148011U61G
    • 1Propanol, 3chloro
    • 3Chloropropyl alcohol
    • 3-chloro-1 propanol
    • 1Chloro3hydroxypropane
    • 3Chloro1hydroxypropane
    • Propanol, 3-chloro-
    • 3-Chloropropane-1-ol
    • Chloropropanol, 3, 1
    • 3-chloranylpropan-1-ol
    • trimethylene chlorohydrine
    • 3-Chloro-1-propanol, 98%
    • CHEMBL1230102
    • Chloro3 propanol1 (French DOT)
    • NSC60190
    • STR03655
    • Tox21_303962
    • AKOS000121342
    • FC38664
    • UN 2849
    • NCGC00357193-01
    • 3CL
    • CAS-627-30-5
    • 3-Chloropropanol-1 [UN2849] [Poison]
    • NS00022565
    • EN300-22342
    • E78849
    • A833956
    • 3-Chloro-1-propanol 100 microg/mL in Acetonitrile
    • Q27251597
    • F0001-1685
    • 210-992-9

  • Applications

    3-Chloro-1-propanol (CAS 627-30-5) is primarily used as an organic synthesis intermediate. It serves as a precursor to 3-aminopropanol derivatives and other glycidyl- or amine-containing building blocks, enabling routes to surfactants, polymer additives, and crosslinkers. In epoxy and coating chemistries, it is employed for conversion to glycidyl ethers or as a reactive intermediate that supports crosslinking and adhesion in coatings and inks. It also finds use in the manufacture of specialty plasticizers and in pharmaceutical synthesis after appropriate functional-group transformations. The specific applications depend on formulation, process, and regulatory constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 908.92
    methanol 1416.29
    isopropanol 568.69
    water 96.5
    ethyl acetate 112.21
    n-propanol 553.9
    acetone 449.66
    n-butanol 497.49
    acetonitrile 261.87
    DMF 755.31
    toluene 26.29
    isobutanol 354.4
    1,4-dioxane 303.27
    methyl acetate 144.72
    THF 496.12
    2-butanone 216.06
    n-pentanol 266.07
    sec-butanol 341.48
    n-hexane 17.97
    ethylene glycol 418.05
    NMP 538.99
    cyclohexane 33.62
    DMSO 1047.83
    n-butyl acetate 190.09
    n-octanol 112.59
    chloroform 234.21
    n-propyl acetate 122.88
    acetic acid 1373.42
    dichloromethane 209.0
    cyclohexanone 375.43
    propylene glycol 331.81
    isopropyl acetate 68.98
    DMAc 376.12
    2-ethoxyethanol 372.37
    isopentanol 308.32
    n-heptane 32.93
    ethyl formate 173.35
    1,2-dichloroethane 144.7
    n-hexanol 244.72
    2-methoxyethanol 691.43
    isobutyl acetate 85.03
    tetrachloromethane 64.54
    n-pentyl acetate 117.76
    transcutol 859.42
    n-heptanol 120.47
    ethylbenzene 20.01
    MIBK 88.44
    2-propoxyethanol 358.86
    tert-butanol 484.84
    MTBE 127.18
    2-butoxyethanol 240.1
    propionic acid 447.57
    o-xylene 30.25
    formic acid 748.44
    diethyl ether 111.98
    m-xylene 27.1
    p-xylene 37.0
    chlorobenzene 65.51
    dimethyl carbonate 45.61
    n-octane 10.36
    formamide 644.08
    cyclopentanone 411.53
    2-pentanone 164.18
    anisole 72.9
    cyclopentyl methyl ether 168.5
    gamma-butyrolactone 414.4
    1-methoxy-2-propanol 373.27
    pyridine 227.86
    3-pentanone 95.55
    furfural 398.18
    n-dodecane 7.57
    diethylene glycol 398.0
    diisopropyl ether 32.54
    tert-amyl alcohol 304.27
    acetylacetone 164.59
    n-hexadecane 7.97
    acetophenone 99.39
    methyl propionate 100.48
    isopentyl acetate 144.57
    trichloroethylene 274.42
    n-nonanol 91.39
    cyclohexanol 315.01
    benzyl alcohol 122.39
    2-ethylhexanol 130.19
    isooctanol 96.42
    dipropyl ether 112.85
    1,2-dichlorobenzene 65.57
    ethyl lactate 94.59
    propylene carbonate 193.45
    n-methylformamide 497.58
    2-pentanol 233.61
    n-pentane 22.12
    1-propoxy-2-propanol 297.23
    1-methoxy-2-propyl acetate 132.23
    2-(2-methoxypropoxy) propanol 202.08
    mesitylene 22.17
    ε-caprolactone 269.09
    p-cymene 35.31
    epichlorohydrin 289.35
    1,1,1-trichloroethane 114.7
    2-aminoethanol 586.51
    morpholine-4-carbaldehyde 460.73
    sulfolane 551.36
    2,2,4-trimethylpentane 13.1
    2-methyltetrahydrofuran 292.2
    n-hexyl acetate 136.34
    isooctane 9.49
    2-(2-butoxyethoxy)ethanol 288.37
    sec-butyl acetate 64.52
    tert-butyl acetate 84.94
    decalin 11.93
    glycerin 476.23
    diglyme 470.57
    acrylic acid 439.02
    isopropyl myristate 51.62
    n-butyric acid 477.18
    acetyl acetate 78.81
    di(2-ethylhexyl) phthalate 70.45
    ethyl propionate 70.49
    nitromethane 761.87
    1,2-diethoxyethane 182.93
    benzonitrile 135.4
    trioctyl phosphate 56.66
    1-bromopropane 80.2
    gamma-valerolactone 461.6
    n-decanol 65.3
    triethyl phosphate 60.77
    4-methyl-2-pentanol 99.7
    propionitrile 183.97
    vinylene carbonate 184.05
    1,1,2-trichlorotrifluoroethane 395.51
    DMS 77.23
    cumene 22.82
    2-octanol 77.78
    2-hexanone 144.38
    octyl acetate 71.53
    limonene 63.7
    1,2-dimethoxyethane 396.62
    ethyl orthosilicate 62.38
    tributyl phosphate 70.29
    diacetone alcohol 185.01
    N,N-dimethylaniline 66.4
    acrylonitrile 245.36
    aniline 111.61
    1,3-propanediol 618.6
    bromobenzene 44.41
    dibromomethane 140.16
    1,1,2,2-tetrachloroethane 236.27
    2-methyl-cyclohexyl acetate 103.04
    tetrabutyl urea 100.73
    diisobutyl methanol 72.5
    2-phenylethanol 119.05
    styrene 28.63
    dioctyl adipate 97.96
    dimethyl sulfate 101.67
    ethyl butyrate 118.13
    methyl lactate 117.71
    butyl lactate 134.24
    diethyl carbonate 70.44
    propanediol butyl ether 262.91
    triethyl orthoformate 95.84
    p-tert-butyltoluene 34.18
    methyl 4-tert-butylbenzoate 119.2
    morpholine 463.21
    tert-butylamine 253.28
    n-dodecanol 50.82
    dimethoxymethane 200.94
    ethylene carbonate 145.19
    cyrene 177.0
    2-ethoxyethyl acetate 130.38
    2-ethylhexyl acetate 111.7
    1,2,4-trichlorobenzene 85.03
    4-methylpyridine 163.34
    dibutyl ether 91.25
    2,6-dimethyl-4-heptanol 72.5
    DEF 224.19
    dimethyl isosorbide 247.53
    tetrachloroethylene 207.55
    eugenol 148.42
    triacetin 150.21
    span 80 213.6
    1,4-butanediol 270.14
    1,1-dichloroethane 117.47
    2-methyl-1-pentanol 187.0
    methyl formate 273.46
    2-methyl-1-butanol 293.72
    n-decane 12.05
    butyronitrile 212.37
    3,7-dimethyl-1-octanol 99.94
    1-chlorooctane 43.49
    1-chlorotetradecane 17.44
    n-nonane 12.55
    undecane 8.95
    tert-butylcyclohexane 13.51
    cyclooctane 9.58
    cyclopentanol 395.28
    tetrahydropyran 292.48
    tert-amyl methyl ether 96.14
    2,5,8-trioxanonane 339.12
    1-hexene 57.13
    2-isopropoxyethanol 229.53
    2,2,2-trifluoroethanol 318.65
    methyl butyrate 133.46

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction