3-(2-Methoxy-phenyl)-propan-1-ol

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  • Identifiers

    CAS number
    10493-37-5

    Molecular formula
    C10H14O2

    SMILES
    COC1=CC=CC=C1CCCO

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Floral 66.8%
    Sweet 65.27%
    Balsamic 49.19%
    Vanilla 43.56%
    Spicy 42.24%
    Rose 40.86%
    Fruity 37.98%
    Anisic 35.52%
    Aromatic 34.93%
    Powdery 28.61%

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  • Properties

    XLogP3-AA
    2.3

    Molecular weight
    166.22 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    279°C

    Flash point est.
    128.28 ˚C

  • Synonyms

    • 3-(2-methoxyphenyl)propan-1-ol
    • 10493-37-5
    • 3-(2-Methoxy-phenyl)-propan-1-ol
    • Benzenepropanol, 2-methoxy-
    • 2-methoxybenzenepropanol
    • 1-Propanol, 3-(o-methoxyphenyl)-
    • 3-Guaiacyl propanol
    • 3-(2-Methoxyphenyl)-1-propanol
    • MFCD00197108
    • 3-(2-methoxyphenyl)propanol
    • 3-o-Methoxyphenylpropan-1-ol
    • Benzenepropanol,2-methoxy-
    • NSC79882
    • 2-Methoxyphenylpropanol
    • SCHEMBL80578
    • CHEMBL82752
    • DTXSID10292035
    • 3-(O-Methoxy phenyl)-1-propanol
    • KAA49337
    • 3-(2-Methoxyphenyl)-1-propanol #
    • NSC-79882
    • NSC105519
    • AKOS005217778
    • DS-6200
    • NSC-105519
    • SY103292
    • CS-0150307
    • F19813
    • EN300-1637233
    • 634-639-7

  • Applications

    3-(2-Methoxy-phenyl)-propan-1-ol (CAS 10493-37-5) is a versatile organic building block that unites a methoxy-substituted aromatic ring with a primary alcohol, widely used as an intermediate in the synthesis of pharmaceuticals and agrochemicals, a precursor to fragrant esters/ethers for flavors and personal care, a starting unit for functional polymers and guaiacyl-based surfactants, and an analytical reference in structure–activity and formulation studies; its –OH group enables derivatization (e.g., esterification, ether formation, or installation of leaving groups for coupling), while the methoxy aryl scaffold imparts stability, moderate hydrophobicity, and π-interactions that can enhance solubility, odor profile, and compatibility in formulations.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 3690.01
    methanol 6038.24
    isopropanol 2187.34
    water 4.45
    ethyl acetate 1948.43
    n-propanol 2438.92
    acetone 3653.74
    n-butanol 1628.34
    acetonitrile 3412.77
    DMF 2732.57
    toluene 339.04
    isobutanol 1291.49
    1,4-dioxane 2966.74
    methyl acetate 1884.38
    THF 2833.99
    2-butanone 1641.12
    n-pentanol 878.0
    sec-butanol 1181.62
    n-hexane 56.23
    ethylene glycol 952.74
    NMP 1468.76
    cyclohexane 118.76
    DMSO 6795.41
    n-butyl acetate 1050.78
    n-octanol 249.86
    chloroform 3255.87
    n-propyl acetate 1117.67
    acetic acid 2585.85
    dichloromethane 5033.23
    cyclohexanone 1808.03
    propylene glycol 784.25
    isopropyl acetate 668.5
    DMAc 966.84
    2-ethoxyethanol 1576.77
    isopentanol 890.38
    n-heptane 52.81
    ethyl formate 1599.69
    1,2-dichloroethane 3390.23
    n-hexanol 651.71
    2-methoxyethanol 2819.55
    isobutyl acetate 438.98
    tetrachloromethane 468.67
    n-pentyl acetate 359.34
    transcutol 2731.12
    n-heptanol 227.83
    ethylbenzene 154.31
    MIBK 482.67
    2-propoxyethanol 1136.05
    tert-butanol 1875.81
    MTBE 1047.75
    2-butoxyethanol 477.44
    propionic acid 1650.37
    o-xylene 181.86
    formic acid 1320.24
    diethyl ether 1640.36
    m-xylene 197.39
    p-xylene 184.51
    chlorobenzene 783.21
    dimethyl carbonate 514.26
    n-octane 20.5
    formamide 2373.1
    cyclopentanone 2290.02
    2-pentanone 1229.37
    anisole 504.44
    cyclopentyl methyl ether 1009.92
    gamma-butyrolactone 2790.54
    1-methoxy-2-propanol 1342.42
    pyridine 1635.88
    3-pentanone 774.15
    furfural 1746.94
    n-dodecane 17.16
    diethylene glycol 1027.83
    diisopropyl ether 227.19
    tert-amyl alcohol 998.0
    acetylacetone 1125.41
    n-hexadecane 20.18
    acetophenone 436.12
    methyl propionate 1219.18
    isopentyl acetate 615.84
    trichloroethylene 4227.89
    n-nonanol 198.15
    cyclohexanol 873.23
    benzyl alcohol 451.45
    2-ethylhexanol 321.68
    isooctanol 185.3
    dipropyl ether 492.81
    1,2-dichlorobenzene 609.35
    ethyl lactate 335.55
    propylene carbonate 1137.65
    n-methylformamide 2752.1
    2-pentanol 709.58
    n-pentane 67.47
    1-propoxy-2-propanol 722.34
    1-methoxy-2-propyl acetate 579.68
    2-(2-methoxypropoxy) propanol 372.51
    mesitylene 131.42
    ε-caprolactone 1416.21
    p-cymene 119.67
    epichlorohydrin 3296.68
    1,1,1-trichloroethane 1629.97
    2-aminoethanol 1499.76
    morpholine-4-carbaldehyde 1579.21
    sulfolane 2821.44
    2,2,4-trimethylpentane 40.09
    2-methyltetrahydrofuran 1929.56
    n-hexyl acetate 485.76
    isooctane 32.15
    2-(2-butoxyethoxy)ethanol 590.68
    sec-butyl acetate 433.26
    tert-butyl acetate 566.07
    decalin 49.55
    glycerin 883.69
    diglyme 1319.59
    acrylic acid 1298.68
    isopropyl myristate 152.86
    n-butyric acid 1863.5
    acetyl acetate 768.61
    di(2-ethylhexyl) phthalate 141.57
    ethyl propionate 678.45
    nitromethane 5181.92
    1,2-diethoxyethane 895.73
    benzonitrile 678.62
    trioctyl phosphate 122.98
    1-bromopropane 1338.4
    gamma-valerolactone 2301.46
    n-decanol 141.31
    triethyl phosphate 198.59
    4-methyl-2-pentanol 270.2
    propionitrile 1706.88
    vinylene carbonate 1051.19
    1,1,2-trichlorotrifluoroethane 1609.74
    DMS 395.47
    cumene 107.24
    2-octanol 148.84
    2-hexanone 758.1
    octyl acetate 205.7
    limonene 196.95
    1,2-dimethoxyethane 2016.18
    ethyl orthosilicate 193.69
    tributyl phosphate 171.09
    diacetone alcohol 645.6
    N,N-dimethylaniline 248.99
    acrylonitrile 2076.19
    aniline 687.58
    1,3-propanediol 1650.17
    bromobenzene 771.81
    dibromomethane 2844.89
    1,1,2,2-tetrachloroethane 2607.89
    2-methyl-cyclohexyl acetate 289.51
    tetrabutyl urea 207.6
    diisobutyl methanol 165.28
    2-phenylethanol 352.25
    styrene 247.82
    dioctyl adipate 228.38
    dimethyl sulfate 728.14
    ethyl butyrate 607.96
    methyl lactate 439.69
    butyl lactate 297.85
    diethyl carbonate 366.47
    propanediol butyl ether 475.79
    triethyl orthoformate 321.73
    p-tert-butyltoluene 109.19
    methyl 4-tert-butylbenzoate 287.16
    morpholine 3286.77
    tert-butylamine 907.04
    n-dodecanol 106.85
    dimethoxymethane 1688.96
    ethylene carbonate 1022.04
    cyrene 370.15
    2-ethoxyethyl acetate 560.98
    2-ethylhexyl acetate 437.73
    1,2,4-trichlorobenzene 672.93
    4-methylpyridine 1205.86
    dibutyl ether 346.4
    2,6-dimethyl-4-heptanol 165.28
    DEF 1228.84
    dimethyl isosorbide 556.89
    tetrachloroethylene 1813.76
    eugenol 312.27
    triacetin 425.17
    span 80 327.07
    1,4-butanediol 664.67
    1,1-dichloroethane 2427.43
    2-methyl-1-pentanol 528.47
    methyl formate 2125.09
    2-methyl-1-butanol 876.92
    n-decane 31.21
    butyronitrile 1492.12
    3,7-dimethyl-1-octanol 222.96
    1-chlorooctane 172.1
    1-chlorotetradecane 59.45
    n-nonane 31.7
    undecane 22.33
    tert-butylcyclohexane 47.31
    cyclooctane 36.13
    cyclopentanol 1095.88
    tetrahydropyran 2340.53
    tert-amyl methyl ether 532.59
    2,5,8-trioxanonane 686.46
    1-hexene 276.66
    2-isopropoxyethanol 789.79
    2,2,2-trifluoroethanol 765.87
    methyl butyrate 1059.39

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1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Narcissus (Japan) 1a 8023-75-4 Narcissus tazetta L. (N. poeticus L.), fam. Amarillidaceae 0.07%
Narcissus tazetta (var. chinensis) 8023-75-4 Narcissus tazetta L., var. chinensis, fam. Amaryllidaceae 0.18%
Narcissus tazetta (var. chinensis) headspace 8023-75-4 Narcissus tazetta L., var. chinensis, fam. Amarillidaceae 0.01%
Anise (Colombia) 8007-70-3 Pimpinella anisum L., fam. Apiaceae (Umbelliferae) 0.08%