(2R)-2-[(2-{[(2R)-1-Hdroxybutan-2-yl]amino}ethyl)amino]butan-1-ol dihydrochloride

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  • Identifiers

    CAS number
    3577-94-4

    Molecular formula
    C10H24N2O2

    SMILES
    CCC(CO)NCCNC(CC)CO

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Fishy 65.28%
    Odorless 43.48%
    Ripe 29.0%
    Cheesy 27.62%
    Alcoholic 25.03%
    Cooling 23.65%
    Savory 22.69%
    Oily 22.26%
    Animal 22.23%
    Sweet 22.11%

     

    Flavor
    Odorless 44.38%
    Sulfurous 31.49%
    Mild 27.17%
    Bland 23.27%
    Sweet-like 22.55%
    Glue 20.08%
    Yeasty 20.07%
    Bloody 20.06%
    Very slight 19.95%
    Skunky 19.51%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -0.1

    pKa est.
    7.15 (neutral)

    Molecular weight
    204.31 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    330°C

    Flash point

    • 166.92 ˚C est.

  • Synonyms

    • Tibutol
    • L-Ethambutol
    • Etambutol
    • 3577-94-4
    • MLS000082702
    • 2-({2-[(1-hydroxybutan-2-yl)amino]ethyl}amino)butan-1-ol
    • SMR000046147
    • EMB
    • 134566-79-3
    • (2R)-2-((2-(((2R)-1-Hdroxybutan-2-yl)amino)ethyl)amino)butan-1-ol dihydrochloride
    • (2R)-2-[(2-{[(2R)-1-Hdroxybutan-2-yl]amino}ethyl)amino]butan-1-ol dihydrochloride
    • Dadibutol (Salt/Mix)
    • Myambutol (Salt/Mix)
    • Opera_ID_842
    • SCHEMBL4029
    • CHEMBL25539
    • 2-[2-(1-hydroxybutan-2-ylamino)ethylamino]butan-1-ol
    • CHEBI:94436
    • DTXSID60859091
    • HMS2230H16
    • HMS3259B06
    • HMS3370L11
    • Ethambutol hydrochloride (Salt/Mix)
    • BBL009957
    • NSC653313
    • STK711105
    • AKOS005530680
    • NC00695
    • NCGC00070253-02
    • 2,2'-(1,2-Ethylenediimino)-di-1-butanol
    • 2,2'-(ETHYLENEDIIMINO)DI-1-BUTANOL
    • 2,2'-(ethane-1,2-diyldiimino)dibutan-1-ol
    • EN300-296080
    • AB00392744-11
    • SR-01000600877
    • SR-01000600877-4
    • Q27166297
    • (2R,2'R)-2,2'-(ethane-1,2-diyldiimino)dibutan-1-ol
    • 2-[2-(1-hydroxybutan-2-ylamino)ethylamino]-1-butanol
    • 2-[(2-([1-(Hydroxymethyl)propyl]amino)ethyl)amino]-1-butanol, (+)-
    • 111-024-7

  • Applications

    This compound, (2R)-2-[(2-{[(2R)-1-Hdroxybutan-2-yl]amino}ethyl)amino]butan-1-ol dihydrochloride (CAS 3577-94-4), is a chiral diamine salt that may be used as a pharmaceutical synthesis intermediate or chiral building block for small-molecule drugs. In materials and coatings, it can serve as a curing agent or crosslinker for epoxy and polyurethane systems, enabling cured films and adhesive formulations. It may also function as a reactive intermediate or linking unit in polymers and specialty chemicals, including ligand precursors for metal-catalyzed processes in catalysis and electronics. In cosmetics/personal care, it can be evaluated as a chiral building block or formulation component. Its use is subject to formulation conditions and local regulatory requirements.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 15.85
    methanol 82.52
    isopropanol 3.91
    water 102.96
    ethyl acetate 3.06
    n-propanol 12.65
    acetone 1.06
    n-butanol 8.96
    acetonitrile 1.01
    DMF 19.03
    toluene 0.51
    isobutanol 8.71
    1,4-dioxane 4.5
    methyl acetate 2.2
    THF 10.95
    2-butanone 1.77
    n-pentanol 5.4
    sec-butanol 5.09
    n-hexane 0.31
    ethylene glycol 73.02
    NMP 90.07
    cyclohexane 0.69
    DMSO 111.92
    n-butyl acetate 5.39
    n-octanol 3.94
    chloroform 7.74
    n-propyl acetate 2.96
    acetic acid 144.12
    dichloromethane 6.87
    cyclohexanone 14.69
    propylene glycol 38.29
    isopropyl acetate 2.61
    DMAc 34.0
    2-ethoxyethanol 26.43
    isopentanol 7.28
    n-heptane 0.75
    ethyl formate 7.1
    1,2-dichloroethane 4.93
    n-hexanol 9.05
    2-methoxyethanol 55.23
    isobutyl acetate 2.61
    tetrachloromethane 3.48
    n-pentyl acetate 3.91
    transcutol 55.78
    n-heptanol 7.1
    ethylbenzene 0.57
    MIBK 1.99
    2-propoxyethanol 29.98
    tert-butanol 6.0
    MTBE 1.45
    2-butoxyethanol 21.68
    propionic acid 42.35
    o-xylene 1.37
    formic acid 327.47
    diethyl ether 0.94
    m-xylene 1.07
    p-xylene 0.86
    chlorobenzene 1.93
    dimethyl carbonate 2.51
    n-octane 0.38
    formamide 158.79
    cyclopentanone 18.17
    2-pentanone 1.81
    anisole 1.31
    cyclopentyl methyl ether 6.21
    gamma-butyrolactone 42.56
    1-methoxy-2-propanol 22.2
    pyridine 4.73
    3-pentanone 2.23
    furfural 51.01
    n-dodecane 0.25
    diethylene glycol 59.23
    diisopropyl ether 0.73
    tert-amyl alcohol 8.36
    acetylacetone 4.23
    n-hexadecane 0.26
    acetophenone 4.08
    methyl propionate 4.26
    isopentyl acetate 6.02
    trichloroethylene 10.72
    n-nonanol 3.93
    cyclohexanol 12.76
    benzyl alcohol 5.81
    2-ethylhexanol 5.55
    isooctanol 6.11
    dipropyl ether 2.57
    1,2-dichlorobenzene 4.08
    ethyl lactate 10.17
    propylene carbonate 25.39
    n-methylformamide 28.7
    2-pentanol 3.43
    n-pentane 0.29
    1-propoxy-2-propanol 17.51
    1-methoxy-2-propyl acetate 10.05
    2-(2-methoxypropoxy) propanol 18.33
    mesitylene 1.16
    ε-caprolactone 24.5
    p-cymene 2.09
    epichlorohydrin 16.4
    1,1,1-trichloroethane 2.92
    2-aminoethanol 72.8
    morpholine-4-carbaldehyde 49.8
    sulfolane 135.67
    2,2,4-trimethylpentane 0.55
    2-methyltetrahydrofuran 6.72
    n-hexyl acetate 4.6
    isooctane 0.3
    2-(2-butoxyethoxy)ethanol 24.08
    sec-butyl acetate 2.37
    tert-butyl acetate 3.96
    decalin 0.59
    glycerin 116.53
    diglyme 31.91
    acrylic acid 56.49
    isopropyl myristate 1.97
    n-butyric acid 40.59
    acetyl acetate 4.84
    di(2-ethylhexyl) phthalate 6.73
    ethyl propionate 3.05
    nitromethane 37.63
    1,2-diethoxyethane 4.03
    benzonitrile 3.51
    trioctyl phosphate 5.46
    1-bromopropane 1.6
    gamma-valerolactone 43.69
    n-decanol 2.79
    triethyl phosphate 7.03
    4-methyl-2-pentanol 3.0
    propionitrile 1.87
    vinylene carbonate 20.23
    1,1,2-trichlorotrifluoroethane 89.93
    DMS 5.71
    cumene 0.97
    2-octanol 3.14
    2-hexanone 1.77
    octyl acetate 2.95
    limonene 3.0
    1,2-dimethoxyethane 10.14
    ethyl orthosilicate 6.5
    tributyl phosphate 6.26
    diacetone alcohol 11.85
    N,N-dimethylaniline 2.26
    acrylonitrile 3.59
    aniline 4.23
    1,3-propanediol 64.1
    bromobenzene 1.45
    dibromomethane 4.12
    1,1,2,2-tetrachloroethane 13.39
    2-methyl-cyclohexyl acetate 7.48
    tetrabutyl urea 7.59
    diisobutyl methanol 3.41
    2-phenylethanol 8.05
    styrene 0.53
    dioctyl adipate 4.83
    dimethyl sulfate 14.67
    ethyl butyrate 5.15
    methyl lactate 16.27
    butyl lactate 12.12
    diethyl carbonate 4.17
    propanediol butyl ether 21.84
    triethyl orthoformate 6.33
    p-tert-butyltoluene 2.24
    methyl 4-tert-butylbenzoate 11.62
    morpholine 10.76
    tert-butylamine 2.73
    n-dodecanol 2.07
    dimethoxymethane 4.97
    ethylene carbonate 15.23
    cyrene 33.64
    2-ethoxyethyl acetate 6.09
    2-ethylhexyl acetate 4.61
    1,2,4-trichlorobenzene 5.68
    4-methylpyridine 2.81
    dibutyl ether 1.59
    2,6-dimethyl-4-heptanol 3.41
    DEF 9.12
    dimethyl isosorbide 33.04
    tetrachloroethylene 16.1
    eugenol 15.49
    triacetin 10.35
    span 80 21.42
    1,4-butanediol 25.05
    1,1-dichloroethane 1.64
    2-methyl-1-pentanol 5.44
    methyl formate 14.37
    2-methyl-1-butanol 9.18
    n-decane 0.38
    butyronitrile 1.93
    3,7-dimethyl-1-octanol 4.09
    1-chlorooctane 1.25
    1-chlorotetradecane 0.6
    n-nonane 0.36
    undecane 0.3
    tert-butylcyclohexane 0.52
    cyclooctane 0.44
    cyclopentanol 17.57
    tetrahydropyran 3.36
    tert-amyl methyl ether 2.37
    2,5,8-trioxanonane 27.04
    1-hexene 0.53
    2-isopropoxyethanol 12.75
    2,2,2-trifluoroethanol 90.44
    methyl butyrate 4.77

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction