28-Homodolichosterone

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  • Identifiers

    CAS number
    85797-14-4

    Molecular formula
    C29H48O5

    SMILES
    C/C=C(/[C@H]([C@@H]([C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC(=O)[C@@H]4[C@@]3(C[C@H]([C@H](C4)O)O)C)C)O)O)\C(C)C

    Safety labels

  • Odor profile

    Fragrance
    Woody 63.93%
    Odorless 41.68%
    Mint 40.37%
    Cooling 38.95%
    Amber 32.1%
    Spicy 32.09%
    Balsamic 29.88%
    Sandalwood 29.82%
    Dry 27.89%
    Herbal 27.4%

     

    Flavor
    Bitter 54.07%
    Herbal 26.24%
    Odorless 25.58%
    Cedarleaf 23.07%
    Sweet-like 21.65%
    Green tea 20.64%
    Bland 20.59%
    Minty 20.34%
    Mentholic 20.32%
    Sandalwood 20.18%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    4.8

    pKa est.
    6.0 (neutral)

    Molecular weight
    476.7 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    122°C

    Flash point

    • 251.34 ˚C est.

  • Synonyms

    • Homodolichosterone
    • 85797-14-4
    • 28-Homodolichosterone
    • DTXSID001316115
    • FS158980
    • (2?,3?,5?,22R,23R,24E)-2,3,22,23-Tetrahydroxystigmast-24(28)-en-6-one
    • (22R,23R,24E)-2alpha,3alpha,22,23-Tetrahydroxy-5alpha-stigmast-24(28)-en-6-one
    • (2a, 3a, 5a, 22R, 23R, 24E)-2, 3, 22, 23- Tetrahydroxy-stigmast- 24(28) - en- 6- one
    • 85797-14-4

  • Applications

    28-Homodolichosterone (CAS 85797-14-4) is primarily encountered as an intermediate and analytical standard in specialized chemical workflows; in pharmaceutical and biochemical research it may serve as a starting material or synthetic building block for steroidal compounds. It is often used as an analytical reference in lipid- and steroid-profiling methods, helping validate chromatography and mass spectrometry workflows. In addition, researchers occasionally evaluate it for cosmetic formulation development or fragrance research as a potential cosmetic ingredient or fragrance-related study. For advanced materials, it has been explored as a hydrophobic component or additive in niche polymer and coating formulations, where its rigid steroidal framework can influence material properties. Overall, applications are largely research-oriented and subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 11.13
    methanol 28.52
    isopropanol 2.18
    water 0.09
    ethyl acetate 1.92
    n-propanol 4.63
    acetone 7.3
    n-butanol 2.38
    acetonitrile 0.84
    DMF 22.42
    toluene 1.84
    isobutanol 1.92
    1,4-dioxane 21.15
    methyl acetate 1.96
    THF 57.97
    2-butanone 3.52
    n-pentanol 2.45
    sec-butanol 0.87
    n-hexane 0.14
    ethylene glycol 2.41
    NMP 19.58
    cyclohexane 0.17
    DMSO 33.8
    n-butyl acetate 2.25
    n-octanol 2.27
    chloroform 3.83
    n-propyl acetate 1.82
    acetic acid 10.51
    dichloromethane 3.08
    cyclohexanone 8.18
    propylene glycol 2.29
    isopropyl acetate 2.0
    DMAc 17.93
    2-ethoxyethanol 15.4
    isopentanol 1.62
    n-heptane 0.16
    ethyl formate 2.08
    1,2-dichloroethane 2.03
    n-hexanol 3.13
    2-methoxyethanol 27.65
    isobutyl acetate 1.65
    tetrachloromethane 0.89
    n-pentyl acetate 4.63
    transcutol 29.71
    n-heptanol 3.77
    ethylbenzene 1.06
    MIBK 2.75
    2-propoxyethanol 25.64
    tert-butanol 1.45
    MTBE 1.22
    2-butoxyethanol 17.73
    propionic acid 2.7
    o-xylene 1.2
    formic acid 9.19
    diethyl ether 2.34
    m-xylene 1.51
    p-xylene 1.16
    chlorobenzene 1.63
    dimethyl carbonate 3.28
    n-octane 0.09
    formamide 8.94
    cyclopentanone 15.68
    2-pentanone 3.19
    anisole 3.42
    cyclopentyl methyl ether 6.32
    gamma-butyrolactone 13.41
    1-methoxy-2-propanol 13.56
    pyridine 8.99
    3-pentanone 2.33
    furfural 12.06
    n-dodecane 0.04
    diethylene glycol 19.21
    diisopropyl ether 0.62
    tert-amyl alcohol 0.81
    acetylacetone 6.9
    n-hexadecane 0.05
    acetophenone 4.06
    methyl propionate 2.78
    isopentyl acetate 2.64
    trichloroethylene 4.86
    n-nonanol 2.66
    cyclohexanol 1.48
    benzyl alcohol 4.69
    2-ethylhexanol 1.32
    isooctanol 2.66
    dipropyl ether 2.11
    1,2-dichlorobenzene 1.54
    ethyl lactate 2.32
    propylene carbonate 4.01
    n-methylformamide 9.44
    2-pentanol 0.85
    n-pentane 0.12
    1-propoxy-2-propanol 11.29
    1-methoxy-2-propyl acetate 7.36
    2-(2-methoxypropoxy) propanol 9.43
    mesitylene 0.87
    ε-caprolactone 6.69
    p-cymene 0.88
    epichlorohydrin 16.43
    1,1,1-trichloroethane 1.09
    2-aminoethanol 6.91
    morpholine-4-carbaldehyde 32.1
    sulfolane 20.54
    2,2,4-trimethylpentane 0.07
    2-methyltetrahydrofuran 5.97
    n-hexyl acetate 4.74
    isooctane 0.07
    2-(2-butoxyethoxy)ethanol 16.87
    sec-butyl acetate 1.2
    tert-butyl acetate 2.81
    decalin 0.14
    glycerin 6.7
    diglyme 28.1
    acrylic acid 3.88
    isopropyl myristate 1.19
    n-butyric acid 3.45
    acetyl acetate 2.4
    di(2-ethylhexyl) phthalate 2.91
    ethyl propionate 1.48
    nitromethane 9.62
    1,2-diethoxyethane 5.75
    benzonitrile 2.16
    trioctyl phosphate 1.89
    1-bromopropane 0.83
    gamma-valerolactone 34.74
    n-decanol 1.33
    triethyl phosphate 1.47
    4-methyl-2-pentanol 0.91
    propionitrile 1.03
    vinylene carbonate 4.93
    1,1,2-trichlorotrifluoroethane 13.11
    DMS 3.56
    cumene 0.81
    2-octanol 1.37
    2-hexanone 2.66
    octyl acetate 2.06
    limonene 0.95
    1,2-dimethoxyethane 16.9
    ethyl orthosilicate 1.57
    tributyl phosphate 1.35
    diacetone alcohol 4.91
    N,N-dimethylaniline 2.78
    acrylonitrile 1.77
    aniline 2.76
    1,3-propanediol 8.79
    bromobenzene 1.4
    dibromomethane 1.83
    1,1,2,2-tetrachloroethane 3.41
    2-methyl-cyclohexyl acetate 2.77
    tetrabutyl urea 2.38
    diisobutyl methanol 0.84
    2-phenylethanol 6.0
    styrene 1.06
    dioctyl adipate 2.64
    dimethyl sulfate 6.26
    ethyl butyrate 1.71
    methyl lactate 4.29
    butyl lactate 5.55
    diethyl carbonate 1.08
    propanediol butyl ether 13.33
    triethyl orthoformate 2.23
    p-tert-butyltoluene 0.88
    methyl 4-tert-butylbenzoate 7.34
    morpholine 21.82
    tert-butylamine 0.55
    n-dodecanol 0.67
    dimethoxymethane 24.6
    ethylene carbonate 3.66
    cyrene 11.66
    2-ethoxyethyl acetate 9.89
    2-ethylhexyl acetate 1.93
    1,2,4-trichlorobenzene 2.23
    4-methylpyridine 4.74
    dibutyl ether 1.2
    2,6-dimethyl-4-heptanol 0.84
    DEF 4.03
    dimethyl isosorbide 15.02
    tetrachloroethylene 3.62
    eugenol 9.08
    triacetin 6.23
    span 80 8.77
    1,4-butanediol 3.37
    1,1-dichloroethane 1.02
    2-methyl-1-pentanol 1.55
    methyl formate 6.75
    2-methyl-1-butanol 1.29
    n-decane 0.12
    butyronitrile 0.99
    3,7-dimethyl-1-octanol 1.51
    1-chlorooctane 0.58
    1-chlorotetradecane 0.14
    n-nonane 0.1
    undecane 0.07
    tert-butylcyclohexane 0.12
    cyclooctane 0.1
    cyclopentanol 2.5
    tetrahydropyran 6.43
    tert-amyl methyl ether 0.94
    2,5,8-trioxanonane 16.57
    1-hexene 0.44
    2-isopropoxyethanol 7.43
    2,2,2-trifluoroethanol 3.54
    methyl butyrate 2.01

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction