2,6-Dimethylmorpholine

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  • Identifiers

    CAS number
    141-91-3

    Molecular formula
    C6H13NO

    SMILES
    CC1CNCC(O1)C

    Safety labels

    Flammable
    Flammable

    Corrosive
    Corrosive

    Acute Toxic
    Acute Toxic

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Nutty 41.61%
    Fishy 37.57%
    Sweet 33.48%
    Roasted 33.47%
    Musty 29.51%
    Meaty 29.38%
    Solvent 26.73%
    Ethereal 24.83%
    Caramellic 24.6%
    Burnt 24.37%

     

    Flavor
    Roasted 35.79%
    Vegetable 32.79%
    Sulfurous 30.54%
    Sweet 28.58%
    Caramel 27.36%
    Green 26.32%
    Bitter 25.78%
    Earthy 24.38%
    Musty 24.09%
    Cauliflower 23.95%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    0.3

    pKa est.
    6.85 (neutral)

    Molecular weight
    115.17 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very fast

    Melting point expt.

    • -121 °F (NTP, 1992)
    • FREEZING POINT: -85 °C

    Boiling point

    • 297 °F at 760 mmHg (NTP, 1992)
    • 146.6 °C @ 760 MM HG

    Flash point

    • 36.41 ˚C est.
    • 112 °F (NTP, 1992)
    • 112 °F (44 °C) OC

    Solubility expt.

    • greater than or equal to 0.1 mg/mL at 66 °F (NTP, 1992)
    • SOL IN ALL PROPORTIONS WITH WATER, ALCOHOL, BENZENE, PETROLEUM ETHER; SOL IN ACETONE

  • Synonyms

    • 2,6-Dimethylmorpholine
    • 141-91-3
    • Morpholine, 2,6-dimethyl-
    • 2,6-DIMETHYL MORPHOLINE
    • DTXSID6022002
    • 2,6-Dimethyl-2,3,5,6-tetrahydro-4H-1,4-oxazine
    • DTXCID002002
    • S5Z1B0318K
    • NSC-60704
    • RefChem:83327
    • 205-509-3
    • 2,6-Dimethyl-Morpholine
    • 2,6-Dimethylmorfolin
    • MFCD00005973
    • 2,6-Dimethylmorfolin [Czech]
    • CCRIS 5910
    • HSDB 4343
    • EINECS 205-509-3
    • NSC 60704
    • BRN 0103036
    • UNII-S5Z1B0318K
    • Morpholine, 2,6-dimethyl-; 2,6-Dimethylmorpholine; NSC 60704
    • fenpropimorph TP2
    • Dodemorph metabolite
    • NSC60704
    • 2,6-Dimethylmorpholine, cis + trans
    • EC 205-509-3
    • 2,6-Dimethylmorpholine,c&t
    • SCHEMBL70413
    • SCHEMBL71767
    • SCHEMBL72440
    • 4-27-00-00674 (Beilstein Handbook Reference)
    • 2,6-Dimethylmorpholine, 97%
    • SCHEMBL5624744
    • SCHEMBL27508768
    • SCHEMBL27720370
    • WLN: T6M DOTJ C1 E1
    • BB_SC-12705
    • STR01928
    • Tox21_303829
    • SBB040955
    • AKOS000119072
    • AKOS016039404
    • AC-1983
    • EBC-153084
    • FD71997
    • PB23755
    • PB30593
    • SB12307
    • SB12308
    • SB33353
    • 2,3,5,6-tetrahydro-4H-1,4-oxazine
    • NCGC00356945-01
    • BP-10246
    • CAS-141-91-3
    • DB-054737
    • NS00076951
    • ST45255407
    • EN300-19075
    • F17632
    • 141D913
    • F2190-0340
    • Z104472602
    • 141-91-3

  • Applications

    2,6-Dimethylmorpholine (CAS number: 141-91-3) is used primarily as a solvent and reaction medium in industrial manufacturing, supporting polymer and resin syntheses, and as a reactive intermediate in the preparation of specialty chemicals such as pharmaceutical precursors. It is commonly employed as a processing solvent in coatings and inks, as a solvent or additive in adhesives and sealants, and as a cleaning medium in surface preparation processes. The compound also serves as a non-nucleophilic base for organic syntheses and as a processing aid in plastics and polyurethane formulations, with use governed by formulation needs and local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 432.96
    methanol 757.51
    isopropanol 189.84
    water 65.64
    ethyl acetate 165.46
    n-propanol 261.47
    acetone 162.56
    n-butanol 218.44
    acetonitrile 188.29
    DMF 179.88
    toluene 62.06
    isobutanol 144.54
    1,4-dioxane 221.24
    methyl acetate 168.82
    THF 370.31
    2-butanone 156.16
    n-pentanol 126.54
    sec-butanol 164.48
    n-hexane 28.76
    ethylene glycol 179.64
    NMP 309.97
    cyclohexane 47.8
    DMSO 215.71
    n-butyl acetate 145.91
    n-octanol 71.53
    chloroform 681.75
    n-propyl acetate 73.77
    acetic acid 721.13
    dichloromethane 498.22
    cyclohexanone 217.02
    propylene glycol 148.98
    isopropyl acetate 77.57
    DMAc 204.03
    2-ethoxyethanol 176.8
    isopentanol 122.99
    n-heptane 35.55
    ethyl formate 149.0
    1,2-dichloroethane 191.94
    n-hexanol 159.45
    2-methoxyethanol 340.91
    isobutyl acetate 48.56
    tetrachloromethane 174.8
    n-pentyl acetate 86.25
    transcutol 366.98
    n-heptanol 76.24
    ethylbenzene 21.62
    MIBK 47.56
    2-propoxyethanol 249.05
    tert-butanol 135.5
    MTBE 99.24
    2-butoxyethanol 123.37
    propionic acid 319.92
    o-xylene 44.59
    formic acid 459.04
    diethyl ether 141.22
    m-xylene 39.54
    p-xylene 34.3
    chlorobenzene 121.44
    dimethyl carbonate 34.56
    n-octane 12.18
    formamide 263.37
    cyclopentanone 271.08
    2-pentanone 103.99
    anisole 54.97
    cyclopentyl methyl ether 146.76
    gamma-butyrolactone 356.49
    1-methoxy-2-propanol 172.42
    pyridine 204.0
    3-pentanone 95.35
    furfural 302.57
    n-dodecane 9.8
    diethylene glycol 232.55
    diisopropyl ether 30.81
    tert-amyl alcohol 133.23
    acetylacetone 92.86
    n-hexadecane 10.42
    acetophenone 58.09
    methyl propionate 112.78
    isopentyl acetate 95.87
    trichloroethylene 393.09
    n-nonanol 61.67
    cyclohexanol 164.2
    benzyl alcohol 75.3
    2-ethylhexanol 81.69
    isooctanol 53.09
    dipropyl ether 87.89
    1,2-dichlorobenzene 103.87
    ethyl lactate 50.61
    propylene carbonate 182.22
    n-methylformamide 199.65
    2-pentanol 107.19
    n-pentane 39.96
    1-propoxy-2-propanol 164.19
    1-methoxy-2-propyl acetate 109.13
    2-(2-methoxypropoxy) propanol 95.9
    mesitylene 24.62
    ε-caprolactone 217.15
    p-cymene 36.45
    epichlorohydrin 268.23
    1,1,1-trichloroethane 221.26
    2-aminoethanol 251.98
    morpholine-4-carbaldehyde 224.91
    sulfolane 296.29
    2,2,4-trimethylpentane 19.44
    2-methyltetrahydrofuran 259.52
    n-hexyl acetate 103.75
    isooctane 9.45
    2-(2-butoxyethoxy)ethanol 128.43
    sec-butyl acetate 46.76
    tert-butyl acetate 59.12
    decalin 14.97
    glycerin 197.78
    diglyme 196.49
    acrylic acid 311.76
    isopropyl myristate 39.91
    n-butyric acid 315.05
    acetyl acetate 133.6
    di(2-ethylhexyl) phthalate 48.41
    ethyl propionate 57.46
    nitromethane 392.17
    1,2-diethoxyethane 123.55
    benzonitrile 95.51
    trioctyl phosphate 36.6
    1-bromopropane 148.66
    gamma-valerolactone 290.41
    n-decanol 44.58
    triethyl phosphate 45.28
    4-methyl-2-pentanol 47.25
    propionitrile 147.46
    vinylene carbonate 167.19
    1,1,2-trichlorotrifluoroethane 288.42
    DMS 68.97
    cumene 20.91
    2-octanol 47.39
    2-hexanone 67.98
    octyl acetate 56.75
    limonene 58.39
    1,2-dimethoxyethane 143.52
    ethyl orthosilicate 46.12
    tributyl phosphate 47.83
    diacetone alcohol 73.13
    N,N-dimethylaniline 40.62
    acrylonitrile 161.04
    aniline 127.55
    1,3-propanediol 250.17
    bromobenzene 108.3
    dibromomethane 335.43
    1,1,2,2-tetrachloroethane 309.84
    2-methyl-cyclohexyl acetate 66.5
    tetrabutyl urea 50.53
    diisobutyl methanol 41.11
    2-phenylethanol 93.24
    styrene 30.45
    dioctyl adipate 58.9
    dimethyl sulfate 61.12
    ethyl butyrate 80.15
    methyl lactate 77.53
    butyl lactate 69.67
    diethyl carbonate 53.25
    propanediol butyl ether 103.67
    triethyl orthoformate 65.51
    p-tert-butyltoluene 35.57
    methyl 4-tert-butylbenzoate 69.73
    morpholine 262.92
    tert-butylamine 95.16
    n-dodecanol 34.95
    dimethoxymethane 101.41
    ethylene carbonate 133.98
    cyrene 84.11
    2-ethoxyethyl acetate 110.32
    2-ethylhexyl acetate 84.28
    1,2,4-trichlorobenzene 131.4
    4-methylpyridine 154.7
    dibutyl ether 68.23
    2,6-dimethyl-4-heptanol 41.11
    DEF 131.75
    dimethyl isosorbide 137.59
    tetrachloroethylene 264.55
    eugenol 72.08
    triacetin 99.81
    span 80 97.33
    1,4-butanediol 102.89
    1,1-dichloroethane 237.75
    2-methyl-1-pentanol 86.3
    methyl formate 139.14
    2-methyl-1-butanol 133.63
    n-decane 16.41
    butyronitrile 143.75
    3,7-dimethyl-1-octanol 66.31
    1-chlorooctane 47.74
    1-chlorotetradecane 20.69
    n-nonane 16.69
    undecane 12.14
    tert-butylcyclohexane 15.76
    cyclooctane 16.96
    cyclopentanol 200.22
    tetrahydropyran 226.68
    tert-amyl methyl ether 88.93
    2,5,8-trioxanonane 146.65
    1-hexene 60.4
    2-isopropoxyethanol 102.45
    2,2,2-trifluoroethanol 271.91
    methyl butyrate 73.74

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction