2,6-Dimethylhydroquinone

Overview IFRA Request a quote

  • Identifiers

    CAS number
    654-42-2

    Molecular formula
    C8H10O2

    SMILES
    CC1=CC(=CC(=C1O)C)O

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Phenolic 83.61%
    Smoky 59.72%
    Spicy 55.3%
    Medicinal 55.02%
    Woody 51.06%
    Burnt 48.18%
    Leathery 37.8%
    Sweet 36.12%
    Dry 31.92%
    Vanilla 31.26%

     

    Flavor
    Phenolic 61.29%
    Bitter 44.51%
    Medicinal 41.45%
    Smoke 37.49%
    Sweet 36.83%
    Smoky 36.68%
    Bacon 35.18%
    Medical 31.46%
    Woody 31.23%
    Vanilla 30.4%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.0

    pKa est.
    11.11 (strong base)

    Molecular weight
    138.16 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    268°C

    Melting point expt.

    • 149 - 151 °C

    Flash point

    • 135.93 ˚C est.

  • Synonyms

    • 2,6-Dimethylhydroquinone
    • 654-42-2
    • 2,6-dimethylbenzene-1,4-diol
    • m-Xylohydroquinone
    • m-Xhq
    • 1,4-Benzenediol, 2,6-dimethyl-
    • m-Xylene-2,5-diol
    • 2,6-Xyloquinol
    • 3,5-Dimethylhydroquinone
    • 2,6-Dimethyl-p-benzohydroquinone
    • Hydroquinone, 2,6-dimethyl-
    • 20F4R79OM2
    • NSC-36868
    • DTXSID8060957
    • RefChem:83324
    • DTXCID5044603
    • 211-505-2
    • 2,6-Dimethyl-1,4-benzenediol
    • 2,6-Xylohydroquinone
    • DMHQ
    • Metaxylohydroquinone
    • MXHQ
    • MFCD00016466
    • 1,4-Dihydroxy-2,6-dimethylbenzene
    • NSC 36868
    • 2,5-Dihydroxy-m-xylene
    • 2,6-dimethyl-benzene-1,4-diol
    • EINECS 211-505-2
    • BRN 1862397
    • AI3-60425
    • 2,6-Dimethylquinol
    • 2, 6-Xylohydroquinone
    • 1, 2,6-dimethyl-
    • Hydroquinone,6-dimethyl-
    • 2,6-dimethyl-hydroquinone
    • SCHEMBL22339
    • 4-06-00-05956 (Beilstein Handbook Reference)
    • UNII-20F4R79OM2
    • 4-hydroxy-2,6-dimethylphenol
    • orb1692315
    • SCHEMBL3123299
    • SCHEMBL9154504
    • 2,6-Dimethylhydroquinone, 8CI
    • CHEMBL4205770
    • 2 pound not6-Dimethylhydroquinone
    • CHEBI:179263
    • 2, 6-Dimethyl-p-benzohydroquinone
    • 2,6-Dimethyl-1,4-benzenediol #
    • 2,6-dimethyl-1,4-dihydroxybenzene
    • NSC36868
    • 1.4-Dihydroxy-2,6-dimethylbenzene
    • 2,6-DIMETHYL-4-HYDROXYPHENOL
    • AKOS006228980
    • CS-W004874
    • DS-1948
    • FD42991
    • HY-W004874
    • 2,6-DIMETHYL-1,4-HYDROQUINONE
    • s10958
    • AC-15541
    • SY016834
    • DB-020242
    • D2667
    • NS00019915
    • ST51038009
    • F018626
    • InChI=1/C8H10O2/c1-5-3-7(9)4-6(2)8(5)10/h3-4,9-10H,1-2H
    • 654-42-2

  • Applications

    2,6-Dimethylhydroquinone (CAS 654-42-2) is commonly used as an organic synthesis intermediate and is frequently evaluated as an antioxidant/stabilizer for polymers and rubber, helping to improve processing stability and product lifetime under heat and environmental exposure. It also serves as a building block in the synthesis of dyes and pigments. In coatings and inks, it can act as a stabilizer or processing aid to enhance resin performance and aging resistance. Additionally, it is used as a starting material for several specialty chemicals, including adhesive formulations, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 734.77
    methanol 1124.61
    isopropanol 473.05
    water 18.26
    ethyl acetate 265.97
    n-propanol 497.79
    acetone 445.96
    n-butanol 368.62
    acetonitrile 424.42
    DMF 522.31
    toluene 56.61
    isobutanol 276.31
    1,4-dioxane 1095.57
    methyl acetate 268.97
    THF 1572.59
    2-butanone 283.26
    n-pentanol 304.12
    sec-butanol 309.04
    n-hexane 50.46
    ethylene glycol 206.02
    NMP 237.86
    cyclohexane 18.87
    DMSO 681.64
    n-butyl acetate 188.37
    n-octanol 171.88
    chloroform 253.09
    n-propyl acetate 178.92
    acetic acid 266.95
    dichloromethane 237.55
    cyclohexanone 267.8
    propylene glycol 138.13
    isopropyl acetate 160.36
    DMAc 193.8
    2-ethoxyethanol 524.31
    isopentanol 247.06
    n-heptane 40.82
    ethyl formate 210.9
    1,2-dichloroethane 217.84
    n-hexanol 352.04
    2-methoxyethanol 711.92
    isobutyl acetate 111.16
    tetrachloromethane 87.94
    n-pentyl acetate 125.53
    transcutol 481.43
    n-heptanol 181.52
    ethylbenzene 49.43
    MIBK 194.6
    2-propoxyethanol 578.43
    tert-butanol 594.67
    MTBE 393.94
    2-butoxyethanol 285.73
    propionic acid 199.52
    o-xylene 50.57
    formic acid 249.07
    diethyl ether 466.8
    m-xylene 66.31
    p-xylene 56.75
    chlorobenzene 75.84
    dimethyl carbonate 109.67
    n-octane 22.66
    formamide 357.63
    cyclopentanone 485.14
    2-pentanone 276.41
    anisole 168.4
    cyclopentyl methyl ether 401.9
    gamma-butyrolactone 553.67
    1-methoxy-2-propanol 477.01
    pyridine 179.41
    3-pentanone 154.31
    furfural 288.79
    n-dodecane 16.64
    diethylene glycol 419.22
    diisopropyl ether 134.66
    tert-amyl alcohol 349.53
    acetylacetone 249.9
    n-hexadecane 17.99
    acetophenone 103.17
    methyl propionate 195.48
    isopentyl acetate 150.93
    trichloroethylene 266.0
    n-nonanol 145.89
    cyclohexanol 176.92
    benzyl alcohol 111.93
    2-ethylhexanol 161.51
    isooctanol 140.24
    dipropyl ether 200.23
    1,2-dichlorobenzene 70.92
    ethyl lactate 89.45
    propylene carbonate 182.94
    n-methylformamide 411.63
    2-pentanol 254.06
    n-pentane 40.36
    1-propoxy-2-propanol 306.3
    1-methoxy-2-propyl acetate 180.11
    2-(2-methoxypropoxy) propanol 148.37
    mesitylene 51.12
    ε-caprolactone 223.44
    p-cymene 43.67
    epichlorohydrin 640.5
    1,1,1-trichloroethane 177.38
    2-aminoethanol 315.92
    morpholine-4-carbaldehyde 392.4
    sulfolane 457.93
    2,2,4-trimethylpentane 26.6
    2-methyltetrahydrofuran 672.87
    n-hexyl acetate 185.07
    isooctane 32.02
    2-(2-butoxyethoxy)ethanol 267.19
    sec-butyl acetate 113.64
    tert-butyl acetate 236.49
    decalin 22.87
    glycerin 205.02
    diglyme 412.65
    acrylic acid 137.91
    isopropyl myristate 82.62
    n-butyric acid 239.88
    acetyl acetate 115.42
    di(2-ethylhexyl) phthalate 56.73
    ethyl propionate 148.96
    nitromethane 482.39
    1,2-diethoxyethane 229.76
    benzonitrile 98.28
    trioctyl phosphate 64.32
    1-bromopropane 158.25
    gamma-valerolactone 515.2
    n-decanol 113.09
    triethyl phosphate 67.37
    4-methyl-2-pentanol 159.82
    propionitrile 267.62
    vinylene carbonate 155.86
    1,1,2-trichlorotrifluoroethane 217.71
    DMS 100.24
    cumene 48.22
    2-octanol 130.06
    2-hexanone 211.31
    octyl acetate 107.05
    limonene 65.58
    1,2-dimethoxyethane 672.29
    ethyl orthosilicate 71.58
    tributyl phosphate 62.9
    diacetone alcohol 268.47
    N,N-dimethylaniline 108.26
    acrylonitrile 255.31
    aniline 97.16
    1,3-propanediol 400.3
    bromobenzene 62.56
    dibromomethane 181.77
    1,1,2,2-tetrachloroethane 206.32
    2-methyl-cyclohexyl acetate 99.71
    tetrabutyl urea 73.97
    diisobutyl methanol 103.01
    2-phenylethanol 141.89
    styrene 50.54
    dioctyl adipate 82.16
    dimethyl sulfate 156.14
    ethyl butyrate 126.75
    methyl lactate 110.81
    butyl lactate 87.47
    diethyl carbonate 79.32
    propanediol butyl ether 171.5
    triethyl orthoformate 92.43
    p-tert-butyltoluene 51.49
    methyl 4-tert-butylbenzoate 128.63
    morpholine 891.03
    tert-butylamine 346.39
    n-dodecanol 86.73
    dimethoxymethane 576.45
    ethylene carbonate 151.97
    cyrene 146.57
    2-ethoxyethyl acetate 155.89
    2-ethylhexyl acetate 111.06
    1,2,4-trichlorobenzene 74.52
    4-methylpyridine 159.09
    dibutyl ether 143.75
    2,6-dimethyl-4-heptanol 103.01
    DEF 199.33
    dimethyl isosorbide 265.54
    tetrachloroethylene 158.55
    eugenol 132.86
    triacetin 99.65
    span 80 130.52
    1,4-butanediol 200.52
    1,1-dichloroethane 210.96
    2-methyl-1-pentanol 202.45
    methyl formate 326.25
    2-methyl-1-butanol 223.16
    n-decane 29.26
    butyronitrile 280.37
    3,7-dimethyl-1-octanol 129.0
    1-chlorooctane 92.45
    1-chlorotetradecane 37.68
    n-nonane 29.15
    undecane 21.38
    tert-butylcyclohexane 31.93
    cyclooctane 13.38
    cyclopentanol 273.26
    tetrahydropyran 632.99
    tert-amyl methyl ether 243.54
    2,5,8-trioxanonane 266.54
    1-hexene 135.82
    2-isopropoxyethanol 331.83
    2,2,2-trifluoroethanol 125.96
    methyl butyrate 181.91

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction