2,6-Dimethyl-p-phenylenediamine

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  • Identifiers

    CAS number
    7218-02-2

    Molecular formula
    C8H12N2

    SMILES
    CC1=CC(=CC(=C1N)C)N

    Safety labels

  • Odor profile

    Fragrance
    Phenolic 36.09%
    Animal 35.97%
    Burnt 32.84%
    Smoky 28.8%
    Sweet 28.51%
    Musty 28.1%
    Meaty 27.65%
    Dry 25.7%
    Roasted 24.83%
    Leathery 24.57%

     

    Flavor
    Phenolic 31.56%
    Meaty 27.82%
    Roasted 27.23%
    Mild 26.12%
    Medicinal 25.42%
    Musty 24.09%
    Coffee 23.44%
    Burnt 22.9%
    Flat 22.41%
    Soybean 22.14%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.3

    pKa est.
    3.65 (weak acid)

    Molecular weight
    136.19 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very slow

    Boiling point est.
    275°C

    Flash point

    • 146.23 ˚C est.

  • Synonyms

    • 7218-02-2
    • 2,6-dimethyl-p-phenylenediamine
    • 4-Amino-2,6-dimethylaniline
    • CCRIS 8131
    • ASK6KXJ6RP
    • 1,4-Benzenediamine, 2,6-dimethyl-
    • IMEXINE OBE
    • UNII-ASK6KXJ6RP
    • 2,6-dimethyl-1,4-phenylenediamine
    • EINECS 230-608-3
    • DTXSID30222511
    • 1,4-diamino-2,6-dimethylbenzene
    • 2,6-dimethyl-1,4-diaminobenzene
    • AMINO-2,6-DIMETHYLANILINE, 4-
    • 2,6-DIMETHYL-1,4-BENZENEDIAMINE
    • P-PHENYLENEDIAMINE, 2,6-DIMETHYL-
    • RefChem:83301
    • DTXCID60145002
    • 2,6-DIMETHYL-P-PHENYLENEDIAMINE [INCI]
    • 230-608-3
    • 2,6-Dimethylbenzene-1,4-diamine
    • MFCD02752808
    • Lidocaine Impurity 35
    • SCHEMBL33589
    • SCHEMBL6739720
    • MJAVQHPPPBDYAN-UHFFFAOYSA-N
    • 2,6-dimethyl-benzene-1,4-diamine
    • AKOS005148118
    • DA-19487
    • CS-0379115
    • NS00043717
    • EN300-187054
    • Q27274096
    • 7218-02-2

  • Applications

    2,6-Dimethyl-p-phenylenediamine (CAS 7218-02-2) is used primarily as an aromatic diamine intermediate in the synthesis of dyes and pigments; it serves as a building block for colorant systems in textiles, coatings, and printing inks; in cosmetics, it is commonly evaluated as an oxidative dye precursor for hair color formulations; in polymer chemistry it can function as a monomer or crosslinking component in specialty polymers and resins, including polyurethanes and epoxies; it may act as a colorant precursor for coatings and plastics, and is sometimes used as a building block for high-performance polymers such as polyamides or polyimides depending on the formulation.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 137.72
    methanol 246.51
    isopropanol 66.84
    water 28.81
    ethyl acetate 131.38
    n-propanol 100.19
    acetone 213.4
    n-butanol 76.55
    acetonitrile 228.26
    DMF 141.79
    toluene 19.56
    isobutanol 49.0
    1,4-dioxane 275.63
    methyl acetate 146.9
    THF 571.11
    2-butanone 140.59
    n-pentanol 50.45
    sec-butanol 46.42
    n-hexane 3.86
    ethylene glycol 40.76
    NMP 168.75
    cyclohexane 2.47
    DMSO 323.46
    n-butyl acetate 98.11
    n-octanol 32.97
    chloroform 117.49
    n-propyl acetate 50.27
    acetic acid 240.38
    dichloromethane 97.1
    cyclohexanone 155.43
    propylene glycol 26.69
    isopropyl acetate 54.2
    DMAc 136.5
    2-ethoxyethanol 122.33
    isopentanol 52.43
    n-heptane 7.33
    ethyl formate 142.9
    1,2-dichloroethane 77.39
    n-hexanol 100.34
    2-methoxyethanol 212.81
    isobutyl acetate 28.03
    tetrachloromethane 46.18
    n-pentyl acetate 44.61
    transcutol 95.86
    n-heptanol 55.33
    ethylbenzene 8.48
    MIBK 56.58
    2-propoxyethanol 198.72
    tert-butanol 98.23
    MTBE 82.84
    2-butoxyethanol 97.63
    propionic acid 103.04
    o-xylene 14.87
    formic acid 246.89
    diethyl ether 95.8
    m-xylene 18.74
    p-xylene 12.01
    chlorobenzene 44.16
    dimethyl carbonate 63.07
    n-octane 3.23
    formamide 270.87
    cyclopentanone 305.26
    2-pentanone 115.14
    anisole 38.91
    cyclopentyl methyl ether 125.11
    gamma-butyrolactone 392.64
    1-methoxy-2-propanol 101.9
    pyridine 104.99
    3-pentanone 75.52
    furfural 254.19
    n-dodecane 2.34
    diethylene glycol 133.28
    diisopropyl ether 20.68
    tert-amyl alcohol 67.15
    acetylacetone 127.33
    n-hexadecane 2.52
    acetophenone 33.87
    methyl propionate 102.19
    isopentyl acetate 72.12
    trichloroethylene 135.03
    n-nonanol 29.5
    cyclohexanol 36.8
    benzyl alcohol 30.25
    2-ethylhexanol 46.88
    isooctanol 40.69
    dipropyl ether 56.99
    1,2-dichlorobenzene 38.13
    ethyl lactate 25.4
    propylene carbonate 133.23
    n-methylformamide 193.55
    2-pentanol 35.58
    n-pentane 3.72
    1-propoxy-2-propanol 97.12
    1-methoxy-2-propyl acetate 78.8
    2-(2-methoxypropoxy) propanol 44.4
    mesitylene 11.97
    ε-caprolactone 115.12
    p-cymene 14.63
    epichlorohydrin 309.07
    1,1,1-trichloroethane 98.98
    2-aminoethanol 69.45
    morpholine-4-carbaldehyde 167.47
    sulfolane 297.54
    2,2,4-trimethylpentane 3.94
    2-methyltetrahydrofuran 227.16
    n-hexyl acetate 47.32
    isooctane 3.52
    2-(2-butoxyethoxy)ethanol 65.91
    sec-butyl acetate 24.67
    tert-butyl acetate 70.84
    decalin 2.72
    glycerin 64.01
    diglyme 136.04
    acrylic acid 87.31
    isopropyl myristate 17.69
    n-butyric acid 143.32
    acetyl acetate 71.78
    di(2-ethylhexyl) phthalate 22.25
    ethyl propionate 43.99
    nitromethane 540.67
    1,2-diethoxyethane 59.67
    benzonitrile 47.3
    trioctyl phosphate 20.6
    1-bromopropane 35.28
    gamma-valerolactone 344.88
    n-decanol 21.73
    triethyl phosphate 26.76
    4-methyl-2-pentanol 25.11
    propionitrile 103.74
    vinylene carbonate 118.65
    1,1,2-trichlorotrifluoroethane 130.56
    DMS 34.48
    cumene 8.91
    2-octanol 27.5
    2-hexanone 61.44
    octyl acetate 27.93
    limonene 22.26
    1,2-dimethoxyethane 176.54
    ethyl orthosilicate 27.35
    tributyl phosphate 20.05
    diacetone alcohol 84.36
    N,N-dimethylaniline 24.23
    acrylonitrile 123.1
    aniline 44.21
    1,3-propanediol 116.5
    bromobenzene 35.57
    dibromomethane 62.27
    1,1,2,2-tetrachloroethane 93.7
    2-methyl-cyclohexyl acetate 37.56
    tetrabutyl urea 25.77
    diisobutyl methanol 23.39
    2-phenylethanol 56.66
    styrene 9.78
    dioctyl adipate 19.84
    dimethyl sulfate 93.63
    ethyl butyrate 52.94
    methyl lactate 45.53
    butyl lactate 32.2
    diethyl carbonate 32.76
    propanediol butyl ether 40.09
    triethyl orthoformate 37.29
    p-tert-butyltoluene 16.16
    methyl 4-tert-butylbenzoate 46.08
    morpholine 219.66
    tert-butylamine 47.72
    n-dodecanol 15.93
    dimethoxymethane 159.08
    ethylene carbonate 105.99
    cyrene 51.85
    2-ethoxyethyl acetate 62.79
    2-ethylhexyl acetate 52.99
    1,2,4-trichlorobenzene 43.16
    4-methylpyridine 89.35
    dibutyl ether 25.7
    2,6-dimethyl-4-heptanol 23.39
    DEF 75.68
    dimethyl isosorbide 92.68
    tetrachloroethylene 80.71
    eugenol 46.35
    triacetin 31.17
    span 80 39.56
    1,4-butanediol 34.7
    1,1-dichloroethane 72.58
    2-methyl-1-pentanol 38.69
    methyl formate 192.66
    2-methyl-1-butanol 46.49
    n-decane 4.02
    butyronitrile 104.31
    3,7-dimethyl-1-octanol 25.74
    1-chlorooctane 17.67
    1-chlorotetradecane 6.47
    n-nonane 3.67
    undecane 2.97
    tert-butylcyclohexane 4.15
    cyclooctane 1.68
    cyclopentanol 72.06
    tetrahydropyran 150.26
    tert-amyl methyl ether 56.83
    2,5,8-trioxanonane 82.98
    1-hexene 13.27
    2-isopropoxyethanol 60.7
    2,2,2-trifluoroethanol 131.15
    methyl butyrate 58.54

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction