2,6-Dimethyl-4-pyridinol

Overview IFRA Request a quote

  • Identifiers

    CAS number
    13603-44-6

    Molecular formula
    C7H9NO

    SMILES
    CC1=CC(=O)C=C(N1)C

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Nutty 42.84%
    Roasted 40.87%
    Burnt 40.24%
    Musty 37.12%
    Animal 31.94%
    Green 30.97%
    Phenolic 30.14%
    Earthy 29.54%
    Coffee 27.16%
    Woody 26.3%

     

    Flavor
    Woody 33.88%
    Phenolic 32.44%
    Bitter 31.83%
    Nutty 30.94%
    Cocoa 29.72%
    Musty 28.06%
    Sweet 24.29%
    Leather 23.36%
    Medical 22.53%
    Almond 22.18%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    0.9

    pKa est.
    6.89 (neutral)

    Molecular weight
    123.15 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    301°C

    Flash point

    • 106.36 ˚C est.

  • Synonyms

    • 2,6-Dimethyl-4-Hydroxypyridine
    • 13603-44-6
    • 2,6-Dimethylpyridin-4-ol
    • 4-hydroxy-2,6-dimethylpyridine
    • 2,6-Dimethyl-4-pyridinol
    • 4-Pyridinol, 2,6-dimethyl-
    • 92JKJ9S198
    • EINECS 237-089-2
    • NSC-111932
    • 4-HYDROXY-2,6-LUTIDINE
    • NSC 111932
    • RefChem:445693
    • 7516-31-6
    • 2,6-dimethylpyridin-4(1H)-one
    • 2,6-dimethyl-1H-pyridin-4-one
    • MFCD00956021
    • 2,6-Dimethyl-4-hydroxy pyridine
    • 2,6-dimethyl-1,4-dihydropyridin-4-one
    • 4(1H)-Pyridinone,2,6-dimethyl-
    • 2,6-Dimethyl-4(1H)-pyridone
    • MLS000056906
    • 2,6-dimethyl-4(1H)-pyridinone
    • SMR000065470
    • UNII-92JKJ9S198
    • 4(1H)-Pyridinone,2,6-dimethyl
    • 2,6-Dimethyl-4-pyridinol; 4-Hydroxy-2,6-dimethylpyridine; 4-Hydroxy-2,6-lutidine; NSC 111932
    • 4(1H)-Pyridinone, 2,6-dimethyl-
    • NSC111932
    • 2,6-Dimethyl-pyridin-4-ol
    • cid_83609
    • SCHEMBL275728
    • 2,6-dimethyl-4(1h)pyridone
    • 2,6-Dimethyl-4-pyridinol #
    • orb1908276
    • SCHEMBL3450126
    • SCHEMBL5898008
    • CHEMBL1429618
    • BDBM38374
    • DTXSID70929234
    • 2,6-dimethyl-4-(1H)-pyridone
    • HMS2492I09
    • HAA51631
    • MFCD00100799
    • SBB055723
    • STK051921
    • AKOS001021914
    • AKOS006229750
    • AB07775
    • AC-6757
    • CS-W013538
    • FG-0432
    • SB52678
    • SY019779
    • DB-011274
    • D3638
    • NS00052897
    • EN300-92391
    • G77935
    • D120901
    • F011702
    • Q27271513
    • Z56754506
    • 4-Hydroxy-2,6-dimethylpyridine; 2,6-Dimethylpyridin-4-ol
    • 13603-44-6

  • Applications

    2,6-Dimethyl-4-pyridinol (CAS 13603-44-6) is typically used as an organic synthesis intermediate and building block in several industries. It serves as a precursor for pharmaceutical and agrochemical compounds (heterocyclic scaffolds) and can be involved in the preparation of specialty chemicals and functional materials. It may be evaluated for use in fragrance and cosmetics chemistry as an odor-related intermediate or aroma scaffold. In polymer and coatings applications, it can be used as a reactive intermediate or additive for modifying properties. It can also function as a ligand or starting point for coordination chemistry and catalysis in research or industrial material development.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 105.43
    methanol 141.0
    isopropanol 66.28
    water 15.65
    ethyl acetate 82.48
    n-propanol 81.9
    acetone 119.4
    n-butanol 68.07
    acetonitrile 86.75
    DMF 127.49
    toluene 23.28
    isobutanol 60.72
    1,4-dioxane 112.2
    methyl acetate 94.3
    THF 255.82
    2-butanone 79.5
    n-pentanol 49.0
    sec-butanol 58.34
    n-hexane 13.1
    ethylene glycol 52.22
    NMP 200.18
    cyclohexane 8.51
    DMSO 129.58
    n-butyl acetate 45.17
    n-octanol 32.78
    chloroform 82.49
    n-propyl acetate 38.67
    acetic acid 182.59
    dichloromethane 81.89
    cyclohexanone 108.85
    propylene glycol 56.15
    isopropyl acetate 42.15
    DMAc 139.8
    2-ethoxyethanol 70.29
    isopentanol 50.66
    n-heptane 8.93
    ethyl formate 59.73
    1,2-dichloroethane 51.24
    n-hexanol 64.93
    2-methoxyethanol 133.47
    isobutyl acetate 27.14
    tetrachloromethane 16.83
    n-pentyl acetate 31.73
    transcutol 152.47
    n-heptanol 26.11
    ethylbenzene 11.33
    MIBK 38.84
    2-propoxyethanol 106.78
    tert-butanol 75.88
    MTBE 49.02
    2-butoxyethanol 47.54
    propionic acid 102.59
    o-xylene 17.75
    formic acid 96.8
    diethyl ether 66.34
    m-xylene 21.09
    p-xylene 16.09
    chlorobenzene 30.58
    dimethyl carbonate 38.13
    n-octane 3.43
    formamide 73.99
    cyclopentanone 155.72
    2-pentanone 68.75
    anisole 30.25
    cyclopentyl methyl ether 96.61
    gamma-butyrolactone 206.87
    1-methoxy-2-propanol 93.85
    pyridine 56.25
    3-pentanone 56.96
    furfural 122.94
    n-dodecane 3.34
    diethylene glycol 94.56
    diisopropyl ether 19.49
    tert-amyl alcohol 58.23
    acetylacetone 72.62
    n-hexadecane 3.63
    acetophenone 32.46
    methyl propionate 76.16
    isopentyl acetate 39.37
    trichloroethylene 87.3
    n-nonanol 27.92
    cyclohexanol 60.52
    benzyl alcohol 30.96
    2-ethylhexanol 32.72
    isooctanol 21.47
    dipropyl ether 37.39
    1,2-dichlorobenzene 28.6
    ethyl lactate 31.32
    propylene carbonate 95.39
    n-methylformamide 85.75
    2-pentanol 44.99
    n-pentane 11.1
    1-propoxy-2-propanol 63.68
    1-methoxy-2-propyl acetate 55.79
    2-(2-methoxypropoxy) propanol 57.44
    mesitylene 13.48
    ε-caprolactone 102.7
    p-cymene 13.25
    epichlorohydrin 137.59
    1,1,1-trichloroethane 54.43
    2-aminoethanol 70.02
    morpholine-4-carbaldehyde 141.61
    sulfolane 188.98
    2,2,4-trimethylpentane 6.0
    2-methyltetrahydrofuran 143.81
    n-hexyl acetate 52.05
    isooctane 4.25
    2-(2-butoxyethoxy)ethanol 69.38
    sec-butyl acetate 27.69
    tert-butyl acetate 44.27
    decalin 5.95
    glycerin 80.28
    diglyme 96.07
    acrylic acid 94.38
    isopropyl myristate 22.27
    n-butyric acid 96.68
    acetyl acetate 57.77
    di(2-ethylhexyl) phthalate 28.72
    ethyl propionate 41.87
    nitromethane 200.24
    1,2-diethoxyethane 46.7
    benzonitrile 35.85
    trioctyl phosphate 21.22
    1-bromopropane 38.57
    gamma-valerolactone 161.95
    n-decanol 21.55
    triethyl phosphate 24.76
    4-methyl-2-pentanol 26.7
    propionitrile 54.42
    vinylene carbonate 78.98
    1,1,2-trichlorotrifluoroethane 89.51
    DMS 52.71
    cumene 11.09
    2-octanol 19.96
    2-hexanone 42.05
    octyl acetate 30.03
    limonene 19.78
    1,2-dimethoxyethane 84.37
    ethyl orthosilicate 23.69
    tributyl phosphate 26.15
    diacetone alcohol 58.61
    N,N-dimethylaniline 24.72
    acrylonitrile 61.43
    aniline 35.59
    1,3-propanediol 77.29
    bromobenzene 22.97
    dibromomethane 54.13
    1,1,2,2-tetrachloroethane 64.57
    2-methyl-cyclohexyl acetate 33.19
    tetrabutyl urea 32.47
    diisobutyl methanol 19.61
    2-phenylethanol 35.28
    styrene 12.08
    dioctyl adipate 32.27
    dimethyl sulfate 61.9
    ethyl butyrate 33.83
    methyl lactate 49.02
    butyl lactate 32.22
    diethyl carbonate 26.68
    propanediol butyl ether 52.21
    triethyl orthoformate 28.12
    p-tert-butyltoluene 13.15
    methyl 4-tert-butylbenzoate 43.89
    morpholine 125.8
    tert-butylamine 41.9
    n-dodecanol 16.96
    dimethoxymethane 92.19
    ethylene carbonate 66.72
    cyrene 58.17
    2-ethoxyethyl acetate 47.23
    2-ethylhexyl acetate 32.38
    1,2,4-trichlorobenzene 38.14
    4-methylpyridine 62.38
    dibutyl ether 29.17
    2,6-dimethyl-4-heptanol 19.61
    DEF 68.88
    dimethyl isosorbide 87.89
    tetrachloroethylene 44.56
    eugenol 42.6
    triacetin 52.86
    span 80 50.38
    1,4-butanediol 37.83
    1,1-dichloroethane 56.21
    2-methyl-1-pentanol 42.35
    methyl formate 78.78
    2-methyl-1-butanol 53.85
    n-decane 5.16
    butyronitrile 54.89
    3,7-dimethyl-1-octanol 30.3
    1-chlorooctane 17.6
    1-chlorotetradecane 8.37
    n-nonane 5.22
    undecane 4.05
    tert-butylcyclohexane 7.06
    cyclooctane 3.61
    cyclopentanol 83.72
    tetrahydropyran 102.8
    tert-amyl methyl ether 44.57
    2,5,8-trioxanonane 78.91
    1-hexene 27.81
    2-isopropoxyethanol 47.91
    2,2,2-trifluoroethanol 84.54
    methyl butyrate 48.58

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction