2,6-Dimethoxycymene

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  • Identifiers

    CAS number
    291774-65-7

    Molecular formula
    C12H18O2

    SMILES
    CC1=C(C=C(C=C1OC)C(C)C)OC

    Safety labels

  • Odor profile

    Fragrance
    Spicy 71.56%
    Herbal 59.1%
    Woody 52.32%
    Phenolic 51.85%
    Earthy 43.06%
    Leathery 35.66%
    Smoky 34.27%
    Medicinal 33.75%
    Camphoreous 32.55%
    Green 30.13%

     

    Flavor
    Herbal 35.81%
    Spice 35.77%
    Woody 33.53%
    Spicy 31.92%
    Musty 31.4%
    Camphor 29.04%
    Earthy 27.82%
    Earth 26.9%
    Phenolic 25.31%
    Pepper 23.82%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    3.4

    pKa est.
    8.3 (weak base)

    Molecular weight
    194.27 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    261°C

    Flash point

    • 94.49 ˚C est.

  • Synonyms

    • 2,6-dimethoxycymene
    • 2,6-Dimethoxy-p-cymene
    • 291774-65-7
    • Benzene, 1,3-dimethoxy-2-methyl-5-(1-methylethyl)-
    • SCHEMBL11436435
    • DTXSID50423881
    • RWENJYLCELUBAE-UHFFFAOYSA-N
    • 1,3-Dimethoxy-2-methyl-5-(propan-2-yl)benzene
    • 291774-65-7

  • Applications

    2,6-Dimethoxycymene (CAS 291774-65-7) is primarily used in the fragrance and flavor industries as an aroma intermediate and odorant, serving as a building block for the synthesis of specialty aroma compounds. In perfumery, it can function as a fragrance ingredient or a fixative component, contributing to spicy, woody, or herbal notes depending on formulation. It is also commonly evaluated as an intermediate in cosmetic and personal care products to impart or modulate scent. In household products such as cleaners and air fresheners, it may be used as a fragrance additive. In industrial manufacturing, it serves as an intermediate for synthesizing more complex aroma or specialty chemicals. Use is typically governed by formulation limits and regulatory considerations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 444.17
    methanol 324.07
    isopropanol 348.41
    water 0.63
    ethyl acetate 363.99
    n-propanol 439.67
    acetone 359.43
    n-butanol 396.72
    acetonitrile 360.42
    DMF 504.85
    toluene 367.58
    isobutanol 302.62
    1,4-dioxane 1201.76
    methyl acetate 415.6
    THF 999.9
    2-butanone 388.73
    n-pentanol 320.34
    sec-butanol 355.05
    n-hexane 49.03
    ethylene glycol 105.51
    NMP 352.28
    cyclohexane 162.37
    DMSO 388.76
    n-butyl acetate 323.14
    n-octanol 168.76
    chloroform 2147.53
    n-propyl acetate 242.57
    acetic acid 315.28
    dichloromethane 1796.45
    cyclohexanone 590.3
    propylene glycol 158.22
    isopropyl acetate 166.44
    DMAc 340.47
    2-ethoxyethanol 404.11
    isopentanol 289.0
    n-heptane 64.6
    ethyl formate 424.74
    1,2-dichloroethane 860.6
    n-hexanol 375.19
    2-methoxyethanol 570.27
    isobutyl acetate 169.03
    tetrachloromethane 401.12
    n-pentyl acetate 197.04
    transcutol 449.3
    n-heptanol 183.59
    ethylbenzene 215.58
    MIBK 147.31
    2-propoxyethanol 434.48
    tert-butanol 365.92
    MTBE 291.49
    2-butoxyethanol 261.21
    propionic acid 303.39
    o-xylene 215.79
    formic acid 85.9
    diethyl ether 345.76
    m-xylene 197.41
    p-xylene 290.71
    chlorobenzene 481.8
    dimethyl carbonate 131.85
    n-octane 33.5
    formamide 161.58
    cyclopentanone 582.66
    2-pentanone 267.99
    anisole 339.58
    cyclopentyl methyl ether 334.32
    gamma-butyrolactone 636.56
    1-methoxy-2-propanol 351.8
    pyridine 911.28
    3-pentanone 211.75
    furfural 685.69
    n-dodecane 28.32
    diethylene glycol 300.72
    diisopropyl ether 79.78
    tert-amyl alcohol 324.46
    acetylacetone 246.45
    n-hexadecane 32.59
    acetophenone 274.96
    methyl propionate 272.9
    isopentyl acetate 257.27
    trichloroethylene 1573.86
    n-nonanol 148.77
    cyclohexanol 415.62
    benzyl alcohol 338.15
    2-ethylhexanol 231.67
    isooctanol 144.83
    dipropyl ether 195.64
    1,2-dichlorobenzene 405.94
    ethyl lactate 141.91
    propylene carbonate 431.68
    n-methylformamide 309.67
    2-pentanol 225.74
    n-pentane 51.31
    1-propoxy-2-propanol 276.3
    1-methoxy-2-propyl acetate 225.59
    2-(2-methoxypropoxy) propanol 173.05
    mesitylene 114.55
    ε-caprolactone 533.66
    p-cymene 143.99
    epichlorohydrin 950.3
    1,1,1-trichloroethane 842.21
    2-aminoethanol 213.32
    morpholine-4-carbaldehyde 512.51
    sulfolane 523.9
    2,2,4-trimethylpentane 32.1
    2-methyltetrahydrofuran 668.33
    n-hexyl acetate 254.05
    isooctane 22.27
    2-(2-butoxyethoxy)ethanol 255.64
    sec-butyl acetate 150.82
    tert-butyl acetate 172.38
    decalin 66.7
    glycerin 171.92
    diglyme 465.98
    acrylic acid 239.51
    isopropyl myristate 103.23
    n-butyric acid 424.79
    acetyl acetate 218.81
    di(2-ethylhexyl) phthalate 113.78
    ethyl propionate 195.09
    nitromethane 443.98
    1,2-diethoxyethane 254.83
    benzonitrile 436.24
    trioctyl phosphate 86.05
    1-bromopropane 525.57
    gamma-valerolactone 731.04
    n-decanol 116.05
    triethyl phosphate 129.64
    4-methyl-2-pentanol 108.48
    propionitrile 366.09
    vinylene carbonate 475.28
    1,1,2-trichlorotrifluoroethane 544.35
    DMS 175.4
    cumene 136.54
    2-octanol 131.4
    2-hexanone 240.24
    octyl acetate 142.39
    limonene 183.31
    1,2-dimethoxyethane 622.02
    ethyl orthosilicate 129.43
    tributyl phosphate 91.17
    diacetone alcohol 210.69
    N,N-dimethylaniline 197.68
    acrylonitrile 414.79
    aniline 378.87
    1,3-propanediol 355.04
    bromobenzene 547.78
    dibromomethane 1214.63
    1,1,2,2-tetrachloroethane 1174.02
    2-methyl-cyclohexyl acetate 203.54
    tetrabutyl urea 114.69
    diisobutyl methanol 108.61
    2-phenylethanol 328.67
    styrene 277.44
    dioctyl adipate 155.97
    dimethyl sulfate 151.45
    ethyl butyrate 224.84
    methyl lactate 135.24
    butyl lactate 147.97
    diethyl carbonate 193.52
    propanediol butyl ether 204.34
    triethyl orthoformate 173.72
    p-tert-butyltoluene 138.44
    methyl 4-tert-butylbenzoate 199.87
    morpholine 1147.24
    tert-butylamine 230.13
    n-dodecanol 94.06
    dimethoxymethane 351.6
    ethylene carbonate 388.46
    cyrene 214.11
    2-ethoxyethyl acetate 251.78
    2-ethylhexyl acetate 226.04
    1,2,4-trichlorobenzene 468.84
    4-methylpyridine 714.1
    dibutyl ether 154.72
    2,6-dimethyl-4-heptanol 108.61
    DEF 281.69
    dimethyl isosorbide 309.66
    tetrachloroethylene 792.75
    eugenol 199.62
    triacetin 191.35
    span 80 191.18
    1,4-butanediol 171.22
    1,1-dichloroethane 794.28
    2-methyl-1-pentanol 268.13
    methyl formate 281.2
    2-methyl-1-butanol 288.11
    n-decane 43.66
    butyronitrile 431.79
    3,7-dimethyl-1-octanol 137.48
    1-chlorooctane 133.29
    1-chlorotetradecane 64.17
    n-nonane 42.25
    undecane 34.36
    tert-butylcyclohexane 56.88
    cyclooctane 47.94
    cyclopentanol 411.77
    tetrahydropyran 928.3
    tert-amyl methyl ether 210.03
    2,5,8-trioxanonane 305.83
    1-hexene 169.69
    2-isopropoxyethanol 262.56
    2,2,2-trifluoroethanol 111.86
    methyl butyrate 297.0

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction