2,6-Dimethoxybenzaldehyde

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  • Identifiers

    CAS number
    3392-97-0

    Molecular formula
    C9H10O3

    SMILES
    COC1=C(C(=CC=C1)OC)C=O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 82.71%
    Spicy 63.87%
    Herbal 53.6%
    Anisic 48.83%
    Vanilla 47.89%
    Green 45.45%
    Phenolic 44.2%
    Aromatic 37.43%
    Floral 36.72%
    Woody 36.35%

     

    Flavor
    Sweet 42.43%
    Woody 37.97%
    Floral 37.32%
    Fruity 36.97%
    Spicy 31.34%
    Herbal 31.16%
    Spice 31.1%
    Vanilla 30.97%
    Balsam 30.47%
    Powdery 29.0%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.0

    pKa est.
    6.23 (neutral)

    Molecular weight
    166.17 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    264°C

    Flash point

    • 104.0 ˚C est.

  • Synonyms

    • 2,6-Dimethoxybenzaldehyde
    • 3392-97-0
    • Benzaldehyde, 2,6-dimethoxy-
    • UNII-54P7CG8V99
    • 54P7CG8V99
    • NSC 72362
    • NSC-72362
    • DTXSID80187545
    • RefChem:83266
    • DTXCID40110036
    • 625-546-2
    • 919-150-1
    • InChI=1/C9H10O3/c1-11-8-4-3-5-9(12-2)7(8)6-10/h3-6H,1-2H
    • WXSGQHKHUYTJNB-UHFFFAOYSA-N
    • MFCD00010862
    • 2,6-dimethoxy-benzaldehyde
    • NSC72362
    • Berberine Impurity 12
    • 2,6 dimethoxybenzaldehyde
    • SCHEMBL170690
    • SCHEMBL374648
    • orb2940477
    • 2,6-Dimethoxybenzaldehyde, 99%
    • 2,6-Dimethoxybenzaldehyde, 98+%
    • SBB006541
    • STL353515
    • AKOS002391855
    • CS-W001249
    • FD70156
    • HY-W001249
    • PB47996
    • AC-26235
    • AS-14438
    • SY048409
    • DB-020221
    • D2778
    • NS00029575
    • ST50824888
    • EN300-114644
    • F10458
    • 392D970
    • F790551
    • doi:10.14272/WXSGQHKHUYTJNB-UHFFFAOYSA-N.1
    • Q27261228
    • F0001-0994
    • Z821306972
    • 3392-97-0

  • Applications

    2,6-Dimethoxybenzaldehyde (CAS 3392-97-0) is commonly used as an intermediate and building block in fragrance and aroma chemistry, facilitating the synthesis of aromatic compounds used in perfumery and flavor applications. It also serves as a starting material for more complex fragrance derivatives in cosmetics and personal care products, as well as for household air fresheners. In industrial manufacturing, it can act as a chemical intermediate for various synthetic routes, including applications in coatings/inks and adhesives, and may be involved as a precursor in polymer or plastics-related chemistry. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 92.52
    methanol 139.49
    isopropanol 53.27
    water 0.86
    ethyl acetate 162.75
    n-propanol 61.8
    acetone 226.26
    n-butanol 49.08
    acetonitrile 236.52
    DMF 458.55
    toluene 89.51
    isobutanol 42.41
    1,4-dioxane 412.26
    methyl acetate 218.82
    THF 374.32
    2-butanone 143.32
    n-pentanol 42.78
    sec-butanol 40.05
    n-hexane 6.33
    ethylene glycol 125.27
    NMP 286.94
    cyclohexane 26.69
    DMSO 541.95
    n-butyl acetate 68.97
    n-octanol 31.62
    chloroform 549.48
    n-propyl acetate 84.13
    acetic acid 142.15
    dichloromethane 719.6
    cyclohexanone 234.24
    propylene glycol 52.35
    isopropyl acetate 64.84
    DMAc 279.28
    2-ethoxyethanol 146.63
    isopentanol 38.66
    n-heptane 11.4
    ethyl formate 202.78
    1,2-dichloroethane 415.68
    n-hexanol 54.86
    2-methoxyethanol 306.96
    isobutyl acetate 50.01
    tetrachloromethane 102.67
    n-pentyl acetate 40.1
    transcutol 156.6
    n-heptanol 27.94
    ethylbenzene 51.69
    MIBK 56.15
    2-propoxyethanol 145.65
    tert-butanol 74.8
    MTBE 53.26
    2-butoxyethanol 65.33
    propionic acid 105.39
    o-xylene 66.39
    formic acid 94.25
    diethyl ether 81.46
    m-xylene 59.18
    p-xylene 66.35
    chlorobenzene 160.71
    dimethyl carbonate 124.56
    n-octane 5.61
    formamide 201.74
    cyclopentanone 308.63
    2-pentanone 97.82
    anisole 119.34
    cyclopentyl methyl ether 124.47
    gamma-butyrolactone 436.59
    1-methoxy-2-propanol 135.97
    pyridine 293.75
    3-pentanone 96.57
    furfural 436.99
    n-dodecane 5.91
    diethylene glycol 205.15
    diisopropyl ether 20.82
    tert-amyl alcohol 49.27
    acetylacetone 174.33
    n-hexadecane 7.0
    acetophenone 113.01
    methyl propionate 163.58
    isopentyl acetate 57.18
    trichloroethylene 689.69
    n-nonanol 30.13
    cyclohexanol 75.4
    benzyl alcohol 108.88
    2-ethylhexanol 41.98
    isooctanol 23.91
    dipropyl ether 51.61
    1,2-dichlorobenzene 152.63
    ethyl lactate 64.02
    propylene carbonate 219.1
    n-methylformamide 289.71
    2-pentanol 27.15
    n-pentane 6.45
    1-propoxy-2-propanol 71.78
    1-methoxy-2-propyl acetate 91.38
    2-(2-methoxypropoxy) propanol 69.12
    mesitylene 39.66
    ε-caprolactone 190.98
    p-cymene 34.87
    epichlorohydrin 511.56
    1,1,1-trichloroethane 295.56
    2-aminoethanol 94.41
    morpholine-4-carbaldehyde 361.43
    sulfolane 453.82
    2,2,4-trimethylpentane 4.96
    2-methyltetrahydrofuran 177.15
    n-hexyl acetate 56.57
    isooctane 4.18
    2-(2-butoxyethoxy)ethanol 84.1
    sec-butyl acetate 44.98
    tert-butyl acetate 69.5
    decalin 15.28
    glycerin 112.78
    diglyme 191.3
    acrylic acid 134.65
    isopropyl myristate 31.67
    n-butyric acid 104.19
    acetyl acetate 122.33
    di(2-ethylhexyl) phthalate 37.96
    ethyl propionate 84.05
    nitromethane 427.45
    1,2-diethoxyethane 67.99
    benzonitrile 149.31
    trioctyl phosphate 27.81
    1-bromopropane 123.37
    gamma-valerolactone 388.01
    n-decanol 24.91
    triethyl phosphate 59.67
    4-methyl-2-pentanol 19.15
    propionitrile 141.16
    vinylene carbonate 255.2
    1,1,2-trichlorotrifluoroethane 352.3
    DMS 90.67
    cumene 36.12
    2-octanol 18.6
    2-hexanone 74.37
    octyl acetate 39.63
    limonene 47.64
    1,2-dimethoxyethane 281.66
    ethyl orthosilicate 47.91
    tributyl phosphate 33.79
    diacetone alcohol 93.4
    N,N-dimethylaniline 78.38
    acrylonitrile 232.76
    aniline 118.78
    1,3-propanediol 117.24
    bromobenzene 177.45
    dibromomethane 384.41
    1,1,2,2-tetrachloroethane 452.46
    2-methyl-cyclohexyl acetate 62.34
    tetrabutyl urea 49.47
    diisobutyl methanol 27.33
    2-phenylethanol 89.79
    styrene 70.11
    dioctyl adipate 51.01
    dimethyl sulfate 212.8
    ethyl butyrate 77.72
    methyl lactate 98.4
    butyl lactate 39.7
    diethyl carbonate 76.62
    propanediol butyl ether 50.76
    triethyl orthoformate 54.88
    p-tert-butyltoluene 33.97
    methyl 4-tert-butylbenzoate 80.71
    morpholine 337.78
    tert-butylamine 40.34
    n-dodecanol 21.43
    dimethoxymethane 283.31
    ethylene carbonate 201.26
    cyrene 106.61
    2-ethoxyethyl acetate 66.37
    2-ethylhexyl acetate 47.84
    1,2,4-trichlorobenzene 174.39
    4-methylpyridine 220.12
    dibutyl ether 36.92
    2,6-dimethyl-4-heptanol 27.33
    DEF 159.8
    dimethyl isosorbide 139.39
    tetrachloroethylene 330.02
    eugenol 84.3
    triacetin 74.21
    span 80 55.46
    1,4-butanediol 57.33
    1,1-dichloroethane 249.35
    2-methyl-1-pentanol 38.35
    methyl formate 335.9
    2-methyl-1-butanol 37.02
    n-decane 8.35
    butyronitrile 113.62
    3,7-dimethyl-1-octanol 33.18
    1-chlorooctane 33.07
    1-chlorotetradecane 17.18
    n-nonane 7.68
    undecane 6.88
    tert-butylcyclohexane 11.56
    cyclooctane 9.45
    cyclopentanol 94.13
    tetrahydropyran 199.23
    tert-amyl methyl ether 44.72
    2,5,8-trioxanonane 141.22
    1-hexene 22.1
    2-isopropoxyethanol 82.17
    2,2,2-trifluoroethanol 104.73
    methyl butyrate 118.72

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction