2,6-Dimethoxy-3,5-pyridinediamine dihydrochloride

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  • Identifiers

    CAS number
    56216-28-5

    Molecular formula
    C7H13Cl2N3O2

    SMILES
    COC1=C(C=C(C(=N1)OC)N)N.Cl.Cl

    Safety labels

    Acute Toxic
    Acute Toxic

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Odorless 33.0%
    Roasted 25.66%
    Earthy 25.13%
    Burnt 24.81%
    Sweet 24.24%
    Musty 21.11%
    Fruity 20.65%
    Meaty 20.32%
    Nutty 19.86%
    Animal 19.53%

     

    Flavor
    Bitter 53.09%
    Roasted 29.95%
    Burnt 23.31%
    Musty 22.91%
    Mild 22.82%
    Coffee 22.31%
    Meaty 22.22%
    Odorless 22.01%
    Earthy 21.65%
    Eugenol 21.37%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    4.29 (weak acid)

    Molecular weight
    242.1 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    354°C

    Flash point

    • 168.99 ˚C est.

  • Synonyms

    • 3,5-Diamino-2,6-dimethoxypyridine dihydrochloride
    • 3,5-Pyridinediamine, 2,6-dimethoxy-, dihydrochloride
    • COLOREX DMP
    • H109UIY001
    • 2,6-Dimethoxy-3,5-pyridinediamine HCl
    • 2,6-Dimethoxy-3,5-pyridinediamine dihydrochloride
    • EINECS 260-062-1
    • 3,5-PYRIDINEDIAMINE, 2,6-DIMETHOXY-, HYDROCHLORIDE (1:2)
    • DTXSID10892438
    • RefChem:445604
    • DTXCID701079619
    • 2,6-DIMETHOXY-3,5-PYRIDINEDIAMINE HCL [INCI]
    • 56216-28-5
    • 2,6-dimethoxypyridine-3,5-diamine dihydrochloride
    • 2,6-Dimethoxypyridine-3,5-diamine Dihydrochloride (>90%)
    • UNII-H109UIY001
    • 2,6-Dimethoxy-pyridine-3,5-diamine Dihydrochloride
    • SCHEMBL2479718
    • WHKIQFYYHZPIBH-UHFFFAOYSA-N
    • CS-0326977
    • NS00087716
    • 2,6-dimethoxypyridine-3,5-diaminedihydrochloride
    • 2,6-dimethoxypyridine-3,5-diamine;dihydrochloride
    • Q27279440
    • 2,6-DIMETHOXY-3,5-DIAMINO PYRIDINE DIHYDROCHLORIDE
    • 56216-28-5

  • Applications

    2,6-Dimethoxy-3,5-pyridinediamine dihydrochloride (CAS 56216-28-5) is primarily used as a synthetic intermediate in pharmaceutical and fine-chemical manufacture. It serves as a building block for heterocyclic compounds and drug-like scaffolds, enabling further functionalization in medicinal-chemistry workflows. In organic synthesis it is employed as a precursor for dyes, pigments, and other specialty chemicals. The dihydrochloride salt form improves handling, crystallinity, and solubility, supporting use in polymer and coating chemistries where diamine linkages are required, such as epoxy and polyimide formulations. It can also function as a ligand in coordination chemistry and catalysis, and is often evaluated for use in advanced materials, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 22.7
    methanol 34.22
    isopropanol 9.11
    water 3.55
    ethyl acetate 4.4
    n-propanol 12.77
    acetone 13.96
    n-butanol 9.76
    acetonitrile 15.81
    DMF 32.95
    toluene 1.48
    isobutanol 6.86
    1,4-dioxane 21.94
    methyl acetate 7.45
    THF 46.31
    2-butanone 7.64
    n-pentanol 8.28
    sec-butanol 6.4
    n-hexane 0.13
    ethylene glycol 20.87
    NMP 42.26
    cyclohexane 0.43
    DMSO 113.65
    n-butyl acetate 4.43
    n-octanol 3.24
    chloroform 8.03
    n-propyl acetate 4.5
    acetic acid 75.79
    dichloromethane 16.06
    cyclohexanone 15.85
    propylene glycol 13.54
    isopropyl acetate 1.92
    DMAc 27.53
    2-ethoxyethanol 38.11
    isopentanol 6.35
    n-heptane 0.41
    ethyl formate 19.11
    1,2-dichloroethane 7.82
    n-hexanol 7.01
    2-methoxyethanol 69.8
    isobutyl acetate 2.48
    tetrachloromethane 1.68
    n-pentyl acetate 3.46
    transcutol 23.0
    n-heptanol 4.96
    ethylbenzene 1.05
    MIBK 2.69
    2-propoxyethanol 25.92
    tert-butanol 8.81
    MTBE 2.72
    2-butoxyethanol 16.5
    propionic acid 13.53
    o-xylene 1.48
    formic acid 105.46
    diethyl ether 2.67
    m-xylene 1.1
    p-xylene 1.55
    chlorobenzene 3.47
    dimethyl carbonate 4.1
    n-octane 0.2
    formamide 104.1
    cyclopentanone 27.63
    2-pentanone 4.81
    anisole 4.65
    cyclopentyl methyl ether 6.51
    gamma-butyrolactone 41.83
    1-methoxy-2-propanol 23.67
    pyridine 20.38
    3-pentanone 2.91
    furfural 69.25
    n-dodecane 0.17
    diethylene glycol 39.46
    diisopropyl ether 0.5
    tert-amyl alcohol 6.41
    acetylacetone 7.16
    n-hexadecane 0.19
    acetophenone 6.92
    methyl propionate 4.82
    isopentyl acetate 4.11
    trichloroethylene 13.94
    n-nonanol 3.32
    cyclohexanol 7.16
    benzyl alcohol 11.05
    2-ethylhexanol 4.11
    isooctanol 3.72
    dipropyl ether 2.85
    1,2-dichlorobenzene 3.87
    ethyl lactate 5.97
    propylene carbonate 19.88
    n-methylformamide 36.93
    2-pentanol 3.06
    n-pentane 0.19
    1-propoxy-2-propanol 11.23
    1-methoxy-2-propyl acetate 5.44
    2-(2-methoxypropoxy) propanol 9.55
    mesitylene 0.71
    ε-caprolactone 16.04
    p-cymene 1.64
    epichlorohydrin 39.91
    1,1,1-trichloroethane 3.24
    2-aminoethanol 26.52
    morpholine-4-carbaldehyde 38.39
    sulfolane 58.61
    2,2,4-trimethylpentane 0.15
    2-methyltetrahydrofuran 17.07
    n-hexyl acetate 4.07
    isooctane 0.08
    2-(2-butoxyethoxy)ethanol 15.3
    sec-butyl acetate 1.93
    tert-butyl acetate 2.43
    decalin 0.23
    glycerin 34.92
    diglyme 28.29
    acrylic acid 20.78
    isopropyl myristate 1.47
    n-butyric acid 16.86
    acetyl acetate 4.04
    di(2-ethylhexyl) phthalate 4.3
    ethyl propionate 3.23
    nitromethane 75.22
    1,2-diethoxyethane 4.79
    benzonitrile 10.01
    trioctyl phosphate 3.01
    1-bromopropane 2.41
    gamma-valerolactone 49.6
    n-decanol 2.48
    triethyl phosphate 3.91
    4-methyl-2-pentanol 1.73
    propionitrile 7.0
    vinylene carbonate 20.74
    1,1,2-trichlorotrifluoroethane 48.14
    DMS 3.45
    cumene 1.0
    2-octanol 2.36
    2-hexanone 4.8
    octyl acetate 2.59
    limonene 2.1
    1,2-dimethoxyethane 33.35
    ethyl orthosilicate 3.61
    tributyl phosphate 2.77
    diacetone alcohol 8.28
    N,N-dimethylaniline 3.9
    acrylonitrile 13.93
    aniline 6.67
    1,3-propanediol 34.6
    bromobenzene 2.57
    dibromomethane 6.96
    1,1,2,2-tetrachloroethane 9.5
    2-methyl-cyclohexyl acetate 4.91
    tetrabutyl urea 4.37
    diisobutyl methanol 1.73
    2-phenylethanol 9.83
    styrene 1.19
    dioctyl adipate 3.42
    dimethyl sulfate 11.32
    ethyl butyrate 4.48
    methyl lactate 8.47
    butyl lactate 5.3
    diethyl carbonate 3.9
    propanediol butyl ether 11.62
    triethyl orthoformate 4.17
    p-tert-butyltoluene 1.42
    methyl 4-tert-butylbenzoate 7.7
    morpholine 30.73
    tert-butylamine 3.24
    n-dodecanol 1.8
    dimethoxymethane 17.52
    ethylene carbonate 14.01
    cyrene 21.7
    2-ethoxyethyl acetate 6.39
    2-ethylhexyl acetate 3.06
    1,2,4-trichlorobenzene 5.56
    4-methylpyridine 10.49
    dibutyl ether 1.8
    2,6-dimethyl-4-heptanol 1.73
    DEF 8.4
    dimethyl isosorbide 19.5
    tetrachloroethylene 8.01
    eugenol 10.73
    triacetin 5.6
    span 80 9.2
    1,4-butanediol 16.01
    1,1-dichloroethane 3.31
    2-methyl-1-pentanol 6.11
    methyl formate 35.96
    2-methyl-1-butanol 6.07
    n-decane 0.25
    butyronitrile 8.48
    3,7-dimethyl-1-octanol 2.49
    1-chlorooctane 0.98
    1-chlorotetradecane 0.48
    n-nonane 0.2
    undecane 0.21
    tert-butylcyclohexane 0.18
    cyclooctane 0.16
    cyclopentanol 13.35
    tetrahydropyran 10.03
    tert-amyl methyl ether 2.35
    2,5,8-trioxanonane 20.34
    1-hexene 0.56
    2-isopropoxyethanol 15.46
    2,2,2-trifluoroethanol 30.55
    methyl butyrate 6.46

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction