2,6-Dihydroxybenzoic Acid

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  • Identifiers

    CAS number
    303-07-1

    Molecular formula
    C7H6O4

    SMILES
    C1=CC(=C(C(=C1)O)C(=O)O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Phenolic 67.08%
    Odorless 56.94%
    Nutty 34.39%
    Medicinal 31.86%
    Burnt 30.89%
    Balsamic 28.23%
    Bitter 26.66%
    Smoky 24.08%
    Musty 22.82%
    Aromatic 22.37%

     

    Flavor
    Phenolic 63.62%
    Nutty 48.72%
    Odorless 46.19%
    Mild 45.37%
    Musty 27.85%
    Sour 27.01%
    Bitter 26.67%
    Faint 26.39%
    Urine 23.39%
    Very mild 22.84%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.2

    pKa est.
    8.13 (weak base)

    Molecular weight
    154.12 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    324°C

    Melting point expt.

    • 165 °C

    Flash point

    • 172.14 ˚C est.

    Solubility expt.

    • 9.56 mg/mL

  • Synonyms

    • 2,6-DIHYDROXYBENZOIC ACID
    • 303-07-1
    • gamma-Resorcylic acid
    • Benzoic acid, 2,6-dihydroxy-
    • 2-Carboxyresorcinol
    • 6-Hydroxysalicylic acid
    • 2,6-Resorcylic acid
    • RSA5G6VRPV
    • NSC-49172
    • DTXSID1059785
    • CHEBI:68465
    • RefChem:445582
    • DTXCID6038164
    • 206-134-8
    • .gamma.-Resorcylic acid
    • MFCD00002462
    • 2,6-dihydroxy benzoic acid
    • 2,6-dihydroxy-benzoic acid
    • 2,6-Dihydroxybenzoicacid
    • gamma-Resorcylsaeure
    • UNII-RSA5G6VRPV
    • EINECS 206-134-8
    • NSC 49172
    • 2,6-Dihydroxybenzoesaeure
    • BRN 2209755
    • ??resorcylic acid
    • ?-Resorcylic acid
    • GRE
    • 2,6-Dihydroxybenzoesaeure [IUPAC]
    • 2_6_dihydroxybenzoic_acid
    • Benzoic acid,6-dihydroxy-
    • Salicylic Acid Impurity 25
    • 2,6-Dihydroxybenzoate, VII
    • 4-10-00-01456 (Beilstein Handbook Reference)
    • SCHEMBL224031
    • SCHEMBL446972
    • CHEMBL454808
    • orb1301419
    • SCHEMBL5468731
    • SCHEMBL6630310
    • 2-carboxy-1,3-dihydroxybenzene
    • SCHEMBL11089353
    • BDBM92712
    • 2,6-Dihydroxybenzoic acid, 98%
    • Benzoic acid, 2,?6-?dihydroxy-
    • BB_SC-02393
    • HY-Y0801
    • NSC49172
    • STR05041
    • AC8078
    • BBL011022
    • EBC-03405
    • s6031
    • SBB058835
    • STK802162
    • AKOS005622669
    • MSK2634-1000M
    • AC-7284
    • FD36812
    • SY005481
    • DB-030809
    • 2,6-Dihydroxybenzoic acid (ACD/Name 4.0)
    • CS-0015783
    • NS00015127
    • R0011
    • ST50824440
    • EN300-75920
    • C21298
    • 303D071
    • AE-562/42007307
    • BENZOIC ACID,2,6-DIHYDROXY MFC7 H6 O4
    • F046148
    • Q4596804
    • Z1184885417
    • 2,6-Dihydroxybenzoic acid Solution in Methanol, 1000ug/mL
    • 2,6-Dihydroxybenzoic acid, Vetec(TM) reagent grade, 98%
    • InChI=1/C7H6O4/c8-4-2-1-3-5(9)6(4)7(10)11/h1-3,8-9H,(H,10,11
    • 303-07-1

  • Applications

    2,6-Dihydroxybenzoic Acid (CAS 303-07-1) is primarily used as an organic-synthesis intermediate, serving as a building block for dye and pigment precursors as well as pharmaceutical and agrochemical intermediates. It also functions as a building block for functional benzoic derivatives in the polymer and plastics industry, including precursors for polyesters or additives with stabilizing or antioxidant potential in polymer systems. Owing to its phenolic and carboxyl groups, the compound can act as a chelating agent or ligand in materials chemistry and catalysis, and is sometimes explored as a precursor for specialized coatings, inks, and surface formulations. Applications are typically pursued with attention to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 692.53
    methanol 934.89
    isopropanol 542.02
    water 5.92
    ethyl acetate 339.08
    n-propanol 451.55
    acetone 699.21
    n-butanol 427.19
    acetonitrile 202.6
    DMF 1579.82
    toluene 8.83
    isobutanol 239.06
    1,4-dioxane 306.45
    methyl acetate 250.86
    THF 3773.93
    2-butanone 381.48
    n-pentanol 336.12
    sec-butanol 283.34
    n-hexane 6.38
    ethylene glycol 424.5
    NMP 634.71
    cyclohexane 0.8
    DMSO 4821.5
    n-butyl acetate 135.01
    n-octanol 89.22
    chloroform 16.01
    n-propyl acetate 223.58
    acetic acid 245.31
    dichloromethane 24.6
    cyclohexanone 244.8
    propylene glycol 434.16
    isopropyl acetate 252.07
    DMAc 545.68
    2-ethoxyethanol 717.18
    isopentanol 287.86
    n-heptane 6.67
    ethyl formate 260.6
    1,2-dichloroethane 54.01
    n-hexanol 315.54
    2-methoxyethanol 1418.36
    isobutyl acetate 85.06
    tetrachloromethane 6.79
    n-pentyl acetate 79.99
    transcutol 351.24
    n-heptanol 110.23
    ethylbenzene 8.97
    MIBK 335.52
    2-propoxyethanol 825.3
    tert-butanol 490.68
    MTBE 139.75
    2-butoxyethanol 247.89
    propionic acid 208.34
    o-xylene 8.26
    formic acid 285.41
    diethyl ether 212.16
    m-xylene 17.42
    p-xylene 8.85
    chlorobenzene 10.75
    dimethyl carbonate 268.13
    n-octane 2.83
    formamide 506.77
    cyclopentanone 874.48
    2-pentanone 583.31
    anisole 66.48
    cyclopentyl methyl ether 422.63
    gamma-butyrolactone 1017.52
    1-methoxy-2-propanol 1392.12
    pyridine 61.09
    3-pentanone 197.69
    furfural 355.83
    n-dodecane 3.39
    diethylene glycol 778.27
    diisopropyl ether 69.32
    tert-amyl alcohol 242.27
    acetylacetone 548.11
    n-hexadecane 3.68
    acetophenone 70.26
    methyl propionate 373.39
    isopentyl acetate 87.47
    trichloroethylene 55.7
    n-nonanol 78.1
    cyclohexanol 118.88
    benzyl alcohol 74.13
    2-ethylhexanol 94.93
    isooctanol 76.47
    dipropyl ether 129.15
    1,2-dichlorobenzene 10.89
    ethyl lactate 199.73
    propylene carbonate 326.81
    n-methylformamide 842.01
    2-pentanol 316.06
    n-pentane 5.59
    1-propoxy-2-propanol 458.56
    1-methoxy-2-propyl acetate 242.76
    2-(2-methoxypropoxy) propanol 160.07
    mesitylene 14.31
    ε-caprolactone 220.64
    p-cymene 11.76
    epichlorohydrin 939.2
    1,1,1-trichloroethane 30.89
    2-aminoethanol 525.06
    morpholine-4-carbaldehyde 494.17
    sulfolane 1603.54
    2,2,4-trimethylpentane 3.91
    2-methyltetrahydrofuran 632.07
    n-hexyl acetate 110.27
    isooctane 8.04
    2-(2-butoxyethoxy)ethanol 253.91
    sec-butyl acetate 122.88
    tert-butyl acetate 266.1
    decalin 2.46
    glycerin 616.08
    diglyme 339.29
    acrylic acid 180.61
    isopropyl myristate 54.17
    n-butyric acid 302.01
    acetyl acetate 129.09
    di(2-ethylhexyl) phthalate 41.07
    ethyl propionate 234.03
    nitromethane 757.24
    1,2-diethoxyethane 115.28
    benzonitrile 44.3
    trioctyl phosphate 52.71
    1-bromopropane 34.14
    gamma-valerolactone 745.39
    n-decanol 62.2
    triethyl phosphate 47.97
    4-methyl-2-pentanol 186.03
    propionitrile 178.36
    vinylene carbonate 158.61
    1,1,2-trichlorotrifluoroethane 321.7
    DMS 76.47
    cumene 9.73
    2-octanol 74.56
    2-hexanone 283.12
    octyl acetate 72.33
    limonene 18.38
    1,2-dimethoxyethane 751.27
    ethyl orthosilicate 41.24
    tributyl phosphate 47.83
    diacetone alcohol 554.79
    N,N-dimethylaniline 45.86
    acrylonitrile 222.96
    aniline 37.04
    1,3-propanediol 703.03
    bromobenzene 6.55
    dibromomethane 15.59
    1,1,2,2-tetrachloroethane 51.35
    2-methyl-cyclohexyl acetate 61.16
    tetrabutyl urea 70.58
    diisobutyl methanol 72.97
    2-phenylethanol 90.51
    styrene 8.17
    dioctyl adipate 66.66
    dimethyl sulfate 472.76
    ethyl butyrate 118.79
    methyl lactate 419.67
    butyl lactate 96.96
    diethyl carbonate 57.79
    propanediol butyl ether 202.83
    triethyl orthoformate 62.79
    p-tert-butyltoluene 14.4
    methyl 4-tert-butylbenzoate 100.27
    morpholine 523.62
    tert-butylamine 158.14
    n-dodecanol 46.09
    dimethoxymethane 1276.63
    ethylene carbonate 149.47
    cyrene 226.43
    2-ethoxyethyl acetate 103.29
    2-ethylhexyl acetate 51.21
    1,2,4-trichlorobenzene 14.61
    4-methylpyridine 74.59
    dibutyl ether 56.01
    2,6-dimethyl-4-heptanol 72.97
    DEF 364.84
    dimethyl isosorbide 310.24
    tetrachloroethylene 27.07
    eugenol 115.71
    triacetin 82.67
    span 80 134.5
    1,4-butanediol 312.5
    1,1-dichloroethane 42.63
    2-methyl-1-pentanol 167.52
    methyl formate 656.79
    2-methyl-1-butanol 202.75
    n-decane 4.84
    butyronitrile 232.97
    3,7-dimethyl-1-octanol 67.9
    1-chlorooctane 25.6
    1-chlorotetradecane 11.32
    n-nonane 4.28
    undecane 4.05
    tert-butylcyclohexane 4.41
    cyclooctane 1.15
    cyclopentanol 340.63
    tetrahydropyran 207.08
    tert-amyl methyl ether 118.71
    2,5,8-trioxanonane 263.04
    1-hexene 29.84
    2-isopropoxyethanol 384.67
    2,2,2-trifluoroethanol 145.07
    methyl butyrate 264.22

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction