2,6-Dihydroxy-4-Methylbenzaldehyde

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  • Identifiers

    CAS number
    526-37-4

    Molecular formula
    C8H8O3

    SMILES
    CC1=CC(=C(C(=C1)O)C=O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Phenolic 65.35%
    Odorless 39.01%
    Medicinal 37.93%
    Burnt 36.22%
    Spicy 35.85%
    Sweet 35.27%
    Woody 33.31%
    Bitter 33.27%
    Smoky 31.09%
    Vanilla 26.16%

     

    Flavor
    Bitter 69.89%
    Phenolic 42.84%
    Mild 28.24%
    Nutty 26.1%
    Odorless 25.99%
    Flat 22.55%
    Medical 22.06%
    Curry 21.92%
    Almond shell 21.89%
    Nitrile 21.76%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.6

    pKa est.
    8.85 (weak base)

    Molecular weight
    152.15 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    254°C

    Flash point

    • 142.91 ˚C est.

  • Synonyms

    • 2,6-Dihydroxy-4-methylbenzaldehyde
    • DTXSID10200574
    • RefChem:445575
    • DTXCID40123065
    • 801-750-9
    • 526-37-4
    • Atranol
    • Benzaldehyde, 2,6-dihydroxy-4-methyl-
    • 2,6-dihydroxy-4-methyl-benzaldehyde
    • p-Orsellinaldehyde
    • orcal
    • CHEMBL223288
    • SCHEMBL3185655
    • CHEBI:144118
    • JASONGFGOLHLGB-UHFFFAOYSA-N
    • EBC-14492
    • MSK001515
    • Atranol, analytical reference material
    • AKOS006292139
    • FD66159
    • CS-0245956
    • NS00134222
    • EN300-314017
    • Z1198164603
    • 2,6-Dihydroxy-4-methylbenzaldehyde, 4-Methyl-|A-resorcylaldehyde, p-Orsellinaldehyde
    • 526-37-4

  • Applications

    2,6-Dihydroxy-4-Methylbenzaldehyde (CAS 526-37-4) is primarily used as an aroma-building block and fragrance intermediate in the perfumery and flavor sectors, where its phenolic benzaldehyde structure contributes to scent notes and serves as a precursor to more complex odorants. It is also employed as a chemical building block in organic synthesis for the manufacture of pharmaceutical intermediates and other specialty chemicals. In cosmetics and personal care, it may function as a fragrance ingredient or fragrance intermediate in compliant formulations. Additionally, due to its multifunctional phenolic aldehyde framework, it is regarded as a versatile starting material for further aroma-related syntheses and industrial intermediates.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 395.81
    methanol 362.99
    isopropanol 282.46
    water 1.9
    ethyl acetate 312.97
    n-propanol 273.82
    acetone 734.93
    n-butanol 213.97
    acetonitrile 421.34
    DMF 674.7
    toluene 9.95
    isobutanol 162.43
    1,4-dioxane 437.93
    methyl acetate 346.42
    THF 1942.14
    2-butanone 331.17
    n-pentanol 152.48
    sec-butanol 173.4
    n-hexane 3.39
    ethylene glycol 140.27
    NMP 482.19
    cyclohexane 1.15
    DMSO 1531.63
    n-butyl acetate 111.47
    n-octanol 62.86
    chloroform 35.09
    n-propyl acetate 173.52
    acetic acid 362.67
    dichloromethane 48.66
    cyclohexanone 272.93
    propylene glycol 184.86
    isopropyl acetate 178.5
    DMAc 254.66
    2-ethoxyethanol 312.43
    isopentanol 164.97
    n-heptane 5.0
    ethyl formate 216.23
    1,2-dichloroethane 72.23
    n-hexanol 151.1
    2-methoxyethanol 671.29
    isobutyl acetate 93.16
    tetrachloromethane 8.66
    n-pentyl acetate 67.23
    transcutol 425.45
    n-heptanol 62.08
    ethylbenzene 8.73
    MIBK 199.45
    2-propoxyethanol 336.26
    tert-butanol 329.72
    MTBE 142.17
    2-butoxyethanol 131.61
    propionic acid 267.08
    o-xylene 9.92
    formic acid 195.45
    diethyl ether 169.37
    m-xylene 17.36
    p-xylene 11.83
    chlorobenzene 21.75
    dimethyl carbonate 185.21
    n-octane 2.36
    formamide 360.28
    cyclopentanone 731.16
    2-pentanone 339.74
    anisole 68.36
    cyclopentyl methyl ether 311.97
    gamma-butyrolactone 1000.7
    1-methoxy-2-propanol 559.42
    pyridine 79.88
    3-pentanone 150.91
    furfural 315.9
    n-dodecane 3.27
    diethylene glycol 302.66
    diisopropyl ether 47.79
    tert-amyl alcohol 171.02
    acetylacetone 416.33
    n-hexadecane 3.62
    acetophenone 70.66
    methyl propionate 279.17
    isopentyl acetate 92.18
    trichloroethylene 112.77
    n-nonanol 55.48
    cyclohexanol 110.06
    benzyl alcohol 60.27
    2-ethylhexanol 64.51
    isooctanol 50.81
    dipropyl ether 75.2
    1,2-dichlorobenzene 23.45
    ethyl lactate 110.91
    propylene carbonate 371.61
    n-methylformamide 459.4
    2-pentanol 158.33
    n-pentane 3.0
    1-propoxy-2-propanol 196.41
    1-methoxy-2-propyl acetate 177.43
    2-(2-methoxypropoxy) propanol 131.06
    mesitylene 13.31
    ε-caprolactone 260.94
    p-cymene 14.7
    epichlorohydrin 752.55
    1,1,1-trichloroethane 65.27
    2-aminoethanol 215.03
    morpholine-4-carbaldehyde 403.48
    sulfolane 947.66
    2,2,4-trimethylpentane 4.13
    2-methyltetrahydrofuran 595.75
    n-hexyl acetate 110.11
    isooctane 5.8
    2-(2-butoxyethoxy)ethanol 188.39
    sec-butyl acetate 103.02
    tert-butyl acetate 208.62
    decalin 3.05
    glycerin 250.42
    diglyme 293.23
    acrylic acid 228.59
    isopropyl myristate 45.94
    n-butyric acid 283.18
    acetyl acetate 175.17
    di(2-ethylhexyl) phthalate 42.8
    ethyl propionate 154.62
    nitromethane 865.41
    1,2-diethoxyethane 108.69
    benzonitrile 58.6
    trioctyl phosphate 42.59
    1-bromopropane 34.06
    gamma-valerolactone 660.26
    n-decanol 43.74
    triethyl phosphate 51.04
    4-methyl-2-pentanol 100.13
    propionitrile 190.52
    vinylene carbonate 221.89
    1,1,2-trichlorotrifluoroethane 237.33
    DMS 100.25
    cumene 10.93
    2-octanol 43.06
    2-hexanone 178.64
    octyl acetate 61.77
    limonene 24.07
    1,2-dimethoxyethane 394.11
    ethyl orthosilicate 44.78
    tributyl phosphate 45.84
    diacetone alcohol 327.67
    N,N-dimethylaniline 41.79
    acrylonitrile 228.89
    aniline 43.96
    1,3-propanediol 340.78
    bromobenzene 14.51
    dibromomethane 27.53
    1,1,2,2-tetrachloroethane 82.25
    2-methyl-cyclohexyl acetate 70.85
    tetrabutyl urea 58.3
    diisobutyl methanol 47.25
    2-phenylethanol 72.92
    styrene 8.4
    dioctyl adipate 66.99
    dimethyl sulfate 285.06
    ethyl butyrate 90.53
    methyl lactate 202.29
    butyl lactate 69.77
    diethyl carbonate 61.52
    propanediol butyl ether 138.61
    triethyl orthoformate 60.47
    p-tert-butyltoluene 17.07
    methyl 4-tert-butylbenzoate 92.97
    morpholine 574.91
    tert-butylamine 110.82
    n-dodecanol 32.78
    dimethoxymethane 579.86
    ethylene carbonate 202.03
    cyrene 157.27
    2-ethoxyethyl acetate 104.65
    2-ethylhexyl acetate 61.98
    1,2,4-trichlorobenzene 34.53
    4-methylpyridine 85.26
    dibutyl ether 49.98
    2,6-dimethyl-4-heptanol 47.25
    DEF 222.68
    dimethyl isosorbide 250.38
    tetrachloroethylene 39.44
    eugenol 91.8
    triacetin 104.31
    span 80 104.93
    1,4-butanediol 117.49
    1,1-dichloroethane 71.15
    2-methyl-1-pentanol 101.5
    methyl formate 445.38
    2-methyl-1-butanol 129.26
    n-decane 4.87
    butyronitrile 195.72
    3,7-dimethyl-1-octanol 61.0
    1-chlorooctane 25.77
    1-chlorotetradecane 11.32
    n-nonane 4.34
    undecane 3.97
    tert-butylcyclohexane 4.82
    cyclooctane 1.03
    cyclopentanol 268.0
    tetrahydropyran 287.06
    tert-amyl methyl ether 99.09
    2,5,8-trioxanonane 211.24
    1-hexene 18.19
    2-isopropoxyethanol 185.6
    2,2,2-trifluoroethanol 159.77
    methyl butyrate 186.26

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction