2,6-Diethylpyrazine

Overview IFRA Request a quote

  • Identifiers

    CAS number
    13067-27-1

    Molecular formula
    C8H12N2

    SMILES
    CCC1=CN=CC(=N1)CC

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Nutty 81.52%
    Roasted 74.39%
    Earthy 59.5%
    Cocoa 59.5%
    Hazelnut 55.72%
    Musty 52.84%
    Potato 52.12%
    Coffee 49.25%
    Green 49.18%
    Meaty 44.91%

     

    Flavor
    Nutty 56.03%
    Roasted 49.12%
    Earthy 45.89%
    Potato 43.53%
    Meaty 38.88%
    Musty 38.5%
    Vegetable 37.88%
    Green 36.74%
    Coffee 35.13%
    Woody 34.97%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.4

    pKa est.
    4.53 (weak acid)

    Molecular weight
    136.19 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Fast

    Boiling point est.
    187°C

    Flash point

    • 69.87 ˚C est.

  • Synonyms

    • 2,6-Diethylpyrazine
    • 13067-27-1
    • Pyrazine, 2,6-diethyl-
    • 2,6-diethyl-pyrazine
    • E1M79S9DNI
    • UNII-E1M79S9DNI
    • DTXSID80156670
    • 2,6-diethyl pyrazine
    • RefChem:83216
    • DTXCID7079161
    • 603-430-2
    • QDWOWLUANUBTGE-UHFFFAOYSA-N
    • 2,6-Diethylpyrazine (contains ~10% inorganics)
    • MFCD18447729
    • SCHEMBL830961
    • SCHEMBL3942618
    • CHEBI:192305
    • NAA06727
    • AKOS006372474
    • NS00024121
    • D86043
    • EN300-194482
    • 13067-27-1

  • Applications

    2,6-Diethylpyrazine is primarily used as an aroma and flavor ingredient, contributing roasted and nutty notes in fragrance and flavor applications. It is commonly evaluated for use in perfumery and food/beverage flavorings, and may appear in cosmetics and personal care formulations as a fragrance component. It may also function as an odorant in household cleaning products. In industrial manufacturing, it can serve as a building block or intermediate in the synthesis of heterocyclic compounds for research and development in chemical, agrochemical, and pharmaceutical applications.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 387.45
    methanol 387.12
    isopropanol 306.84
    water 1.73
    ethyl acetate 444.64
    n-propanol 348.27
    acetone 673.64
    n-butanol 333.22
    acetonitrile 527.73
    DMF 896.35
    toluene 383.03
    isobutanol 308.64
    1,4-dioxane 631.61
    methyl acetate 460.74
    THF 864.66
    2-butanone 566.06
    n-pentanol 295.22
    sec-butanol 328.29
    n-hexane 115.89
    ethylene glycol 94.9
    NMP 901.89
    cyclohexane 185.84
    DMSO 790.34
    n-butyl acetate 711.34
    n-octanol 283.36
    chloroform 2492.99
    n-propyl acetate 403.2
    acetic acid 526.07
    dichloromethane 2502.5
    cyclohexanone 919.24
    propylene glycol 125.24
    isopropyl acetate 273.24
    DMAc 666.28
    2-ethoxyethanol 319.56
    isopentanol 282.45
    n-heptane 133.61
    ethyl formate 532.16
    1,2-dichloroethane 1179.61
    n-hexanol 395.9
    2-methoxyethanol 455.99
    isobutyl acetate 259.91
    tetrachloromethane 529.0
    n-pentyl acetate 395.9
    transcutol 715.91
    n-heptanol 245.93
    ethylbenzene 263.65
    MIBK 248.97
    2-propoxyethanol 409.8
    tert-butanol 318.2
    MTBE 307.57
    2-butoxyethanol 312.31
    propionic acid 413.86
    o-xylene 274.67
    formic acid 140.55
    diethyl ether 333.36
    m-xylene 263.58
    p-xylene 393.44
    chlorobenzene 808.14
    dimethyl carbonate 217.87
    n-octane 69.71
    formamide 200.5
    cyclopentanone 993.67
    2-pentanone 422.85
    anisole 362.35
    cyclopentyl methyl ether 439.38
    gamma-butyrolactone 1137.85
    1-methoxy-2-propanol 333.7
    pyridine 960.12
    3-pentanone 377.08
    furfural 1119.18
    n-dodecane 61.82
    diethylene glycol 238.97
    diisopropyl ether 134.03
    tert-amyl alcohol 319.87
    acetylacetone 457.87
    n-hexadecane 70.09
    acetophenone 399.72
    methyl propionate 394.29
    isopentyl acetate 519.34
    trichloroethylene 2361.77
    n-nonanol 230.26
    cyclohexanol 352.98
    benzyl alcohol 316.22
    2-ethylhexanol 318.56
    isooctanol 194.57
    dipropyl ether 350.39
    1,2-dichlorobenzene 806.67
    ethyl lactate 196.02
    propylene carbonate 807.34
    n-methylformamide 455.91
    2-pentanol 229.81
    n-pentane 100.15
    1-propoxy-2-propanol 366.15
    1-methoxy-2-propyl acetate 366.96
    2-(2-methoxypropoxy) propanol 267.63
    mesitylene 193.57
    ε-caprolactone 728.33
    p-cymene 258.76
    epichlorohydrin 1110.54
    1,1,1-trichloroethane 1218.44
    2-aminoethanol 171.46
    morpholine-4-carbaldehyde 720.54
    sulfolane 1328.44
    2,2,4-trimethylpentane 67.98
    2-methyltetrahydrofuran 679.74
    n-hexyl acetate 518.44
    isooctane 46.99
    2-(2-butoxyethoxy)ethanol 332.16
    sec-butyl acetate 229.81
    tert-butyl acetate 255.56
    decalin 103.91
    glycerin 155.84
    diglyme 627.91
    acrylic acid 394.68
    isopropyl myristate 208.72
    n-butyric acid 549.44
    acetyl acetate 315.91
    di(2-ethylhexyl) phthalate 205.84
    ethyl propionate 331.8
    nitromethane 762.85
    1,2-diethoxyethane 398.83
    benzonitrile 708.14
    trioctyl phosphate 167.85
    1-bromopropane 715.12
    gamma-valerolactone 991.72
    n-decanol 179.28
    triethyl phosphate 212.43
    4-methyl-2-pentanol 135.19
    propionitrile 502.53
    vinylene carbonate 830.72
    1,1,2-trichlorotrifluoroethane 726.88
    DMS 346.31
    cumene 201.28
    2-octanol 203.49
    2-hexanone 416.79
    octyl acetate 276.13
    limonene 343.41
    1,2-dimethoxyethane 598.16
    ethyl orthosilicate 196.28
    tributyl phosphate 210.13
    diacetone alcohol 259.56
    N,N-dimethylaniline 288.06
    acrylonitrile 656.23
    aniline 387.67
    1,3-propanediol 250.37
    bromobenzene 1003.25
    dibromomethane 1657.98
    1,1,2,2-tetrachloroethane 1738.22
    2-methyl-cyclohexyl acetate 335.5
    tetrabutyl urea 272.13
    diisobutyl methanol 170.31
    2-phenylethanol 365.37
    styrene 346.2
    dioctyl adipate 300.12
    dimethyl sulfate 343.24
    ethyl butyrate 457.34
    methyl lactate 199.6
    butyl lactate 284.95
    diethyl carbonate 337.95
    propanediol butyl ether 288.25
    triethyl orthoformate 290.3
    p-tert-butyltoluene 218.68
    methyl 4-tert-butylbenzoate 342.33
    morpholine 619.51
    tert-butylamine 249.35
    n-dodecanol 148.83
    dimethoxymethane 450.31
    ethylene carbonate 645.84
    cyrene 278.59
    2-ethoxyethyl acetate 380.8
    2-ethylhexyl acetate 428.2
    1,2,4-trichlorobenzene 841.39
    4-methylpyridine 881.05
    dibutyl ether 369.45
    2,6-dimethyl-4-heptanol 170.31
    DEF 537.98
    dimethyl isosorbide 473.27
    tetrachloroethylene 1240.01
    eugenol 332.7
    triacetin 357.05
    span 80 283.5
    1,4-butanediol 146.29
    1,1-dichloroethane 1191.54
    2-methyl-1-pentanol 265.07
    methyl formate 457.54
    2-methyl-1-butanol 301.65
    n-decane 93.9
    butyronitrile 593.1
    3,7-dimethyl-1-octanol 239.42
    1-chlorooctane 307.18
    1-chlorotetradecane 131.66
    n-nonane 98.12
    undecane 73.54
    tert-butylcyclohexane 94.89
    cyclooctane 70.15
    cyclopentanol 441.0
    tetrahydropyran 649.41
    tert-amyl methyl ether 253.55
    2,5,8-trioxanonane 430.14
    1-hexene 289.65
    2-isopropoxyethanol 229.07
    2,2,2-trifluoroethanol 191.62
    methyl butyrate 514.96

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction