2,6-Diethyl-3,5-dimethylpyrazine

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  • Identifiers

    CAS number
    18940-74-4

    Molecular formula
    C10H16N2

    SMILES
    CCC1=C(N=C(C(=N1)CC)C)C

    Safety labels

  • Odor profile

    Fragrance
    Nutty 74.81%
    Roasted 68.84%
    Earthy 63.99%
    Cocoa 57.87%
    Burnt 57.82%
    Musty 55.76%
    Hazelnut 55.53%
    Coffee 48.68%
    Potato 47.5%
    Chocolate 47.47%

     

    Flavor
    Nutty 62.32%
    Earthy 57.05%
    Roasted 53.99%
    Potato 49.89%
    Meaty 48.32%
    Hazelnut 47.58%
    Musty 47.18%
    Roast 43.05%
    Burnt 42.28%
    Coffee 41.18%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.2

    pKa est.
    5.17 (weak acid)

    Molecular weight
    164.25 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately slow

    Boiling point est.
    224°C

    Flash point

    • 79.2 ˚C est.

  • Synonyms

    • 2,6-Diethyl-3,5-dimethylpyrazine
    • 18940-74-4
    • RefChem:83210
    • LQIGIQZSHAYEKN-UHFFFAOYSA-N
    • Pyrazine, 2,6-diethyl-3,5-dimethyl-
    • BJL23XD5UT
    • SCHEMBL10391849
    • CHEBI:193708
    • DTXSID501301090
    • 2,6-Dimethyl-3,5-diethylpyrazine
    • 3,5-Diethyl-2,6-dimethylpyrazine
    • AKOS006370980
    • 18940-74-4

  • Applications

    2,6-Diethyl-3,5-dimethylpyrazine (CAS 18940-74-4) is used primarily as an aroma and flavor ingredient in the fragrance and flavor industries, contributing roasted, nutty, and cocoa-like notes; it is commonly evaluated as an odorant for cosmetics/personal care products and for household cleaners and air fresheners, as well as for specialized coatings and inks to impart a warm character; it may also serve as an intermediate in the synthesis of other pyrazine-based aroma compounds for the flavor and fragrance sectors, and can appear in polymer or materials formulations where odor performance is desired, subject to local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 840.99
    methanol 971.06
    isopropanol 600.0
    water 2.44
    ethyl acetate 1038.16
    n-propanol 829.52
    acetone 1027.03
    n-butanol 795.71
    acetonitrile 952.44
    DMF 1237.93
    toluene 1025.73
    isobutanol 646.52
    1,4-dioxane 1628.3
    methyl acetate 907.31
    THF 2140.06
    2-butanone 1042.73
    n-pentanol 700.59
    sec-butanol 732.2
    n-hexane 540.27
    ethylene glycol 129.53
    NMP 1370.58
    cyclohexane 732.83
    DMSO 937.02
    n-butyl acetate 1440.59
    n-octanol 598.32
    chloroform 5091.69
    n-propyl acetate 825.05
    acetic acid 675.01
    dichloromethane 5027.47
    cyclohexanone 1817.54
    propylene glycol 162.63
    isopropyl acetate 642.37
    DMAc 993.41
    2-ethoxyethanol 619.1
    isopentanol 623.05
    n-heptane 445.79
    ethyl formate 938.53
    1,2-dichloroethane 2352.75
    n-hexanol 947.39
    2-methoxyethanol 853.88
    isobutyl acetate 581.6
    tetrachloromethane 1359.11
    n-pentyl acetate 867.73
    transcutol 1092.34
    n-heptanol 513.6
    ethylbenzene 724.26
    MIBK 561.24
    2-propoxyethanol 849.29
    tert-butanol 591.72
    MTBE 840.92
    2-butoxyethanol 583.32
    propionic acid 594.99
    o-xylene 685.41
    formic acid 218.35
    diethyl ether 1246.04
    m-xylene 697.06
    p-xylene 1032.55
    chlorobenzene 1614.51
    dimethyl carbonate 429.06
    n-octane 229.3
    formamide 308.0
    cyclopentanone 1797.67
    2-pentanone 912.2
    anisole 814.52
    cyclopentyl methyl ether 1240.85
    gamma-butyrolactone 1911.78
    1-methoxy-2-propanol 571.88
    pyridine 1787.79
    3-pentanone 851.42
    furfural 1668.16
    n-dodecane 157.17
    diethylene glycol 409.91
    diisopropyl ether 415.16
    tert-amyl alcohol 636.9
    acetylacetone 883.47
    n-hexadecane 181.52
    acetophenone 764.39
    methyl propionate 794.22
    isopentyl acetate 1083.18
    trichloroethylene 3950.99
    n-nonanol 485.16
    cyclohexanol 844.89
    benzyl alcohol 615.85
    2-ethylhexanol 708.24
    isooctanol 409.02
    dipropyl ether 931.15
    1,2-dichlorobenzene 1491.12
    ethyl lactate 319.45
    propylene carbonate 1239.32
    n-methylformamide 717.75
    2-pentanol 549.57
    n-pentane 410.9
    1-propoxy-2-propanol 644.28
    1-methoxy-2-propyl acetate 752.09
    2-(2-methoxypropoxy) propanol 435.31
    mesitylene 487.32
    ε-caprolactone 1384.11
    p-cymene 580.02
    epichlorohydrin 2112.48
    1,1,1-trichloroethane 2394.25
    2-aminoethanol 275.28
    morpholine-4-carbaldehyde 1151.57
    sulfolane 1749.13
    2,2,4-trimethylpentane 196.06
    2-methyltetrahydrofuran 1664.12
    n-hexyl acetate 1091.35
    isooctane 133.29
    2-(2-butoxyethoxy)ethanol 545.35
    sec-butyl acetate 534.08
    tert-butyl acetate 575.14
    decalin 327.62
    glycerin 190.55
    diglyme 1102.5
    acrylic acid 493.61
    isopropyl myristate 446.33
    n-butyric acid 937.81
    acetyl acetate 723.82
    di(2-ethylhexyl) phthalate 367.09
    ethyl propionate 761.91
    nitromethane 1023.24
    1,2-diethoxyethane 969.76
    benzonitrile 1225.27
    trioctyl phosphate 312.94
    1-bromopropane 1711.89
    gamma-valerolactone 1777.16
    n-decanol 365.56
    triethyl phosphate 436.7
    4-methyl-2-pentanol 313.82
    propionitrile 969.56
    vinylene carbonate 1319.71
    1,1,2-trichlorotrifluoroethane 1003.32
    DMS 706.19
    cumene 520.39
    2-octanol 455.58
    2-hexanone 829.55
    octyl acetate 562.64
    limonene 754.46
    1,2-dimethoxyethane 1274.21
    ethyl orthosilicate 426.3
    tributyl phosphate 392.4
    diacetone alcohol 432.97
    N,N-dimethylaniline 648.75
    acrylonitrile 1066.41
    aniline 788.64
    1,3-propanediol 441.58
    bromobenzene 2051.11
    dibromomethane 3453.11
    1,1,2,2-tetrachloroethane 2936.52
    2-methyl-cyclohexyl acetate 681.72
    tetrabutyl urea 470.94
    diisobutyl methanol 334.61
    2-phenylethanol 726.53
    styrene 875.86
    dioctyl adipate 548.02
    dimethyl sulfate 531.57
    ethyl butyrate 956.28
    methyl lactate 283.45
    butyl lactate 481.81
    diethyl carbonate 689.48
    propanediol butyl ether 435.91
    triethyl orthoformate 624.45
    p-tert-butyltoluene 508.55
    methyl 4-tert-butylbenzoate 596.34
    morpholine 1454.53
    tert-butylamine 530.47
    n-dodecanol 292.41
    dimethoxymethane 1053.59
    ethylene carbonate 1100.37
    cyrene 440.12
    2-ethoxyethyl acetate 813.69
    2-ethylhexyl acetate 1006.99
    1,2,4-trichlorobenzene 1479.57
    4-methylpyridine 1746.78
    dibutyl ether 909.49
    2,6-dimethyl-4-heptanol 334.61
    DEF 1028.38
    dimethyl isosorbide 860.58
    tetrachloroethylene 2305.4
    eugenol 538.87
    triacetin 649.31
    span 80 455.78
    1,4-butanediol 254.16
    1,1-dichloroethane 2232.41
    2-methyl-1-pentanol 630.1
    methyl formate 715.34
    2-methyl-1-butanol 673.7
    n-decane 265.37
    butyronitrile 1218.44
    3,7-dimethyl-1-octanol 473.07
    1-chlorooctane 702.68
    1-chlorotetradecane 287.73
    n-nonane 297.0
    undecane 194.86
    tert-butylcyclohexane 277.65
    cyclooctane 307.07
    cyclopentanol 882.58
    tetrahydropyran 1845.36
    tert-amyl methyl ether 680.64
    2,5,8-trioxanonane 713.4
    1-hexene 1005.38
    2-isopropoxyethanol 439.28
    2,2,2-trifluoroethanol 259.5
    methyl butyrate 988.1

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction