2,6-Dibromophenol

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  • Identifiers

    CAS number
    608-33-3

    Molecular formula
    C6H4Br2O

    SMILES
    C1=CC(=C(C(=C1)Br)O)Br

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Phenolic 59.56%
    Burnt 46.08%
    Smoky 44.9%
    Odorless 34.98%
    Meaty 34.03%
    Medicinal 33.95%
    Spicy 28.96%
    Savory 25.65%
    Vanilla 24.5%
    Roasted 23.7%

     

    Flavor
    Bitter 43.44%
    Mild 31.77%
    Meaty 30.92%
    Phenolic 26.23%
    Sulfurous 24.55%
    Odorless 24.13%
    Roasted 21.65%
    Penetrating 20.59%
    Very strong 20.56%
    Scallion 20.37%

     

    Odor impact est.
    Medium

    Odor threshold

    • The flavor threshold for 2,6-dibromophenol in drinking water is 0.0005 ug/L. /flavor threshold/

  • Properties

    XLogP3-AA
    3.4

    pKa est.
    6.97 (neutral)

    Molecular weight
    251.9 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Melting point expt.

    • 56.5 °C
    • 56 - 57 °C

    Boiling point

    • 255 °C; 162 °C at 21 mm Hg

    Flash point

    • 94.87 ˚C est.

    Solubility expt.

    • Very soluble in ethanol, ether

  • Synonyms

    • 2,6-DIBROMOPHENOL
    • 608-33-3
    • Phenol, 2,6-dibromo-
    • 27MIP05EAV
    • DTXSID0060561
    • NSC-6214
    • CHEBI:19391
    • 2,6-DBP
    • RefChem:83148
    • DTXCID9042883
    • 210-161-0
    • 2,6-Dibromo-phenol
    • MFCD00002152
    • 2,6-Bis(Bromanyl)phenol
    • CHEMBL111507
    • 59779-25-8
    • UNII-27MIP05EAV
    • HSDB 7652
    • NSC 6214
    • EINECS 210-161-0
    • 94N
    • 2,6-Dibromophenol, 99%
    • SCHEMBL320975
    • SCHEMBL416446
    • orb1303728
    • orb3026080
    • SCHEMBL1045881
    • MSK2934
    • NSC6214
    • 2,6-DIBROMOPHENOL [HSDB]
    • HY-Y1667
    • BDBM50150789
    • SBB101028
    • AKOS009152462
    • 2,6-Dibromophenol, analytical standard
    • CS-W009153
    • FD21596
    • AC-23653
    • AS-14432
    • PD158453
    • SY014521
    • DB-005881
    • D3384
    • NS00034466
    • ST50826657
    • EN300-29657
    • 608D333
    • AJ-087/41885654
    • F077432
    • Q209273
    • Phenol, 2,6-dibromo-; 2,6-Dibromophenol; NSC 6214
    • Z285522740
    • InChI=1/C6H4Br2O/c7-4-2-1-3-5(8)6(4)9/h1-3,9
    • 608-33-3

  • Applications

    2,6-Dibromophenol (CAS 608-33-3) is used primarily as an organic synthesis intermediate; in practice it is employed as a building block to prepare other aryl bromide derivatives, as well as intermediates for pharmaceutical and agrochemical compounds. It also serves as a precursor in polymer and plastics chemistry for brominated phenol derivatives and related specialty chemicals. Additionally, it may be explored as a starting material for flame-retardant formulations or stabilizers, depending on formulation needs and local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 43.82
    methanol 36.68
    isopropanol 32.52
    water 0.6
    ethyl acetate 44.74
    n-propanol 38.81
    acetone 51.45
    n-butanol 41.31
    acetonitrile 15.84
    DMF 76.86
    toluene 17.58
    isobutanol 27.62
    1,4-dioxane 119.07
    methyl acetate 43.02
    THF 231.63
    2-butanone 48.96
    n-pentanol 48.11
    sec-butanol 34.32
    n-hexane 5.34
    ethylene glycol 17.28
    NMP 96.9
    cyclohexane 4.21
    DMSO 75.36
    n-butyl acetate 65.79
    n-octanol 35.47
    chloroform 43.0
    n-propyl acetate 57.63
    acetic acid 38.6
    dichloromethane 35.8
    cyclohexanone 61.66
    propylene glycol 14.94
    isopropyl acetate 47.16
    DMAc 73.51
    2-ethoxyethanol 110.98
    isopentanol 39.93
    n-heptane 13.43
    ethyl formate 33.97
    1,2-dichloroethane 27.62
    n-hexanol 54.71
    2-methoxyethanol 108.62
    isobutyl acetate 43.96
    tetrachloromethane 9.49
    n-pentyl acetate 57.46
    transcutol 257.78
    n-heptanol 39.71
    ethylbenzene 15.44
    MIBK 55.31
    2-propoxyethanol 121.88
    tert-butanol 44.96
    MTBE 53.24
    2-butoxyethanol 86.0
    propionic acid 24.26
    o-xylene 16.53
    formic acid 22.12
    diethyl ether 61.82
    m-xylene 19.04
    p-xylene 16.52
    chlorobenzene 18.12
    dimethyl carbonate 28.29
    n-octane 6.42
    formamide 41.15
    cyclopentanone 87.89
    2-pentanone 59.61
    anisole 54.13
    cyclopentyl methyl ether 91.34
    gamma-butyrolactone 89.86
    1-methoxy-2-propanol 93.48
    pyridine 45.34
    3-pentanone 37.87
    furfural 85.26
    n-dodecane 4.99
    diethylene glycol 97.22
    diisopropyl ether 32.61
    tert-amyl alcohol 45.53
    acetylacetone 68.63
    n-hexadecane 5.53
    acetophenone 49.64
    methyl propionate 39.59
    isopentyl acetate 59.81
    trichloroethylene 46.4
    n-nonanol 37.35
    cyclohexanol 36.71
    benzyl alcohol 42.51
    2-ethylhexanol 45.92
    isooctanol 36.49
    dipropyl ether 66.24
    1,2-dichlorobenzene 20.6
    ethyl lactate 37.1
    propylene carbonate 49.73
    n-methylformamide 40.96
    2-pentanol 38.21
    n-pentane 6.89
    1-propoxy-2-propanol 100.86
    1-methoxy-2-propyl acetate 91.24
    2-(2-methoxypropoxy) propanol 87.58
    mesitylene 16.05
    ε-caprolactone 70.02
    p-cymene 25.93
    epichlorohydrin 108.28
    1,1,1-trichloroethane 23.7
    2-aminoethanol 29.0
    morpholine-4-carbaldehyde 131.27
    sulfolane 98.63
    2,2,4-trimethylpentane 6.04
    2-methyltetrahydrofuran 125.05
    n-hexyl acetate 59.59
    isooctane 6.4
    2-(2-butoxyethoxy)ethanol 122.84
    sec-butyl acetate 48.1
    tert-butyl acetate 69.81
    decalin 5.45
    glycerin 29.9
    diglyme 181.37
    acrylic acid 23.48
    isopropyl myristate 38.89
    n-butyric acid 38.14
    acetyl acetate 31.87
    di(2-ethylhexyl) phthalate 32.65
    ethyl propionate 44.68
    nitromethane 61.79
    1,2-diethoxyethane 116.04
    benzonitrile 30.63
    trioctyl phosphate 27.55
    1-bromopropane 21.94
    gamma-valerolactone 134.49
    n-decanol 30.42
    triethyl phosphate 36.25
    4-methyl-2-pentanol 33.29
    propionitrile 20.75
    vinylene carbonate 41.84
    1,1,2-trichlorotrifluoroethane 75.52
    DMS 43.73
    cumene 15.61
    2-octanol 33.11
    2-hexanone 60.46
    octyl acetate 43.36
    limonene 36.44
    1,2-dimethoxyethane 153.86
    ethyl orthosilicate 40.37
    tributyl phosphate 31.17
    diacetone alcohol 86.91
    N,N-dimethylaniline 42.02
    acrylonitrile 22.76
    aniline 29.96
    1,3-propanediol 46.51
    bromobenzene 15.25
    dibromomethane 24.25
    1,1,2,2-tetrachloroethane 40.77
    2-methyl-cyclohexyl acetate 57.61
    tetrabutyl urea 43.74
    diisobutyl methanol 38.93
    2-phenylethanol 55.78
    styrene 17.11
    dioctyl adipate 49.77
    dimethyl sulfate 40.13
    ethyl butyrate 60.13
    methyl lactate 34.92
    butyl lactate 48.71
    diethyl carbonate 36.53
    propanediol butyl ether 61.51
    triethyl orthoformate 55.18
    p-tert-butyltoluene 27.53
    methyl 4-tert-butylbenzoate 64.45
    morpholine 123.75
    tert-butylamine 30.57
    n-dodecanol 24.93
    dimethoxymethane 102.65
    ethylene carbonate 35.54
    cyrene 90.81
    2-ethoxyethyl acetate 84.0
    2-ethylhexyl acetate 52.96
    1,2,4-trichlorobenzene 29.26
    4-methylpyridine 43.39
    dibutyl ether 49.31
    2,6-dimethyl-4-heptanol 38.93
    DEF 65.76
    dimethyl isosorbide 158.44
    tetrachloroethylene 30.83
    eugenol 75.36
    triacetin 66.16
    span 80 74.12
    1,4-butanediol 28.59
    1,1-dichloroethane 22.46
    2-methyl-1-pentanol 45.85
    methyl formate 35.89
    2-methyl-1-butanol 34.35
    n-decane 7.68
    butyronitrile 26.66
    3,7-dimethyl-1-octanol 39.36
    1-chlorooctane 22.28
    1-chlorotetradecane 12.21
    n-nonane 6.99
    undecane 6.03
    tert-butylcyclohexane 7.41
    cyclooctane 3.39
    cyclopentanol 46.2
    tetrahydropyran 83.56
    tert-amyl methyl ether 55.85
    2,5,8-trioxanonane 149.51
    1-hexene 17.35
    2-isopropoxyethanol 94.45
    2,2,2-trifluoroethanol 24.95
    methyl butyrate 50.77

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction