2,6-Di-tert-butyl-4-methylpyridine

Overview IFRA Request a quote

  • Identifiers

    CAS number
    38222-83-2

    Molecular formula
    C14H23N

    SMILES
    CC1=CC(=NC(=C1)C(C)(C)C)C(C)(C)C

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Green 58.11%
    Woody 47.51%
    Earthy 44.11%
    Vetiver 34.9%
    Leathery 33.91%
    Leafy 31.19%
    Burnt 30.73%
    Mint 30.68%
    Dry 30.63%
    Animal 30.26%

     

    Flavor
    Musty 36.68%
    Camphor 32.55%
    Green 31.92%
    Earthy 31.01%
    Woody 26.55%
    Earth 25.13%
    Phenolic 25.05%
    Mild 24.29%
    Green pepper 23.13%
    Burnt 22.15%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    4.6

    pKa est.
    6.25 (neutral)

    Molecular weight
    205.34 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately fast

    Boiling point est.
    218°C

    Flash point

    • 85.5 ˚C est.

  • Synonyms

    • 2,6-Di-tert-butyl-4-methylpyridine
    • 38222-83-2
    • 2,6-ditert-butyl-4-methylpyridine
    • DTBMP
    • 2,6-di-t-Butyl-4-methylpyridine
    • MFCD00006305
    • Pyridine, 2,6-bis(1,1-dimethylethyl)-4-methyl-
    • 2,6-di-tert-butyl-4-picoline
    • UNII-83004E89V5
    • 4-methyl-2,6-di-tert-butylpyridine
    • EINECS 253-834-4
    • 2,6-di-tert-butyl-4-methyl-pyridine
    • NSC-175792
    • 83004E89V5
    • 2,6-bis(1,1-dimethylethyl)-4-methylpyridine
    • DTXSID10191615
    • 2,6-di-t-butyl-4-methyl-pyridine
    • NSC 175792
    • 2,6-DI-TERT-BUTYL-4-METHYLPYRIDINE [MI]
    • IDINE, 2,6-BIS(1,1-DIMETHYLETHYL)-4-METHYL-
    • 2,6-di-tert-Butyl-4-picoline; 2,6-Bis(tert-butyl)-4-methylpyridine;2,6-Di-tert-butyl-4-methylpyridine; 4-Methyl-2,6-di-tert-butylpyridine;DTBMP; NSC 175792
    • 2,6-ditert-butyl-4-methyl-pyridine
    • NSC175792
    • 2,6Ditertbutyl4picoline
    • SCHEMBL37832
    • 4Methyl2,6ditertbutylpyridine
    • DTXCID50114106
    • 2,6-di-t-butyl 4-methylpyridine
    • 2,6-di-tert-butyl-4methylpyridine
    • 2,6-di-t- butyl-4-methylpyridine
    • 2,6-di-t-butyl-4-methyl pyridine
    • 2,6-di-tert-butyl4-methyl-pyridine
    • 2,6-di-tertbutyl-4-methyl-pyridine
    • AC1509
    • BBL102260
    • STL556059
    • 2,6-di(tert-butyl)-4-methylpyridine
    • 2,6-di-tert-butyl-4-methyl pyridine
    • AKOS015838101
    • AC-5133
    • CS-W007500
    • FD11107
    • HY-W007500
    • SB52248
    • 2,6-di-tert-butyl-(4-methylpyridine)
    • 2,6Bis(1,1dimethylethyl)4methylpyridine
    • SY005669
    • TS-00365
    • 2,6-Di-tert-butyl-4-methylpyridine, 98%
    • DB-049250
    • D2419
    • NS00030360
    • EN300-316978
    • AE-562/42754364
    • Q27269366
    • 253-834-4

  • Applications

    2,6-Di-tert-butyl-4-methylpyridine (CAS 38222-83-2) is commonly used as a building block for synthesizing substituted pyridines in pharmaceutical, agrochemical, and materials research; it can also function as a hindered base or a ligand in organic catalytic processes and selective transformations. It is considered an important intermediate for diversifying pyridine scaffolds to support medicinal chemistry research, and may serve as a precursor for specialty ligands and catalysts used in synthesis and industrial production.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 68.53
    methanol 36.62
    isopropanol 98.38
    water 0.29
    ethyl acetate 180.76
    n-propanol 102.83
    acetone 203.02
    n-butanol 119.5
    acetonitrile 101.18
    DMF 292.14
    toluene 313.82
    isobutanol 128.66
    1,4-dioxane 278.16
    methyl acetate 205.49
    THF 610.06
    2-butanone 289.71
    n-pentanol 131.91
    sec-butanol 157.7
    n-hexane 173.73
    ethylene glycol 17.38
    NMP 500.22
    cyclohexane 195.23
    DMSO 147.75
    n-butyl acetate 394.91
    n-octanol 224.03
    chloroform 731.98
    n-propyl acetate 219.71
    acetic acid 79.59
    dichloromethane 460.11
    cyclohexanone 501.73
    propylene glycol 53.16
    isopropyl acetate 181.5
    DMAc 411.15
    2-ethoxyethanol 109.8
    isopentanol 149.34
    n-heptane 225.55
    ethyl formate 146.34
    1,2-dichloroethane 261.47
    n-hexanol 300.27
    2-methoxyethanol 122.64
    isobutyl acetate 234.21
    tetrachloromethane 166.69
    n-pentyl acetate 249.81
    transcutol 237.48
    n-heptanol 208.68
    ethylbenzene 322.74
    MIBK 210.67
    2-propoxyethanol 256.42
    tert-butanol 184.34
    MTBE 289.79
    2-butoxyethanol 226.18
    propionic acid 113.25
    o-xylene 303.27
    formic acid 14.93
    diethyl ether 158.62
    m-xylene 294.22
    p-xylene 447.99
    chlorobenzene 339.13
    dimethyl carbonate 99.85
    n-octane 113.06
    formamide 26.22
    cyclopentanone 587.22
    2-pentanone 229.7
    anisole 321.39
    cyclopentyl methyl ether 384.07
    gamma-butyrolactone 473.95
    1-methoxy-2-propanol 155.84
    pyridine 348.8
    3-pentanone 232.18
    furfural 417.49
    n-dodecane 93.71
    diethylene glycol 107.11
    diisopropyl ether 140.64
    tert-amyl alcohol 234.96
    acetylacetone 246.2
    n-hexadecane 103.96
    acetophenone 332.32
    methyl propionate 188.69
    isopentyl acetate 434.91
    trichloroethylene 571.49
    n-nonanol 211.74
    cyclohexanol 228.67
    benzyl alcohol 208.82
    2-ethylhexanol 328.27
    isooctanol 192.5
    dipropyl ether 307.36
    1,2-dichlorobenzene 356.59
    ethyl lactate 142.42
    propylene carbonate 394.65
    n-methylformamide 92.12
    2-pentanol 138.98
    n-pentane 107.12
    1-propoxy-2-propanol 292.56
    1-methoxy-2-propyl acetate 311.88
    2-(2-methoxypropoxy) propanol 258.49
    mesitylene 241.16
    ε-caprolactone 420.18
    p-cymene 336.69
    epichlorohydrin 421.41
    1,1,1-trichloroethane 459.79
    2-aminoethanol 39.38
    morpholine-4-carbaldehyde 382.42
    sulfolane 524.59
    2,2,4-trimethylpentane 104.32
    2-methyltetrahydrofuran 482.41
    n-hexyl acetate 373.12
    isooctane 81.25
    2-(2-butoxyethoxy)ethanol 248.87
    sec-butyl acetate 202.35
    tert-butyl acetate 252.01
    decalin 169.82
    glycerin 56.02
    diglyme 359.53
    acrylic acid 97.7
    isopropyl myristate 233.31
    n-butyric acid 172.22
    acetyl acetate 139.51
    di(2-ethylhexyl) phthalate 233.87
    ethyl propionate 207.3
    nitromethane 144.86
    1,2-diethoxyethane 208.93
    benzonitrile 303.98
    trioctyl phosphate 185.0
    1-bromopropane 284.4
    gamma-valerolactone 520.53
    n-decanol 180.49
    triethyl phosphate 205.24
    4-methyl-2-pentanol 131.04
    propionitrile 162.22
    vinylene carbonate 324.9
    1,1,2-trichlorotrifluoroethane 291.18
    DMS 239.56
    cumene 285.66
    2-octanol 188.25
    2-hexanone 280.84
    octyl acetate 268.33
    limonene 392.89
    1,2-dimethoxyethane 275.8
    ethyl orthosilicate 198.46
    tributyl phosphate 193.35
    diacetone alcohol 224.53
    N,N-dimethylaniline 348.25
    acrylonitrile 155.87
    aniline 203.99
    1,3-propanediol 62.31
    bromobenzene 433.89
    dibromomethane 383.02
    1,1,2,2-tetrachloroethane 579.48
    2-methyl-cyclohexyl acetate 397.63
    tetrabutyl urea 259.78
    diisobutyl methanol 203.12
    2-phenylethanol 312.84
    styrene 292.59
    dioctyl adipate 290.07
    dimethyl sulfate 162.05
    ethyl butyrate 316.02
    methyl lactate 120.98
    butyl lactate 233.58
    diethyl carbonate 221.01
    propanediol butyl ether 217.59
    triethyl orthoformate 272.46
    p-tert-butyltoluene 348.12
    methyl 4-tert-butylbenzoate 377.97
    morpholine 284.2
    tert-butylamine 174.44
    n-dodecanol 161.01
    dimethoxymethane 176.61
    ethylene carbonate 257.38
    cyrene 321.47
    2-ethoxyethyl acetate 217.79
    2-ethylhexyl acetate 407.48
    1,2,4-trichlorobenzene 432.56
    4-methylpyridine 432.43
    dibutyl ether 290.12
    2,6-dimethyl-4-heptanol 203.12
    DEF 252.76
    dimethyl isosorbide 487.88
    tetrachloroethylene 297.23
    eugenol 296.19
    triacetin 284.01
    span 80 308.85
    1,4-butanediol 48.64
    1,1-dichloroethane 351.26
    2-methyl-1-pentanol 175.57
    methyl formate 97.6
    2-methyl-1-butanol 162.79
    n-decane 133.6
    butyronitrile 189.06
    3,7-dimethyl-1-octanol 246.36
    1-chlorooctane 266.91
    1-chlorotetradecane 149.57
    n-nonane 136.38
    undecane 108.54
    tert-butylcyclohexane 181.73
    cyclooctane 123.75
    cyclopentanol 239.09
    tetrahydropyran 385.24
    tert-amyl methyl ether 281.54
    2,5,8-trioxanonane 297.42
    1-hexene 260.94
    2-isopropoxyethanol 130.69
    2,2,2-trifluoroethanol 41.59
    methyl butyrate 279.72

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction