(25R)-24-Methylene-3-oxo-9,19-cyclolanostan-26-oic acid

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  • Identifiers

    CAS number
    17984-17-7

    Molecular formula
    C31H48O3

    SMILES
    C[C@H](CCC(=C)[C@@H](C)C(=O)O)[C@H]1CC[C@@]2([C@@]1(CC[C@]34[C@H]2CC[C@@H]5[C@]3(C4)CCC(=O)C5(C)C)C)C

    Safety labels

  • Odor profile

    Fragrance
    Woody 88.64%
    Amber 54.9%
    Sandalwood 47.48%
    Cedar 47.05%
    Dry 46.35%
    Vetiver 41.52%
    Musk 35.31%
    Balsamic 33.19%
    Animal 32.76%
    Powdery 29.11%

     

    Flavor
    Woody 54.27%
    Wood 25.47%
    Herbal 24.22%
    Bitter 22.1%
    Sandalwood 22.06%
    Fir needle 21.31%
    Cedarleaf 20.91%
    Camphor 20.78%
    Balsam 20.22%
    Clary 19.91%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    8.9

    pKa est.
    7.47 (neutral)

    Molecular weight
    468.7 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    507°C

    Flash point

    • 195.98 ˚C est.

  • Synonyms

    • CHEMBL3953079
    • SCHEMBL29934767
    • (25R)-24-Methylene-3-oxo-9,19-cyclolanostan-26-oic acid
    • DTXSID001204021
    • 17984-17-7
    • (25R)-24-Methylidene-3-oxo-9beta-9,19-cyclolanostan-26-oic acid
    • 17984-17-7

  • Applications

    (25R)-24-Methylene-3-oxo-9,19-cyclolanostan-26-oic acid (CAS 17984-17-7) is primarily used as a chiral building block and intermediate in pharmaceutical steroid synthesis, supporting semi-synthetic corticosteroids and other steroidal drugs. In research and development, it serves as a scaffold for structure–activity investigations of lanostane-type compounds and is used as a reference material for analytical characterization in labs. Its carboxylic acid functionality allows conversion to esters, amides, and other derivatives to broaden synthetic routes. Additionally, it is considered a starting material for sterol-derived cosmetic ingredients and specialty industrial products. In some cases, it is evaluated as a reference standard and explored as a basis for biomaterial or specialty polymer research leveraging the rigid lanostane framework.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 8.73
    methanol 4.91
    isopropanol 9.03
    water 0.01
    ethyl acetate 4.81
    n-propanol 9.81
    acetone 5.53
    n-butanol 8.9
    acetonitrile 1.77
    DMF 15.7
    toluene 3.77
    isobutanol 6.2
    1,4-dioxane 11.98
    methyl acetate 3.59
    THF 25.21
    2-butanone 7.01
    n-pentanol 5.06
    sec-butanol 5.19
    n-hexane 0.17
    ethylene glycol 1.11
    NMP 12.31
    cyclohexane 0.19
    DMSO 6.37
    n-butyl acetate 4.78
    n-octanol 2.07
    chloroform 12.92
    n-propyl acetate 3.29
    acetic acid 5.86
    dichloromethane 6.56
    cyclohexanone 9.74
    propylene glycol 2.56
    isopropyl acetate 6.03
    DMAc 17.08
    2-ethoxyethanol 11.74
    isopentanol 6.85
    n-heptane 0.14
    ethyl formate 2.26
    1,2-dichloroethane 4.14
    n-hexanol 5.87
    2-methoxyethanol 18.79
    isobutyl acetate 3.55
    tetrachloromethane 2.07
    n-pentyl acetate 6.16
    transcutol 26.87
    n-heptanol 4.23
    ethylbenzene 1.7
    MIBK 6.45
    2-propoxyethanol 27.95
    tert-butanol 6.38
    MTBE 5.12
    2-butoxyethanol 15.77
    propionic acid 4.22
    o-xylene 1.94
    formic acid 2.17
    diethyl ether 5.37
    m-xylene 2.65
    p-xylene 1.8
    chlorobenzene 3.63
    dimethyl carbonate 3.78
    n-octane 0.06
    formamide 3.17
    cyclopentanone 11.8
    2-pentanone 7.0
    anisole 5.62
    cyclopentyl methyl ether 6.84
    gamma-butyrolactone 10.28
    1-methoxy-2-propanol 24.35
    pyridine 9.93
    3-pentanone 5.01
    furfural 9.39
    n-dodecane 0.03
    diethylene glycol 12.78
    diisopropyl ether 1.66
    tert-amyl alcohol 4.47
    acetylacetone 8.21
    n-hexadecane 0.04
    acetophenone 5.02
    methyl propionate 5.3
    isopentyl acetate 6.58
    trichloroethylene 10.27
    n-nonanol 2.58
    cyclohexanol 4.15
    benzyl alcohol 5.5
    2-ethylhexanol 2.42
    isooctanol 3.45
    dipropyl ether 3.19
    1,2-dichlorobenzene 3.41
    ethyl lactate 3.42
    propylene carbonate 5.45
    n-methylformamide 5.7
    2-pentanol 4.58
    n-pentane 0.23
    1-propoxy-2-propanol 16.88
    1-methoxy-2-propyl acetate 13.33
    2-(2-methoxypropoxy) propanol 10.49
    mesitylene 1.38
    ε-caprolactone 9.26
    p-cymene 1.21
    epichlorohydrin 14.16
    1,1,1-trichloroethane 4.6
    2-aminoethanol 4.54
    morpholine-4-carbaldehyde 19.33
    sulfolane 11.87
    2,2,4-trimethylpentane 0.18
    2-methyltetrahydrofuran 8.31
    n-hexyl acetate 6.11
    isooctane 0.16
    2-(2-butoxyethoxy)ethanol 13.79
    sec-butyl acetate 3.17
    tert-butyl acetate 7.65
    decalin 0.18
    glycerin 4.91
    diglyme 24.09
    acrylic acid 3.66
    isopropyl myristate 1.82
    n-butyric acid 8.16
    acetyl acetate 3.99
    di(2-ethylhexyl) phthalate 3.54
    ethyl propionate 3.63
    nitromethane 6.66
    1,2-diethoxyethane 6.55
    benzonitrile 3.26
    trioctyl phosphate 2.14
    1-bromopropane 2.72
    gamma-valerolactone 25.82
    n-decanol 1.36
    triethyl phosphate 2.58
    4-methyl-2-pentanol 3.53
    propionitrile 3.29
    vinylene carbonate 5.6
    1,1,2-trichlorotrifluoroethane 12.86
    DMS 5.14
    cumene 1.19
    2-octanol 1.97
    2-hexanone 4.63
    octyl acetate 2.44
    limonene 1.38
    1,2-dimethoxyethane 13.73
    ethyl orthosilicate 3.03
    tributyl phosphate 1.92
    diacetone alcohol 10.78
    N,N-dimethylaniline 3.93
    acrylonitrile 3.62
    aniline 5.51
    1,3-propanediol 9.76
    bromobenzene 3.24
    dibromomethane 4.4
    1,1,2,2-tetrachloroethane 8.3
    2-methyl-cyclohexyl acetate 4.59
    tetrabutyl urea 2.95
    diisobutyl methanol 1.82
    2-phenylethanol 8.22
    styrene 1.81
    dioctyl adipate 3.23
    dimethyl sulfate 5.68
    ethyl butyrate 3.62
    methyl lactate 5.86
    butyl lactate 6.97
    diethyl carbonate 2.31
    propanediol butyl ether 9.3
    triethyl orthoformate 4.46
    p-tert-butyltoluene 1.34
    methyl 4-tert-butylbenzoate 9.51
    morpholine 17.45
    tert-butylamine 2.92
    n-dodecanol 0.7
    dimethoxymethane 16.91
    ethylene carbonate 4.69
    cyrene 9.92
    2-ethoxyethyl acetate 10.98
    2-ethylhexyl acetate 4.62
    1,2,4-trichlorobenzene 4.89
    4-methylpyridine 8.31
    dibutyl ether 1.51
    2,6-dimethyl-4-heptanol 1.82
    DEF 6.79
    dimethyl isosorbide 17.25
    tetrachloroethylene 5.97
    eugenol 10.81
    triacetin 7.34
    span 80 8.57
    1,4-butanediol 3.03
    1,1-dichloroethane 4.32
    2-methyl-1-pentanol 4.04
    methyl formate 2.86
    2-methyl-1-butanol 5.36
    n-decane 0.09
    butyronitrile 3.89
    3,7-dimethyl-1-octanol 2.07
    1-chlorooctane 0.64
    1-chlorotetradecane 0.16
    n-nonane 0.07
    undecane 0.05
    tert-butylcyclohexane 0.19
    cyclooctane 0.09
    cyclopentanol 4.71
    tetrahydropyran 8.91
    tert-amyl methyl ether 3.67
    2,5,8-trioxanonane 13.98
    1-hexene 0.83
    2-isopropoxyethanol 8.23
    2,2,2-trifluoroethanol 2.68
    methyl butyrate 4.01

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction