2,5,5-Trimethyl-5,6,7,8-tetrahydroquinoline

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  • Identifiers

    CAS number
    136150-24-8

    Molecular formula
    C12H17N

    SMILES
    CC1=NC2=C(C=C1)C(CCC2)(C)C

    Safety labels

  • Odor profile

    Fragrance
    Animal 49.32%
    Earthy 44.65%
    Musk 43.06%
    Woody 41.61%
    Leathery 41.6%
    Tobacco 40.75%
    Sweet 38.29%
    Musty 33.6%
    Amber 33.12%
    Nutty 32.73%

     

    Flavor
    Earthy 44.06%
    Musty 40.14%
    Woody 38.29%
    Nutty 34.5%
    Roasted 29.95%
    Earth 28.04%
    Camphor 27.53%
    Tobacco 27.39%
    Leather 26.34%
    Burnt 25.7%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    3.4

    pKa est.
    7.07 (neutral)

    Molecular weight
    175.27 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately slow

    Boiling point est.
    240°C

    Flash point

    • 100.98 ˚C est.

  • Synonyms

    • 136150-24-8
    • 2,5,5-Trimethyl-5,6,7,8-tetrahydroquinoline
    • DTXSID10768306
    • 136150-24-8

  • Applications

    2,5,5-Trimethyl-5,6,7,8-tetrahydroquinoline is primarily used as a synthetic intermediate in medicinal chemistry, providing a saturated quinoline scaffold for the construction of heterocyclic amines and related frameworks; it is commonly employed as a building block in pharmaceutical research and process development. In fragrance and cosmetics, the compound may be evaluated as a fragrance intermediate or odorant precursor, contributing to scent profiles or serving as a scaffold for cosmetic ingredient development. In specialty chemicals, it may serve as a starting point for agrochemical research and for polymer additive development, supporting further functionalization to diversify chemistries. It can also be used in research settings as a precursor for synthesizing related saturated heterocycles and chiral amines for catalysis or materials science.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 201.21
    methanol 219.95
    isopropanol 157.22
    water 0.39
    ethyl acetate 345.07
    n-propanol 202.49
    acetone 340.95
    n-butanol 205.4
    acetonitrile 400.05
    DMF 406.74
    toluene 481.91
    isobutanol 168.37
    1,4-dioxane 932.81
    methyl acetate 347.48
    THF 1105.89
    2-butanone 346.95
    n-pentanol 146.94
    sec-butanol 153.45
    n-hexane 133.46
    ethylene glycol 20.67
    NMP 441.79
    cyclohexane 314.69
    DMSO 223.25
    n-butyl acetate 571.27
    n-octanol 181.0
    chloroform 1336.57
    n-propyl acetate 235.03
    acetic acid 143.83
    dichloromethane 1147.81
    cyclohexanone 731.1
    propylene glycol 37.67
    isopropyl acetate 210.68
    DMAc 330.93
    2-ethoxyethanol 130.3
    isopentanol 180.68
    n-heptane 187.96
    ethyl formate 275.53
    1,2-dichloroethane 575.18
    n-hexanol 441.01
    2-methoxyethanol 212.46
    isobutyl acetate 193.06
    tetrachloromethane 270.56
    n-pentyl acetate 257.13
    transcutol 545.88
    n-heptanol 176.65
    ethylbenzene 207.95
    MIBK 193.94
    2-propoxyethanol 403.87
    tert-butanol 187.35
    MTBE 286.92
    2-butoxyethanol 202.17
    propionic acid 149.9
    o-xylene 260.64
    formic acid 36.24
    diethyl ether 379.65
    m-xylene 290.38
    p-xylene 297.18
    chlorobenzene 549.1
    dimethyl carbonate 142.78
    n-octane 61.36
    formamide 61.4
    cyclopentanone 675.48
    2-pentanone 296.49
    anisole 270.54
    cyclopentyl methyl ether 510.77
    gamma-butyrolactone 658.34
    1-methoxy-2-propanol 167.13
    pyridine 710.97
    3-pentanone 290.87
    furfural 477.4
    n-dodecane 49.33
    diethylene glycol 167.08
    diisopropyl ether 141.18
    tert-amyl alcohol 162.57
    acetylacetone 280.64
    n-hexadecane 57.51
    acetophenone 234.16
    methyl propionate 275.24
    isopentyl acetate 430.45
    trichloroethylene 948.33
    n-nonanol 161.22
    cyclohexanol 287.65
    benzyl alcohol 184.92
    2-ethylhexanol 302.86
    isooctanol 137.79
    dipropyl ether 429.67
    1,2-dichlorobenzene 420.88
    ethyl lactate 88.64
    propylene carbonate 399.09
    n-methylformamide 192.83
    2-pentanol 131.5
    n-pentane 110.74
    1-propoxy-2-propanol 296.69
    1-methoxy-2-propyl acetate 336.21
    2-(2-methoxypropoxy) propanol 195.9
    mesitylene 185.26
    ε-caprolactone 511.32
    p-cymene 204.25
    epichlorohydrin 607.92
    1,1,1-trichloroethane 558.42
    2-aminoethanol 58.3
    morpholine-4-carbaldehyde 496.73
    sulfolane 487.98
    2,2,4-trimethylpentane 50.52
    2-methyltetrahydrofuran 720.57
    n-hexyl acetate 355.9
    isooctane 39.05
    2-(2-butoxyethoxy)ethanol 246.95
    sec-butyl acetate 163.45
    tert-butyl acetate 208.02
    decalin 103.27
    glycerin 48.26
    diglyme 465.58
    acrylic acid 122.52
    isopropyl myristate 159.29
    n-butyric acid 255.41
    acetyl acetate 219.11
    di(2-ethylhexyl) phthalate 147.05
    ethyl propionate 202.26
    nitromethane 278.42
    1,2-diethoxyethane 405.0
    benzonitrile 388.0
    trioctyl phosphate 110.11
    1-bromopropane 484.72
    gamma-valerolactone 690.49
    n-decanol 126.77
    triethyl phosphate 138.6
    4-methyl-2-pentanol 95.18
    propionitrile 376.57
    vinylene carbonate 417.31
    1,1,2-trichlorotrifluoroethane 251.87
    DMS 266.75
    cumene 151.33
    2-octanol 125.35
    2-hexanone 247.34
    octyl acetate 199.87
    limonene 296.51
    1,2-dimethoxyethane 376.01
    ethyl orthosilicate 143.14
    tributyl phosphate 138.85
    diacetone alcohol 170.01
    N,N-dimethylaniline 201.58
    acrylonitrile 351.27
    aniline 303.61
    1,3-propanediol 100.25
    bromobenzene 664.16
    dibromomethane 824.74
    1,1,2,2-tetrachloroethane 666.71
    2-methyl-cyclohexyl acetate 253.01
    tetrabutyl urea 172.53
    diisobutyl methanol 137.38
    2-phenylethanol 291.45
    styrene 242.4
    dioctyl adipate 183.99
    dimethyl sulfate 157.0
    ethyl butyrate 321.81
    methyl lactate 87.28
    butyl lactate 155.84
    diethyl carbonate 211.37
    propanediol butyl ether 150.2
    triethyl orthoformate 221.4
    p-tert-butyltoluene 190.73
    methyl 4-tert-butylbenzoate 224.55
    morpholine 743.78
    tert-butylamine 170.54
    n-dodecanol 106.47
    dimethoxymethane 339.76
    ethylene carbonate 374.02
    cyrene 178.35
    2-ethoxyethyl acetate 306.68
    2-ethylhexyl acetate 403.17
    1,2,4-trichlorobenzene 428.67
    4-methylpyridine 649.95
    dibutyl ether 313.14
    2,6-dimethyl-4-heptanol 137.38
    DEF 327.32
    dimethyl isosorbide 397.47
    tetrachloroethylene 489.15
    eugenol 192.02
    triacetin 249.27
    span 80 207.13
    1,4-butanediol 46.45
    1,1-dichloroethane 549.69
    2-methyl-1-pentanol 151.39
    methyl formate 201.25
    2-methyl-1-butanol 174.86
    n-decane 80.39
    butyronitrile 390.07
    3,7-dimethyl-1-octanol 175.34
    1-chlorooctane 207.93
    1-chlorotetradecane 95.02
    n-nonane 81.06
    undecane 61.53
    tert-butylcyclohexane 83.53
    cyclooctane 113.68
    cyclopentanol 274.11
    tetrahydropyran 900.92
    tert-amyl methyl ether 211.07
    2,5,8-trioxanonane 328.4
    1-hexene 270.56
    2-isopropoxyethanol 120.12
    2,2,2-trifluoroethanol 58.07
    methyl butyrate 257.52

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction