2,5-Dinitrophenol

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  • Identifiers

    CAS number
    329-71-5

    Molecular formula
    C6H4N2O5

    SMILES
    C1=CC(=C(C=C1[N+](=O)[O-])O)[N+](=O)[O-]

    Safety labels

    Acute Toxic
    Acute Toxic

    Health Hazard
    Health

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Odorless 57.51%
    Sweet 45.42%
    Phenolic 26.51%
    Powdery 26.32%
    Vanilla 25.5%
    Balsamic 24.9%
    Creamy 24.44%
    Burnt 23.77%
    Bitter 23.71%
    Fatty 23.19%

     

    Flavor
    Bitter 63.34%
    Odorless 53.84%
    Mild 30.28%
    Very mild 24.71%
    Bland 23.12%
    Nutty 21.37%
    Nitrile 21.21%
    Sweet-like 20.62%
    Bread crust 20.21%
    Yeast 20.14%

     

    Odor impact est.
    Low

    Odor threshold

    • Detection: 2.4 mg/L

  • Properties

    XLogP3-AA
    1.8

    pKa est.
    6.98 (neutral)

    Molecular weight
    184.11 g/mol

    Melting point expt.

    • 226.4 °F (USCG, 1999)
    • 108 °C
    • MP: also stated as 104 °C

    Flash point

    • 175.69 ˚C est.

    Solubility expt.

    • Soluble in ether, benzene
    • Slightly soluble in cold alcohol; soluble in hot alcohol, fixed alkali hydroxides
    • In water, 0.68 g/L
    • In water, 385 mg/L at 25 °C

  • Synonyms

    • 2,5-DINITROPHENOL
    • 329-71-5
    • Phenol, 2,5-dinitro-
    • gamma-Dinitrophenol
    • 2,5-DNP
    • 2,5-Dinitrofenol
    • .gamma.-Dinitrophenol
    • Phenol, gamma-dinitro-
    • Phenol, .gamma.-dinitro-
    • 2,5-Dinitrofenol [Czech]
    • CCRIS 3103
    • HSDB 6304
    • EINECS 206-348-1
    • UNII-HSD25Q268Z
    • NSC 90441
    • BRN 1913411
    • HSD25Q268Z
    • CHEBI:40810
    • NSC-90441
    • DTXSID9022021
    • 2,5-DINITROPHENOL [MI]
    • 2,5-DINITROPHENOL [HSDB]
    • 2,5-DINITROPHENOL (WETTED WITH CA. 20% WATER) (UNIT WEIGHT ON DRY WEIGHT BASIS)
    • 2,5-Dinitro-Phenol
    • 2,5-Dinitrophenol (Wetted with water >20%)
    • 2,5-Dinitrophenol ( betta )
    • gammaDinitrophenol
    • 2,5Dinitrofenol
    • Phenol, gammadinitro
    • Phenol, 2,5dinitro
    • WLN: WNR BQ DNW
    • 2,5-Dinitrophenol, 97%
    • 2,5-Dinitrofenol (Spanish)
    • SCHEMBL547995
    • 1-Hydroxy-2,5-dinitrobenzene
    • 2,5DNP
    • CHEMBL107513
    • DTXCID202021
    • SCHEMBL17347349
    • NSC90441
    • STK399770
    • AKOS003247471
    • DB-020135
    • D0841
    • NS00029395
    • T70783
    • A821536
    • Q15726130
    • F0001-0975
    • 206-348-1

  • Applications

    2,5-Dinitrophenol (CAS 329-71-5) is primarily used as a reactive building block in organic synthesis. In industry, it serves as an intermediate for the production of nitroaromatic dyes and pigments, and as a precursor for intermediates used in agrochemical and pharmaceutical manufacturing. It also appears as a precursor for functional nitroaromatic compounds in polymer and coatings applications. In laboratory settings, 2,5-Dinitrophenol can be employed as a reagent or intermediate in analytical and synthetic workflows, under appropriate handling and regulatory controls.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 70.56
    methanol 151.36
    isopropanol 41.88
    water 2.97
    ethyl acetate 139.13
    n-propanol 55.8
    acetone 308.35
    n-butanol 40.17
    acetonitrile 166.97
    DMF 651.44
    toluene 27.48
    isobutanol 27.7
    1,4-dioxane 213.91
    methyl acetate 188.35
    THF 301.39
    2-butanone 252.35
    n-pentanol 47.56
    sec-butanol 57.61
    n-hexane 2.37
    ethylene glycol 67.78
    NMP 376.11
    cyclohexane 2.75
    DMSO 864.17
    n-butyl acetate 85.69
    n-octanol 63.16
    chloroform 19.77
    n-propyl acetate 112.62
    acetic acid 56.78
    dichloromethane 42.18
    cyclohexanone 170.87
    propylene glycol 33.31
    isopropyl acetate 77.29
    DMAc 567.81
    2-ethoxyethanol 234.57
    isopentanol 32.78
    n-heptane 4.67
    ethyl formate 87.06
    1,2-dichloroethane 70.23
    n-hexanol 50.16
    2-methoxyethanol 266.03
    isobutyl acetate 27.73
    tetrachloromethane 4.06
    n-pentyl acetate 72.91
    transcutol 441.75
    n-heptanol 39.97
    ethylbenzene 20.47
    MIBK 76.42
    2-propoxyethanol 178.33
    tert-butanol 53.49
    MTBE 56.28
    2-butoxyethanol 96.84
    propionic acid 62.21
    o-xylene 28.38
    formic acid 93.43
    diethyl ether 98.57
    m-xylene 20.38
    p-xylene 20.17
    chlorobenzene 17.75
    dimethyl carbonate 108.4
    n-octane 4.02
    formamide 258.82
    cyclopentanone 237.31
    2-pentanone 165.44
    anisole 87.61
    cyclopentyl methyl ether 92.85
    gamma-butyrolactone 244.33
    1-methoxy-2-propanol 159.27
    pyridine 123.29
    3-pentanone 161.68
    furfural 181.09
    n-dodecane 5.04
    diethylene glycol 209.08
    diisopropyl ether 23.77
    tert-amyl alcohol 61.47
    acetylacetone 221.07
    n-hexadecane 5.72
    acetophenone 102.33
    methyl propionate 162.75
    isopentyl acetate 50.42
    trichloroethylene 74.98
    n-nonanol 60.69
    cyclohexanol 43.13
    benzyl alcohol 64.67
    2-ethylhexanol 32.79
    isooctanol 25.54
    dipropyl ether 48.06
    1,2-dichlorobenzene 19.03
    ethyl lactate 77.28
    propylene carbonate 77.55
    n-methylformamide 314.0
    2-pentanol 37.94
    n-pentane 2.88
    1-propoxy-2-propanol 105.59
    1-methoxy-2-propyl acetate 102.16
    2-(2-methoxypropoxy) propanol 126.54
    mesitylene 13.5
    ε-caprolactone 137.45
    p-cymene 15.82
    epichlorohydrin 233.15
    1,1,1-trichloroethane 23.63
    2-aminoethanol 67.48
    morpholine-4-carbaldehyde 375.08
    sulfolane 320.08
    2,2,4-trimethylpentane 2.08
    2-methyltetrahydrofuran 130.92
    n-hexyl acetate 100.26
    isooctane 1.31
    2-(2-butoxyethoxy)ethanol 180.43
    sec-butyl acetate 58.46
    tert-butyl acetate 82.34
    decalin 2.7
    glycerin 69.73
    diglyme 259.98
    acrylic acid 65.12
    isopropyl myristate 49.55
    n-butyric acid 49.05
    acetyl acetate 64.19
    di(2-ethylhexyl) phthalate 29.85
    ethyl propionate 112.39
    nitromethane 395.87
    1,2-diethoxyethane 152.43
    benzonitrile 59.66
    trioctyl phosphate 32.25
    1-bromopropane 29.49
    gamma-valerolactone 299.84
    n-decanol 50.38
    triethyl phosphate 39.52
    4-methyl-2-pentanol 20.56
    propionitrile 97.13
    vinylene carbonate 71.2
    1,1,2-trichlorotrifluoroethane 129.89
    DMS 92.43
    cumene 12.56
    2-octanol 39.38
    2-hexanone 138.7
    octyl acetate 71.86
    limonene 24.13
    1,2-dimethoxyethane 327.73
    ethyl orthosilicate 31.31
    tributyl phosphate 37.76
    diacetone alcohol 123.23
    N,N-dimethylaniline 57.87
    acrylonitrile 150.08
    aniline 40.54
    1,3-propanediol 78.96
    bromobenzene 12.71
    dibromomethane 23.03
    1,1,2,2-tetrachloroethane 58.77
    2-methyl-cyclohexyl acetate 46.12
    tetrabutyl urea 70.97
    diisobutyl methanol 19.78
    2-phenylethanol 66.4
    styrene 24.28
    dioctyl adipate 59.6
    dimethyl sulfate 203.25
    ethyl butyrate 72.84
    methyl lactate 116.68
    butyl lactate 60.65
    diethyl carbonate 44.45
    propanediol butyl ether 107.25
    triethyl orthoformate 44.73
    p-tert-butyltoluene 15.05
    methyl 4-tert-butylbenzoate 72.75
    morpholine 219.12
    tert-butylamine 21.34
    n-dodecanol 39.21
    dimethoxymethane 303.02
    ethylene carbonate 61.53
    cyrene 107.53
    2-ethoxyethyl acetate 115.14
    2-ethylhexyl acetate 42.61
    1,2,4-trichlorobenzene 25.59
    4-methylpyridine 103.75
    dibutyl ether 65.97
    2,6-dimethyl-4-heptanol 19.78
    DEF 243.88
    dimethyl isosorbide 149.82
    tetrachloroethylene 37.38
    eugenol 87.76
    triacetin 89.85
    span 80 81.62
    1,4-butanediol 55.34
    1,1-dichloroethane 29.74
    2-methyl-1-pentanol 37.59
    methyl formate 240.99
    2-methyl-1-butanol 34.23
    n-decane 7.79
    butyronitrile 62.85
    3,7-dimethyl-1-octanol 40.99
    1-chlorooctane 30.24
    1-chlorotetradecane 14.52
    n-nonane 6.79
    undecane 6.4
    tert-butylcyclohexane 2.13
    cyclooctane 1.84
    cyclopentanol 45.4
    tetrahydropyran 106.73
    tert-amyl methyl ether 68.13
    2,5,8-trioxanonane 215.25
    1-hexene 12.48
    2-isopropoxyethanol 128.71
    2,2,2-trifluoroethanol 49.96
    methyl butyrate 129.27

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction