2,5-Dimethyloxazole

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  • Identifiers

    CAS number
    23012-11-5

    Molecular formula
    C5H7NO

    SMILES
    CC1=CN=C(O1)C

    Safety labels

    Flammable
    Flammable

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Green 74.85%
    Nutty 71.73%
    Roasted 67.19%
    Meaty 56.42%
    Vegetable 54.21%
    Sweet 47.55%
    Musty 46.87%
    Burnt 46.68%
    Cocoa 45.93%
    Earthy 43.7%

     

    Flavor
    Roasted 63.26%
    Nutty 58.37%
    Coffee 52.44%
    Burnt 44.06%
    Cocoa 42.89%
    Roast 39.89%
    Vegetable 37.08%
    Chocolate 35.62%
    Meaty 35.14%
    Musty 33.97%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.1

    pKa est.
    5.22 (weak acid)

    Molecular weight
    97.12 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point

    • 117.00 to 118.00 °C. @ 760.00 mm Hg

    Flash point

    • 21.33 ˚C est.

  • Synonyms

    • 2,5-Dimethyloxazole
    • 23012-11-5
    • 2,5-dimethyl-1,3-oxazole
    • Oxazole, 2,5-dimethyl-
    • Oxazole, 2,5-dimethyl
    • EINECS 245-380-0
    • UNII-9N2TP6H91D
    • 9N2TP6H91D
    • DTXSID80177567
    • RefChem:82965
    • DTXCID40100058
    • 245-380-0
    • NSAUQTCATRWAJC-UHFFFAOYSA-N
    • 2,5-dimethyl-oxazole
    • MFCD18250011
    • SCHEMBL74349
    • SCHEMBL268792
    • SCHEMBL5536350
    • SCHEMBL5537140
    • CHEBI:195691
    • YAA01211
    • AC5679
    • AKOS027326012
    • AB72158
    • SY040818
    • CS-0214804
    • NS00048224
    • EN300-194809
    • Q27272771
    • 23012-11-5

  • Applications

    Chemical name: 2,5-Dimethyloxazole; CAS number: 23012-11-5. 2,5-Dimethyloxazole is used primarily as an intermediate and building block in organic synthesis. In industrial practice, it is commonly evaluated as a precursor to heterocyclic compounds in pharmaceutical and agrochemical research and development. It also serves as a scaffold for medicinal chemistry explorations and as a starting material for oxazole-containing polymers in materials science. Additionally, it is used in R&D workflows as a general reagent for heterocycle synthesis, supporting library generation and process development.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 431.11
    methanol 585.64
    isopropanol 344.46
    water 103.21
    ethyl acetate 250.67
    n-propanol 353.4
    acetone 344.02
    n-butanol 318.35
    acetonitrile 289.36
    DMF 584.92
    toluene 175.96
    isobutanol 308.72
    1,4-dioxane 450.02
    methyl acetate 293.43
    THF 565.91
    2-butanone 288.81
    n-pentanol 207.73
    sec-butanol 330.08
    n-hexane 54.53
    ethylene glycol 222.55
    NMP 662.5
    cyclohexane 57.14
    DMSO 499.82
    n-butyl acetate 93.2
    n-octanol 104.76
    chloroform 569.83
    n-propyl acetate 95.08
    acetic acid 389.26
    dichloromethane 610.38
    cyclohexanone 286.83
    propylene glycol 239.45
    isopropyl acetate 145.1
    DMAc 680.03
    2-ethoxyethanol 337.39
    isopentanol 259.97
    n-heptane 29.08
    ethyl formate 176.77
    1,2-dichloroethane 297.47
    n-hexanol 152.24
    2-methoxyethanol 632.05
    isobutyl acetate 68.43
    tetrachloromethane 150.08
    n-pentyl acetate 91.17
    transcutol 479.19
    n-heptanol 80.81
    ethylbenzene 69.34
    MIBK 134.24
    2-propoxyethanol 296.92
    tert-butanol 402.26
    MTBE 308.01
    2-butoxyethanol 149.69
    propionic acid 258.92
    o-xylene 124.21
    formic acid 339.19
    diethyl ether 302.27
    m-xylene 125.32
    p-xylene 95.0
    chlorobenzene 179.72
    dimethyl carbonate 127.81
    n-octane 14.31
    formamide 368.68
    cyclopentanone 344.82
    2-pentanone 215.53
    anisole 166.88
    cyclopentyl methyl ether 300.59
    gamma-butyrolactone 391.33
    1-methoxy-2-propanol 434.1
    pyridine 300.75
    3-pentanone 196.02
    furfural 406.17
    n-dodecane 14.83
    diethylene glycol 266.53
    diisopropyl ether 93.93
    tert-amyl alcohol 379.71
    acetylacetone 229.31
    n-hexadecane 15.87
    acetophenone 126.86
    methyl propionate 243.91
    isopentyl acetate 88.2
    trichloroethylene 452.11
    n-nonanol 92.16
    cyclohexanol 258.95
    benzyl alcohol 143.42
    2-ethylhexanol 90.77
    isooctanol 68.69
    dipropyl ether 97.53
    1,2-dichlorobenzene 157.46
    ethyl lactate 74.67
    propylene carbonate 189.88
    n-methylformamide 343.66
    2-pentanol 211.87
    n-pentane 64.29
    1-propoxy-2-propanol 174.62
    1-methoxy-2-propyl acetate 133.03
    2-(2-methoxypropoxy) propanol 160.88
    mesitylene 75.35
    ε-caprolactone 256.76
    p-cymene 47.45
    epichlorohydrin 462.28
    1,1,1-trichloroethane 316.95
    2-aminoethanol 334.48
    morpholine-4-carbaldehyde 541.85
    sulfolane 420.69
    2,2,4-trimethylpentane 42.44
    2-methyltetrahydrofuran 473.72
    n-hexyl acetate 143.06
    isooctane 22.38
    2-(2-butoxyethoxy)ethanol 197.03
    sec-butyl acetate 79.34
    tert-butyl acetate 155.66
    decalin 35.51
    glycerin 327.43
    diglyme 308.87
    acrylic acid 250.35
    isopropyl myristate 61.14
    n-butyric acid 255.64
    acetyl acetate 148.98
    di(2-ethylhexyl) phthalate 72.94
    ethyl propionate 110.41
    nitromethane 497.29
    1,2-diethoxyethane 148.32
    benzonitrile 141.96
    trioctyl phosphate 48.31
    1-bromopropane 242.74
    gamma-valerolactone 461.39
    n-decanol 67.8
    triethyl phosphate 56.8
    4-methyl-2-pentanol 110.1
    propionitrile 220.91
    vinylene carbonate 196.63
    1,1,2-trichlorotrifluoroethane 343.48
    DMS 120.5
    cumene 58.11
    2-octanol 67.7
    2-hexanone 115.92
    octyl acetate 82.28
    limonene 72.86
    1,2-dimethoxyethane 361.83
    ethyl orthosilicate 58.98
    tributyl phosphate 58.98
    diacetone alcohol 185.9
    N,N-dimethylaniline 134.16
    acrylonitrile 233.51
    aniline 232.42
    1,3-propanediol 351.5
    bromobenzene 170.51
    dibromomethane 385.89
    1,1,2,2-tetrachloroethane 356.19
    2-methyl-cyclohexyl acetate 80.66
    tetrabutyl urea 80.97
    diisobutyl methanol 54.61
    2-phenylethanol 115.66
    styrene 86.23
    dioctyl adipate 84.14
    dimethyl sulfate 217.56
    ethyl butyrate 77.41
    methyl lactate 153.6
    butyl lactate 77.07
    diethyl carbonate 59.16
    propanediol butyl ether 151.9
    triethyl orthoformate 67.22
    p-tert-butyltoluene 49.11
    methyl 4-tert-butylbenzoate 143.26
    morpholine 519.56
    tert-butylamine 281.86
    n-dodecanol 53.24
    dimethoxymethane 370.63
    ethylene carbonate 158.35
    cyrene 155.8
    2-ethoxyethyl acetate 137.49
    2-ethylhexyl acetate 74.35
    1,2,4-trichlorobenzene 193.8
    4-methylpyridine 319.15
    dibutyl ether 93.68
    2,6-dimethyl-4-heptanol 54.61
    DEF 300.07
    dimethyl isosorbide 222.93
    tetrachloroethylene 237.99
    eugenol 132.17
    triacetin 145.05
    span 80 128.54
    1,4-butanediol 164.08
    1,1-dichloroethane 360.03
    2-methyl-1-pentanol 192.01
    methyl formate 256.39
    2-methyl-1-butanol 292.61
    n-decane 21.01
    butyronitrile 213.96
    3,7-dimethyl-1-octanol 102.67
    1-chlorooctane 68.11
    1-chlorotetradecane 32.57
    n-nonane 21.05
    undecane 17.15
    tert-butylcyclohexane 38.49
    cyclooctane 23.84
    cyclopentanol 313.1
    tetrahydropyran 347.82
    tert-amyl methyl ether 265.51
    2,5,8-trioxanonane 238.54
    1-hexene 105.75
    2-isopropoxyethanol 219.11
    2,2,2-trifluoroethanol 196.84
    methyl butyrate 131.1

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction